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Searching for up to 100 curated homologs for Pf6N2E2_1522 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_1522 (327 a.a.)

Found high-coverage hits (≥70%) to 74 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ADH_MORSE / Q8GIX7 Alcohol dehydrogenase; ADH; EC 1.1.1.1 from Moraxella sp. (strain TAE123) (see 3 papers)
Q8GIX7 alcohol dehydrogenase (EC 1.1.1.1) from Moraxella sp. (see paper)
    35% identity, 99% coverage of query (195 bits)

4z6kA / Q8GIX7 Alcohol dehydrogenase from the antarctic psychrophile moraxella sp. Tae 123
    35% identity, 99% coverage of query (195 bits)

RR42_RS34260 Alcohol dehydrogenase (EC 1.1.1.1) from Cupriavidus basilensis FW507-4G11
    35% identity, 99% coverage of query (186 bits)

6iqdA / P42327 Crystal structure of alcohol dehydrogenase from geobacillus stearothermophilus (see paper)
    34% identity, 99% coverage of query (186 bits)

furX / Q46UZ9 furfuryl alcohol dehydrogenase (EC 1.1.1.1) from Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (see paper)
    35% identity, 99% coverage of query (182 bits)

3s2eA / Q46UZ9 Crystal structure of furx nadh complex 1
    35% identity, 99% coverage of query (182 bits)

1lluA / Q9HTD9 The ternary complex of pseudomonas aeruginosa alcohol dehydrogenase with its coenzyme and weak substrate (see paper)
    36% identity, 99% coverage of query (182 bits)

3s2fE Crystal structure of furx nadh:furfural
    35% identity, 99% coverage of query (182 bits)

3s2fA Crystal structure of furx nadh:furfural
    35% identity, 99% coverage of query (182 bits)

3s2eE Crystal structure of furx nadh complex 1
    35% identity, 99% coverage of query (182 bits)

P42328 alcohol dehydrogenase (EC 1.1.1.1) from Geobacillus stearothermophilus (see 8 papers)
1rjwA / P42328 Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r (see paper)
    32% identity, 99% coverage of query (177 bits)

P12311 Alcohol dehydrogenase; ADH-T; EC 1.1.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
    33% identity, 99% coverage of query (177 bits)

3piiA Crystal structure of mutant of ht- alcohol dehydrogenase with substrate analogue butyramide
    32% identity, 99% coverage of query (177 bits)

3meqA / A0A0H3G9R2 Crystal structure of alcohol dehydrogenase from brucella melitensis
    34% identity, 99% coverage of query (174 bits)

Q6RS93 alcohol dehydrogenase (EC 1.1.1.1) from Parageobacillus thermoglucosidasius (see paper)
    32% identity, 99% coverage of query (174 bits)

Q8L3C9 alcohol dehydrogenase (EC 1.1.1.1) from Flavobacterium frigidimaris (see paper)
    33% identity, 99% coverage of query (171 bits)

6n7lC / A0A077EGR8 Crystal structure of an alcohol dehydrogenase from elizabethkingia anophelis nuhp1
    32% identity, 99% coverage of query (166 bits)

6z42A / E1V3M3 The low resolution structure of a zinc-dependent alcohol dehydrogenase from halomonas elongata.
    35% identity, 99% coverage of query (162 bits)

adhA / Q8NLX9 Zn2+-dependent alcohol dehydrogenase (EC 1.1.1.1; EC 1.1.1.244) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 5 papers)
    30% identity, 99% coverage of query (152 bits)

CH_124303 alcohol dehydrogenase 1 from Magnaporthe grisea 70-15 (see paper)
    31% identity, 99% coverage of query (145 bits)

NOTN_ASPSM / E1ACQ9 Alcohol dehydrogenase notN; Notoamide biosynthesis cluster protein N; EC 1.1.1.1 from Aspergillus sp. (strain MF297-2) (see 3 papers)
    32% identity, 97% coverage of query (144 bits)

A3MVR8 alcohol dehydrogenase (EC 1.1.1.1) from Pyrobaculum calidifontis (see paper)
    31% identity, 99% coverage of query (142 bits)

2eerB / Q96XE0 Structural study of project id st2577 from sulfolobus tokodaii strain7
    33% identity, 100% coverage of query (134 bits)

F9VMI9 alcohol dehydrogenase (EC 1.1.1.1) from Sulfurisphaera tokodaii (see paper)
    30% identity, 100% coverage of query (127 bits)

Build an alignment

Build an alignment for Pf6N2E2_1522 and 24 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

E3UTQ9 allyl-alcohol dehydrogenase (EC 1.1.1.54) from Fusarium oxysporum (see paper)
    27% identity, 99% coverage of query (124 bits)

P39462 alcohol dehydrogenase (EC 1.1.1.1) from Saccharolobus solfataricus (see 7 papers)
1jvbA / P39462 Alcohol dehydrogenase from the archaeon sulfolobus solfataricus (see paper)
    32% identity, 100% coverage of query (121 bits)

1r37A Alcohol dehydrogenase from sulfolobus solfataricus complexed with NAD(h) and 2-ethoxyethanol
    32% identity, 100% coverage of query (121 bits)

P39462 NAD-dependent alcohol dehydrogenase; EC 1.1.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
    32% identity, 100% coverage of query (121 bits)

patD / A0A075TMP0 neopatulin dehydrogenase from Penicillium expansum (see paper)
PATD_PENEN / A0A075TMP0 Alcohol dehydrogenase patD; Patulin biosynthesis cluster protein D; EC 1.1.1.- from Penicillium expansum (Blue mold rot fungus) (see 8 papers)
    32% identity, 97% coverage of query (120 bits)

T1WVG5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
    29% identity, 96% coverage of query (119 bits)

chnD / Q9F7D8 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) from Acinetobacter sp. (strain SE19) (see paper)
    32% identity, 97% coverage of query (117 bits)

T1WUT6 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
    29% identity, 90% coverage of query (116 bits)

P50381 alcohol dehydrogenase (EC 1.1.1.1) from Sulfolobus sp. (see paper)
RC3adh / CAA87591.1 alcohol dehydrogenase from Sulfolobus sp (see paper)
    31% identity, 100% coverage of query (116 bits)

PATD_ASPCL / A1CFL1 Alcohol dehydrogenase patD; Patulin synthesis protein D; EC 1.1.1.- from Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) (see 3 papers)
    33% identity, 91% coverage of query (115 bits)

ADHA_SYNY3 / P74721 Aldehyde reductase AdhA; Alcohol dehydrogenase AdhA; EC 1.1.1.2 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 3 papers)
P74721 alcohol dehydrogenase (EC 1.1.1.1) from Synechocystis sp. PCC 6803 (see paper)
    32% identity, 92% coverage of query (112 bits)

W6CX26 alcohol dehydrogenase (EC 1.1.1.1); aryl-alcohol dehydrogenase (EC 1.1.1.90); aryl-alcohol dehydrogenase (NADP+) (EC 1.1.1.91) from Yokenella sp. (see paper)
    28% identity, 99% coverage of query (110 bits)

Q7XWU3 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Oryza sativa Japonica Group (see paper)
    29% identity, 91% coverage of query (109 bits)

A0A1D6BJ11 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Triticum aestivum (see paper)
    29% identity, 80% coverage of query (108 bits)

YddN / b1478 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
adhP / P39451 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli (strain K12) (see 5 papers)
4gkvB / P39451 Structure of escherichia coli adhp (ethanol-inducible dehydrogenase) with bound NAD (see paper)
    29% identity, 99% coverage of query (107 bits)

7bu2B / P27250 Structure of alcohol dehydrogenase yjgb from escherichia coli (see paper)
    28% identity, 95% coverage of query (105 bits)

Ahr / b4269 NADPH-dependent aldehyde reductase Ahr (EC 1.1.1.2) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ahr / P27250 NADPH-dependent aldehyde reductase Ahr (EC 1.1.1.2) from Escherichia coli (strain K12) (see 11 papers)
AHR_ECOLI / P27250 Aldehyde reductase Ahr; Zinc-dependent alcohol dehydrogenase Ahr; EC 1.1.1.2 from Escherichia coli (strain K12) (see 3 papers)
P27250 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Escherichia coli (see paper)
    28% identity, 95% coverage of query (105 bits)

7bu3A Structure of alcohol dehydrogenase yjgb in complex with NADP from escherichia coli
    28% identity, 95% coverage of query (105 bits)

alrA / BAB12270.1 NADP-dependent alcohol dehydrogenase from Acinetobacter sp. M-1 (see paper)
    30% identity, 92% coverage of query (104 bits)

5o9dA Crystal structure of r. Ruber adh-a, mutant y294f, w295a, y54f, f43h, h39y
    31% identity, 100% coverage of query (104 bits)

6ffxA Crystal structure of r. Ruber adh-a, mutant f43h (see paper)
    31% identity, 100% coverage of query (103 bits)

6c49A / A0A1E3MC83 Crystal structure of alcohol dehydrogenase from acinetobacter baumannii
    28% identity, 91% coverage of query (103 bits)

araDH / Q97YM2 D-arabinose 1-dehydrogenase subunit (EC 1.1.1.427) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see 2 papers)
ARADH_SACS2 / Q97YM2 D-arabinose 1-dehydrogenase (NADP(+)); AraDH; D-Ara dehydrogenase; EC 1.1.1.427 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
Q97YM2 D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) from Saccharolobus solfataricus (see 2 papers)
    28% identity, 100% coverage of query (100 bits)

1uufA / P75691 Crystal structure of a zinc-type alcohol dehydrogenase-like protein yahk
    34% identity, 71% coverage of query (100 bits)

ADHC1_MYCS2 / P0CH36 NADP-dependent alcohol dehydrogenase C 1; Ms-ADHC 1; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
ADHC2_MYCS2 / P0CH37 NADP-dependent alcohol dehydrogenase C 2; Ms-ADHC 2; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
    29% identity, 74% coverage of query (99.0 bits)

6isvB / M5A8V4 Structure of acetophenone reductase from geotrichum candidum nbrc 4597 in complex with NAD (see paper)
    29% identity, 99% coverage of query (95.5 bits)

1h2bB / Q9Y9P9 Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon aeropyrum pernix at 1.65a resolution (see paper)
    27% identity, 100% coverage of query (95.1 bits)

4ejmA Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021 bound to NADP
    30% identity, 83% coverage of query (92.0 bits)

4ej6A / Q92PZ3 Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021
    30% identity, 83% coverage of query (92.0 bits)

4c4oB / O42703 Structure of carbonyl reductase cpcr2 from candida parapsilosis in complex with nadh
    29% identity, 95% coverage of query (86.3 bits)

3wlfA Crystal structure of (r)-carbonyl reductase from candida parapsilosis in complex with (r)-1-phenyl-1,2-ethanediol
    29% identity, 95% coverage of query (86.3 bits)

3wnqA Crystal structure of (r)-carbonyl reductase h49a mutant from candida parapsilosis in complex with 2-hydroxyacetophenone
    29% identity, 95% coverage of query (82.0 bits)

4jbiA 2.35a resolution structure of NADPH bound thermostable alcohol dehydrogenase from pyrobaculum aerophilum
    27% identity, 100% coverage of query (80.5 bits)

4jbhA 2.2a resolution structure of cobalt and zinc bound thermostable alcohol dehydrogenase from pyrobaculum aerophilum
    27% identity, 100% coverage of query (80.5 bits)

4jbgA / Q8ZUP0 1.75a resolution structure of a thermostable alcohol dehydrogenase from pyrobaculum aerophilum (see paper)
    27% identity, 100% coverage of query (80.5 bits)

1vj0A / Q9WYR7 Crystal structure of alcohol dehydrogenase (tm0436) from thermotoga maritima at 2.00 a resolution
    25% identity, 97% coverage of query (70.5 bits)

2eihA / Q5SL27 Crystal structure of NAD-dependent alcohol dehydrogenase
    28% identity, 99% coverage of query (68.9 bits)

6ljhA Crystal structure of alcohol dehydrogenase 1 from artemisia annua in complex with NAD+
    25% identity, 77% coverage of query (65.1 bits)

P80467 Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Saara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii)
    26% identity, 97% coverage of query (65.1 bits)

7cyiD / A0A2U1Q018 Crystal structure of alcohol dehydrogenase 1 from artemisia annua
    25% identity, 77% coverage of query (65.1 bits)

4cpdA / B2ZRE3 Alcohol dehydrogenase tadh from thermus sp. Atn1
    28% identity, 72% coverage of query (64.7 bits)

ADHX_MYXGL / P80360 Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Myxine glutinosa (Atlantic hagfish) (see paper)
    28% identity, 97% coverage of query (64.7 bits)

4idfA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADPH and hmf
    25% identity, 94% coverage of query (53.5 bits)

4ideA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADP+ and edhmf
    25% identity, 94% coverage of query (53.5 bits)

4iddA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADPH and ehmf
    25% identity, 94% coverage of query (53.5 bits)

4idcA Structure of the fragaria x ananassa enone oxidoreductase in complex with NADPH and hdmf
    25% identity, 94% coverage of query (53.5 bits)

4idbA / O23939 Structure of the fragaria x ananassa enone oxidoreductase in complex with NADP+ (see paper)
    25% identity, 94% coverage of query (53.5 bits)

1iyzA / Q8L3C8 Crystal structures of the quinone oxidoreductase from thermus thermophilus hb8 and its complex with NADPH (see paper)
    27% identity, 83% coverage of query (50.1 bits)

ENOXC_FRAAN / Q941I0 2-methylene-furan-3-one reductase; Enone oxidoreductase; FaEO; Quinone oxidoreductase; FaQR; EC 1.3.1.105 from Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana) (see 2 papers)
Q941I0 2-methylene-furan-3-one reductase (EC 1.3.1.105) from Fragaria x ananassa (see 2 papers)
    26% identity, 92% coverage of query (49.3 bits)

6ie0B / O34788 X-ray crystal structure of 2r,3r-butanediol dehydrogenase from bacillus subtilis
    25% identity, 84% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory