Searching for up to 100 curated homologs for Pf1N1B4_1627 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_1627 (211 a.a.)
Found high-coverage hits (≥70%) to 39 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
hisB / BAC65272.1 imidazoleglycerol-phosphate dehydratase from Burkholderia multivorans (see paper)
77% identity, 92% coverage of query (311 bits)
BPHYT_RS17700 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Burkholderia phytofirmans PsJN
77% identity, 92% coverage of query (309 bits)
HIS5B_ARATH / O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O23346 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Arabidopsis thaliana (see paper)
50% identity, 98% coverage of query (209 bits)
HISN5A / P34047 imidazoleglycerolphosphate dehydratase (EC 4.2.1.19) from Arabidopsis thaliana (see 2 papers)
HIS5A_ARATH / P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
53% identity, 92% coverage of query (208 bits)
HIS7_CRYNJ / P0CO22 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) (see paper)
51% identity, 93% coverage of query (207 bits)
5el9A / O23346 A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
52% identity, 93% coverage of query (205 bits)
5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348
51% identity, 92% coverage of query (201 bits)
HIS7_SPILD / D2QPE6 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896 / Claus 1) (see paper)
48% identity, 96% coverage of query (194 bits)
2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase
52% identity, 86% coverage of query (191 bits)
7oj5A / A0A072VQG6 Cryo-em structure of medicago truncatula hisn5 protein
52% identity, 86% coverage of query (189 bits)
4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate
51% identity, 87% coverage of query (189 bits)
4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution
51% identity, 87% coverage of query (189 bits)
4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution
51% identity, 87% coverage of query (189 bits)
6fwhA / L8H477 Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
48% identity, 92% coverage of query (188 bits)
4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution
51% identity, 87% coverage of query (188 bits)
6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution
48% identity, 92% coverage of query (187 bits)
HisB / b2022 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
hisB / P06987 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (EC 4.2.1.19; EC 3.1.3.15) from Escherichia coli (strain K12) (see 11 papers)
46% identity, 97% coverage of query (184 bits)
HIS7_ECO57 / Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
46% identity, 97% coverage of query (184 bits)
1rhyB / P0CO22 Crystal structure of imidazole glycerol phosphate dehydratase (see paper)
47% identity, 85% coverage of query (175 bits)
HIS7_BACTN / Q8ABA7 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) (see paper)
45% identity, 95% coverage of query (175 bits)
hisB / CAQ00039.1 imidazoleglycerol-phosphate dehydratase from Rhodococcus erythropolis (see paper)
43% identity, 93% coverage of query (166 bits)
H9C4A4 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) from Kazachstania humilis (see paper)
40% identity, 93% coverage of query (161 bits)
HIS3 imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19 from Candida albicans (see paper)
38% identity, 92% coverage of query (159 bits)
HIS7_YEAST / P06633 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
39% identity, 93% coverage of query (159 bits)
his5 / GI|3116116 imidazoleglycerol-phosphate dehydratase His5; EC 4.2.1.19 from Schizosaccharomyces pombe (see 2 papers)
his5 / AAA92791.1 imidazoleglycerol-phosphate dehydratase from Schizosaccharomyces pombe (see paper)
41% identity, 92% coverage of query (158 bits)
6ezmU / P06633 Imidazoleglycerol-phosphate dehydratase from saccharomyces cerevisiae (see paper)
40% identity, 92% coverage of query (158 bits)
P40374 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
41% identity, 92% coverage of query (158 bits)
HIS7_MYCTU / P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
42% identity, 87% coverage of query (154 bits)
2ae8B / P64373 Crystal structure of imidazoleglycerol-phosphate dehydratase from staphylococcus aureus subsp. Aureus n315
46% identity, 78% coverage of query (148 bits)
4gquA / P9WML9 Crystal structure of hisb from mycobacterium tuberculosis
41% identity, 82% coverage of query (142 bits)
5xdsA Crystal structure of mycobacterium tuberculosis hisb bound with an inhibitor
41% identity, 82% coverage of query (142 bits)
4lomA Crystal structure of mycobacterium tuberculosis hisb in complex with its substrate
41% identity, 82% coverage of query (142 bits)
7fcyA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
41% identity, 82% coverage of query (142 bits)
7dnqA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
41% identity, 82% coverage of query (142 bits)
7ddvA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
41% identity, 82% coverage of query (142 bits)
4lpfA Crystal structure of mycobacterium tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
41% identity, 82% coverage of query (142 bits)
hisB imidazoleglycerol-phosphate dehydratase; EC 4.2.1.19 from Emericella nidulans (see 2 papers)
34% identity, 93% coverage of query (138 bits)
5dnlA / P58880 Crystal structure of igpd from pyrococcus furiosus in complex with (s)-c348 (see paper)
39% identity, 89% coverage of query (103 bits)
5dnxA Crystal structure of igpd from pyrococcus furiosus in complex with (r)-c348
39% identity, 89% coverage of query (103 bits)
Build an alignment for Pf1N1B4_1627 and 39 homologs with ≥ 30% identity
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Lawrence Berkeley National Laboratory