Searching for up to 100 curated homologs for PP_1458 FitnessBrowser__Putida:PP_1458 (432 a.a.)
Found high-coverage hits (≥70%) to 34 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YhjE / b3523 putative transporter YhjE from Escherichia coli K-12 substr. MG1655 (see 3 papers)
TC 2.A.1.6.10 / P37643 Inner membrane metabolite transport protein YhjE from Escherichia coli (strain K12) (see 4 papers)
55% identity, 97% coverage of query (383 bits)
ABAF_ACIBT / P0DPR5 Fosfomycin resistance protein AbaF; Acinetobacter baumannii fosfomycin efflux from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see paper)
37% identity, 96% coverage of query (282 bits)
YeeM / b1981 shikimate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
shiA / P76350 shikimate:H+ symporter from Escherichia coli (strain K12) (see 3 papers)
SHIA_ECOLI / P76350 Shikimate transporter; Shikimate permease from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.1.6.6 / P76350 Shikimate:H+ symporter from Escherichia coli (see 5 papers)
37% identity, 99% coverage of query (270 bits)
TC 2.A.1.6.5 / Q45082 4-Methyl-o-phthalate:H+ symporter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
36% identity, 100% coverage of query (246 bits)
ProP proline/betaine MFS transporter / b4111 osmolyte:H+ symporter ProP from Escherichia coli K-12 substr. MG1655 (see 64 papers)
proP / P0C0L7 osmolyte:H+ symporter ProP from Escherichia coli (strain K12) (see 66 papers)
PROP_ECOLI / P0C0L7 Proline/betaine transporter; Proline porter II; PPII from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.6.4 / P0C0L7 (Proline/glycine-betaine):(H+/Na+) symporter, ProP (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1-carboxymethyl-pyridinium) (subject to osmotic activation). Transmembrane helix I and periplasmic loop 1 are involved in osmosensing and osmoprotectant transport from Escherichia coli (see 6 papers)
proP / RF|NP_418535 proline porter II from Escherichia coli K12 (see 22 papers)
proP / AAB00919.1 a proline/betaine transporter from Escherichia coli (see paper)
34% identity, 96% coverage of query (241 bits)
SHIA_CORGB / A4QH18 Shikimate transporter; Shikimate permease from Corynebacterium glutamicum (strain R) (see paper)
38% identity, 100% coverage of query (238 bits)
OUSA_DICD3 / Q47421 Glycine betaine/proline/ectoine/pipecolic acid transporter OusA; Osmoprotectant uptake system A from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see 3 papers)
33% identity, 96% coverage of query (220 bits)
TC 2.A.1.6.13 / M1Q159 Acetate/monochloroacetate permease, Deh4p, of 468 aas and 12 TMSs from Dehalococcoides mccartyi DCMB5
33% identity, 96% coverage of query (212 bits)
AO353_03810 Alpha-ketoglutarate permease, MFS superfamily from Pseudomonas fluorescens FW300-N2E3
34% identity, 98% coverage of query (204 bits)
AO356_17790 alpha-ketoglutarate permease (MHS family) from Pseudomonas fluorescens FW300-N2C3
34% identity, 98% coverage of query (199 bits)
YdfJ / b1543 putative transporter YdfJ from Escherichia coli K-12 substr. MG1655 (see 3 papers)
YDFJ_ECOLI / P77228 Putative transporter YdfJ from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.6.9 / P77228 YdfJ. Can function as an inward rectifying K+ channel when expressed in animal cells as measured by whole cell patch clamping. Blocked by barium and protopine from Escherichia coli (strain K12) (see 4 papers)
33% identity, 92% coverage of query (197 bits)
TC 2.A.1.6.8 / Q7X4L6 The acetate/monochloroacetate (haloacid) permease, Deh4p (Km = 5.5 mμM for acetate; 9 mμM for monochloroacetate) from Burkholderia cepacia (see 2 papers)
37% identity, 72% coverage of query (184 bits)
TC 2.A.1.6.11 / F8SVK1 Acetate/haloacid transporter, Dehp2, with a possible atypical topology from Burkholderia sp. MBA4
33% identity, 76% coverage of query (173 bits)
WitA / b2587 α-ketoglutarate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 6 papers)
kgtP / P0AEX3 α-ketoglutarate:H+ symporter from Escherichia coli (strain K12) (see 6 papers)
KGTP_ECOLI / P0AEX3 Alpha-ketoglutarate permease from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.6.2 / P0AEX3 α-Ketoglutarate (oxoglutarate):H+ symporter from Escherichia coli (see 9 papers)
33% identity, 93% coverage of query (167 bits)
TC 2.A.1.6.1 / P16482 Citrate:H+ symporter from Klebsiella pneumoniae (see paper)
30% identity, 97% coverage of query (164 bits)
HSERO_RS16820 2-oxoglutarate:H+ symporter from Herbaspirillum seropedicae SmR1
31% identity, 100% coverage of query (164 bits)
Build an alignment for PP_1458 and 16 homologs with ≥ 30% identity
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citA / GB|AAA88472.1 citrate transporter from Escherichia coli (see paper)
29% identity, 90% coverage of query (161 bits)
tcuC / P0A2G3 propane-1,2,3-tricarboxylate-proton symporter from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
CITA_SALTY / P0A2G3 Citrate-proton symporter; Citrate carrier protein; Citrate transporter; Citrate utilization determinant; Citrate utilization protein A from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 2.A.1.6.7 / P0A2G3 The citrate/tricarballylate:H+ symporter (CitA or TcuC); probably orthologous to 2.A.1.6.1 from Salmonella typhimurium (see 2 papers)
29% identity, 93% coverage of query (158 bits)
TC 2.A.1.6.3 / Q52000 Dicarboxylate:H+ symporter from Pseudomonas putida
32% identity, 93% coverage of query (155 bits)
PROP_CORGL / Q79VC4 Ectoine/proline transporter ProP from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
29% identity, 95% coverage of query (154 bits)
TC 3.A.7.9.1 / Q5ZYB5 TphA aka ProP, component of The Icm/Dot or Dot/Icm multicomponent protein secretion system. IcmS and IcmW form a complex that interacts with and may translocate substrate proteins (Ninio et al., 2005; De Buck et al., 2007; Cambronne and Roy, 2007). The crystal structure of the IcmR-IcmQ complex has been solved (Raychaudhury et al., 2009). Legionella pneumophila survives and replicates inside host cells by secreting ~300 effectors through the defective in organelle trafficking (Dot)/intracellular multiplication (Icm) type IVB secretion system (T4BSS). Ghosal et al. 2019, using electron cryotomography mapped the location of the core and accessory components of the Legionella core transmembrane subcomplex, revealing a well-ordered central channel that opens into a large, windowed secretion chamber with an unusual 13-fold symmetry. Immunofluorescence microscopy deciphered an early-stage assembly process that begins with the targeting of Dot/Icm components to the bacterial poles. Polar targeting of this T4BSS is mediated by two Dot/Icm proteins, DotU and IcmF, that are homologues of the T6SS membrane complex components TssL and TssM, suggesting that the Dot/Icm T4BSS is a hybrid system. Thus, the Dot/Icm complex assembles in an 'axial-to-peripheral' pattern from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) (see paper)
33% identity, 87% coverage of query (152 bits)
TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
28% identity, 80% coverage of query (87.8 bits)
NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
NANX_ECOLI / P39352 Sialic acid transporter NanX from Escherichia coli (strain K12) (see 3 papers)
25% identity, 93% coverage of query (72.4 bits)
8et8A Cryo-em structure of the organic cation transporter 1 in complex with verapamil
24% identity, 83% coverage of query (56.6 bits)
8et7A / O15245 Cryo-em structure of the organic cation transporter 1 in complex with diphenhydramine (see paper)
24% identity, 83% coverage of query (56.6 bits)
8jtzA / O15245 Hoct1 in complex with spironolactone in outward facing partially occluded conformation (see paper)
26% identity, 92% coverage of query (55.1 bits)
8jttA Hoct1 in complex with metformin in outward occluded conformation
26% identity, 82% coverage of query (55.1 bits)
S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
26% identity, 92% coverage of query (54.7 bits)
S22A1_RAT / Q63089 Solute carrier family 22 member 1; Organic cation transporter 1; rOCT1 from Rattus norvegicus (Rat) (see 27 papers)
TC 2.A.1.19.1 / Q63089 The basolateral multivalent, potential-sensitive, organic cation (tetramethyl-ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-transmitters, etc.) transporter (uni-porter)-1, Oct1 from Rattus norvegicus (Rat) (see 18 papers)
24% identity, 75% coverage of query (49.7 bits)
8sc2A / O15245 Human oct1 bound to diltiazem in inward-open conformation (see paper)
27% identity, 74% coverage of query (49.3 bits)
S22A1_MOUSE / O08966 Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1 from Mus musculus (Mouse) (see 12 papers)
24% identity, 75% coverage of query (47.8 bits)
8et9A / O15244 Cryo-em structure of the organic cation transporter 2 in complex with 1-methyl-4-phenylpyridinium (see paper)
24% identity, 83% coverage of query (47.4 bits)
S22A2_RAT / Q9R0W2 Solute carrier family 22 member 2; Organic cation transporter 2; rOCT2 from Rattus norvegicus (Rat) (see 15 papers)
TC 2.A.1.19.19 / Q9R0W2 The rat kidney basolateral potential-driven symport carrier, Oct2 (transports tetraethylammonium and many other organic cations) from Rattus norvegicus (see 12 papers)
21% identity, 75% coverage of query (46.6 bits)
8sc6A Human oct1 bound to thiamine in inward-open conformation
28% identity, 74% coverage of query (46.2 bits)
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Lawrence Berkeley National Laboratory