Searching for up to 100 curated homologs for Pf1N1B4_1020 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_1020 (332 a.a.)
Found high-coverage hits (≥70%) to 63 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
3dufA / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
40% identity, 98% coverage of query (241 bits)
Q7NAZ8 pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Mycoplasma gallisepticum (see paper)
38% identity, 94% coverage of query (237 bits)
ODPA_BACCE / Q4MTG0 Pyruvate dehydrogenase E1 component subunit alpha; EC 1.2.4.1 from Bacillus cereus (see paper)
40% identity, 98% coverage of query (235 bits)
pdhA / AAC24932.1 pyruvate decarboxylase E-1 alpha subunit from Bacillus subtilis (see 3 papers)
39% identity, 98% coverage of query (233 bits)
1w85A The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2
39% identity, 97% coverage of query (230 bits)
ppdcα / A0A222AKA3 phenylpyruvate decarboxylase α subunit (EC 4.1.1.43) from Streptomyces virginiae (see paper)
A0A222AKA3 phenylpyruvate decarboxylase (EC 4.1.1.43) from Streptomyces virginiae (see paper)
41% identity, 96% coverage of query (228 bits)
BKDA_MYCTU / P9WIS3 3-methyl-2-oxobutanoate dehydrogenase subunit alpha; Branched-chain alpha-ketoacid dehydrogenase E1 component subunit alpha; BCKADH E1-alpha; EC 1.2.4.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
42% identity, 97% coverage of query (221 bits)
Q53592 branched-chain alpha-keto acid dehydrogenase system (EC 1.2.1.25) from Streptomyces avermitilis (see paper)
40% identity, 99% coverage of query (221 bits)
3dv0A Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
38% identity, 97% coverage of query (220 bits)
pdhA / P75390 α subunit from Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (see 3 papers)
36% identity, 95% coverage of query (219 bits)
3dv0E / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
37% identity, 97% coverage of query (213 bits)
1w88A The crystal structure of pyruvate dehydrogenase e1(d180n,e183q) bound to the peripheral subunit binding domain of e2
36% identity, 97% coverage of query (211 bits)
ODBA_THET8 / Q5SLR4 2-oxoisovalerate dehydrogenase subunit alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
37% identity, 95% coverage of query (196 bits)
1umbA / Q5SLR4 Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
37% identity, 95% coverage of query (195 bits)
1umdA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate
37% identity, 95% coverage of query (195 bits)
1umcA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate
37% identity, 95% coverage of query (195 bits)
Q72GU1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Thermus thermophilus (see paper)
37% identity, 95% coverage of query (192 bits)
bfmBAA / P37940 2-keto-isovalerate dehydrogenase component α subunit (EC 1.2.4.4) from Bacillus subtilis (strain 168) (see 2 papers)
36% identity, 91% coverage of query (189 bits)
ODBA1_ARATH / Q9LPL5 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
35% identity, 97% coverage of query (189 bits)
Q9HIA3 branched-chain-2-oxoacid decarboxylase (subunit 1/2) (EC 4.1.1.72) from Thermoplasma acidophilum (see paper)
33% identity, 97% coverage of query (186 bits)
bkdA1 / GI|790514 2-oxoisovalerate dehydrogenase subunit alpha; EC 1.2.4.4 from Pseudomonas putida (see 4 papers)
34% identity, 94% coverage of query (184 bits)
1qs0A / P09060 Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
34% identity, 94% coverage of query (184 bits)
AO356_22990 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2C3
34% identity, 96% coverage of query (181 bits)
ODBA2_ARATH / Q84JL2 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
34% identity, 94% coverage of query (181 bits)
Pf6N2E2_481 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E2
33% identity, 96% coverage of query (179 bits)
ODBA_CAEEL / O45924 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; EC 1.2.4.4 from Caenorhabditis elegans (see paper)
34% identity, 97% coverage of query (177 bits)
AO353_26635 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens FW300-N2E3
33% identity, 96% coverage of query (167 bits)
PfGW456L13_3540 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Pseudomonas fluorescens GW456-L13
33% identity, 96% coverage of query (166 bits)
SMc03201 branched-chain alpha-ketoacid dehydrogenase, E1 component alpha subunit (EC 1.2.4.4) from Sinorhizobium meliloti 1021
33% identity, 94% coverage of query (162 bits)
P50136 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Mus musculus (see paper)
31% identity, 96% coverage of query (161 bits)
ODBA_RAT / P11960 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Rattus norvegicus (Rat) (see paper)
31% identity, 96% coverage of query (161 bits)
BCKDHA / P12694 branched-chain α-keto acid dehydrogenase E1 component α subunit (EC 1.2.4.4) from Homo sapiens (see 15 papers)
ODBA_HUMAN / P12694 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Homo sapiens (Human) (see 13 papers)
P12694 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Homo sapiens (see 5 papers)
31% identity, 96% coverage of query (158 bits)
ODBA_BOVIN / P11178 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Bos taurus (Bovine) (see paper)
30% identity, 95% coverage of query (152 bits)
Build an alignment for Pf1N1B4_1020 and 33 homologs with ≥ 30% identity
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2bewA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
29% identity, 96% coverage of query (150 bits)
2bevA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
29% identity, 96% coverage of query (150 bits)
2beuA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
29% identity, 96% coverage of query (150 bits)
2bffA / P12694 Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch (see paper)
29% identity, 96% coverage of query (149 bits)
1wciA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
29% identity, 96% coverage of query (149 bits)
1dtwA Human branched-chain alpha-keto acid dehydrogenase
29% identity, 96% coverage of query (149 bits)
A2XPT6 pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Oryza sativa Indica Group (see paper)
29% identity, 91% coverage of query (134 bits)
1v1mA / P12694 Crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine (see paper)
28% identity, 96% coverage of query (134 bits)
P74490 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Synechocystis sp. PCC 6803 (see 2 papers)
30% identity, 91% coverage of query (130 bits)
P27745 acetoin dehydrogenase system (EC 2.3.1.190) from Alcaligenes eutrophus H16 (see paper)
GI|141894 acetoin:2,6-dichlorophenolindophenol oxidoreductase, alpha subunit; EC 1.1.1.- from Ralstonia eutropha H16 (see 2 papers)
acoA / AAA21948.1 acetoin:DCPIP oxidoreductase-alpha from Cupriavidus necator (see paper)
31% identity, 92% coverage of query (128 bits)
1oluA Roles of his291-alpha and his146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase
28% identity, 96% coverage of query (126 bits)
2bfcA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
28% identity, 96% coverage of query (125 bits)
Q46142 acetoin dehydrogenase system (EC 2.3.1.190) from Clostridium magnum (see paper)
acoA TPP-dependent acetoin dehydrogenase complex, E1 component, alpha subunit; EC 1.1.1.- from Clostridium magnum (see paper)
AAA21744.1 TPP-dependent acetoin dehydrogenase alpha-subunit from Clostridium magnum (see paper)
28% identity, 92% coverage of query (124 bits)
Q97YF6 acetoin dehydrogenase system (EC 2.3.1.190) from Saccharolobus solfataricus (see paper)
30% identity, 86% coverage of query (119 bits)
ODPA_YEAST / P16387 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; Pyruvate dehydrogenase complex component E1 alpha; PDHE1-A; EC 1.2.4.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P16387 pyruvate dehydrogenase system (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Saccharomyces cerevisiae (see 2 papers)
27% identity, 92% coverage of query (116 bits)
ACOA_BACSU / O31404 Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 3 papers)
28% identity, 77% coverage of query (112 bits)
acoA / Q3A7P1 acetoin:DCPIP oxidoreductase α subunit from Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (see paper)
acoA / AAA18915.1 acetoin:DCPIP oxidoreductase alpha subunit from Pelobacter carbinolicus (see paper)
28% identity, 92% coverage of query (111 bits)
ODPA1_ARATH / P52901 Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial; PDHE1-A; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
25% identity, 92% coverage of query (107 bits)
ODPAT_HUMAN / P29803 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; PDHE1-A type II; EC 1.2.4.1 from Homo sapiens (Human) (see 5 papers)
30% identity, 77% coverage of query (107 bits)
ODPA_MOUSE / P35486 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Mus musculus (Mouse) (see 6 papers)
P35486 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Mus musculus (see 2 papers)
28% identity, 92% coverage of query (105 bits)
G3H5K6 pyruvate dehydrogenase system (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Cricetulus griseus (see paper)
28% identity, 92% coverage of query (105 bits)
ODPA_RAT / P26284 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 92% coverage of query (103 bits)
6cfoA Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate
27% identity, 92% coverage of query (100 bits)
1ni4A Human pyruvate dehydrogenase
27% identity, 92% coverage of query (100 bits)
PDHA1 / P08559 pyruvate dehydrogenase E1 component α subunit (somatic) from Homo sapiens (see 6 papers)
ODPA_HUMAN / P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Homo sapiens (Human) (see 24 papers)
P08559 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Homo sapiens (see 2 papers)
27% identity, 92% coverage of query (100 bits)
3exeA / P08559 Crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex (see paper)
27% identity, 92% coverage of query (100 bits)
Q10489 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; PDHE1-A; EC 1.2.4.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
26% identity, 92% coverage of query (99.0 bits)
P26267 Pyruvate dehydrogenase E1 component subunit alpha type I, mitochondrial; PDHA1; PDHE1-A; EC 1.2.4.1 from Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
25% identity, 92% coverage of query (98.6 bits)
ODPA2_ARATH / Q8H1Y0 Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial; PDHE1-A; Protein IAA-CONJUGATE-RESISTANT 4; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8H1Y0 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Arabidopsis thaliana (see paper)
24% identity, 88% coverage of query (94.4 bits)
6cerA / P08559 Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
27% identity, 92% coverage of query (82.4 bits)
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