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Searching for up to 100 curated homologs for PP_1722 PP_1722 ABC transporter, ATP-binding protein (329 a.a.)

Found high-coverage hits (≥70%) to 66 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    55% identity, 80% coverage of query (286 bits)

TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
    45% identity, 86% coverage of query (268 bits)

TC 3.A.1.1.5 / P54933 SmoK aka POLK, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (see paper)
    46% identity, 89% coverage of query (255 bits)

TC 3.A.1.20.2 / Q9KLQ5 Fe(3+) ions import ATP-binding protein FbpC, component of Hexose-phosphate transporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    40% identity, 98% coverage of query (254 bits)

YagC / b0262 CP4-6 prophage; ABC transporter ATP-binding protein AfuC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    45% identity, 82% coverage of query (253 bits)

PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
    43% identity, 90% coverage of query (252 bits)

TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
    41% identity, 90% coverage of query (247 bits)

A0A142UTH4 ABC-type polyamine transporter (subunit 4/4) (EC 7.6.2.11) from Streptococcus suis (see paper)
    45% identity, 86% coverage of query (243 bits)

Q8YM92 ABC-type polyamine transporter (subunit 3/3) (EC 7.6.2.11) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    48% identity, 73% coverage of query (242 bits)

TC 3.A.1.11.7 / Q97Q42 Spermidine/putrescine import ATP-binding protein PotA, component of The spermidine/putrescine uptake porter, PotABCD from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    44% identity, 86% coverage of query (240 bits)

2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
    47% identity, 74% coverage of query (235 bits)

SMc04256 ABC transporter for D-Cellobiose and D-Salicin, ATPase component from Sinorhizobium meliloti 1021
    49% identity, 73% coverage of query (235 bits)

TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
    43% identity, 87% coverage of query (235 bits)

SM_b20002 ABC transporter for Lactose, ATPase component from Sinorhizobium meliloti 1021
    49% identity, 72% coverage of query (234 bits)

PHNT_SALTY / P96063 Putative 2-aminoethylphosphonate import ATP-binding protein PhnT from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.11.5 / P96063 PhnT aka STM0428, component of 2-aminoethyl phosphonate porter from Salmonella typhimurium (see 2 papers)
    49% identity, 73% coverage of query (234 bits)

Psest_0871 maltose ABC transporter, ATPase component MalK from Pseudomonas stutzeri RCH2
    49% identity, 72% coverage of query (234 bits)

TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    48% identity, 74% coverage of query (232 bits)

PGA1_c13180 ABC transporter for D-Sorbitol, ATPase component from Phaeobacter inhibens BS107
    41% identity, 99% coverage of query (232 bits)

TC 3.A.1.11.3 / Q44383 MotB, component of Mannopine porter from Agrobacterium tumefaciens (see paper)
    47% identity, 74% coverage of query (231 bits)

mtlK / Q4KC54 polyol ABC-type transporterATP-binding component MtlK from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    43% identity, 82% coverage of query (231 bits)

TC 3.A.1.1.12 / Q9AI63 PalK, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    49% identity, 74% coverage of query (231 bits)

HSERO_RS17020 ABC transporter for D-sorbitol/xylitol, ATPase component from Herbaspirillum seropedicae SmR1
    51% identity, 72% coverage of query (230 bits)

TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    47% identity, 72% coverage of query (230 bits)

AO356_00010 ABC transporter for D-Sorbitol, ATPase component from Pseudomonas fluorescens FW300-N2C3
    41% identity, 83% coverage of query (230 bits)

1g291 / Q9YGA6 Malk (see paper)
    45% identity, 84% coverage of query (229 bits)

MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    39% identity, 89% coverage of query (224 bits)

MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
    39% identity, 90% coverage of query (224 bits)

2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    39% identity, 89% coverage of query (222 bits)

3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
    39% identity, 89% coverage of query (222 bits)

3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
    39% identity, 89% coverage of query (222 bits)

3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
    39% identity, 89% coverage of query (222 bits)

3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
    39% identity, 89% coverage of query (222 bits)

1q12A Crystal structure of the atp-bound e. Coli malk
    39% identity, 88% coverage of query (222 bits)

8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
    46% identity, 71% coverage of query (221 bits)

sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    47% identity, 72% coverage of query (218 bits)

8hprC Lpqy-sugabc in state 4
    45% identity, 71% coverage of query (218 bits)

8hprD Lpqy-sugabc in state 4
    45% identity, 71% coverage of query (218 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    44% identity, 76% coverage of query (210 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    42% identity, 72% coverage of query (202 bits)

3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
    40% identity, 97% coverage of query (200 bits)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    39% identity, 81% coverage of query (197 bits)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    39% identity, 81% coverage of query (197 bits)

GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
    39% identity, 81% coverage of query (197 bits)

2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    39% identity, 84% coverage of query (197 bits)

2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    34% identity, 88% coverage of query (159 bits)

MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
    36% identity, 71% coverage of query (149 bits)

6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
    35% identity, 71% coverage of query (148 bits)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
    35% identity, 71% coverage of query (148 bits)

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
    35% identity, 71% coverage of query (148 bits)

Build an alignment

Build an alignment for PP_1722 and 49 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
    28% identity, 84% coverage of query (99.0 bits)

7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
    29% identity, 72% coverage of query (97.8 bits)

STE6_YEAST / P12866 Alpha-factor-transporting ATPase; Mating factor A secretion protein STE6; Multiple drug resistance protein homolog; P-glycoprotein; EC 7.4.2.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P12866 ABC-type alpha-factor-pheromone transporter (EC 7.4.2.7) from Saccharomyces cerevisiae (see paper)
TC 3.A.1.206.1 / P12866 a-Factor sex pheromone (a hydrophobic isoprenylated (farnesylated) carboxymethylated peptide) exporter, Ste6 from Saccharomyces cerevisiae (Baker's yeast) (see 9 papers)
STE6 / RF|NP_012713.1 alpha-factor-transporting ATPase from Saccharomyces cerevisiae
    29% identity, 71% coverage of query (97.1 bits)

MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
    32% identity, 78% coverage of query (96.3 bits)

ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
    27% identity, 75% coverage of query (95.9 bits)

8dncA Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen and adp
    28% identity, 77% coverage of query (94.7 bits)

8dkuA / O67181 Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen (see paper)
    28% identity, 77% coverage of query (94.7 bits)

4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
    29% identity, 73% coverage of query (92.8 bits)

8bmpB / Q1GBI9 Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp (see paper)
    29% identity, 77% coverage of query (91.7 bits)

5d3mB Folate ecf transporter: amppnp bound state
    29% identity, 77% coverage of query (91.7 bits)

8sx7A Bovine multidrug resistance protein 4 (mrp4) bound to dhea-s in msp lipid nanodisc
    29% identity, 80% coverage of query (90.5 bits)

8sx8A Bovine multidrug resistance protein 4 (mrp4) bound to prostaglandin e1 in msp lipid nanodisc
    29% identity, 80% coverage of query (90.5 bits)

8bmsB Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
    29% identity, 77% coverage of query (90.1 bits)

3gd7A / P13569,P68187 Crystal structure of human nbd2 complexed with n6-phenylethyl-atp (p- atp)
    27% identity, 89% coverage of query (90.1 bits)

8swnA / F1MUC1 Bovine multidrug resistance protein 4 (mrp4) e1202q mutant bound to atp in msp lipid nanodisc (see paper)
    27% identity, 86% coverage of query (86.7 bits)

7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
    27% identity, 74% coverage of query (82.4 bits)

7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
    27% identity, 75% coverage of query (81.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory