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Searching for up to 100 curated homologs for Pf1N1B4_1025 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_1025 (434 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PfGW456L13_4962 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens GW456-L13
    96% identity, 100% coverage of query (866 bits)

AO353_15550 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens FW300-N2E3
    94% identity, 100% coverage of query (854 bits)

Pf6N2E2_5290 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens FW300-N2E2
    90% identity, 100% coverage of query (826 bits)

HGD_PSEPK / Q88E47 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
Q88E47 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas putida (see paper)
    82% identity, 100% coverage of query (743 bits)

4aq6D / Q88E47 Substrate bound homogentisate 1,2-dioxygenase (see paper)
    83% identity, 98% coverage of query (738 bits)

3zdsA Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    83% identity, 98% coverage of query (738 bits)

3zdsF Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    83% identity, 98% coverage of query (737 bits)

3zdsC Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    83% identity, 98% coverage of query (737 bits)

HGD_PSEPU / Q6EMI9 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    80% identity, 99% coverage of query (724 bits)

RR42_RS31275 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Cupriavidus basilensis FW507-4G11
    61% identity, 98% coverage of query (547 bits)

HGD_RHIME / Q9X4F5 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    54% identity, 98% coverage of query (458 bits)

Q9ZRA2 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Arabidopsis thaliana (see paper)
    54% identity, 96% coverage of query (446 bits)

HGD_MOUSE / O09173 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Mus musculus (Mouse) (see paper)
    51% identity, 98% coverage of query (438 bits)

HGD / Q93099 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Homo sapiens (see paper)
HGD_HUMAN / Q93099 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Homo sapiens (Human) (see 14 papers)
    50% identity, 98% coverage of query (431 bits)

HGD_EMENI / Q00667 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
GI|2832726 homogentisate dioxygenase; EC 1.13.11.5; EC 1.13.11.15 from Emericella nidulans (see 2 papers)
hmgA / CAA05042.1 homogentisate dioxygenase from Aspergillus nidulans (see paper)
    53% identity, 97% coverage of query (429 bits)

B8YB76 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Bos taurus (see 2 papers)
    51% identity, 98% coverage of query (426 bits)

HMGA_ASPFU / Q4WHT9 Homogentisate 1,2-dioxygenase hmgA; Homogentisate oxygenase hmgA; Homogentisic acid oxidase hmgA; Homogentisicase hmgA; L-tyrosine degradation gene cluster protein hmgA; Pyomelanin biosynthesis cluster protein hmgA; EC 1.13.11.5 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    52% identity, 97% coverage of query (421 bits)

1ey2A / Q93099 Human homogentisate dioxygenase with fe(ii) (see paper)
    50% identity, 94% coverage of query (404 bits)

HGD_CAEEL / Q9Y041 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Caenorhabditis elegans (see paper)
    49% identity, 97% coverage of query (404 bits)

Q6JDV6 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Exophiala lecanii-corni (see paper)
    49% identity, 96% coverage of query (389 bits)

Build an alignment

Build an alignment for Pf1N1B4_1025 and 20 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory