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Searching for up to 100 curated homologs for Pf1N1B4_4280 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_4280 (341 a.a.)

Found high-coverage hits (≥70%) to 44 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AO353_21365 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2E3
    97% identity, 98% coverage of query (655 bits)

AO356_23190 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2C3
    96% identity, 98% coverage of query (637 bits)

PS417_11875 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas simiae WCS417
    93% identity, 98% coverage of query (630 bits)

BWI76_RS03095 Inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella michiganensis M5al
    73% identity, 98% coverage of query (509 bits)

iolG / A0A0H3FQ94 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56) (see 2 papers)
    72% identity, 98% coverage of query (503 bits)

iolG / P26935 inositol 2-dehydrogenase monomer (EC 1.1.1.18; EC 1.1.1.369) from Bacillus subtilis (strain 168) (see 5 papers)
IOLG_BACSU / P26935 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; MI 2-dehydrogenase/DCI 3-dehydrogenase; EC 1.1.1.18; EC 1.1.1.369 from Bacillus subtilis (strain 168) (see 3 papers)
P26935 inositol 2-dehydrogenase (EC 1.1.1.18); D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Bacillus subtilis (see 7 papers)
    62% identity, 98% coverage of query (451 bits)

3nt5A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor and product inosose
    62% identity, 98% coverage of query (450 bits)

3nt4A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor nadh and inositol
    62% identity, 98% coverage of query (450 bits)

3nt2B Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    62% identity, 98% coverage of query (450 bits)

3nt2A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    62% identity, 98% coverage of query (450 bits)

4l8vA / P26935 Crystal structure of a12k/d35s mutant myo-inositol dehydrogenase from bacillus subtilis with bound cofactor NADP (see paper)
    61% identity, 98% coverage of query (446 bits)

3ec7A / Q8ZK57 Crystal structure of putative dehydrogenase from salmonella typhimurium lt2
    50% identity, 98% coverage of query (351 bits)

E1U887 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    47% identity, 98% coverage of query (314 bits)

4minA / A0A0J9X1Y2 Crystal structure of myo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD
    47% identity, 98% coverage of query (313 bits)

4mjlD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD and d-chiro-inositol
    47% identity, 98% coverage of query (313 bits)

4mioD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    47% identity, 98% coverage of query (313 bits)

4mioA Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    47% identity, 98% coverage of query (313 bits)

Q8NTY7 inositol 2-dehydrogenase (EC 1.1.1.18) from Corynebacterium glutamicum (see paper)
    40% identity, 99% coverage of query (234 bits)

Build an alignment

Build an alignment for Pf1N1B4_4280 and 18 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

4n54A / A0A0J9X1Y7 Crystal structure of scyllo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD(h) and scyllo-inositol
    26% identity, 95% coverage of query (124 bits)

E1U888 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    25% identity, 98% coverage of query (124 bits)

3ceaA / F9ULF9 Crystal structure of myo-inositol 2-dehydrogenase (np_786804.1) from lactobacillus plantarum at 2.40 a resolution
    25% identity, 96% coverage of query (122 bits)

iolG / Q9WYP5 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
IOLG_THEMA / Q9WYP5 Myo-inositol 2-dehydrogenase; EC 1.1.1.18 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9WYP5 D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Thermotoga maritima (see paper)
    28% identity, 95% coverage of query (117 bits)

iolX / P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (strain 168) (see paper)
IOLX_BACSU / P40332 scyllo-inositol 2-dehydrogenase (NAD(+)); EC 1.1.1.370 from Bacillus subtilis (strain 168) (see paper)
P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (see 2 papers)
    28% identity, 87% coverage of query (112 bits)

HSERO_RS12095 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Herbaspirillum seropedicae SmR1
    27% identity, 94% coverage of query (102 bits)

SM_b20899 Inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti 1021
MI2D_RHIME / O68965 Inositol 2-dehydrogenase; Myo-inositol 2-dehydrogenase; MI-dehydrogenase; EC 1.1.1.18 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
O68965 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti (see paper)
    29% identity, 89% coverage of query (100 bits)

Q9EZV8 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium fredii (see paper)
    28% identity, 89% coverage of query (96.3 bits)

mocA / GB|CAA55269.1 rhizopine catabolism protein MocA from Sinorhizobium meliloti (see paper)
    27% identity, 92% coverage of query (91.7 bits)

6jw7A / Q6L737 The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin a (see paper)
    27% identity, 72% coverage of query (73.9 bits)

6jw6A The crystal structure of kand2 in complex with NAD
    27% identity, 72% coverage of query (73.9 bits)

6jw8A The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin b
    27% identity, 72% coverage of query (73.9 bits)

3e18A / Q929L3 Crystal structure of NAD-binding protein from listeria innocua
    26% identity, 75% coverage of query (68.2 bits)

ntdC / O07564 glucose-6-phosphate 3-dehydrogenase (EC 1.1.1.361) from Bacillus subtilis (strain 168) (see 4 papers)
NTDC_BACSU / O07564 Glucose-6-phosphate 3-dehydrogenase; EC 1.1.1.361 from Bacillus subtilis (strain 168) (see 3 papers)
O07564 glucose-6-phosphate 3-dehydrogenase (EC 1.1.1.361) from Bacillus subtilis (see 2 papers)
    24% identity, 89% coverage of query (63.2 bits)

7x2yA / A0A076PYH9 Crystal structure of cis-4,5-dihydrodiol phthalate dehydrogenase in complex with NAD+ and 3-hydroxybenzoate (see paper)
    24% identity, 72% coverage of query (60.1 bits)

5uhwA / B9JK80 Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+ and magnesium
    24% identity, 95% coverage of query (58.2 bits)

apsD / B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium radiobacter (strain K84 / ATCC BAA-868) (see paper)
APSD_RHIR8 / B9JK80 D-apiose dehydrogenase; EC 1.1.1.420 from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter) (see paper)
B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium tumefaciens (see paper)
    24% identity, 95% coverage of query (58.2 bits)

5uiaA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, r-2,3-dihydroxyisovalerate and magnesium
    24% identity, 95% coverage of query (58.2 bits)

5ui9A Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, 2 -hydroxy-2-hydroxymethyl propanoic acid and magnesium
    24% identity, 95% coverage of query (58.2 bits)

5uhzA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, d-apionate and magnesium
    24% identity, 95% coverage of query (58.2 bits)

UGNO_METMP / Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase; UDP-GlcNAc oxidoreductase; UDP-N-acetyl-alpha-D-glucosamine:NAD(+) 3-oxidoreductase; EC 1.1.1.374 from Methanococcus maripaludis (strain S2 / LL) (see paper)
Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Methanococcus maripaludis (see paper)
    24% identity, 74% coverage of query (57.8 bits)

DHDH_RABIT / Q9TV70 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Ory2DD; EC 1.3.1.20; EC 1.1.1.179 from Oryctolagus cuniculus (Rabbit) (see 2 papers)
    29% identity, 72% coverage of query (57.4 bits)

APSD_PARG4 / B1G894 D-apiose dehydrogenase; EC 1.1.1.420 from Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M) (see paper)
    24% identity, 70% coverage of query (55.8 bits)

D4GR07 L-arabinose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.376) from Haloferax volcanii (see paper)
    25% identity, 72% coverage of query (54.3 bits)

KIJDR_ACTKI / B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase; 3-ketoreductase; NADPH-dependent C3-ketoreductase; EC 1.1.1.384 from Actinomadura kijaniata (see paper)
B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase (EC 1.1.1.384) from Actinomadura kijaniata (see paper)
    24% identity, 72% coverage of query (48.1 bits)

3rc1A / B3TMR8 Crystal structure of kijd10, a 3-ketoreductase from actinomadura kijaniata incomplex with NADP and tdp-benzene (see paper)
    24% identity, 72% coverage of query (47.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory