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Searching for up to 100 curated homologs for Pf1N1B4_5009 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_5009 (173 a.a.)

Found high-coverage hits (≥70%) to 47 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q88GF8 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas putida (see paper)
    83% identity, 100% coverage of query (306 bits)

gloA / P16635 glyoxalase I monomer (EC 4.4.1.5) from Pseudomonas putida (see 2 papers)
    81% identity, 100% coverage of query (296 bits)

LGUL_MOUSE / Q9CPU0 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Mus musculus (Mouse) (see paper)
Q9CPU0 lactoylglutathione lyase (EC 4.4.1.5) from Mus musculus (see 2 papers)
    61% identity, 91% coverage of query (209 bits)

4kykA / Q9CPU0 Crystal structure of mouse glyoxalase i complexed with indomethacin (see paper)
    61% identity, 91% coverage of query (209 bits)

LGUL_RAT / Q6P7Q4 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Rattus norvegicus (Rat) (see paper)
    61% identity, 91% coverage of query (209 bits)

4kyhA Crystal structure of mouse glyoxalase i complexed with zopolrestat
    61% identity, 91% coverage of query (209 bits)

2za0A Crystal structure of mouse glyoxalase i complexed with methyl-gerfelin
    61% identity, 91% coverage of query (209 bits)

6l0uB Crystal structure of mouse glyoxalase i complexed with a small molecule inhibitor
    61% identity, 91% coverage of query (209 bits)

4kykB Crystal structure of mouse glyoxalase i complexed with indomethacin
    61% identity, 91% coverage of query (209 bits)

4pv5A Crystal structure of mouse glyoxalase i in complexed with 18-beta- glycyrrhetinic acid
    61% identity, 91% coverage of query (209 bits)

4opnA Crystal structure of mouse glyoxalase i complexed with mah
    61% identity, 91% coverage of query (209 bits)

4x2aA Crystal structure of mouse glyoxalase i complexed with baicalein
    61% identity, 91% coverage of query (209 bits)

LGUL_HUMAN / Q04760 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Homo sapiens (Human) (see 6 papers)
Q04760 lactoylglutathione lyase (EC 4.4.1.5) from Homo sapiens (see 8 papers)
    60% identity, 89% coverage of query (202 bits)

7wt0A / Q04760 Human glyoxalase i (with c-ter his tag) in complex with tlsc702 (see paper)
    60% identity, 89% coverage of query (202 bits)

3w0tA Human glyoxalase i with an n-hydroxypyridone derivative inhibitor
    60% identity, 89% coverage of query (201 bits)

3vw9A Human glyoxalase i with an n-hydroxypyridone inhibitor
    60% identity, 89% coverage of query (201 bits)

1qipA Human glyoxalase i complexed with s-p- nitrobenzyloxycarbonylglutathione
    60% identity, 89% coverage of query (201 bits)

1qinA Human glyoxalase i complexed with s-(n-hydroxy-n-p- iodophenylcarbamoyl) glutathione
    60% identity, 89% coverage of query (201 bits)

1froA Human glyoxalase i with benzyl-glutathione inhibitor
    60% identity, 89% coverage of query (201 bits)

3w0uA Human glyoxalase i with an n-hydroxypyridone inhibitor
    60% identity, 89% coverage of query (201 bits)

7wszA Human glyoxalase i (with c-ter his tag) in glycerol-bound form
    60% identity, 89% coverage of query (201 bits)

Q9HU72 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas aeruginosa (see paper)
    59% identity, 94% coverage of query (200 bits)

1bh5A Human glyoxalase i q33e, e172q double mutant
    60% identity, 89% coverage of query (200 bits)

CAA88233.1 glyoxalase-I from Solanum lycopersicum (see paper)
    55% identity, 92% coverage of query (193 bits)

O04885 lactoylglutathione lyase (EC 4.4.1.5) from Brassica juncea (see 2 papers)
    55% identity, 91% coverage of query (192 bits)

LGUL_SOYBN / Q9ZS21 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; GmGlyoxI; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Glycine max (Soybean) (Glycine hispida) (see paper)
Q9ZS21 lactoylglutathione lyase (EC 4.4.1.5) from Glycine max (see paper)
glxI / CAA09177.1 glyoxalase I from Glycine max (see paper)
    52% identity, 91% coverage of query (185 bits)

Q696X2 lactoylglutathione lyase (EC 4.4.1.5) from Parastagonospora nodorum (see paper)
    50% identity, 91% coverage of query (159 bits)

GLO1 / P50107 glyoxalase I (EC 4.4.1.5) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
LGUL_YEAST / P50107 Glyoxalase I; Glx I; Aldoketomutase; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; actoylglutathione lyase; EC 4.4.1.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    50% identity, 84% coverage of query (149 bits)

D6QLX5 lactoylglutathione lyase (EC 4.4.1.5) from Starmerella magnoliae (see paper)
    45% identity, 89% coverage of query (148 bits)

LGUL_SCHPO / Q09751 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
glo1 / RF|NP_596010.1 glyoxalase I; EC 4.4.1.5 from Schizosaccharomyces pombe (see 3 papers)
    48% identity, 90% coverage of query (146 bits)

Q71KM3 lactoylglutathione lyase (EC 4.4.1.5) from Plasmodium falciparum (see paper)
    41% identity, 84% coverage of query (127 bits)

Q9HY85 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas aeruginosa (see paper)
    38% identity, 84% coverage of query (92.8 bits)

P0A0T3 lactoylglutathione lyase (EC 4.4.1.5) from Neisseria meningitidis (see paper)
    39% identity, 83% coverage of query (92.0 bits)

Q9I5L8 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas aeruginosa (see paper)
    36% identity, 84% coverage of query (91.3 bits)

4mttA / Q9I5L8 Ni- and zn-bound gloa2 at low resolution (see paper)
    36% identity, 84% coverage of query (91.3 bits)

GloA / b1651 glyoxalase I (EC 4.4.1.5) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
gloA / P0AC81 lactoylglutathione lyase (EC 4.4.1.5) from Escherichia coli (strain K12) (see 19 papers)
LGUL_ECOLI / P0AC81 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Escherichia coli (strain K12) (see 6 papers)
P0AC81 lactoylglutathione lyase (EC 4.4.1.5) from Escherichia coli (see 3 papers)
gloA / RF|NP_416168.1 lactoylglutathione lyase; EC 4.4.1.5 from Shigella flexneri (see 5 papers)
    32% identity, 83% coverage of query (81.3 bits)

1fa5A / P0AC81 Crystal structure of the zn(ii)-bound glyoxalase i of escherichia coli (see paper)
    32% identity, 84% coverage of query (80.9 bits)

1fa6A Crystal structure of the co(ii)-bound glyoxalase i of escherichia coli
    32% identity, 84% coverage of query (80.9 bits)

GLX1_ARATH / O65398 Lactoylglutathione lyase GLX1; Glyoxalase I; AtGLX1; GlyI; EC 4.4.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    33% identity, 86% coverage of query (77.8 bits)

LGUC_ARATH / Q8W593 Probable lactoylglutathione lyase, chloroplastic; Glyoxalase I; EC 4.4.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    32% identity, 84% coverage of query (70.9 bits)

2c21A / Q68RJ8 Specificity of the trypanothione-dependednt leishmania major glyoxalase i: structure and biochemical comparison with the human enzyme (see paper)
    31% identity, 85% coverage of query (66.6 bits)

Q68RJ8 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania major (see 2 papers)
    31% identity, 85% coverage of query (66.6 bits)

Q2PYM9 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania infantum (see paper)
    32% identity, 82% coverage of query (66.2 bits)

Build an alignment

Build an alignment for Pf1N1B4_5009 and 43 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

6bnnA / B6TPH0 Crystal structure of v278e-glyoxalase i mutant from zea mays in space group p4(1)2(1)2 (see paper)
    29% identity, 85% coverage of query (64.7 bits)

LGUL_ORYSJ / Q948T6 Lactoylglutathione lyase; Aldoketomutase; Allergen Glb33; Glyoxalase I; Glx I; Glyoxylase I 11; OsGLYI-11; OsGLYI11; Ketone-aldehyde mutase; Methylglyoxalase; PP33; S-D-lactoylglutathione methylglyoxal lyase; Allergen Ory s Glyoxalase I; EC 4.4.1.5 from Oryza sativa subsp. japonica (Rice) (see 7 papers)
Q948T6 lactoylglutathione lyase (EC 4.4.1.5) from Oryza sativa Japonica Group (see 2 papers)
    30% identity, 84% coverage of query (64.3 bits)

5d7zA Crystal structure of glyoxalase i from zea mays
    29% identity, 85% coverage of query (64.3 bits)

Q5XQR1 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania donovani (see paper)
    31% identity, 82% coverage of query (63.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory