Searching for up to 100 curated homologs for Pf6N2E2_1312 4-hydroxyphenylacetate symporter, major facilitator superfamily (MFS) (434 a.a.)
Found high-coverage hits (≥70%) to 45 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
43% identity, 99% coverage of query (358 bits)
TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
38% identity, 97% coverage of query (317 bits)
ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
39% identity, 94% coverage of query (301 bits)
YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
39% identity, 92% coverage of query (266 bits)
BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
38% identity, 94% coverage of query (248 bits)
PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
34% identity, 88% coverage of query (229 bits)
H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
34% identity, 97% coverage of query (228 bits)
BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
34% identity, 91% coverage of query (218 bits)
Build an alignment for Pf6N2E2_1312 and 8 homologs with ≥ 30% identity
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CH_124132 transporter of Nicotinic Acid from Magnaporthe grisea 70-15 (see paper)
26% identity, 88% coverage of query (159 bits)
CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
29% identity, 71% coverage of query (157 bits)
orf19.3232 putative transporter from Candida albicans (see paper)
26% identity, 91% coverage of query (151 bits)
CH_124318 MFS transporter from Magnaporthe grisea 70-15 (see 2 papers)
28% identity, 85% coverage of query (143 bits)
CH_124029 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
28% identity, 78% coverage of query (138 bits)
EFUF_HORCR / A0A2Z4HQ22 MFS-type transporter efuF; Enfumafungin biosynthesis cluster protein F from Hormonema carpetanum (see paper)
27% identity, 79% coverage of query (127 bits)
CH_124204 putative monocarboxylate exporter from Magnaporthe grisea 70-15 (see paper)
26% identity, 85% coverage of query (125 bits)
TNA1 putative nicotinic acid transporter from Candida albicans (see paper)
26% identity, 81% coverage of query (120 bits)
YIZG_SCHPO / Q9US44 Uncharacterized transporter C1002.16c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
27% identity, 71% coverage of query (117 bits)
CH_124323 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see 2 papers)
25% identity, 76% coverage of query (112 bits)
YFZ4_SCHPO / Q9US37 Uncharacterized transporter C1039.04 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
29% identity, 80% coverage of query (108 bits)
orf19.2397.3 putative uncharacterized protein VHT1 from Candida albicans (see paper)
23% identity, 89% coverage of query (106 bits)
HXNP_EMENI / C8VJW1 Major facilitator-type transporter hxnP; Nicotinate catabolism cluster protein hxnP from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
26% identity, 71% coverage of query (100 bits)
FEN2_YEAST / P25621 Pantothenate transporter FEN2; Fenpropimorph resistance protein 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
TC 2.A.1.14.18 / P25621 Pantothenate:H+ symporter, Fen2 from Saccharomyces cerevisiae (Baker's yeast) (see 7 papers)
FEN2 / RF|NP_009957.1 pantothenate transporter FEN2 from Saccharomyces cerevisiae
25% identity, 75% coverage of query (87.4 bits)
TC 2.A.1.14.11 / P53322 Plasma membrane, high affinity nicotinate permease, Tna1 from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
TNA1 / RF|NP_011776.1 high-affinity nicotinic acid transporter from Saccharomyces cerevisiae
25% identity, 71% coverage of query (85.1 bits)
P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
25% identity, 71% coverage of query (85.1 bits)
VHT1_SCHPO / O13880 Vitamin H transporter 1; H(+)/biotin symporter vht1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
TC 2.A.1.14.19 / O13880 Plasma membrane, high affinity vitamin H transporter 1 (H+:biotin symporter), Vht1 (Stolz, 2003) from Schizosaccharomyces pombe (Fission yeast) (see 2 papers)
vht1 / GB|AAO22560.1 vitamin H transporter 1 from Schizosaccharomyces pombe (see 3 papers)
24% identity, 87% coverage of query (82.8 bits)
GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
25% identity, 90% coverage of query (80.1 bits)
CH_124130 conserved hypothetical protein from Magnaporthe grisea 70-15 (see paper)
25% identity, 70% coverage of query (76.3 bits)
LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
23% identity, 95% coverage of query (73.9 bits)
PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
24% identity, 97% coverage of query (73.2 bits)
GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP. Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
24% identity, 96% coverage of query (73.2 bits)
TC 2.A.1.14.26 / F2YPN7 The plasma membrane Lethal (2)01810 glutamate uptake porter (Km=0.07μM) (Inhibited by aspartate) from Drosophila melanogaster
23% identity, 88% coverage of query (70.9 bits)
PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
26% identity, 84% coverage of query (58.5 bits)
MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
21% identity, 80% coverage of query (56.2 bits)
6zguA Crystal structure of a mfs transporter with bound 3-(2-methylphenyl) propanoic acid at 2.41 angstroem resolution
24% identity, 82% coverage of query (51.6 bits)
6zgtA Crystal structure of a mfs transporter with bound 2-naphthoic acid at 2.39 angstroem resolution
24% identity, 82% coverage of query (51.6 bits)
6zgsA / A0LNN5 Crystal structure of a mfs transporter with bound 3-phenylpropanoic acid at 2.39 angstroem resolution
24% identity, 82% coverage of query (51.6 bits)
6g9xA Crystal structure of a mfs transporter at 2.54 angstroem resolution
24% identity, 82% coverage of query (51.2 bits)
SFMCT_SYNFM / A0LNN5 L-lactate transporter; SfMCT from Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) (see paper)
23% identity, 82% coverage of query (49.7 bits)
6zgrA Crystal structure of a mfs transporter with bound 1- hydroxynaphthalene-2-carboxylic acid at 2.67 angstroem resolution
23% identity, 86% coverage of query (49.3 bits)
Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans
22% identity, 70% coverage of query (48.5 bits)
6zgrB Crystal structure of a mfs transporter with bound 1- hydroxynaphthalene-2-carboxylic acid at 2.67 angstroem resolution
24% identity, 82% coverage of query (45.8 bits)
6zguB Crystal structure of a mfs transporter with bound 3-(2-methylphenyl) propanoic acid at 2.41 angstroem resolution
24% identity, 82% coverage of query (44.7 bits)
6zgtB Crystal structure of a mfs transporter with bound 2-naphthoic acid at 2.39 angstroem resolution
24% identity, 82% coverage of query (44.7 bits)
6zgsB Crystal structure of a mfs transporter with bound 3-phenylpropanoic acid at 2.39 angstroem resolution
24% identity, 82% coverage of query (44.7 bits)
6g9xB / A0LNN5 Crystal structure of a mfs transporter at 2.54 angstroem resolution (see paper)
24% identity, 82% coverage of query (44.3 bits)
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Lawrence Berkeley National Laboratory