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Searching for up to 100 curated homologs for PP_4491 FitnessBrowser__Putida:PP_4491 (118 a.a.)

Found high-coverage hits (≥70%) to 10 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q02I31 Putative pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Pseudomonas aeruginosa (strain UCBPP-PA14)
    86% identity, 100% coverage of query (218 bits)

Q48G05 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Pseudomonas syringae (see paper)
    85% identity, 100% coverage of query (213 bits)

PDL2_ARATH / Q6QJ72 Pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial; 4-alpha-hydroxy-tetrahydropterin dehydratase; PCD/DCoH-like protein 2; EC 4.2.1.96 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    34% identity, 91% coverage of query (74.3 bits)

Build an alignment

Build an alignment for PP_4491 and 3 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

ATP1_ARATH / Q9LU63 Probable pterin-4-alpha-carbinolamine dehydratase, chloroplastic; 4-alpha-hydroxy-tetrahydropterin dehydratase; PCD/DCoH-like protein 1; Protein AIRP2 TARGET PROTEIN 1; Protein SDIR1-INTERACTING PROTEIN 1; EC 4.2.1.96 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    27% identity, 92% coverage of query (58.5 bits)

Q2Q449 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Toxoplasma gondii (see paper)
    30% identity, 78% coverage of query (52.8 bits)

2v6tB / Q2Q449 Crystal structure of a complex of pterin-4a-carbinolamine dehydratase from toxoplasma gondii with 7,8-dihydrobiopterin (see paper)
    30% identity, 78% coverage of query (52.8 bits)

PHS_DROME / O76454 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Drosophila melanogaster (Fruit fly) (see paper)
    28% identity, 80% coverage of query (48.5 bits)

PHS2_MOUSE / Q9CZL5 Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor; EC 4.2.1.96 from Mus musculus (Mouse) (see paper)
    32% identity, 87% coverage of query (46.2 bits)

PCBD1 / P61457 Pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96) from Homo sapiens (see paper)
PHS_HUMAN / P61457 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Homo sapiens (Human) (see 5 papers)
PHS_RAT / P61459 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Rattus norvegicus (Rat) (see 7 papers)
    30% identity, 81% coverage of query (41.2 bits)

1f93A / P61459 Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator dcoh (see paper)
    30% identity, 81% coverage of query (41.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory