Searching for up to 100 curated homologs for PP_4632 FitnessBrowser__Putida:PP_4632 (245 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
42% identity, 91% coverage of query (164 bits)
Build an alignment for PP_4632 and 1 homologs with ≥ 30% identity
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5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
28% identity, 91% coverage of query (96.3 bits)
pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
26% identity, 90% coverage of query (84.3 bits)
gra-orf6 / BAD51477.1 ketoreductase from Streptomyces violaceoruber (see 3 papers)
27% identity, 90% coverage of query (75.5 bits)
A0A6B7HD48 tropinone reductase II (EC 1.1.1.236) from Przewalskia tangutica (see paper)
26% identity, 89% coverage of query (70.1 bits)
B2L2W9 tropinone reductase II (EC 1.1.1.236) from Anisodus acutangulus (see paper)
25% identity, 89% coverage of query (69.3 bits)
TR2 / Q6KF77 tropinone reductase (EC 1.1.1.236) from Solanum tuberosum (see paper)
24% identity, 89% coverage of query (67.8 bits)
5iz4A / Q13GL4 Crystal structure of a putative short-chain dehydrogenase/reductase from burkholderia xenovorans
28% identity, 71% coverage of query (67.0 bits)
TRII / CAB52307.1 tropinone reductase II from Solanum tuberosum (see paper)
24% identity, 89% coverage of query (65.9 bits)
swb2 / D2KTX1 3-hydroxykynurenate reductase/dehydratase from Streptomyces sp. SNA15896 (see paper)
26% identity, 89% coverage of query (65.5 bits)
TR2 / P50163 tropinone reductase (EC 1.1.1.236) from Datura stramonium (see paper)
TRN2_DATST / P50163 Tropinone reductase 2; Tropinone reductase II; TR-II; EC 1.1.1.236 from Datura stramonium (Jimsonweed) (Common thornapple) (see paper)
P50163 tropinone reductase II (EC 1.1.1.236) from Datura stramonium (see 3 papers)
25% identity, 89% coverage of query (65.5 bits)
2ae2A / P50163 Tropinone reductase-ii complexed with NADP+ and pseudotropine (see paper)
25% identity, 89% coverage of query (65.1 bits)
1ipfA Tropinone reductase-ii complexed with NADPH and tropinone
25% identity, 89% coverage of query (65.1 bits)
1ipeA Tropinone reductase-ii complexed with NADPH
25% identity, 89% coverage of query (65.1 bits)
8bcjB / Q9HZ96 Crystal structure of short-chain dehydrogenase pa3128 from pseudomonas aeruginosa pao1 in complex with NADP+
28% identity, 91% coverage of query (64.3 bits)
fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
24% identity, 93% coverage of query (63.9 bits)
4b79A / Q9HWT0 The aeropath project and pseudomonas aeruginosa high-throughput crystallographic studies for assessment of potential targets in early stage drug discovery. (see paper)
27% identity, 89% coverage of query (63.5 bits)
4bo8A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7a resolution
27% identity, 90% coverage of query (62.0 bits)
4bo2A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9a resolution
27% identity, 90% coverage of query (62.0 bits)
4bo0A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4a resolution
27% identity, 90% coverage of query (62.0 bits)
FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
24% identity, 92% coverage of query (61.6 bits)
Q2FZ53 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Staphylococcus aureus (see paper)
24% identity, 92% coverage of query (61.2 bits)
3jq8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7- trimethyl-7,8-dihydropteridine-2,4-diamine (dx3)
25% identity, 90% coverage of query (61.2 bits)
5ha5D Crystal structure of an NAD-bound oxidoreductase from brucella ovis
24% identity, 89% coverage of query (60.8 bits)
Q31QF3 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Synechococcus elongatus PCC 7942 = FACHB-805 (see paper)
26% identity, 91% coverage of query (59.7 bits)
B2L2W8 tropinone reductase I (EC 1.1.1.206) from Anisodus acutangulus (see 3 papers)
27% identity, 75% coverage of query (59.3 bits)
4nbtA / A9NFJ2 Crystal structure of fabg from acholeplasma laidlawii (see paper)
24% identity, 90% coverage of query (59.3 bits)
A3GF07 carbonyl reductase (NADPH) (EC 1.1.1.184) from Scheffersomyces stipitis (see 2 papers)
28% identity, 88% coverage of query (59.3 bits)
4bnxA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 6-(4-(2-chloroanilino)- 1h-quinazolin-2-ylidene)cyclohexa-2, 4-dien-1-one at 2.3a resolution
26% identity, 90% coverage of query (59.3 bits)
4bnyA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8a resolution
26% identity, 90% coverage of query (59.3 bits)
R4QQK2 tropinone reductase I (EC 1.1.1.206) from Anisodus luridus (see paper)
27% identity, 75% coverage of query (58.9 bits)
4dmmB / Q31QF3 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
26% identity, 91% coverage of query (58.9 bits)
4bo5A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-chlorophenyl)-4- pyrrol-1-yl-1,3,5-triazin-2-amine at 2.6a resolution
25% identity, 90% coverage of query (58.9 bits)
3gn1C Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00067116)
26% identity, 90% coverage of query (58.9 bits)
4bo6A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2,3-dihydroindol-1-yl-(2- thiophen-3-yl-1,3-thiazol-4-yl)methanone at 2.8a resolution
27% identity, 90% coverage of query (58.9 bits)
4k6fB / B4EAU4 X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
27% identity, 90% coverage of query (58.5 bits)
3bmqA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax5)
26% identity, 90% coverage of query (58.5 bits)
4bo9A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 5-(2-(furan-2-ylmethoxy) phenyl)-2-phenyltetrazole at 2.9a resolution
27% identity, 90% coverage of query (58.5 bits)
3jq7C Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
26% identity, 90% coverage of query (58.5 bits)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
24% identity, 90% coverage of query (58.2 bits)
6rx6A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 4 (nmt- c0026)
26% identity, 90% coverage of query (58.2 bits)
6rx0A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 3 (nmt- c0013)
26% identity, 90% coverage of query (58.2 bits)
6howA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 2a (f219).
26% identity, 90% coverage of query (58.2 bits)
6gexA Trypanosoma brucei ptr1 in complex with inhibitor 2h (f246)
26% identity, 90% coverage of query (58.2 bits)
6gdoA Trypanosoma brucei ptr1 in complex with inhibitor 2g (f240)
26% identity, 90% coverage of query (58.2 bits)
5k6aA Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
26% identity, 90% coverage of query (58.2 bits)
2x9nA High resolution structure of tbptr1 in complex with cyromazine
26% identity, 90% coverage of query (58.2 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
26% identity, 92% coverage of query (57.8 bits)
FABG_AQUAE / O67610 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Aquifex aeolicus (strain VF5)
24% identity, 89% coverage of query (57.8 bits)
6geyA Trypanosoma brucei ptr1 in complex with inhibitor 4g (f125)
26% identity, 92% coverage of query (57.8 bits)
6gdpA Trypanosoma brucei ptr1 in complex with inhibitor 4l (f162)
26% identity, 92% coverage of query (57.8 bits)
4clhA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.8 bits)
4cleA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.8 bits)
DCXR_CAEEL / Q21929 L-xylulose reductase; XR; Dicarbonyl/L-xylulose reductase; DCXR; Short-chain dehydrogenase 21; EC 1.1.1.10 from Caenorhabditis elegans (see 2 papers)
Q21929 L-xylulose reductase (EC 1.1.1.10) from Caenorhabditis elegans (see paper)
23% identity, 89% coverage of query (57.4 bits)
5jdcA Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
26% identity, 90% coverage of query (57.4 bits)
5jcxA Trypanosoma brucei ptr1 in complex with inhibitor np-29
26% identity, 90% coverage of query (57.4 bits)
5jcjA Trypanosoma brucei ptr1 in complex with inhibitor nmt-h037 (compound 7)
26% identity, 90% coverage of query (57.4 bits)
5izcA Trypanosoma brucei ptr1 in complex with inhibitor f032
26% identity, 90% coverage of query (57.4 bits)
4wcfA Trypanosoma brucei ptr1 in complex with inhibitor 9
26% identity, 90% coverage of query (57.4 bits)
4cmeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.4 bits)
4cm9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.4 bits)
3jqgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4- methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (ax6)
26% identity, 90% coverage of query (57.4 bits)
3jqfA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5- triazine-2,4,6-triamine (ax2)
26% identity, 90% coverage of query (57.4 bits)
3jqeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (dx8)
26% identity, 90% coverage of query (57.4 bits)
3jqdA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-4-oxo-6-phenyl-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (dx7)
26% identity, 90% coverage of query (57.4 bits)
3jqcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-bromo-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (ju2)
26% identity, 90% coverage of query (57.4 bits)
3jqbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-5-(2-phenylethyl)-3,7-dihydro-4h-pyrrolo[2,3-d]pyrimidin-4-one (dx6)
26% identity, 90% coverage of query (57.4 bits)
3jqaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-1,9-dihydro-6h-purine-6-thione (dx4)
26% identity, 90% coverage of query (57.4 bits)
3jq9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (ax1)
26% identity, 90% coverage of query (57.4 bits)
3jq7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
26% identity, 90% coverage of query (57.4 bits)
3jq6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7- bis(1-methylethyl)pteridine-2,4-diamine (dx1)
26% identity, 90% coverage of query (57.4 bits)
3gn2A Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00066730)
26% identity, 90% coverage of query (57.4 bits)
2yhiA Trypanosoma brucei ptr1 in complex with inhibitor wh16
26% identity, 90% coverage of query (57.4 bits)
2wd8A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00071204
26% identity, 90% coverage of query (57.4 bits)
2wd7A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066750
26% identity, 90% coverage of query (57.4 bits)
2vz0A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066641
26% identity, 90% coverage of query (57.4 bits)
8of2A Trypanosoma brucei pteridine reductase 1 (tbptr1) in complex with 2,4, 6 triamminopyrimidine (tap)
26% identity, 90% coverage of query (57.4 bits)
6tbxA Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
26% identity, 90% coverage of query (57.4 bits)
6hnrA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 1 (f217)
26% identity, 90% coverage of query (57.4 bits)
6hncA Trypanosoma brucei ptr1 in complex with cycloguanil
26% identity, 90% coverage of query (57.4 bits)
5jdiA Trypanosoma brucei ptr1 in complex with cofactor and inhibitor nmt- h024 (compound 2)
26% identity, 90% coverage of query (57.4 bits)
6gcqA Trypanosoma brucei ptr1 in complex with inhibitor 2b (f192)
26% identity, 90% coverage of query (57.4 bits)
6gcpA Trypanosoma brucei ptr1 in complex with inhibitor 2d (f186)
26% identity, 90% coverage of query (57.4 bits)
6gckA Trypanosoma brucei ptr1 in complex with inhibitor 1e (f206)
26% identity, 90% coverage of query (57.4 bits)
4cm1A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.4 bits)
6t62A / V5VHN7 Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
24% identity, 90% coverage of query (57.0 bits)
7opjA Trypanosoma brucei ptr1 (tbptr1) in complex with pyrimethamine
26% identity, 90% coverage of query (57.0 bits)
6gd4A Trypanosoma brucei ptr1 in complex with inhibitor 4c (f188)
26% identity, 90% coverage of query (57.0 bits)
6gclA Trypanosoma brucei ptr1 in complex with inhibitor 3a (f020)
26% identity, 90% coverage of query (57.0 bits)
4wcdA Trypanosoma brucei ptr1 in complex with inhibitor 10
26% identity, 90% coverage of query (57.0 bits)
4cmkA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.0 bits)
4cm8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.0 bits)
4clrA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.0 bits)
2x9vA High resolution structure of tbptr1 with trimetrexate
26% identity, 90% coverage of query (57.0 bits)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii
24% identity, 90% coverage of query (57.0 bits)
4bo7A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2,3-dihydro-1h-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6a resolution
27% identity, 90% coverage of query (57.0 bits)
4cmiA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.0 bits)
4cmgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.0 bits)
4cmaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.0 bits)
4cm6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 90% coverage of query (57.0 bits)
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