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Searching for up to 100 curated homologs for PP_3165 FitnessBrowser__Putida:PP_3165 (442 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 2.A.1.15.5 / O30513 Benzoate porter, BenK from Acinetobacter calcoaceticus (see 2 papers)
    47% identity, 98% coverage of query (413 bits)

TC 2.A.1.15.7 / Q6FBB3 Aromatic compound (benzoate) uptake transporter of 450 aas from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
    48% identity, 99% coverage of query (401 bits)

PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    35% identity, 91% coverage of query (241 bits)

genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    37% identity, 87% coverage of query (238 bits)

proT / BAB32694.1 putative transporter from Pseudomonas straminea (see 2 papers)
    35% identity, 96% coverage of query (223 bits)

PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
    35% identity, 96% coverage of query (219 bits)

NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    30% identity, 99% coverage of query (207 bits)

MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
    33% identity, 99% coverage of query (204 bits)

GALT_PSEPU / E8ZB61 Gallate transporter; Gallate permease from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
galT / CBJ94499.1 gallic acid permease from Pseudomonas putida (see paper)
    34% identity, 90% coverage of query (199 bits)

TC 2.A.1.15.3 / Q46M63 2,4-Dichlorophenoxyacetate porter (see 5 papers)
    31% identity, 98% coverage of query (181 bits)

TC 2.A.1.15.14 / Q8VUZ0 Probable uptake transporter for 2,4-dichlorophenoxyacetic acid (2,4-D), CadK from Bradyrhizobium sp. HW13
    32% identity, 88% coverage of query (175 bits)

Build an alignment

Build an alignment for PP_3165 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

TC 2.A.1.15.6 / O24842 Vanillate porter, VanK (see 4 papers)
    29% identity, 89% coverage of query (169 bits)

YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
    31% identity, 93% coverage of query (150 bits)

TC 2.A.1.15.11 / Q6M372 The Vanillate porter, VanK from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    27% identity, 99% coverage of query (145 bits)

NIAP_BACSU / O34691 Putative niacin/nicotinamide transporter NiaP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.82.4 / O34691 Niacin uptake porter NiaP from Bacillus subtilis (see 2 papers)
    27% identity, 93% coverage of query (138 bits)

SVOP_XENLA / Q2XWK0 Synaptic vesicle 2-related protein; SV2-related protein from Xenopus laevis (African clawed frog) (see paper)
    26% identity, 90% coverage of query (132 bits)

SVOP_BOVIN / Q1JP63 Synaptic vesicle 2-related protein; SV2-related protein from Bos taurus (Bovine) (see paper)
    26% identity, 92% coverage of query (130 bits)

SVOP_RAT / Q9Z2I7 Synaptic vesicle 2-related protein; SV2-related protein from Rattus norvegicus (Rat) (see paper)
    26% identity, 92% coverage of query (118 bits)

TC 2.A.1.82.3 / Q8BFT9 Synaptic vesicle 2-related protein (SV2-related protein), SVOP from Mus musculus (see 4 papers)
    27% identity, 92% coverage of query (117 bits)

TC 2.A.1.15.8 / O24723 Probable 1-hydroxy-2-naphthoate transporter, orf1 (see paper)
    27% identity, 89% coverage of query (116 bits)

YgcS / b2771 putative transporter YgcS from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 2.A.1.1.95 / Q46909 Inner membrane metabolite transport protein YgcS from Escherichia coli (strain K12) (see 3 papers)
    28% identity, 88% coverage of query (108 bits)

TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
    26% identity, 82% coverage of query (108 bits)

NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT.  N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli.  It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
    27% identity, 84% coverage of query (107 bits)

NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
YJHB_ECOLI / P39352 Putative metabolite transport protein YjhB from Escherichia coli (strain K12) (see paper)
    26% identity, 91% coverage of query (102 bits)

TC 2.A.1.82.1 / F2CRE4 The barley copper uptake porter, CT-1 of 749 aas; nearly identical to the wheat orthologue from Hordeum vulgare var. distichum
    24% identity, 90% coverage of query (102 bits)

TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
    27% identity, 80% coverage of query (98.6 bits)

OCT7_ARATH / Q940M4 Organic cation/carnitine transporter 7; AtOCT7 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    24% identity, 87% coverage of query (86.3 bits)

TC 2.A.1.19.35 / A6NK97 Solute carrier family 22 member 20 (Organic anion transporter 6; OAT6) of 555 aas and 12 probable TMSs. This protein is an apparent anionic odorant transporter in the olfactory epithelium of mice from Homo sapiens (see 3 papers)
    26% identity, 82% coverage of query (81.6 bits)

S22AK_MOUSE / Q80UJ1 Solute carrier family 22 member 20; Organic anion transporter 6 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.1.19.16 / Q80UJ1 The organic anion transporter, Oat6 or SLC22a20 of 556 aas and 12 TMSs from Mus musculus (Mouse) (see 6 papers)
    24% identity, 90% coverage of query (81.6 bits)

PHT19_ARATH / Q9S735 Probable inorganic phosphate transporter 1-9; AtPht1;9; H(+)/Pi cotransporter from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    24% identity, 89% coverage of query (79.3 bits)

PHT14_ORYSJ / Q8H6H2 Probable inorganic phosphate transporter 1-4; OsPT4; OsPht1;4; H(+)/Pi cotransporter; OsPT1 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
    23% identity, 88% coverage of query (79.3 bits)

TC 2.A.1.9.4 / Q01MW8 Pht1;2(1;4) (PT2), a low affinity Pi uptake transporter, functioning throughout the plant (Ai et al., 2009) (76% identical to 2.A.1.9.3) from Oryza sativa subsp. indica (see paper)
    23% identity, 88% coverage of query (79.0 bits)

S22A5_HUMAN / O76082 Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5 from Homo sapiens (Human) (see 28 papers)
TC 2.A.1.19.3 / O76082 The polyspecific organic cation (L- and D-carnitine, butyryl-L-carnitine, acetyl carnitine, γ-butyro-betaine, glycinebetaine, β-lactam antibiotics with a quaternary nitrogen such as cephaloridine, and others):Na+ symporter, OCTN2 (SLC22A5). Carnitine is transporter with high affinity (2 - 20 μM0 (Ingoglia et al. 2015). Associated with Crohn''s disease (Barton et al., 2005) as well as primary carnitine deficiency from Homo sapiens (Human) (see 28 papers)
    24% identity, 82% coverage of query (76.6 bits)

S22AL_MOUSE / Q9WTN6 Solute carrier family 22 member 21; Organic cation/carnitine transporter 3; Solute carrier family 22 member 9 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.1.19.41 / Q9WTN6 Organocation transporter, OCTN3.  Identified only in mouse; mediates carnitine transport (Pochini et al. 2013).  81% identical to 2.A.1.19.3.  Also called SLC22a21 and SLC22a9 from Mus musculus
    24% identity, 82% coverage of query (75.9 bits)

S22A6_MOUSE / Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 6 papers)
    25% identity, 86% coverage of query (75.1 bits)

S22A6_HUMAN / Q4U2R8 Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 from Homo sapiens (Human) (see 20 papers)
TC 2.A.1.19.31 / Q4U2R8 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1), from Homo sapiens (see 17 papers)
    26% identity, 86% coverage of query (74.3 bits)

S22A6_PSEAM / O57379 Solute carrier family 22 member 6; Organic anion transporter 1; Renal organic anion transporter 1; ROAT1; fROAT1 from Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) (see paper)
    23% identity, 74% coverage of query (71.2 bits)

8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
    24% identity, 86% coverage of query (71.2 bits)

8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
    24% identity, 79% coverage of query (70.9 bits)

8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
    24% identity, 79% coverage of query (70.9 bits)

S22A7_HUMAN / Q9Y694 Solute carrier family 22 member 7; Novel liver transporter; NLT; Organic anion transporter 2; hOAT2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.1.19.25 / Q9Y694 Solute carrier family 22 member 7 (liver transporter) (Organic anion transporter 2) (hOAT2), transports cyclic nucleotodes and the anti-viral drug, acyclovir (Dahlin et al. 2013). Expressed in liver, kidney, brain and red blood cells from Homo sapiens (see 9 papers)
    27% identity, 78% coverage of query (64.3 bits)

Q9VCA2 Organic cation transporter protein from Drosophila melanogaster (Fruit fly)
    25% identity, 79% coverage of query (63.5 bits)

S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
    25% identity, 80% coverage of query (55.5 bits)

S22AE_MOUSE / Q497L9 Solute carrier family 22 member 14 from Mus musculus (Mouse) (see 2 papers)
    24% identity, 77% coverage of query (54.3 bits)

S22A2_RABIT / Q8MJI6 Solute carrier family 22 member 2; Organic cation transporter 2 from Oryctolagus cuniculus (Rabbit) (see paper)
    25% identity, 84% coverage of query (49.7 bits)

7zh6A Structure of human oct3 in complex with inhibitor corticosterone
    23% identity, 80% coverage of query (49.7 bits)

O42885 Putative inorganic phosphate transporter C8E4.01c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    22% identity, 87% coverage of query (47.8 bits)

7zhaA / O75751 Structure of human oct3 in complex with inhibitor decynium-22 (see paper)
    22% identity, 80% coverage of query (47.4 bits)

S22A3_HUMAN / O75751 Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; OCT3 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.24 / O75751 Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) from Homo sapiens (see 3 papers)
    22% identity, 80% coverage of query (45.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory