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Searching for up to 100 curated homologs for Pf1N1B4_4413 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_4413 (451 a.a.)

Found high-coverage hits (≥70%) to 70 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

DctA / b3528 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
dctA / P0A830 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli (strain K12) (see 23 papers)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12) (see 6 papers)
dctA / GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli (see 5 papers)
    55% identity, 94% coverage of query (499 bits)

TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
    57% identity, 94% coverage of query (491 bits)

DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    56% identity, 93% coverage of query (490 bits)

AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
    58% identity, 91% coverage of query (490 bits)

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
    55% identity, 97% coverage of query (488 bits)

TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
    55% identity, 93% coverage of query (459 bits)

TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis (see 2 papers)
    52% identity, 92% coverage of query (432 bits)

GLTT_BACSU / O07605 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus subtilis (strain 168) (see 2 papers)
    38% identity, 93% coverage of query (319 bits)

GltP / b4077 glutamate/aspartate : H+ symporter GltP from Escherichia coli K-12 substr. MG1655 (see paper)
gltP / P21345 glutamate/aspartate : H+ symporter GltP from Escherichia coli (strain K12) (see 5 papers)
GLTP_ECOLI / P21345 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.23.1.1 / P21345 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) from Escherichia coli (see 6 papers)
    40% identity, 90% coverage of query (306 bits)

GLTT_GEOSE / P24943 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 3 papers)
TC 2.A.23.1.2 / P24943 Glutamate/aspartate:Na+ + H+ symporter from Bacillus stearothermophilus (see 4 papers)
gltT / GI|143000 proton/sodium-glutamate symport protein GltT from Geobacillus stearothermophilus (see 4 papers)
    38% identity, 85% coverage of query (285 bits)

GLTT_BACCA / P24944 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus caldotenax (see 2 papers)
gltT / GI|143002 proton/sodium-glutamate symport protein GltT from Bacillus caldotenax (see 4 papers)
    38% identity, 86% coverage of query (284 bits)

GLTP_BACSU / P39817 Proton/glutamate-aspartate symporter; Proton/glutamate symport protein from Bacillus subtilis (strain 168) (see paper)
GltP / AAA82878.1 proton/glutamate symport protein from Bacillus subtilis (see paper)
    38% identity, 86% coverage of query (262 bits)

AO356_01905 L-aspartate transporter from Pseudomonas fluorescens FW300-N2C3
    40% identity, 80% coverage of query (226 bits)

RR42_RS03990 aspartate:proton symporter Glt from Cupriavidus basilensis FW507-4G11
    33% identity, 90% coverage of query (224 bits)

GLT_PYRHO / O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 9 papers)
TC 2.A.23.1.5 / O59010 Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ from Pyrococcus horikoshii (see 2 papers)
    32% identity, 88% coverage of query (205 bits)

2nwwA Crystal structure of gltph in complex with tboa
    32% identity, 86% coverage of query (203 bits)

6x15A / O59010 Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
    32% identity, 87% coverage of query (202 bits)

6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa
    32% identity, 86% coverage of query (200 bits)

Psest_4075 symporter for L-glutamate, L-glutamine, and L-proline from Pseudomonas stutzeri RCH2
    32% identity, 90% coverage of query (199 bits)

6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine
    32% identity, 87% coverage of query (199 bits)

6bauA Crystal structure of gltph r397c in complex with l-cysteine
    32% identity, 86% coverage of query (198 bits)

Sama_1319 symporter for L-glutamate, L-glutamine, and L-aspartate from Shewanella amazonensis SB2B
    33% identity, 85% coverage of query (192 bits)

6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate
    32% identity, 88% coverage of query (190 bits)

6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis)
    32% identity, 88% coverage of query (189 bits)

6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound
    32% identity, 88% coverage of query (189 bits)

5e9sA / Q5JID0 Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
    32% identity, 88% coverage of query (188 bits)

6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor
    32% identity, 88% coverage of query (188 bits)

6bmiA Crystal structure of gltph r397c in complex with l-serine
    31% identity, 86% coverage of query (178 bits)

Build an alignment

Build an alignment for Pf1N1B4_4413 and 28 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

7awmA / P43003,Q15758 Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
    29% identity, 79% coverage of query (140 bits)

AAAT_MOUSE / P51912 Neutral amino acid transporter B(0); ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Mus musculus (Mouse) (see 4 papers)
TC 2.A.23.3.2 / P51912 Insulin-activated, Na+-dependet amino acid (serine, alanine, glutamate, glutamine and other neutral amino acids):amino acid antiporter (Ndaru et al. 2019). Also transports homocysteine from Mus musculus (Mouse) (see 2 papers)
Slc1a5 neutral amino acid transporter B(0) from Mus musculus (see paper)
    29% identity, 86% coverage of query (132 bits)

AAAT_BOVIN / Q95JC7 Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Bos taurus (Bovine) (see paper)
    29% identity, 90% coverage of query (132 bits)

EAA3_RABIT / P31597 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Oryctolagus cuniculus (Rabbit) (see paper)
    25% identity, 87% coverage of query (132 bits)

AAAT_RABIT / O19105 Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Oryctolagus cuniculus (Rabbit) (see paper)
    30% identity, 81% coverage of query (132 bits)

5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101
    28% identity, 79% coverage of query (131 bits)

EAA1_AMBTI / O57321 Excitatory amino acid transporter 1; SEAAT1; Sodium-dependent glutamate/aspartate transporter; GLAST from Ambystoma tigrinum (Eastern tiger salamander) (see 2 papers)
    26% identity, 90% coverage of query (128 bits)

TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
    25% identity, 85% coverage of query (127 bits)

7xr4A / P43004 Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
    27% identity, 84% coverage of query (127 bits)

7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613
    27% identity, 84% coverage of query (127 bits)

8cv2A / P43005 Human excitatory amino acid transporter 3 (eaat3) in an outward facing sodium-bound state (see paper)
    27% identity, 85% coverage of query (124 bits)

8ctcA Human excitatory amino acid transporter 3 (eaat3) with bound glutamate in an intermediate outward facing state
    28% identity, 85% coverage of query (124 bits)

8cuaA Human excitatory amino acid transporter 3 (eaat3) with bound potassium in an intermediate outward facing state
    28% identity, 85% coverage of query (124 bits)

AAAT_RAT / D3ZJ25 Neutral amino acid transporter B(0); ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2 from Rattus norvegicus (Rat) (see paper)
    28% identity, 86% coverage of query (123 bits)

EAA3_MOUSE / P51906 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Mus musculus (Mouse) (see 6 papers)
    25% identity, 80% coverage of query (122 bits)

EAA3_RAT / P51907 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Rattus norvegicus (Rat) (see 4 papers)
    25% identity, 80% coverage of query (122 bits)

7vr7A Inward-facing structure of human eaat2 in the way213613-bound state
    27% identity, 84% coverage of query (122 bits)

6x2zA Heaat3-ofs-asp
    27% identity, 85% coverage of query (121 bits)

EAA2_RAT / P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat) (see 3 papers)
TC 2.A.23.2.2 / P31596 Glutamate/aspartate:Na+ symporter, GLT1; GLUT-R; EAAT2. Interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). Cotransports glutamic acid with three Na+ followed by countertransport of K+ (Teichman et al., 2009). The C-terminal 74aa domain regulates transport activity (Leinenweber et al., 2011). Hippocampal glutamate transporter 1 (GLT-1) levels parallel memory training (Heo et al., 2011). GLT-1 is regulated by MAGI-1 from Rattus norvegicus (Rat) (see 5 papers)
    25% identity, 94% coverage of query (119 bits)

7nsgA Structure of human excitatory amino acid transporter 3 (eaat3) in complex with hip-b
    28% identity, 85% coverage of query (119 bits)

6s3qA Structure of human excitatory amino acid transporter 3 (eaat3) in complex with tfb-tboa
    28% identity, 85% coverage of query (119 bits)

O35874 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Mus musculus (Mouse)
    26% identity, 89% coverage of query (119 bits)

7bcsA Asct2 in the presence of the inhibitor lc-bpe (position "down") in the outward-open conformation.
    28% identity, 83% coverage of query (119 bits)

7bcqA Asct2 in the presence of the inhibitor lc-bpe (position "up") in the outward-open conformation.
    28% identity, 83% coverage of query (119 bits)

6mpbB / Q15758 Cryo-em structure of the human neutral amino acid transporter asct2 (see paper)
    28% identity, 83% coverage of query (118 bits)

AAAT_HUMAN / Q15758 Neutral amino acid transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Homo sapiens (Human) (see 13 papers)
TC 2.A.23.3.3 / Q15758 Broad-specificity amino acid:Na+ symporter, LAT1, M7V1, RDR, RDRC or SLC1A5 (transports most neutral, zwitterionic and dibasic amino acids either uptake or bidirectional transport) (Scalise et al. 2018). Required for intracellular multiplication of Legionella pneumophila (Wieland et al., 2005). SLC7A5 with accessory protein SLC3A2 (the heavy chain; TC# 8.A.9.2.2) mediates bidirectional transport of amino acids and regulates mTOR and autophagy from Homo sapiens (Human) (see 13 papers)
SLC1A5 / RF|NP_005619.1 neutral amino acid transporter B(0) from Homo sapiens (see paper)
    27% identity, 89% coverage of query (118 bits)

EAA1_MOUSE / P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse) (see 6 papers)
    24% identity, 95% coverage of query (118 bits)

EAA2_MOUSE / P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse) (see 6 papers)
    25% identity, 94% coverage of query (118 bits)

EAA1_HUMAN / P43003 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Homo sapiens (Human) (see 8 papers)
TC 2.A.23.2.6 / P43003 Excitatory amino acid transporter 1 (EAAT1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) from Homo sapiens (see 9 papers)
    24% identity, 89% coverage of query (117 bits)

EAA1_RAT / P24942 Excitatory amino acid transporter 1; Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; GLAST; GLAST-1; Solute carrier family 1 member 3 from Rattus norvegicus (Rat) (see 4 papers)
TC 2.A.23.2.1 / P24942 Glutamate/aspartate:Na+ symporter, GLAST or EAAT1, Structural rearrangements have been probed by Leighton et al., 2006). EAAT1 interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). CEAT1 couples glutamate uptake to the symport of 3 Na+ and 1 H+ followed by the antiport of 1 K+. It can function as an uncoupled anion, water and/or urea channel (Vandenberg et al., 2011). Large collective motions regulate the functional properties of EAAT1 trimers from Rattus norvegicus (Rat) (see 5 papers)
Slc1a3 / RF|NP_062098.1 excitatory amino acid transporter 1 from Rattus norvegicus (see paper)
    24% identity, 95% coverage of query (117 bits)

EAA1_BOVIN / P46411 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Bos taurus (Bovine) (see paper)
    24% identity, 89% coverage of query (117 bits)

EAA2_HUMAN / P43004 Excitatory amino acid transporter 2; Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.23.2.7 / P43004 Excitatory amino acid transporter 2, EAAT2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) from Homo sapiens (see 9 papers)
    24% identity, 92% coverage of query (116 bits)

SATT_HUMAN / P43007 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Homo sapiens (Human) (see 7 papers)
TC 2.A.23.3.1 / P43007 Neutral amino acid (alanine, serine, cysteine, threonine):Na+ symporter. Also transports homocysteine (Jiang et al., 2007). AscT1 is the Syncytin-1 (Q9UQF0) receptor. Syncytin-1, of 538 aas with 4-7 TMSs, is a viral fusion protein and is involved in the development of multiple sclerosis (Antony et al. 2007). Mutation causes nuerological problems including global developmental delay, severe progressive microcephaly, seizures, spasticity and thin corpus callosum (CC) from Homo sapiens (Human) (see 9 papers)
SLC1A4 / RF|NP_003029.2 neutral amino acid transporter A from Homo sapiens (see paper)
    25% identity, 90% coverage of query (112 bits)

EAA3_HUMAN / P43005 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Homo sapiens (Human) (see 9 papers)
TC 2.A.23.2.3 / P43005 Glutamate/aspartate/cysteine:Na+ symporter, EAAC1; EAAT3, SLC1A1 (Li+ can replace Na+; EAAC1 also mediates glutamate-independent anion conductance.) Cotransports glutamic acid with three Na+ followed by countertransport of K+(Teichman et al., 2009). The 50 residue 4B-4C loop (following TMS4) binds Na+ (Koch et al., 2007). (The dicarboxylic aminoaciduria protein in humans; NP_004161; Bröer, 2008a; 2008b). Neutralizing aspartate 83 modifies substrate translocation from Homo sapiens (Human) (see 6 papers)
    26% identity, 85% coverage of query (112 bits)

EAA4_HUMAN / P48664 Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Homo sapiens (Human) (see 2 papers)
TC 2.A.23.2.8 / P48664 Excitatory amino acid transporter 4, EAAT4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6) from Homo sapiens (see 2 papers)
    27% identity, 92% coverage of query (111 bits)

TC 2.A.23.2.10 / Q10901 Excitatory amino acid transporter (Sodium-dependent glutamate/aspartate transporter), Gkt-1 of 503 aas and 9 - 11 TMSs from Caenorhabditis elegans (see 5 papers)
    24% identity, 90% coverage of query (111 bits)

Q10901 Excitatory amino acid transporter; Sodium-dependent glutamate/ aspartate transporter from Caenorhabditis elegans
    24% identity, 90% coverage of query (111 bits)

EAA4_RAT / O35921 Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Rattus norvegicus (Rat) (see 2 papers)
    26% identity, 92% coverage of query (110 bits)

TC 2.A.23.2.12 / B0W0K5 Dicarboxylic acid over dicarboxylic amino acid from Culex quinquefasciatus
    26% identity, 81% coverage of query (101 bits)

Q21353 Putative sodium-dependent excitatory amino acid transporter glt-3 from Caenorhabditis elegans
    22% identity, 79% coverage of query (94.7 bits)

EAA5_HUMAN / O00341 Excitatory amino acid transporter 5; Retinal glutamate transporter; Solute carrier family 1 member 7 from Homo sapiens (Human) (see paper)
TC 2.A.23.2.5 / O00341 solute carrier family 1 (glutamate transporter), member 7 from Homo sapiens (see 4 papers)
    24% identity, 95% coverage of query (92.4 bits)

EAA5_MOUSE / Q8JZR4 Excitatory amino acid transporter 5; Solute carrier family 1 member 7 from Mus musculus (Mouse) (see 2 papers)
    25% identity, 94% coverage of query (90.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory