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Searching for up to 100 curated homologs for Pf1N1B4_2146 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_2146 (357 a.a.)

Found high-coverage hits (≥70%) to 90 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ALR_PSETA / B9WZ64 Alanine racemase; EC 5.1.1.1 from Pseudomonas taetrolens (see paper)
    83% identity, 100% coverage of query (618 bits)

dadX / Q88CB2 alanine racemase (EC 5.1.1.10) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 7 papers)
DADX_PSEPK / Q88CB2 Alanine racemase, catabolic; EC 5.1.1.1 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    83% identity, 100% coverage of query (614 bits)

1rcqA / Q9HTQ2 The 1.45 a crystal structure of alanine racemase from a pathogenic bacterium, pseudomonas aeruginosa, contains both internal and external aldimine forms (see paper)
dadX / AAD47081.1 catabolic alanine racemase DadX from Pseudomonas aeruginosa (see paper)
    73% identity, 100% coverage of query (551 bits)

ALR2_PSEAE / Q9HTQ2 Alanine racemase, catabolic; EC 5.1.1.1 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HTQ2 alanine racemase (EC 5.1.1.1) from Pseudomonas aeruginosa (see 2 papers)
    73% identity, 100% coverage of query (551 bits)

DadB / b1190 alanine racemase 2 (EC 5.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
dadX / P29012 alanine racemase 2 (EC 5.1.1.10) from Escherichia coli (strain K12) (see 26 papers)
ALR2_ECOLI / P29012 Alanine racemase, catabolic; EC 5.1.1.1 from Escherichia coli (strain K12) (see paper)
    48% identity, 99% coverage of query (327 bits)

dadX / AAC36881.1 catabolic alanine racemase from Escherichia coli (see paper)
    48% identity, 99% coverage of query (322 bits)

ALR1_PSEAE / Q9HUN4 Alanine racemase, biosynthetic; EC 5.1.1.1 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9HUN4 alanine racemase (EC 5.1.1.1) from Pseudomonas aeruginosa (see paper)
6a2fA / Q9HUN4 Crystal structure of biosynthetic alanine racemase from pseudomonas aeruginosa (see paper)
    49% identity, 99% coverage of query (321 bits)

alr / AAD47082.1 biosynthetic alanine racemase from Pseudomonas aeruginosa (see paper)
    49% identity, 99% coverage of query (320 bits)

ALR2_SALTY / P06191 Alanine racemase, catabolic; EC 5.1.1.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    47% identity, 99% coverage of query (320 bits)

Alr / b4053 alanine racemase 1 (EC 5.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
alr / P0A6B4 alanine racemase 1 (EC 5.1.1.10) from Escherichia coli (strain K12) (see 25 papers)
ALR1_ECOLI / P0A6B4 Alanine racemase, biosynthetic; EC 5.1.1.1 from Escherichia coli (strain K12) (see paper)
ALR1_SHIFL / P0A6B5 Alanine racemase, biosynthetic; EC 5.1.1.1 from Shigella flexneri (see paper)
P0A6B4 alanine racemase (EC 5.1.1.1) from Escherichia coli (see 3 papers)
P0A6B5 alanine racemase (EC 5.1.1.1) from Shigella flexneri (see paper)
P0A6B6 alanine racemase (EC 5.1.1.1) from Shigella boydii (see paper)
    47% identity, 99% coverage of query (318 bits)

2rjhA Crystal structure of biosynthetic alaine racemase in d-cycloserine- bound form from escherichia coli
    47% identity, 99% coverage of query (318 bits)

Q93HP9 alanine racemase (EC 5.1.1.1) from Shigella sonnei (see paper)
    47% identity, 99% coverage of query (317 bits)

Q932V0 alanine racemase (EC 5.1.1.1) from Shigella dysenteriae (see paper)
    47% identity, 99% coverage of query (317 bits)

3b8tA / P0A6B4 Crystal structure of escherichia coli alaine racemase mutant p219a (see paper)
    47% identity, 99% coverage of query (315 bits)

4xbjA Y274f alanine racemase from e. Coli inhibited by l-ala-p
    47% identity, 98% coverage of query (315 bits)

ALR_VIBCH / Q9KUY6 Alanine racemase; EC 5.1.1.1 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
    47% identity, 100% coverage of query (313 bits)

ALR1_SALTY / P0A1A3 Alanine racemase, biosynthetic; EC 5.1.1.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
alr / GI|153865 alanine racemase, biosynthetic; EC 5.1.1.1 from Salmonella enterica subsp. enterica serovar Typhimurium (see 3 papers)
    46% identity, 99% coverage of query (307 bits)

Q62JA4 alanine racemase (EC 5.1.1.1) from Burkholderia mallei (see paper)
Q63SZ2 alanine racemase (EC 5.1.1.1) from Burkholderia pseudomallei (see paper)
    47% identity, 98% coverage of query (305 bits)

ALR1_SCHPO / O59828 Alanine racemase, catabolic; EC 5.1.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
O59828 alanine racemase (EC 5.1.1.1) from Schizosaccharomyces pombe (see paper)
alr1 / GI|3136037 alanine racemase Alr1; EC 5.1.1.1 from Schizosaccharomyces pombe (see 2 papers)
    42% identity, 99% coverage of query (297 bits)

A0KL98 alanine racemase (EC 5.1.1.1) from Aeromonas hydrophila subsp. hydrophila (see paper)
    44% identity, 99% coverage of query (293 bits)

Q63ME6 alanine racemase (EC 5.1.1.1) from Burkholderia pseudomallei (see paper)
    48% identity, 98% coverage of query (291 bits)

P45257 alanine racemase (EC 5.1.1.1) from Haemophilus influenzae (see paper)
    41% identity, 97% coverage of query (272 bits)

D0C5Y6 alanine racemase (EC 5.1.1.1) from Acinetobacter baumannii (see paper)
    38% identity, 99% coverage of query (259 bits)

Q8R860 alanine racemase (EC 5.1.1.1) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
    35% identity, 99% coverage of query (212 bits)

4y2wA / Q8RAK6 Crystal structure of a thermostable alanine racemase from thermoanaerobacter tengcongensis mb4 (see paper)
    33% identity, 99% coverage of query (196 bits)

ALR_METMP / Q6LX41 Alanine racemase; EC 5.1.1.1 from Methanococcus maripaludis (strain S2 / LL) (see paper)
    34% identity, 99% coverage of query (196 bits)

Q8RAK6 alanine racemase (EC 5.1.1.1) from Caldanaerobacter subterraneus subsp. tengcongensis (see 2 papers)
    33% identity, 99% coverage of query (195 bits)

ALR_STRPN / P0A2W8 Alanine racemase; EC 5.1.1.1 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see paper)
P0A2W8 alanine racemase (EC 5.1.1.1) from Streptococcus pneumoniae (see 2 papers)
    37% identity, 99% coverage of query (187 bits)

Q1WV14 alanine racemase (EC 5.1.1.1) from Ligilactobacillus salivarius (see paper)
    35% identity, 99% coverage of query (186 bits)

Q8DSF4 alanine racemase (EC 5.1.1.1) from Streptococcus mutans serotype c (see 2 papers)
    35% identity, 99% coverage of query (179 bits)

3e5pB / Q837J0 Crystal structure of alanine racemase from e.Faecalis (see paper)
    34% identity, 99% coverage of query (176 bits)

5fagA / O86786 Alanine racemase from streptomyces coelicolor a3(2) with bound propionate inhibitor (see paper)
    38% identity, 98% coverage of query (176 bits)

O86786 alanine racemase (EC 5.1.1.1) from Streptomyces coelicolor (see paper)
    38% identity, 98% coverage of query (176 bits)

3e6eA Crystal structure of alanine racemase from e.Faecalis complex with cycloserine
    34% identity, 99% coverage of query (176 bits)

5fajA Alanine racemase from streptomyces coelicolor a3(2) in complex with d- cycloserine
    38% identity, 98% coverage of query (176 bits)

Q1XG01 alanine racemase (EC 5.1.1.1) from Helicobacter pylori (see 2 papers)
    33% identity, 99% coverage of query (174 bits)

Q180W0 alanine racemase (EC 5.1.1.1) from Clostridioides difficile (see 2 papers)
    32% identity, 99% coverage of query (169 bits)

ALR_PERPY / Q9S5V6 Alanine racemase; EC 5.1.1.1 from Peribacillus psychrosaccharolyticus (Bacillus psychrosaccharolyticus) (see paper)
Q9S5V6 alanine racemase (EC 5.1.1.1) from Peribacillus psychrosaccharolyticus (see paper)
ala / GB|BAA76373.1 alanine racemase; EC 5.1.1.1 from Bacillus psychrosaccharolyticus (see paper)
    34% identity, 99% coverage of query (167 bits)

ALR_MYCTU / P9WQA9 Alanine racemase; EC 5.1.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WQA9 alanine racemase (EC 5.1.1.1) from Mycobacterium tuberculosis (see 4 papers)
    35% identity, 97% coverage of query (166 bits)

6sczA / P9WQA9 Mycobacterium tuberculosis alanine racemase inhibited by dcs (see paper)
    35% identity, 97% coverage of query (166 bits)

1xfcA The 1.9 a crystal structure of alanine racemase from mycobacterium tuberculosis contains a conserved entryway into the active site
    35% identity, 97% coverage of query (164 bits)

ALR_AQUPY / Q9RER4 Alanine racemase; EC 5.1.1.1 from Aquifex pyrophilus
    32% identity, 99% coverage of query (162 bits)

5yycA / D3FSP1 Crystal structure of alanine racemase from bacillus pseudofirmus (of4) (see paper)
    33% identity, 99% coverage of query (161 bits)

5irpA / P94494 Crystal structure of the alanine racemase bsu17640 from bacillus subtilis (see paper)
    31% identity, 97% coverage of query (158 bits)

P94494 alanine racemase (EC 5.1.1.1) from Bacillus subtilis (see paper)
    31% identity, 97% coverage of query (158 bits)

6q70A Crystal structure of the alanine racemase bsu17640 from bacillus subtilis in the presence of hepes
    31% identity, 97% coverage of query (158 bits)

ALR1_STAAM / P63479 Alanine racemase 1; EC 5.1.1.1 from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
P63479 alanine racemase (EC 5.1.1.1) from Staphylococcus aureus (see paper)
    33% identity, 99% coverage of query (157 bits)

1vfsA / Q65YW7 Crystal structure of d-cycloserine-bound form of alanine racemase from d-cycloserine-producing streptomyces lavendulae (see paper)
    36% identity, 98% coverage of query (157 bits)

6g59A / P63479 Structure of the alanine racemase from staphylococcus aureus in complex with an pyridoxal-6- phosphate derivative (see paper)
    33% identity, 99% coverage of query (157 bits)

6g58A Structure of the alanine racemase from staphylococcus aureus in complex with a pyridoxal 5' phosphate-derivative
    33% identity, 99% coverage of query (157 bits)

1vfhA Crystal structure of alanine racemase from d-cycloserine producing streptomyces lavendulae
    36% identity, 98% coverage of query (157 bits)

7xllA / A0A2L0E502 Alanine racemase from lactobacillus sakei uonuma-1. (see paper)
    33% identity, 100% coverage of query (156 bits)

4lusB Alanine racemase [clostridium difficile 630]
    31% identity, 99% coverage of query (155 bits)

ALR_CORGL / Q8RSU9 Alanine racemase; EC 5.1.1.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
    33% identity, 95% coverage of query (153 bits)

4lutA / Q180W0 Alanine racemase [clostridium difficile 630] complex with cycloserine (see paper)
    31% identity, 99% coverage of query (151 bits)

2vd8A / A0A6L7HC45 The crystal structure of alanine racemase from bacillus anthracis (ba0252) (see paper)
    33% identity, 97% coverage of query (150 bits)

2vd9A The crystal structure of alanine racemase from bacillus anthracis (ba0252) with bound l-ala-p
    33% identity, 97% coverage of query (150 bits)

ALR_MYCSM / P94967 Alanine racemase; EC 5.1.1.1 from Mycolicibacterium smegmatis (Mycobacterium smegmatis) (see paper)
    35% identity, 85% coverage of query (147 bits)

Q208U6 alanine racemase (EC 5.1.1.1) from Bacillus thuringiensis (see paper)
    33% identity, 97% coverage of query (147 bits)

ALR_MYCAV / Q9L888 Alanine racemase; EC 5.1.1.1 from Mycobacterium avium (see paper)
    34% identity, 97% coverage of query (147 bits)

vanT / Q9X3P3 serine/alanine racemase monomer (EC 5.1.1.10) from Enterococcus gallinarum (see 2 papers)
VANT_ENTGA / Q9X3P3 Serine/alanine racemase; Vancomycin C-type resistance protein VanT; EC 5.1.1.-; EC 5.1.1.1 from Enterococcus gallinarum (see 2 papers)
    32% identity, 94% coverage of query (145 bits)

2dy3D / Q8RSU9 Crystal structure of alanine racemase from corynebacterium glutamicum
    33% identity, 95% coverage of query (142 bits)

P10725 alanine racemase (EC 5.1.1.1) from Bacillus subtilis (see paper)
    31% identity, 99% coverage of query (141 bits)

1epvA / P10724 Alanine racemase with bound inhibitor derived from d- cycloserine (see paper)
    33% identity, 99% coverage of query (140 bits)

ALR_GEOSE / P10724 Alanine racemase; EC 5.1.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 8 papers)
P10724 alanine racemase (EC 5.1.1.1) from Geobacillus stearothermophilus (see 11 papers)
ala alanine racemase; EC 5.1.1.1 from Geobacillus stearothermophilus (see 8 papers)
    33% identity, 99% coverage of query (140 bits)

ala / PDB|1SFT_A alanine racemase from Geobacillus stearothermophilus (see 2 papers)
    33% identity, 99% coverage of query (140 bits)

1sftA Alanine racemase
    33% identity, 99% coverage of query (140 bits)

1l6gA Alanine racemase bound with n-(5'-phosphopyridoxyl)-d-alanine
    33% identity, 99% coverage of query (140 bits)

1l6fA Alanine racemase bound with n-(5'-phosphopyridoxyl)-l-alanine
    33% identity, 99% coverage of query (140 bits)

1bd0A Alanine racemase complexed with alanine phosphonate
    33% identity, 99% coverage of query (140 bits)

1ftxA Crystal structure of alanine racemase in complex with d-alanine phosphonate
    33% identity, 99% coverage of query (140 bits)

1xqlA Effect of a y265f mutant on the transamination based cycloserine inactivation of alanine racemase
    32% identity, 99% coverage of query (139 bits)

1xqkA Effect of a y265f mutant on the transamination based cycloserine inactivation of alanine racemase
    32% identity, 99% coverage of query (139 bits)

ala / PDB|1NIU_A alanine racemase from Geobacillus stearothermophilus (see 3 papers)
    32% identity, 99% coverage of query (137 bits)

Q04DI1 alanine racemase (EC 5.1.1.1) from Oenococcus oeni (see paper)
    30% identity, 99% coverage of query (135 bits)

Build an alignment

Build an alignment for Pf1N1B4_2146 and 75 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

LYSR_OENOB / Q04HB7 Lysine racemase; EC 5.1.1.5 from Oenococcus oeni (strain ATCC BAA-331 / PSU-1) (see 2 papers)
Q04HB7 lysine racemase (EC 5.1.1.5) from Oenococcus oeni (see paper)
    28% identity, 96% coverage of query (127 bits)

4a3qA / P63479 The 2.15 angstrom resolution crystal structure of staphylococcus aureus alanine racemase (see paper)
    31% identity, 99% coverage of query (124 bits)

3co8A / Q04HB7 Crystal structure of alanine racemase from oenococcus oeni (see paper)
    27% identity, 96% coverage of query (123 bits)

4fs9A / I6LNY0 Complex structure of a broad specificity amino acid racemase (bar) within the reactive intermediate (see paper)
    31% identity, 89% coverage of query (112 bits)

5zl6A / Q03Z32 Histidine racemase from leuconostoc mesenteroides subsp. Sake nbrc 102480 (see paper)
    28% identity, 90% coverage of query (110 bits)

alr / Q88GJ9 amino acid racemase (EC 5.1.1.10) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
BSR_PSEPK / Q88GJ9 Broad specificity amino-acid racemase; Broad spectrum racemase; EC 5.1.1.10 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    32% identity, 89% coverage of query (109 bits)

Q03Z32 histidine racemase (EC 5.1.1.24) from Leuconostoc mesenteroides subsp. mesenteroides (see paper)
    28% identity, 90% coverage of query (108 bits)

BSR_PSEPU / I6LNY0 Broad specificity amino-acid racemase; EC 5.1.1.10 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 2 papers)
    31% identity, 89% coverage of query (108 bits)

BSR_PSETA / I0J1I6 Broad specificity amino-acid racemase; Arginine racemase; Broad substrate specificity racemase; EC 5.1.1.10 from Pseudomonas taetrolens (see 2 papers)
I0J1I6 amino-acid racemase (EC 5.1.1.10) from Pseudomonas taetrolens (see paper)
    29% identity, 89% coverage of query (104 bits)

BSR_AERHH / A0KLG5 Broad specificity amino-acid racemase; Broad spectrum racemase; EC 5.1.1.10 from Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) (see paper)
    27% identity, 89% coverage of query (100 bits)

4bf5A / A0KLG5 Structure of broad spectrum racemase from aeromonas hydrophila (see paper)
    27% identity, 89% coverage of query (100 bits)

LYR_PROMI / M4GGR9 Lysine racemase; EC 5.1.1.5 from Proteus mirabilis (see paper)
M4GGR9 lysine racemase (EC 5.1.1.5) from Proteus mirabilis (see paper)
    26% identity, 89% coverage of query (95.5 bits)

B9WYE8 alanine racemase (EC 5.1.1.1) from Penaeus japonicus (see paper)
    26% identity, 87% coverage of query (94.4 bits)

bsrV / Q9KSE5 broad specificity amino-acid racemase (EC 5.1.1.10) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 4 papers)
BSR_VIBCH / Q9KSE5 Broad specificity amino-acid racemase; Broad spectrum racemase; EC 5.1.1.10 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 3 papers)
    25% identity, 84% coverage of query (91.7 bits)

4beuA / Q9KSE5 Structure of vibrio cholerae broad spectrum racemase (see paper)
    25% identity, 84% coverage of query (91.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory