Searching for up to 100 curated homologs for PP_1379 FitnessBrowser__Putida:PP_1379 (450 a.a.)
Found high-coverage hits (≥70%) to 64 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
RR42_RS32055 3-carboxymuconate cycloisomerase PcaB (EC 5.5.1.2) from Cupriavidus basilensis FW507-4G11
54% identity, 95% coverage of query (408 bits)
pcaB / AAC37149.1 beta-carboxy-cis,cis-muconate cycloisomerase from Acinetobacter baylyi (see 11 papers)
47% identity, 96% coverage of query (393 bits)
YBN5_SCHPO / O42889 Uncharacterized protein C8E4.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 97% coverage of query (349 bits)
pcaB2 / Q2HNY9 3-carboxymuconate lactonizing enzyme type 2 (EC 5.5.1.2) from Hydrogenophaga intermedia (see 2 papers)
44% identity, 92% coverage of query (325 bits)
TAD1 / A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
TAD1_USTMD / A0A0U2UYC4 Trans-aconitate decarboxylase 1; Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein TAD1; EC 4.1.1.113 from Ustilago maydis (Corn smut fungus) (see 2 papers)
A0A0U2UYC4 trans-aconitate decarboxylase (EC 4.1.1.113) from Ustilago maydis (see paper)
38% identity, 96% coverage of query (313 bits)
2SL_DICD3 / E0SKP1 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
39% identity, 96% coverage of query (292 bits)
2SL_ENTI1 / E6LDH5 N-acetyl-S-(2-succino)cysteine lyase; S-(2-succino) lyase; 2SL; EC 4.3.2.- from Enterococcus italicus (strain DSM 15952 / CCUG 50447 / LMG 22039 / TP 1.5) (see paper)
37% identity, 94% coverage of query (277 bits)
creD / A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
CRED_STRCM / A0A0K2JL82 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces cremeus (see 3 papers)
A0A0K2JL82 nitrosuccinate lyase (EC 4.3.99.5) from Streptomyces cremeus (see paper)
42% identity, 96% coverage of query (265 bits)
CREDH_STRDJ / K4R6W4 Nitrosuccinate lyase; EC 4.3.99.5 from Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768) (see paper)
42% identity, 95% coverage of query (264 bits)
MJ0929 / Q58339 adenylosuccinate lyase (EC 4.3.2.2) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
35% identity, 95% coverage of query (258 bits)
5xnzA / A0A0K2JL82 Crystal structure of cred complex with fumarate (see paper)
41% identity, 96% coverage of query (251 bits)
PUR8_STAAW / Q7A0G9 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Staphylococcus aureus (strain MW2) (see paper)
Q7A0G9 adenylosuccinate lyase (EC 4.3.2.2) from Staphylococcus aureus (see paper)
30% identity, 96% coverage of query (202 bits)
2x75A / Q7A0G9 Staphylococcus aureus adenylosuccinate lyase (see paper)
30% identity, 96% coverage of query (196 bits)
Q2HNZ1 3-Carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2) from Agrobacterium tumefaciens (see paper)
37% identity, 76% coverage of query (194 bits)
PUR8_BACSU / P12047 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; Glutamyl--tRNA ligase regulatory factor; EC 4.3.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
P12047 adenylosuccinate lyase (EC 4.3.2.2) from Bacillus subtilis (see paper)
purB / GI|143366 (glutamyl-trna synthetase regulatory factor); EC 4.3.2.2 from Bacillus subtilis (see 4 papers)
30% identity, 94% coverage of query (191 bits)
toyF / B6CWI9 succinylo-toyocamycin phosphate lyase from Streptomyces rimosus (see paper)
36% identity, 99% coverage of query (189 bits)
pcaB / AAF34266.1 3-carboxy-cis,cis-muconate cycloisomerase from Agrobacterium tumefaciens (see 2 papers)
36% identity, 79% coverage of query (187 bits)
Build an alignment for PP_1379 and 17 homologs with ≥ 30% identity
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PUR8_THEMA / Q9X0I0 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
27% identity, 94% coverage of query (175 bits)
Q8ZY28 adenylosuccinate lyase (EC 4.3.2.2) from Pyrobaculum aerophilum (see paper)
29% identity, 81% coverage of query (108 bits)
4eeiB / Q5NIQ1 Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with amp and succinate
23% identity, 90% coverage of query (105 bits)
5hw2A Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with fumaric acid
25% identity, 76% coverage of query (103 bits)
ADSL / P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 3 papers)
PUR8_HUMAN / P30566 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Homo sapiens (Human) (see 14 papers)
P30566 adenylosuccinate lyase (EC 4.3.2.2) from Homo sapiens (see 5 papers)
27% identity, 97% coverage of query (94.0 bits)
B2LS18 adenylosuccinate lyase (EC 4.3.2.2) from Ctenopharyngodon idella (see paper)
26% identity, 97% coverage of query (93.2 bits)
5nx9D / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
26% identity, 97% coverage of query (91.7 bits)
ADE13 enzyme of adenine biosynthesis from Candida albicans (see paper)
25% identity, 94% coverage of query (84.0 bits)
PUR8_CHICK / P21265 Adenylosuccinate lyase; ADSL; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Gallus gallus (Chicken) (see paper)
26% identity, 95% coverage of query (81.6 bits)
purB / AAA92731.1 adenylosuccinate lyase from Escherichia coli (see paper)
26% identity, 94% coverage of query (80.5 bits)
2ptqA Crystal structure of escherichia coli adenylosuccinate lyase mutant h171n with bound amp and fumarate
26% identity, 94% coverage of query (78.6 bits)
Ade / b1131 adenylosuccinate lyase (EC 4.3.2.2) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
purB / P0AB89 adenylosuccinate lyase (EC 4.3.2.2) from Escherichia coli (strain K12) (see 8 papers)
PUR8_ECOLI / P0AB89 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Escherichia coli (strain K12) (see 3 papers)
purB / MB|P0AB89 adenylosuccinate lyase from Escherichia coli K12 (see 2 papers)
26% identity, 94% coverage of query (77.8 bits)
3gzhA / Q8X737 Crystal structure of phosphate-bound adenylosuccinate lyase from e. Coli (see paper)
26% identity, 94% coverage of query (77.0 bits)
Q8X737 adenylosuccinate lyase (EC 4.3.2.2) from Escherichia coli (see paper)
26% identity, 94% coverage of query (77.0 bits)
D3ZW08 adenylosuccinate lyase (EC 4.3.2.2) from Rattus norvegicus (see paper)
25% identity, 97% coverage of query (75.9 bits)
Q8NRN8 fumarate hydratase (EC 4.2.1.2) from Corynebacterium glutamicum (see 2 papers)
28% identity, 73% coverage of query (74.3 bits)
5nxaB Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
27% identity, 77% coverage of query (74.3 bits)
ade13 / Q05911 Ade13 (EC 4.3.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
25% identity, 94% coverage of query (73.9 bits)
PUR8_VIBC3 / A0A0H3AL67 Adenylosuccinate lyase; ASL; Adenylosuccinase; EC 4.3.2.2 from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) (see paper)
24% identity, 94% coverage of query (73.9 bits)
Q05911 Adenylosuccinate lyase; ASL; Adenylosuccinase; ASase; EC 4.3.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
25% identity, 94% coverage of query (73.9 bits)
5nxaA Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate
25% identity, 97% coverage of query (73.2 bits)
5vkwB / A0A1D8PT56 Crystal structure of adenylosuccinate lyase ade13 from candida albicans
24% identity, 94% coverage of query (72.8 bits)
Q9P870 argininosuccinate lyase (EC 4.3.2.1) from Agaricus bisporus (see paper)
27% identity, 73% coverage of query (71.6 bits)
5eytA / G4VQX9 Crystal structure of adenylosuccinate lyase from schistosoma mansoni in complex with amp (see paper)
25% identity, 77% coverage of query (70.9 bits)
Q5SKT5 fumarate hydratase (EC 4.2.1.2) from Thermus thermophilus (see paper)
26% identity, 94% coverage of query (70.5 bits)
5nx9C / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl) in complex with its products amp and fumarate (see paper)
25% identity, 97% coverage of query (69.3 bits)
ade8 / RF|NP_596735.1 adenylosuccinate lyase Ade8; EC 4.3.2.2 from Schizosaccharomyces pombe (see paper)
25% identity, 76% coverage of query (68.9 bits)
2qgaC / A5KBL5 Plasmodium vivax adenylosuccinate lyase pv003765 with amp bound
24% identity, 80% coverage of query (68.2 bits)
ARG4 argininosuccinate lyase from Candida albicans (see paper)
22% identity, 78% coverage of query (67.0 bits)
FUMC_SACS2 / P39461 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
P39461 fumarate hydratase (EC 4.2.1.2) from Saccharolobus solfataricus (see paper)
23% identity, 73% coverage of query (67.0 bits)
2e9fB / Q5SLL0 Crystal structure of t.Th.Hb8 argininosuccinate lyase complexed with l-arginine
29% identity, 71% coverage of query (66.2 bits)
FUMC_RICPR / Q9ZCQ4 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Rickettsia prowazekii (strain Madrid E) (see paper)
Q9ZCQ4 fumarate hydratase (EC 4.2.1.2) from Rickettsia prowazekii (see paper)
27% identity, 73% coverage of query (65.9 bits)
5nxaC / A0A384E0N4 Crystal structure of neanderthal adenylosuccinate lyase (adsl)in complex with its products aicar and fumarate (see paper)
24% identity, 97% coverage of query (65.5 bits)
1tj7B / P11447 Structure determination and refinement at 2.44 a resolution of argininosuccinate lyase from e. Coli (see paper)
25% identity, 75% coverage of query (65.1 bits)
FUMH_YEAST / P08417 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
P08417 fumarate hydratase (EC 4.2.1.2) from Saccharomyces cerevisiae (see 2 papers)
25% identity, 81% coverage of query (60.8 bits)
4adlA Crystal structures of rv1098c in complex with malate
28% identity, 73% coverage of query (56.6 bits)
FUMC_MYCTU / P9WN93 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WN93 fumarate hydratase (EC 4.2.1.2) from Mycobacterium tuberculosis (see paper)
28% identity, 73% coverage of query (56.2 bits)
4apbD / P9WN93 Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate (see paper)
28% identity, 73% coverage of query (54.7 bits)
3r6qA A triclinic-lattice structure of aspartase from bacillus sp. Ym55-1
21% identity, 71% coverage of query (48.9 bits)
6s7zA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-((3,4-dihydroisoquinolin-2(1h)- yl)sulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl) acetamide
27% identity, 73% coverage of query (46.2 bits)
6s88A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-((1,2,4,5-tetrahydro- 3h-benzo[d]azepin-3-yl)sulfonyl)phenyl)-2-(4-oxo-3,4- dihydrophthalazin-1-yl)acetamide
27% identity, 73% coverage of query (46.2 bits)
6s7wA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(quinolin-4-yl)acetamide
27% identity, 73% coverage of query (46.2 bits)
6s7sA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-(n-phenylsulfamoyl) phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
27% identity, 73% coverage of query (46.2 bits)
5f91A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator (n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)
26% identity, 73% coverage of query (44.3 bits)
6s7uA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(1h-indol-3-yl)acetamide
26% identity, 73% coverage of query (44.3 bits)
6s7kA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-(n-methylsulfamoyl) phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
26% identity, 73% coverage of query (44.3 bits)
6s43A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azocan-1-ylsulfonyl)-2- methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
26% identity, 73% coverage of query (44.3 bits)
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