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Searching for up to 100 curated homologs for PP_3191 FitnessBrowser__Putida:PP_3191 (350 a.a.)

Found high-coverage hits (≥70%) to 95 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7nbcAAA / Q9GZT4 structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
    37% identity, 88% coverage of query (192 bits)

SRR / Q9GZT4 Serine racemase (EC 5.1.1.10) from Homo sapiens (see 4 papers)
SRR_HUMAN / Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 3 papers)
    37% identity, 89% coverage of query (192 bits)

7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen
    37% identity, 88% coverage of query (192 bits)

7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen
    37% identity, 88% coverage of query (192 bits)

7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen
    37% identity, 88% coverage of query (192 bits)

7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    37% identity, 88% coverage of query (192 bits)

7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen
    37% identity, 88% coverage of query (192 bits)

3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
    37% identity, 92% coverage of query (192 bits)

6zspAAA serine racemase bound to atp and malonate.
    36% identity, 91% coverage of query (191 bits)

7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen
    37% identity, 88% coverage of query (190 bits)

F7ZG00 serine racemase (EC 5.1.1.18) from Roseobacter litoralis (see paper)
    38% identity, 89% coverage of query (189 bits)

BHCB_PARDP / A1B8Z2 beta-hydroxyaspartate dehydratase; EC 4.2.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
    37% identity, 88% coverage of query (183 bits)

TSAL_THEMA / Q9WYJ1 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine dehydratase; EC 4.3.1.19; EC 4.3.1.17 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    40% identity, 87% coverage of query (182 bits)

L0N5C4 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. N99 (see paper)
    36% identity, 90% coverage of query (180 bits)

TD_NICAT / Q9AXU4 Threonine dehydratase; Threonine deaminase; EC 4.3.1.19 from Nicotiana attenuata (Coyote tobacco) (see 2 papers)
Q9AXU4 threonine ammonia-lyase (EC 4.3.1.19) from Nicotiana attenuata (see paper)
    36% identity, 83% coverage of query (179 bits)

Q54HH2 D-Serine ammonia-lyase (EC 4.3.1.18) from Dictyostelium discoideum (see paper)
    35% identity, 87% coverage of query (179 bits)

CCNA_03750 threonine deaminase (EC 4.3.1.19) from Caulobacter crescentus NA1000
    39% identity, 86% coverage of query (177 bits)

TD2_SOLLC / P25306 Threonine dehydratase 2 biosynthetic, chloroplastic; SlTD2; Threonine deaminase 2; EC 4.3.1.17; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 5 papers)
    37% identity, 89% coverage of query (174 bits)

thadh / A4F2N8 L-threo-3-hydroxy aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. (see 2 papers)
LTHAD_PSESP / A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see 2 papers)
A4F2N8 threo-3-hydroxy-L-aspartate ammonia-lyase (EC 4.3.1.16) from Pseudomonas sp. T62 (see paper)
    37% identity, 89% coverage of query (173 bits)

sr / Q2PGG3 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Arabidopsis thaliana (see paper)
SRR_ARATH / Q2PGG3 Serine racemase; AtSR; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q2PGG3 serine racemase (EC 5.1.1.18) from Arabidopsis thaliana (see paper)
    34% identity, 89% coverage of query (173 bits)

A0A0U5AKI6 serine racemase (EC 5.1.1.18) from Crassostrea gigas (see paper)
    36% identity, 86% coverage of query (170 bits)

SRR_ORYSJ / Q7XSN8 Serine racemase; D-serine dehydratase; D-serine ammonia-lyase; L-serine dehydratase; L-serine ammonia-lyase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
Q7XSN8 serine racemase (EC 5.1.1.18) from Oryza sativa (see paper)
    31% identity, 89% coverage of query (169 bits)

Ga0059261_3694 threonine deaminase (EC 4.3.1.19) from Sphingomonas koreensis DSMZ 15582
    38% identity, 86% coverage of query (169 bits)

TSAL_GEOSL / Q74FW6 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine/serine ammonia-lyase; EC 4.3.1.19; EC 4.3.1.17 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74FW6 threonine ammonia-lyase (EC 4.3.1.19) from Geobacter sulfurreducens (see paper)
    41% identity, 86% coverage of query (167 bits)

LTHAD_YEAST / P36007 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; EC 4.3.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    36% identity, 88% coverage of query (167 bits)

SRR_SCHPO / O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
O59791 serine racemase (EC 5.1.1.18) from Schizosaccharomyces pombe (see 2 papers)
    32% identity, 88% coverage of query (166 bits)

2zpuA / O59791 Crystal structure of modified serine racemase from s.Pombe. (see paper)
    32% identity, 88% coverage of query (166 bits)

1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp
    32% identity, 88% coverage of query (166 bits)

1v71A Crystal structure of s.Pombe serine racemase
    32% identity, 88% coverage of query (166 bits)

2zr8A Crystal structure of modified serine racemase complexed with serine
    32% identity, 88% coverage of query (166 bits)

SRR_MOUSE / Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see 5 papers)
    36% identity, 87% coverage of query (164 bits)

CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
    32% identity, 88% coverage of query (161 bits)

A0A0U4MRI4 serine racemase (EC 5.1.1.18) from Penaeus monodon (see paper)
    35% identity, 87% coverage of query (161 bits)

ILV / CAA10977.1 threonine deaminase from Blastobotrys adeninivorans (see paper)
    38% identity, 83% coverage of query (160 bits)

ILV1 putative uncharacterized protein ILV1 from Candida albicans (see paper)
    35% identity, 83% coverage of query (160 bits)

sr / A5HUN0 serine racemase/D-serine ammonia-lyase (EC 5.1.1.10) from Hordeum vulgare (see paper)
A5HUN0 serine racemase (EC 5.1.1.18) from Hordeum vulgare (see paper)
    32% identity, 89% coverage of query (159 bits)

3hmkA Crystal structure of serine racemase
    36% identity, 89% coverage of query (159 bits)

SRR_RAT / Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see 2 papers)
Q76EQ0 serine racemase (EC 5.1.1.18) from Rattus norvegicus (see 6 papers)
    36% identity, 87% coverage of query (157 bits)

Asr / BAE78960.1 aspartate racemase from Scapharca broughtonii (see paper)
    37% identity, 88% coverage of query (157 bits)

THDH_SCHPO / O94634 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    37% identity, 83% coverage of query (156 bits)

5cvcA / F5CAQ9 Structure of maize serine racemase (see paper)
    32% identity, 87% coverage of query (153 bits)

B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica (see paper)
    37% identity, 88% coverage of query (153 bits)

F5CAQ9 serine racemase (EC 5.1.1.18) from Zea mays (see paper)
    31% identity, 89% coverage of query (153 bits)

FSDH_RALPI / Q10725 Phenylserine dehydratase; EC 4.2.1.- from Ralstonia pickettii (Burkholderia pickettii) (see 2 papers)
    34% identity, 85% coverage of query (152 bits)

Tdc / b3117 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
tdcB / P0AGF6 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli (strain K12) (see 25 papers)
TDCB_ECOLI / P0AGF6 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Escherichia coli (strain K12) (see 4 papers)
tdcB / RF|NP_417587 threonine ammonia-lyase; EC 4.3.1.19 from Escherichia coli K12 (see 7 papers)
    36% identity, 88% coverage of query (152 bits)

TDCB_SALTY / P11954 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    36% identity, 88% coverage of query (149 bits)

2gn2A / P11954 Crystal structure of tetrameric biodegradative threonine deaminase (tdcb) from salmonella typhimurium in complex with cmp at 2.5a resolution (hexagonal form) (see paper)
    36% identity, 88% coverage of query (149 bits)

TD1_SOLLC / A0FKE6 Threonine dehydratase 1 biosynthetic, chloroplastic; SlTD1; Threonine deaminase 1; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 2 papers)
    38% identity, 83% coverage of query (149 bits)

A0QY48 L-serine ammonia-lyase (EC 4.3.1.17) from Mycolicibacterium smegmatis (see paper)
    38% identity, 81% coverage of query (148 bits)

Ile / b3772 threonine deaminase (EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ilvA / P04968 threonine deaminase (EC 4.3.1.19) from Escherichia coli (strain K12) (see 21 papers)
ILVA_ECOLI / P04968 L-threonine dehydratase biosynthetic IlvA; Threonine deaminase; EC 4.3.1.19 from Escherichia coli (strain K12) (see 4 papers)
P04968 threonine ammonia-lyase (EC 4.3.1.19) from Escherichia coli (see paper)
    35% identity, 85% coverage of query (148 bits)

1tdjA / P04968 Threonine deaminase (biosynthetic) from e. Coli (see paper)
    35% identity, 85% coverage of query (148 bits)

V6QU65 threonine ammonia-lyase (EC 4.3.1.19) from Fusarium graminearum (see paper)
    37% identity, 81% coverage of query (147 bits)

Q93968 serine racemase (EC 5.1.1.18) from Caenorhabditis elegans (see paper)
    37% identity, 79% coverage of query (145 bits)

THDH_YEAST / P00927 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    37% identity, 79% coverage of query (145 bits)

CH_124219 threonine deaminase [Arxula adeninivorans] from Magnaporthe grisea 70-15 (see paper)
    38% identity, 77% coverage of query (144 bits)

A0A0U5A554 aspartate racemase (EC 5.1.1.13) from Penaeus monodon (see paper)
    34% identity, 91% coverage of query (144 bits)

K1QH67 aspartate racemase (EC 5.1.1.13) from Crassostrea gigas (see paper)
    33% identity, 87% coverage of query (139 bits)

AKS11_ALTAL / V5Y0V0 Threonine dehydratase-like protein AKTS1-1; AK-toxin biosynthesis protein S1-1; EC 4.3.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 4 papers)
    35% identity, 77% coverage of query (138 bits)

ilvA / AAA96639.1 threonine dehydratase from Bacillus subtilis (see 3 papers)
    32% identity, 86% coverage of query (136 bits)

Q2V0H1 serine racemase (EC 5.1.1.18) from Pyrobaculum islandicum (see paper)
    38% identity, 82% coverage of query (125 bits)

A0QX60 threonine ammonia-lyase (EC 4.3.1.19) from Mycolicibacterium smegmatis (see paper)
    34% identity, 89% coverage of query (124 bits)

Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum (see paper)
    31% identity, 88% coverage of query (118 bits)

1ve5A / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
    37% identity, 86% coverage of query (116 bits)

1ve5D / Q5SLL4 Crystal structure of t.Th. Hb8 threonine deaminase
    34% identity, 86% coverage of query (99.8 bits)

Build an alignment

Build an alignment for PP_3191 and 64 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

A2GMG5 cysteine synthase (EC 2.5.1.47) from Trichomonas vaginalis (see paper)
    27% identity, 84% coverage of query (70.5 bits)

4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
    30% identity, 84% coverage of query (69.7 bits)

7qgtA / P35520 Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa. (see paper)
    30% identity, 84% coverage of query (69.3 bits)

CBS / P35520 cystathionine β-synthase monomer (EC 4.2.1.22) from Homo sapiens (see 12 papers)
CBS_HUMAN / P35520 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Homo sapiens (Human) (see 43 papers)
P35520 cystathionine beta-synthase (EC 4.2.1.22) from Homo sapiens (see 18 papers)
    30% identity, 84% coverage of query (69.3 bits)

CS1 / A2EI82 O-phosphoserine sulfhydrylase monomer (EC 2.5.1.47; EC 2.5.1.65) from Trichomonas vaginalis (strain ATCC PRA-98 / G3) (see paper)
    27% identity, 84% coverage of query (69.3 bits)

7qgtB Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa.
    30% identity, 84% coverage of query (69.3 bits)

Cbs / P32232 cystathionine β-synthase subunit (EC 4.2.1.22) from Rattus norvegicus (see 2 papers)
CBS_RAT / P32232 Cystathionine beta-synthase; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase; EC 4.2.1.22 from Rattus norvegicus (Rat) (see 3 papers)
    31% identity, 84% coverage of query (68.2 bits)

A0A0U3SCD8 L-3-cyanoalanine synthase (EC 4.4.1.9) from Pieris rapae (see paper)
    28% identity, 75% coverage of query (66.6 bits)

CYSK_SCHPO / O59701 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 3 papers)
cys11 / RF|NP_595332.1 cysteine synthase from Schizosaccharomyces pombe (see 2 papers)
    25% identity, 82% coverage of query (66.6 bits)

A0A220K8D8 L-3-cyanoalanine synthase (EC 4.4.1.9) from Anthocharis cardamines (see paper)
    28% identity, 77% coverage of query (66.6 bits)

P29848 S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) (EC 2.5.1.144); cysteine synthase (EC 2.5.1.47) from Salmonella enterica subsp. enterica serovar Typhimurium (see 9 papers)
    26% identity, 83% coverage of query (65.1 bits)

A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    28% identity, 81% coverage of query (63.2 bits)

CysM / b2421 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1; EC 4.4.1.28) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
cysM / P16703 cysteine synthase B (EC 2.5.1.47; EC 2.5.1.144; EC 4.4.1.1) from Escherichia coli (strain K12) (see 15 papers)
CYSM_ECOLI / P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
    26% identity, 84% coverage of query (61.2 bits)

A0A220K8D2 L-3-cyanoalanine synthase (EC 4.4.1.9) from Aporia crataegi (see paper)
    28% identity, 72% coverage of query (61.2 bits)

2bhtA / P16703 Crystal structure of o-acetylserine sulfhydrylase b (see paper)
    26% identity, 84% coverage of query (60.8 bits)

THRC_METAC / Q8TQD4 Threonine synthase; TS; EC 4.2.3.1 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
GB|AAM05023.1 threonine synthase; EC 4.2.3.1 from Methanosarcina acetivorans C2A (see paper)
    29% identity, 81% coverage of query (60.5 bits)

STDH_YEAST / P25379 Catabolic L-serine/threonine dehydratase; EC 4.3.1.17; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    24% identity, 81% coverage of query (60.1 bits)

A0A0F6AQU1 cysteine synthase (EC 2.5.1.47) from Brucella abortus (see paper)
    25% identity, 82% coverage of query (59.7 bits)

SDSL / Q96GA7 Serine dehydratase-like (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens (see paper)
SDSL_HUMAN / Q96GA7 Serine dehydratase-like; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; Serine dehydratase 2; SDH 2; EC 4.3.1.19; EC 4.3.1.17 from Homo sapiens (Human) (see paper)
Q96GA7 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens (see paper)
    26% identity, 88% coverage of query (58.5 bits)

6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    28% identity, 82% coverage of query (55.8 bits)

6nmxA / A8HUA2 Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
    28% identity, 82% coverage of query (55.8 bits)

2rkbA / Q96GA7 Serine dehydratase like-1 from human cancer cells (see paper)
    26% identity, 86% coverage of query (55.1 bits)

2zsjA / O66740 Crystal structure of threonine synthase from aquifex aeolicus vf5
    26% identity, 81% coverage of query (53.9 bits)

6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala
    27% identity, 82% coverage of query (49.7 bits)

6cuzA Engineered trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3r)- ethylserine bound as the amino-acrylate
    26% identity, 81% coverage of query (46.2 bits)

5t6mA Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound
    26% identity, 81% coverage of query (46.2 bits)

6cutA Engineered holo trpb from pyrococcus furiosus, pftrpb7e6 with (2s,3s)- isopropylserine bound as the external aldimine
    26% identity, 81% coverage of query (46.2 bits)

5ixjD / Q8U093 Tryptophan synthase beta-subunit from pyrococcus furiosus with l- threonine non-covalently bound in the active site (see paper)
    26% identity, 81% coverage of query (45.8 bits)

5dw3A Tryptophan synthase beta-subunit from pyrococcus furiosus with product l-tryptophan non-covalently bound in the active site
    25% identity, 81% coverage of query (45.4 bits)

5vm5D Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9, with ser bound
    27% identity, 81% coverage of query (45.1 bits)

CAS2_SOLTU / Q9FS29 Bifunctional L-3-cyanoalanine synthase/cysteine synthase 2, mitochondrial; EC 2.5.1.47; EC 4.4.1.9 from Solanum tuberosum (Potato) (see paper)
Q9FS29 L-3-cyanoalanine synthase (EC 4.4.1.9) from Solanum tuberosum (see paper)
    25% identity, 84% coverage of query (43.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory