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Searching for up to 100 curated homologs for PP_5137 PP_5137 ferric iron ABC transporter, ATP-binding protein (352 a.a.)

Found high-coverage hits (≥70%) to 33 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
    45% identity, 87% coverage of query (250 bits)

YagC / b0262 CP4-6 prophage; ABC transporter ATP-binding protein AfuC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    39% identity, 97% coverage of query (248 bits)

1g291 / Q9YGA6 Malk (see paper)
    43% identity, 87% coverage of query (247 bits)

MALK_THELN / Q9YGA6 Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 5 papers)
    43% identity, 87% coverage of query (247 bits)

2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
    43% identity, 85% coverage of query (246 bits)

TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    46% identity, 73% coverage of query (245 bits)

Dshi_0546 ABC transporter for Xylitol, ATPase component from Dinoroseobacter shibae DFL-12
    45% identity, 79% coverage of query (239 bits)

CysA / b2422 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
CysA / P16676 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.6.1 / P16676 CysA aka B2422, component of Sulfate/thiosulfate porter from Escherichia coli (see 5 papers)
    44% identity, 86% coverage of query (236 bits)

TC 3.A.1.20.2 / Q9KLQ5 Fe(3+) ions import ATP-binding protein FbpC, component of Hexose-phosphate transporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    44% identity, 78% coverage of query (236 bits)

TC 3.A.1.11.3 / Q44383 MotB, component of Mannopine porter from Agrobacterium tumefaciens (see paper)
    42% identity, 85% coverage of query (236 bits)

TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    39% identity, 97% coverage of query (233 bits)

PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
    42% identity, 90% coverage of query (229 bits)

TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
    44% identity, 77% coverage of query (228 bits)

XACK_HALVD / D4GP39 Xylose/arabinose import ATP-binding protein XacK; EC 7.5.2.13 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
    37% identity, 98% coverage of query (228 bits)

PS417_22130 glucose/xylose ABC transporter, ATPase component from Pseudomonas simiae WCS417
    45% identity, 71% coverage of query (227 bits)

TC 3.A.1.1.30 / Q88P35 GtsD (GLcK), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
    41% identity, 84% coverage of query (225 bits)

YdcT / b1441 putative ABC transporter ATP-binding protein YdcT from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ydcT / P77795 putative ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see 3 papers)
YDCT_ECOLI / P77795 Uncharacterized ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see paper)
    41% identity, 92% coverage of query (225 bits)

8hprC Lpqy-sugabc in state 4
    39% identity, 93% coverage of query (207 bits)

8hprD Lpqy-sugabc in state 4
    37% identity, 93% coverage of query (207 bits)

8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
    43% identity, 74% coverage of query (207 bits)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    36% identity, 87% coverage of query (204 bits)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    36% identity, 87% coverage of query (204 bits)

GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
    36% identity, 87% coverage of query (204 bits)

3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
    43% identity, 79% coverage of query (196 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    33% identity, 97% coverage of query (186 bits)

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    35% identity, 75% coverage of query (122 bits)

7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
    32% identity, 73% coverage of query (108 bits)

6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
    32% identity, 73% coverage of query (106 bits)

Build an alignment

Build an alignment for PP_5137 and 28 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
    28% identity, 84% coverage of query (103 bits)

8f5bA / P78363 Human abca4 structure in complex with amp-pnp
    31% identity, 72% coverage of query (103 bits)

7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
    31% identity, 72% coverage of query (103 bits)

7lkzA Structure of atp-bound human abca4
    31% identity, 73% coverage of query (101 bits)

ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
    25% identity, 74% coverage of query (71.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory