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Searching for up to 100 curated homologs for PP_2830 FitnessBrowser__Putida:PP_2830 (450 a.a.)

Found high-coverage hits (≥70%) to 30 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
    67% identity, 93% coverage of query (552 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    54% identity, 92% coverage of query (442 bits)

BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
    43% identity, 91% coverage of query (315 bits)

H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
    42% identity, 86% coverage of query (289 bits)

ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
    38% identity, 90% coverage of query (274 bits)

YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
    38% identity, 89% coverage of query (261 bits)

NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    37% identity, 88% coverage of query (249 bits)

TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    37% identity, 94% coverage of query (244 bits)

Build an alignment

Build an alignment for PP_2830 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

CH_124029 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 85% coverage of query (160 bits)

CH_124319 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 90% coverage of query (156 bits)

YHDC_SCHPO / Q9P6J0 Uncharacterized transporter C1683.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    27% identity, 76% coverage of query (140 bits)

CH_124317 phthalate transporter from Magnaporthe grisea 70-15 (see paper)
    31% identity, 74% coverage of query (130 bits)

CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
    27% identity, 85% coverage of query (121 bits)

CH_124204 putative monocarboxylate exporter from Magnaporthe grisea 70-15 (see paper)
    27% identity, 91% coverage of query (119 bits)

VHT1_SCHPO / O13880 Vitamin H transporter 1; H(+)/biotin symporter vht1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
TC 2.A.1.14.19 / O13880 Plasma membrane, high affinity vitamin H transporter 1 (H+:biotin symporter), Vht1 (Stolz, 2003) from Schizosaccharomyces pombe (Fission yeast) (see 2 papers)
vht1 / GB|AAO22560.1 vitamin H transporter 1 from Schizosaccharomyces pombe (see 3 papers)
    27% identity, 72% coverage of query (101 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    25% identity, 90% coverage of query (94.0 bits)

LIZ1_SCHPO / O43000 Pantothenate transporter liz1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
TC 2.A.1.14.17 / O43000 Pantothenate:H+ symporter, Liz1 (mutants cause abnormal mitosis due to a defect in ribonucleotide reductase) from Schizosaccharomyces pombe (Fission yeast) (see 3 papers)
liz1 / RF|NP_596430.1 pantothenate transporter liz1 from Schizosaccharomyces pombe (see 4 papers)
    25% identity, 71% coverage of query (90.1 bits)

GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
    23% identity, 90% coverage of query (84.7 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    25% identity, 88% coverage of query (84.0 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    23% identity, 85% coverage of query (82.4 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    24% identity, 72% coverage of query (81.6 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    24% identity, 72% coverage of query (81.6 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    21% identity, 88% coverage of query (75.1 bits)

6zguA Crystal structure of a mfs transporter with bound 3-(2-methylphenyl) propanoic acid at 2.41 angstroem resolution
    26% identity, 78% coverage of query (56.6 bits)

6zgtA Crystal structure of a mfs transporter with bound 2-naphthoic acid at 2.39 angstroem resolution
    26% identity, 78% coverage of query (56.6 bits)

6zgsA / A0LNN5 Crystal structure of a mfs transporter with bound 3-phenylpropanoic acid at 2.39 angstroem resolution
    26% identity, 78% coverage of query (56.6 bits)

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans
    24% identity, 81% coverage of query (55.1 bits)

6g9xA Crystal structure of a mfs transporter at 2.54 angstroem resolution
    26% identity, 74% coverage of query (52.0 bits)

SFMCT_SYNFM / A0LNN5 L-lactate transporter; SfMCT from Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) (see paper)
    26% identity, 78% coverage of query (49.7 bits)

S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
    20% identity, 86% coverage of query (45.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory