Searching for up to 100 curated homologs for PP_5168 PP_5168 sulfate/thiosulfate import ATP-binding protein (329 a.a.)
Found high-coverage hits (≥70%) to 95 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
CysA / b2422 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
CysA / P16676 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.6.1 / P16676 CysA aka B2422, component of Sulfate/thiosulfate porter from Escherichia coli (see 5 papers)
68% identity, 74% coverage of query (337 bits)
TC 3.A.1.6.3 / P0A4W2 Sulfate/thiosulfate import ATP-binding protein CysA aka RV2397C aka MT2468 aka MTCY253.24, component of Sulfate porter from Mycobacterium tuberculosis (see 3 papers)
48% identity, 97% coverage of query (300 bits)
TC 3.A.1.6.7 / Q6QJE1 Chloroplast ATP-binding protein, component of The chloroplast sulfate transporter, SulP/SulP2/Sabc/Sbp from Chlamydomonas reinhardtii (see 2 papers)
45% identity, 93% coverage of query (266 bits)
Q8YM92 ABC-type polyamine transporter (subunit 3/3) (EC 7.6.2.11) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
51% identity, 73% coverage of query (259 bits)
YagC / b0262 CP4-6 prophage; ABC transporter ATP-binding protein AfuC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
42% identity, 91% coverage of query (258 bits)
TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
39% identity, 95% coverage of query (247 bits)
TC 3.A.1.20.2 / Q9KLQ5 Fe(3+) ions import ATP-binding protein FbpC, component of Hexose-phosphate transporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
39% identity, 92% coverage of query (246 bits)
TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
46% identity, 77% coverage of query (243 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
50% identity, 73% coverage of query (242 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
48% identity, 77% coverage of query (238 bits)
Pf1N1B4_5115 sucrose ABC transporter, ATPase component from Pseudomonas fluorescens FW300-N1B4
40% identity, 89% coverage of query (238 bits)
Ac3H11_2066 glucose ABC transporter, ATPase component from Acidovorax sp. GW101-3H11
46% identity, 73% coverage of query (234 bits)
TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
39% identity, 97% coverage of query (233 bits)
TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
49% identity, 73% coverage of query (232 bits)
PGA1_c27970 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Phaeobacter inhibens BS107
41% identity, 96% coverage of query (232 bits)
Ac3H11_2941 ABC transporter for D-Sorbitol, ATPase component from Acidovorax sp. GW101-3H11
45% identity, 72% coverage of query (232 bits)
TC 3.A.1.1.10 / Q9KWT9 AlgS, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
algS / BAB03314.1 AlgS from Sphingomonas sp (see paper)
39% identity, 93% coverage of query (232 bits)
CYSA_ANTAG / Q85A69 Sulfate/thiosulfate import ATP-binding protein CysA; Sulfate-transporting ATPase; EC 7.3.2.3 from Anthoceros angustus (Hornwort) (Anthoceros formosae) (see 2 papers)
47% identity, 72% coverage of query (231 bits)
TC 3.A.1.1.34 / O32151 Uncharacterized ABC transporter ATP-binding protein YurJ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (strain 168)
46% identity, 72% coverage of query (231 bits)
SMc02869 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Sinorhizobium meliloti 1021
42% identity, 88% coverage of query (229 bits)
PS417_12700 ABC transporter for D-Mannitol and D-Sorbitol, ATPase component from Pseudomonas simiae WCS417
47% identity, 72% coverage of query (229 bits)
TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
45% identity, 72% coverage of query (228 bits)
PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
47% identity, 73% coverage of query (228 bits)
TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
47% identity, 72% coverage of query (227 bits)
TC 3.A.1.1.49 / O30494 MtlK, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
47% identity, 72% coverage of query (227 bits)
TC 3.A.1.1.12 / Q9AI63 PalK, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
47% identity, 71% coverage of query (226 bits)
BPHYT_RS16095 ABC transporter for D-Sorbitol, ATPase component from Burkholderia phytofirmans PsJN
46% identity, 75% coverage of query (226 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
47% identity, 72% coverage of query (226 bits)
1g291 / Q9YGA6 Malk (see paper)
46% identity, 71% coverage of query (225 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
45% identity, 72% coverage of query (215 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
45% identity, 72% coverage of query (215 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
45% identity, 72% coverage of query (215 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
45% identity, 72% coverage of query (215 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
45% identity, 72% coverage of query (215 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
45% identity, 72% coverage of query (215 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
45% identity, 72% coverage of query (213 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
45% identity, 72% coverage of query (213 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
46% identity, 72% coverage of query (213 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
41% identity, 73% coverage of query (192 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
39% identity, 73% coverage of query (180 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
39% identity, 73% coverage of query (180 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
39% identity, 73% coverage of query (180 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
36% identity, 96% coverage of query (176 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
39% identity, 71% coverage of query (167 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
40% identity, 72% coverage of query (165 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
40% identity, 72% coverage of query (164 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
40% identity, 72% coverage of query (164 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
41% identity, 71% coverage of query (163 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
41% identity, 71% coverage of query (163 bits)
2olkA Abc protein artp in complex with adp-beta-s
41% identity, 71% coverage of query (163 bits)
2oljA Abc protein artp in complex with adp/mg2+
41% identity, 71% coverage of query (163 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
40% identity, 71% coverage of query (162 bits)
2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
37% identity, 72% coverage of query (152 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
32% identity, 75% coverage of query (151 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
32% identity, 75% coverage of query (150 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
32% identity, 75% coverage of query (150 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
32% identity, 75% coverage of query (150 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
35% identity, 71% coverage of query (132 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
32% identity, 71% coverage of query (127 bits)
6mbnA / P0A9V1 Lptb e163q in complex with atp (see paper)
31% identity, 74% coverage of query (124 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
34% identity, 72% coverage of query (122 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
33% identity, 73% coverage of query (122 bits)
Build an alignment for PP_5168 and 62 homologs with ≥ 30% identity
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6mjpA / O30650 Lptb(e163q)fgc from vibrio cholerae (see paper)
29% identity, 73% coverage of query (115 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
32% identity, 70% coverage of query (108 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
32% identity, 70% coverage of query (108 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
31% identity, 70% coverage of query (108 bits)
4zirB Crystal structure of ecfaa' heterodimer bound to amppnp
31% identity, 75% coverage of query (104 bits)
2pmkA Crystal structures of an isolated abc-atpase in complex with tnp-adp
31% identity, 71% coverage of query (103 bits)
2ff7A The abc-atpase of the abc-transporter hlyb in the adp bound state
31% identity, 71% coverage of query (103 bits)
1xefA Crystal structure of the atp/mg2+ bound composite dimer of hlyb-nbd
31% identity, 71% coverage of query (103 bits)
4hluC / Q9X1Z1 Structure of the ecfa-a' heterodimer bound to adp (see paper)
31% identity, 75% coverage of query (103 bits)
3b5jA Crystal structures of the s504a mutant of an isolated abc-atpase in complex with tnp-adp
31% identity, 71% coverage of query (102 bits)
7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
31% identity, 71% coverage of query (102 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
28% identity, 86% coverage of query (101 bits)
7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
33% identity, 71% coverage of query (101 bits)
8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
31% identity, 71% coverage of query (101 bits)
FhuC / b0151 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FhuC / P07821 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli (strain K12) (see paper)
FHUC_ECOLI / P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.14.3 / P07821 FhuC aka B0151, component of Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter from Escherichia coli (see 6 papers)
fhuC / GB|BAB96727.2 ferrichrome transport ATP-binding protein FhuC; EC 3.6.3.34 from Escherichia coli K12 (see 8 papers)
28% identity, 71% coverage of query (99.0 bits)
6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
32% identity, 70% coverage of query (95.9 bits)
7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
32% identity, 70% coverage of query (95.9 bits)
7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
32% identity, 70% coverage of query (95.9 bits)
7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
32% identity, 70% coverage of query (95.9 bits)
7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
32% identity, 70% coverage of query (95.9 bits)
7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
32% identity, 70% coverage of query (95.5 bits)
6c0vA Molecular structure of human p-glycoprotein in the atp-bound, outward- facing conformation
31% identity, 70% coverage of query (94.4 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
27% identity, 71% coverage of query (93.2 bits)
7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
28% identity, 70% coverage of query (91.7 bits)
3vx4D / Q8DW05 Crystal structure of the nucleotide-binding domain of s. Mutans coma, a bifunctional atp-binding cassette transporter involved in the quorum-sensing pathway (see paper)
32% identity, 71% coverage of query (90.5 bits)
7r89B / Q9H221 The structure of human abcg5/abcg8 purified from yeast (see paper)
26% identity, 71% coverage of query (87.0 bits)
2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp
32% identity, 71% coverage of query (85.5 bits)
Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
32% identity, 71% coverage of query (85.5 bits)
ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
24% identity, 83% coverage of query (85.1 bits)
7r8bB / Q9H221 The structure of human abcg5/abcg8 supplemented with cholesterol (see paper)
26% identity, 71% coverage of query (85.1 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
30% identity, 74% coverage of query (77.8 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
24% identity, 80% coverage of query (77.0 bits)
ABCBB_RAT / O70127 Bile salt export pump; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein; EC 7.6.2.- from Rattus norvegicus (Rat) (see 12 papers)
29% identity, 70% coverage of query (68.6 bits)
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