Sites on a Tree

 

Searching for up to 100 curated homologs for Pf1N1B4_5112 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_5112 (390 a.a.)

Found high-coverage hits (≥70%) to 59 curated proteins.

Removed hits that are identical to the query, leaving 58

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    45% identity, 99% coverage of query (351 bits)

6jahA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with glucose
    45% identity, 100% coverage of query (351 bits)

6jagA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with sucrose
    45% identity, 100% coverage of query (351 bits)

6jadA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with palatinose
    45% identity, 100% coverage of query (351 bits)

6j9yA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with maltose
    45% identity, 100% coverage of query (351 bits)

6jamA / Q5SLD7 Crystal structure of abc transporter alpha-glycoside-binding mutant protein r356a in complex with trehalose (see paper)
    45% identity, 100% coverage of query (348 bits)

6jaiA Crystal structure of abc transporter alpha-glycoside-binding mutant protein d118a in complex with maltose
    45% identity, 100% coverage of query (348 bits)

6jb0A Crystal structure of abc transporter alpha-glycoside-binding mutant protein w287a in complex with trehalose
    45% identity, 100% coverage of query (346 bits)

SM_b20325 ABC transporter for D-trehalose/D-maltose/sucrose, substrate-binding component (ThuE) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q7 ThuE aka RB0311 aka SMB20325, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    45% identity, 94% coverage of query (340 bits)

TC 3.A.1.1.19 / Q8L126 PalE, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
palE / BAB96538.1 PalE from Agrobacterium tumefaciens (see 3 papers)
    46% identity, 100% coverage of query (338 bits)

TC 3.A.1.1.12 / Q9AI68 PalE, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    42% identity, 99% coverage of query (327 bits)

6dtqA / G4XU73 Maltose bound t. Maritima male3 (see paper)
    37% identity, 98% coverage of query (267 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    37% identity, 98% coverage of query (267 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    34% identity, 95% coverage of query (206 bits)

smoF / A9CEY9 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol binding protein from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SMOF_AGRFC / A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    33% identity, 95% coverage of query (205 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    33% identity, 95% coverage of query (205 bits)

7yzsAAA Sulfoquinovosyl binding protein
    33% identity, 95% coverage of query (204 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    33% identity, 99% coverage of query (200 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    33% identity, 99% coverage of query (200 bits)

7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme
    33% identity, 95% coverage of query (200 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    33% identity, 99% coverage of query (197 bits)

Build an alignment

Build an alignment for Pf1N1B4_5112 and 21 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    27% identity, 83% coverage of query (105 bits)

LPQY_MYCT3 / G7CES0 Trehalose-binding lipoprotein LpqY; Extracellular solute-binding protein; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
    27% identity, 83% coverage of query (87.4 bits)

7apeA / G7CES0 Crystal structure of lpqy from mycobacterium thermoresistible in complex with trehalose (see paper)
    27% identity, 83% coverage of query (87.0 bits)

5iaiA / B9JM84 Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
    23% identity, 89% coverage of query (76.6 bits)

lpqY / P9WGU9 trehalose-binding lipoprotein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
LPQY_MYCTU / P9WGU9 Trehalose-binding lipoprotein LpqY; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / Q7D8J9 PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    26% identity, 85% coverage of query (76.6 bits)

8jadA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-17
    26% identity, 85% coverage of query (76.6 bits)

8jacA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-16
    26% identity, 85% coverage of query (76.6 bits)

8ja9A Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-03
    26% identity, 85% coverage of query (76.6 bits)

8ja7E / P9WGU9 Cryo-em structure of mycobacterium tuberculosis lpqy-sugabc in complex with trehalose
    26% identity, 85% coverage of query (76.3 bits)

8jabA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-06
    26% identity, 85% coverage of query (76.3 bits)

7cafE / A0R2C3 Mycobacterium smegmatis lpqy-sugabc complex in the pre-translocation state (see paper)
    26% identity, 80% coverage of query (73.6 bits)

2gh9A / Q72I44 Thermus thermophilus maltotriose binding protein bound with maltotriose (see paper)
    25% identity, 82% coverage of query (68.2 bits)

5ysbA Crystal structure of beta-1,2-glucooligosaccharide binding protein in ligand-free form
    25% identity, 84% coverage of query (67.4 bits)

Q92AS8 ABC-type beta-glucan transporter (EC 7.5.2.3) from Listeria innocua (see paper)
    25% identity, 84% coverage of query (67.0 bits)

5ysdB / Q92AS8 Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose (see paper)
    25% identity, 84% coverage of query (67.0 bits)

5ysdA Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose
    25% identity, 84% coverage of query (67.0 bits)

4qrzA / A9CGI0 Crystal structure of sugar transporter atu4361 from agrobacterium fabrum c58, target efi-510558, with bound maltotriose
    23% identity, 86% coverage of query (64.7 bits)

4qsdA Crystal structure of atu4361 sugar transporter from agrobacterium fabrum c58, target efi-510558, with bound sucrose
    23% identity, 86% coverage of query (64.7 bits)

TC 3.A.1.1.44 / Q7AKP1 Putative maltose-binding protein, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    23% identity, 86% coverage of query (63.9 bits)

5ci5A / A8F7X5 Crystal structure of an abc transporter solute binding protein from thermotoga lettingae tmo (tlet_1705, target efi-510544) bound with alpha-d-tagatose
    24% identity, 74% coverage of query (62.8 bits)

PGA1_c13210 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Phaeobacter inhibens BS107
    24% identity, 73% coverage of query (59.7 bits)

4ryaA / B9JRF8 Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
    22% identity, 76% coverage of query (57.4 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    23% identity, 89% coverage of query (57.0 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    23% identity, 89% coverage of query (56.2 bits)

2zyoA / Q9AJF5 Crystal structure of cyclo/maltodextrin-binding protein complexed with maltotetraose (see paper)
    26% identity, 82% coverage of query (56.2 bits)

8artB / C9ZHD5 Abc transporter binding protein male from streptomyces scabiei in complex with maltose
    23% identity, 86% coverage of query (55.8 bits)

4g68A / J9PBT4 Biochemical and structural insights into xylan utilization by the thermophilic bacteriumcaldanaerobius polysaccharolyticus (see paper)
    26% identity, 73% coverage of query (55.5 bits)

MANBP_PSEAE / Q9I1E0 Mannitol-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    22% identity, 89% coverage of query (53.5 bits)

BPHYT_RS16115 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
    22% identity, 74% coverage of query (53.1 bits)

3jzjA / B0B0V1 Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
    26% identity, 73% coverage of query (51.6 bits)

3k02A Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.
    26% identity, 73% coverage of query (51.6 bits)

TC 3.A.1.1.40 / Q9WZR7 Predicted chitobiose porter. Regulated by chitobiose-responsive regulator ChiR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    22% identity, 72% coverage of query (51.2 bits)

TC 3.A.1.1.49 / O30491 MtlE, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    23% identity, 73% coverage of query (47.0 bits)

3py7A / P06931,P0AEX9 Crystal structure of full-length bovine papillomavirus oncoprotein e6 in complex with ld1 motif of paxillin at 2.3a resolution (see paper)
    24% identity, 81% coverage of query (44.7 bits)

6smvA / P0AEX9,P36813,Q92585 Structure of hpv49 e6 protein in complex with maml1 lxxll motif
    24% identity, 81% coverage of query (44.3 bits)

6slmA / P0AEX9,P17386,Q05086 Crystal structure of full-length hpv31 e6 oncoprotein in complex with lxxll peptide of ubiquitin ligase e6ap (see paper)
    24% identity, 81% coverage of query (43.9 bits)

6sjvA / A0A376KDN7,P06463,Q05086 Structure of hpv18 e6 oncoprotein in complex with mutant e6ap lxxll motif
    25% identity, 81% coverage of query (43.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory