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Searching for up to 100 curated homologs for Pf1N1B4_5129 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_5129 (467 a.a.)

Found high-coverage hits (≥70%) to 26 curated proteins.

Removed hits that are identical to the query, leaving 25

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

CA265_RS19855 D-galacturonate transporter ExuT from Pedobacter sp. GW460-11-11-14-LB5
    53% identity, 99% coverage of query (478 bits)

BT4105 D-galacturonate transporter ExuT from Bacteroides thetaiotaomicron VPI-5482
    48% identity, 96% coverage of query (432 bits)

HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
    30% identity, 86% coverage of query (177 bits)

Build an alignment

Build an alignment for Pf1N1B4_5129 and 3 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

ExuT / b3093 hexuronate transporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
exuT / P0AA78 hexuronate transporter from Escherichia coli (strain K12) (see 3 papers)
EXUT_ECOLI / P0AA78 Hexuronate transporter; Aldohexuronate transport system from Escherichia coli (strain K12) (see 5 papers)
    28% identity, 95% coverage of query (162 bits)

TC 2.A.1.14.2 / P0AA78 Hexuronate (glucuronate; galacturonate) porter, ExuT (Nemoz et al. 1976). It also transports D-glucose (HJ Kim et al., Front. Microbiol., 23 January 2020) from Escherichia coli (see 3 papers)
    28% identity, 95% coverage of query (161 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    25% identity, 91% coverage of query (139 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    25% identity, 87% coverage of query (132 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    23% identity, 88% coverage of query (112 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    27% identity, 74% coverage of query (111 bits)

ANTR1_ARATH / O82390 Sodium-dependent phosphate transport protein 1, chloroplastic; Anion transporter 1; Na(+)/PI cotransporter 1; Phosphate transporter PHT4;1; Sodium/phosphate cotransporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
O82390 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see 2 papers)
TC 2.A.1.14.22 / O82390 The chloroplast thylakoid Na+:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008). Residues essential for function have been identified from Arabidopsis thaliana (see 7 papers)
    24% identity, 87% coverage of query (99.8 bits)

ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    24% identity, 87% coverage of query (98.2 bits)

ANTR4_ARATH / Q66GI9 Probable anion transporter 4, chloroplastic; Phosphate transporter PHT4;3 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    26% identity, 88% coverage of query (97.4 bits)

ANTR6_ARATH / Q3E9A0 Probable anion transporter 6, chloroplastic; Phosphate transporter PHT4;5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    23% identity, 92% coverage of query (82.8 bits)

ANTR5_ARATH / Q9FKV1 Probable anion transporter 5; Phosphate transporter PHT4;6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    23% identity, 88% coverage of query (80.9 bits)

S17A9_RAT / P0DX21 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Rattus norvegicus (Rat) (see 2 papers)
    23% identity, 87% coverage of query (74.3 bits)

TC 2.A.1.14.26 / F2YPN7 The plasma membrane Lethal (2)01810 glutamate uptake porter (Km=0.07μM) (Inhibited by aspartate) from Drosophila melanogaster
    23% identity, 71% coverage of query (69.7 bits)

S17A9_MOUSE / Q8VCL5 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Mus musculus (Mouse) (see 5 papers)
    22% identity, 87% coverage of query (68.2 bits)

BWI76_RS23725 2-deoxy-D-ribonate transporter 2 from Klebsiella michiganensis M5al
    23% identity, 88% coverage of query (67.0 bits)

S17A9_HUMAN / Q9BYT1 Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; Vesicular nucleotide transporter; VNUT from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.14.21 / Q9BYT1 The vesicular purine nucleotide (ADP, ATP, GTP) transporter, VNUT or SLC17A9. It is found in synaptic vesicles and chromafin granules (Sawada et al., 2008)) and is associated with disseminated superficial actinic porokeratosis (DSAP), a rare autosomal dominant genodermatosis (Cui et al. 2014). It plays a key role in purinergic signaling through its ability to transport nucleotides using the pmf. It catalyzes Cl--dependent transport activity involving essential arginines in the transmembrane region. Ketoacids inhibit these transporters through modulation of Cl- activation, but Cl- and the arginine residues are not important for ATP binding (Iwai et al. 2019). High expression of SLC17A9 correlates with a poor prognosis for colorectal cancer from Homo sapiens (Human) (see 5 papers)
    23% identity, 84% coverage of query (66.6 bits)

PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
    25% identity, 83% coverage of query (61.6 bits)

PS417_07260 2-deoxy-D-ribonate transporter 2 from Pseudomonas simiae WCS417
    23% identity, 93% coverage of query (58.9 bits)

A0A0H3JLD7 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Staphylococcus aureus (see paper)
    23% identity, 98% coverage of query (53.9 bits)

TC 2.A.1.53.2 / Q5ZUB4 The valine uptake permease, PhtJ (required for maximal growth in macrophages and Acanthamoeba castellanii) (see paper)
    20% identity, 82% coverage of query (52.8 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    23% identity, 74% coverage of query (50.4 bits)

MOT12_RAT / D4A734 Monocarboxylate transporter 12; MCT 12; Solute carrier family 16 member 12 from Rattus norvegicus (Rat) (see 3 papers)
    23% identity, 89% coverage of query (49.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory