Searching for up to 100 curated homologs for Pf1N1B4_4478 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_4478 (423 a.a.)
Found high-coverage hits (≥70%) to 28 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PfGW456L13_3542 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Pseudomonas fluorescens GW456-L13
93% identity, 100% coverage of query (759 bits)
Pf6N2E2_479 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Pseudomonas fluorescens FW300-N2E2
85% identity, 100% coverage of query (701 bits)
SMc03203 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Sinorhizobium meliloti 1021
54% identity, 100% coverage of query (416 bits)
P11961 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
39% identity, 99% coverage of query (266 bits)
pdhC / AAC24934.1 dihydrolipoamide acetyltransferase E2 from Bacillus subtilis (see 3 papers)
37% identity, 99% coverage of query (261 bits)
P21883 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; S complex, 48 kDa subunit; EC 2.3.1.12 from Bacillus subtilis (strain 168)
37% identity, 99% coverage of query (261 bits)
Q6FYD4 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella quintana (see paper)
34% identity, 100% coverage of query (242 bits)
ODB2_CAEEL / Q23571 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; Dihydrolipoamide branched-chain transacylase E2; EC 2.3.1.168 from Caenorhabditis elegans (see paper)
33% identity, 99% coverage of query (219 bits)
ODB2_ARATH / Q9M7Z1 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCE2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; Protein DARK INDUCIBLE 3; EC 2.3.1.168 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
31% identity, 97% coverage of query (214 bits)
Q9RH46 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Coxiella burnetii (see paper)
30% identity, 99% coverage of query (214 bits)
Q8GCY1 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bartonella vinsonii (see paper)
33% identity, 100% coverage of query (209 bits)
HP15_1631 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Marinobacter adhaerens HP15
34% identity, 90% coverage of query (206 bits)
ODB2_BOVIN / P11181 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Bos taurus (Bovine) (see 2 papers)
32% identity, 99% coverage of query (206 bits)
DBT / P11182 branched-chain α-keto acid dehydrogenase complex E2 component subunit (EC 2.3.1.168) from Homo sapiens (see 9 papers)
ODB2_HUMAN / P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; 52 kDa mitochondrial autoantigen of primary biliary cirrhosis; Branched chain 2-oxo-acid dehydrogenase complex component E2; BCOADC-E2; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; BCKDH-E2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Homo sapiens (Human) (see 9 papers)
P11182 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Homo sapiens (see 3 papers)
32% identity, 99% coverage of query (206 bits)
E2(o) subunit / b0727 dihydrolipoyltranssuccinylase (EC 2.3.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
sucB / P0AFG6 2-oxoglutarate dehydrogenase E2 subunit (EC 2.3.1.61) from Escherichia coli (strain K12) (see paper)
ODO2_ECOLI / P0AFG6 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli (strain K12) (see 3 papers)
P0AFG6 2-oxoglutarate dehydrogenase system (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Escherichia coli (see 6 papers)
SucB-lipoate / ECOCYC|SUCB-LIPOATE dihydrolipoyltranssuccinase from Escherichia coli K12 (see 3 papers)
sucB / PDB|1PMR dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Escherichia coli K12 (see 14 papers)
30% identity, 100% coverage of query (200 bits)
P16263 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Bacillus subtilis (see paper)
33% identity, 99% coverage of query (199 bits)
Q98UJ6 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Gallus gallus (see paper)
30% identity, 99% coverage of query (196 bits)
BKDC_MYCTU / O06159 Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex; Branched-chain alpha-ketoacid dehydrogenase complex component E2; BCKADH E2; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
34% identity, 98% coverage of query (187 bits)
Build an alignment for Pf1N1B4_4478 and 18 homologs with ≥ 30% identity
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ODO2_YEAST / P19262 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; DLST; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; OGDHC subunit E2; Alpha-ketoglutarate dehydrogenase subunit E2; alpha-KGDHC subunit E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; EC 2.3.1.61 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P19262 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Saccharomyces cerevisiae (see paper)
29% identity, 99% coverage of query (186 bits)
P20708 dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Azotobacter vinelandii (see paper)
31% identity, 99% coverage of query (182 bits)
Q8QHL7 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Oncorhynchus mykiss (see paper)
30% identity, 99% coverage of query (180 bits)
acoC TPP-dependent acetoin dehydrogenase complex, E2 component, dihydrolipoyllysine-residue acetyltransferase; EC 2.3.1.12 from Clostridium magnum (see paper)
AAA21747.1 dihydrolipoamide acetyltransferase from Clostridium magnum (see paper)
29% identity, 99% coverage of query (177 bits)
ODP2_CORGL / Q8NNJ2 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2; EC 2.3.1.12 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
Q8NNJ2 pyruvate dehydrogenase system (subunit 2/3) (EC 1.2.1.104); 2-oxoglutarate dehydrogenase system (subunit 2/3) (EC 1.2.1.105); dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) from Corynebacterium glutamicum (see 3 papers)
31% identity, 97% coverage of query (177 bits)
AceF / b0115 pyruvate dehydrogenase, E2 subunit (EC 2.3.1.12) from Escherichia coli K-12 substr. MG1655 (see 48 papers)
aceF / P06959 pyruvate dehydrogenase E2 subunit (EC 2.3.1.12) from Escherichia coli (strain K12) (see 48 papers)
P06959 pyruvate dehydrogenase system (EC 1.2.1.104); prephenate dehydrogenase (EC 1.3.1.12); dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12) from Escherichia coli (see 6 papers)
AceF-lipoate / ECOCYC|ACEF-LIPOATE pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2 from Escherichia coli K12 (see 2 papers)
aceF / PDB|1QJO dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; EC 2.3.1.12 from Escherichia coli K12 (see 23 papers)
30% identity, 98% coverage of query (177 bits)
P06959 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2; EC 2.3.1.12 from Escherichia coli (strain K12)
30% identity, 98% coverage of query (177 bits)
ODP2_FUSO4 / A0A0D2Y5A7 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; FoDLAT; DLAT; EC 2.3.1.12 from Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato) (see paper)
31% identity, 99% coverage of query (158 bits)
ODP2_CHATD / G0S4X6 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; MRP3; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 3 papers)
28% identity, 99% coverage of query (152 bits)
DLAT / P10515 pyruvate dehydrogenase E2 component from Homo sapiens (see 5 papers)
ODP2_HUMAN / P10515 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2; EC 2.3.1.12 from Homo sapiens (Human) (see 10 papers)
P10515 pyruvate dehydrogenase system (subunit 2/5) (EC 1.2.1.104) from Homo sapiens (see 4 papers)
28% identity, 95% coverage of query (138 bits)
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