Sites on a Tree

 

Searching for up to 100 curated homologs for Pf6N2E2_2136 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_2136 (273 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YeaE / b1781 methylglyoxal reductase YeaE from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yeaE / P76234 methylglyoxal reductase YeaE (EC 1.1.1.21) from Escherichia coli (strain K12) (see 3 papers)
    56% identity, 100% coverage of query (318 bits)

5c7hA / Q92NR7 Crystal structure of aldo-keto reductase from sinorhizobium meliloti 1021 in complex with NADPH
    58% identity, 97% coverage of query (303 bits)

4pmjA Crystal structure of a putative oxidoreductase from sinorhizobium meliloti 1021 in complex with NADP
    58% identity, 97% coverage of query (303 bits)

6ciaA / A6T7Q7 Crystal structure of aldo-keto reductase from klebsiella pneumoniae in complex with NADPH.
    56% identity, 97% coverage of query (302 bits)

4wghA Crystal structure of aldo/keto reductase from klebsiella pneumoniae in complex with NADP and acetate at 1.8 a resolution
    56% identity, 97% coverage of query (302 bits)

6kikA / Q9X265 Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
    42% identity, 92% coverage of query (176 bits)

Q9X265 carbonyl reductase (NADPH) (EC 1.1.1.184) from Thermotoga maritima (see 2 papers)
    42% identity, 92% coverage of query (176 bits)

6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat
    42% identity, 92% coverage of query (176 bits)

5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
    42% identity, 92% coverage of query (176 bits)

Q8TZM9 alcohol dehydrogenase (EC 1.1.1.1) from Pyrococcus furiosus (see 2 papers)
    41% identity, 89% coverage of query (158 bits)

Q5JI09 alcohol dehydrogenase (EC 1.1.1.1) from Thermococcus kodakarensis (see paper)
    41% identity, 89% coverage of query (154 bits)

F2YCN5 D-xylose reductase (EC 1.1.1.307) from Zymomonas mobilis subsp. mobilis (see paper)
    31% identity, 96% coverage of query (131 bits)

4gieA / Q4DJ07 Crystal structure of prostaglandin f synthase from trypanosoma cruzi bound to NADP (see paper)
    34% identity, 92% coverage of query (130 bits)

Q4DJ07 prostaglandin-F synthase (EC 1.1.1.188) from Trypanosoma cruzi (see paper)
    34% identity, 92% coverage of query (130 bits)

4fziA Crystal structure of prostaglandin f synthase from trypanosoma cruzi
    34% identity, 92% coverage of query (130 bits)

PGFS_TRYBB / Q9GV41 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Trypanosoma brucei brucei (see paper)
    31% identity, 94% coverage of query (121 bits)

1vbjA / Q9GV41 The crystal structure of prostaglandin f synthase from trypanosoma brucei
    31% identity, 94% coverage of query (121 bits)

DkgB / b0207 methylglyoxal reductase DkgB (EC 1.1.1.91; EC 1.1.1.346) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
dkgB / P30863 methylglyoxal reductase DkgB (EC 1.1.1.21; EC 1.1.1.91; EC 1.1.1.346) from Escherichia coli (strain K12) (see 5 papers)
dkgB / MB|P30863 2,5-diketo-D-gluconic acid reductase B; EC 1.1.1.274 from Escherichia coli K12 (see 5 papers)
    31% identity, 92% coverage of query (120 bits)

3v0sA / Q3L181 Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
    32% identity, 93% coverage of query (119 bits)

PGFS_LEIMA / P22045 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Leishmania major (see paper)
P22045 prostaglandin-F synthase (EC 1.1.1.188) from Leishmania major (see paper)
    32% identity, 95% coverage of query (118 bits)

4g5dA / P22045 X-ray crystal structure of prostaglandin f synthase from leishmania major friedlin bound to NADPH (see paper)
    32% identity, 95% coverage of query (118 bits)

A0QV10 Aldo-keto reductase MSMEG_2408/MSMEI_2347; EC 1.1.1.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    32% identity, 92% coverage of query (118 bits)

A0A3P3ZE14 prostaglandin-F synthase (EC 1.1.1.188) from Leishmania braziliensis (see paper)
    32% identity, 95% coverage of query (115 bits)

YdjG / b1771 NADH-dependent methylglyoxal reductase from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydjG / P77256 NADH-dependent methylglyoxal reductase from Escherichia coli (strain K12) (see 4 papers)
AKRMG_ECOLI / P77256 NADH-specific methylglyoxal reductase; AKR11B2; EC 1.1.1.- from Escherichia coli (strain K12) (see 3 papers)
ydjG / RF|NP_416285 uncharacterized oxidoreductase ydjG from Escherichia coli K12 (see paper)
    30% identity, 90% coverage of query (114 bits)

GS69_BACSU / P80874 Aldo-keto reductase YhdN; AKR11B; General stress protein 69; GSP69; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 3 papers)
    35% identity, 71% coverage of query (112 bits)

yvgN / O32210 glyoxal/methylglyoxal reductase (EC 1.1.1.283; EC 1.1.1.91) from Bacillus subtilis (strain 168) (see 3 papers)
GR_BACSU / O32210 Glyoxal reductase; GR; Methylglyoxal reductase; EC 1.1.1.-; EC 1.1.1.283 from Bacillus subtilis (strain 168) (see paper)
    34% identity, 95% coverage of query (111 bits)

3d3fA / O32210 Crystal structure of yvgn and cofactor NADPH from bacillus subtilis (see paper)
    34% identity, 95% coverage of query (111 bits)

AK1A1_RAT / P51635 Aldo-keto reductase family 1 member A1; 3-DG-reducing enzyme; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Rattus norvegicus (Rat) (see 4 papers)
P51635 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Rattus norvegicus (see 2 papers)
    30% identity, 93% coverage of query (111 bits)

AKR1E2 / P82125 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Sus scrofa (see paper)
AKCL2_PIG / P82125 1,5-anhydro-D-fructose reductase; AF reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member CL2; Aldo-keto reductase family 1 member E2; EC 1.1.1.263 from Sus scrofa (Pig) (see paper)
    31% identity, 90% coverage of query (110 bits)

3wbwA / Q5FT75 Crystal structure of gox0644 in complex with NADPH
    31% identity, 92% coverage of query (109 bits)

Q5FT75 carbonyl reductase (NADPH) (EC 1.1.1.184) from Gluconobacter oxydans (see paper)
    31% identity, 92% coverage of query (109 bits)

1pz1A / P80874 Structure of NADPH-dependent family 11 aldo-keto reductase akr11b(holo) (see paper)
    35% identity, 71% coverage of query (109 bits)

AK1BF_HUMAN / C9JRZ8 Aldo-keto reductase family 1 member B15; Estradiol 17-beta-dehydrogenase AKR1B15; Farnesol dehydrogenase; Testosterone 17beta-dehydrogenase; EC 1.1.1.-; EC 1.1.1.300; EC 1.1.1.54; EC 1.1.1.216; EC 1.1.1.64 from Homo sapiens (Human) (see 3 papers)
C9JRZ8 acetoacetyl-CoA reductase (EC 1.1.1.36); 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) from Homo sapiens (see paper)
    30% identity, 90% coverage of query (109 bits)

4gabA Human akr1b10 mutant v301l complexed with NADP+ and fidarestat
    30% identity, 90% coverage of query (109 bits)

4ga8A Human akr1b10 mutant v301l complexed with NADP+ and sorbinil
    30% identity, 90% coverage of query (109 bits)

5m2fX Crystal structure of human akr1b10 complexed with NADP+ and the synthetic retinoid uvi2008
    30% identity, 90% coverage of query (109 bits)

5liyX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk204
    30% identity, 90% coverage of query (109 bits)

5lixX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk184
    30% identity, 90% coverage of query (109 bits)

5liwX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk319
    30% identity, 90% coverage of query (109 bits)

5liuX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor idd388
    30% identity, 90% coverage of query (109 bits)

5likX Crystal structure of human akr1b10 complexed with NADP+ and the inhibitor mk181
    30% identity, 90% coverage of query (109 bits)

4xzlX Crystal structure of human akr1b10 complexed with NADP+ and jf0049
    30% identity, 90% coverage of query (109 bits)

4wevX Crystal structure of human akr1b10 complexed with NADP+ and sulindac
    30% identity, 90% coverage of query (109 bits)

4iccX Crystal structure of human akr1b10 complexed with NADP+ and jf0064
    30% identity, 90% coverage of query (109 bits)

AK1BA_HUMAN / O60218 Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase; EC 1.1.1.300; EC 1.1.1.54 from Homo sapiens (Human) (see 7 papers)
O60218 aldose reductase (EC 1.1.1.21) from Homo sapiens (see 2 papers)
    30% identity, 90% coverage of query (108 bits)

4gq0A / O60218 Crystal structure of akr1b10 complexed with NADP+ and caffeic acid phenethyl ester
    30% identity, 90% coverage of query (108 bits)

1zuaX Crystal structure of akr1b10 complexed with NADP+ and tolrestat
    30% identity, 90% coverage of query (108 bits)

5y7nA Crystal structure of akr1b10 in complex with NADP+ and androst-4-ene- 3-beta-6-alpha-diol
    30% identity, 90% coverage of query (108 bits)

4jiiX Crystal structure of akr1b10 complexed with NADP+ and zopolrestat
    30% identity, 90% coverage of query (108 bits)

4jihA Crystal structure of akr1b10 complexed with NADP+ and epalrestat
    30% identity, 90% coverage of query (108 bits)

4i5xA Crystal structure of akr1b10 complexed with NADP+ and flufenamic acid
    30% identity, 90% coverage of query (108 bits)

Build an alignment

Build an alignment for Pf6N2E2_2136 and 51 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Akr1a4 / Q9JII6 alcohol dehydrogenase [NADP+] (EC 1.1.1.19) from Mus musculus (see 4 papers)
AK1A1_MOUSE / Q9JII6 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Mus musculus (Mouse) (see 5 papers)
Q540D7 aldehyde dehydrogenase (NADP+) (EC 1.2.1.4) from Mus musculus (see paper)
Q9JII6 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Mus musculus (see paper)
    29% identity, 93% coverage of query (107 bits)

PR / Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 2 papers)
PERR_RAUSE / Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see 2 papers)
Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 3 papers)
    29% identity, 85% coverage of query (107 bits)

akr5f1 organophosphate reductase from Klebsiella sp. F51-1-2 (see paper)
    31% identity, 95% coverage of query (107 bits)

AKR1_SOYBN / C6TBN2 Probable aldo-keto reductase 1; GmAKR1; EC 1.1.1.- from Glycine max (Soybean) (Glycine hispida) (see paper)
    29% identity, 85% coverage of query (107 bits)

AKR1A1 / P50578 aldehyde reductase (EC 1.1.1.2) from Sus scrofa (see paper)
AK1A1_PIG / P50578 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Sus scrofa (Pig) (see paper)
P50578 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Sus scrofa (see 2 papers)
3fx4A / P50578 Porcine aldehyde reductase in ternary complex with inhibitor (see paper)
    29% identity, 93% coverage of query (107 bits)

3h4gA Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
    29% identity, 92% coverage of query (107 bits)

3cv7A Crystal structure of porcine aldehyde reductase ternary complex
    29% identity, 92% coverage of query (106 bits)

AK1C1_MACFU / Q95JH6 Aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD-1; DD1; EC 1.1.1.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.357; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; EC 1.1.1.149 from Macaca fuscata fuscata (Japanese macaque) (see paper)
    29% identity, 92% coverage of query (104 bits)

YPR1_YEAST / Q12458 Putative reductase 1; EC 1.1.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    29% identity, 92% coverage of query (104 bits)

GCY1 putative uncharacterized protein from Candida albicans (see paper)
    30% identity, 92% coverage of query (104 bits)

AK1A1_HUMAN / P14550 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Homo sapiens (Human) (see 4 papers)
    29% identity, 93% coverage of query (103 bits)

5uxfA Crystal structure of mouse recon (akr1c13) in complex with cyclic di- amp
    27% identity, 92% coverage of query (103 bits)

ALKR4_ARATH / Q93ZN2 Probable aldo-keto reductase 4; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 95% coverage of query (102 bits)

AK1C1_MACFA / Q95JH7 Aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD-1; DD1; EC 1.1.1.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.357; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; EC 1.1.1.149 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
    29% identity, 92% coverage of query (102 bits)

ALRA_DICDI / Q6IMN8 Aldose reductase A; ARA; Aldehyde reductase A; AlrA; EC 1.1.1.21 from Dictyostelium discoideum (Social amoeba) (see paper)
Q6IMN8 methylglyoxal reductase (NADPH) (EC 1.1.1.283) from Dictyostelium discoideum (see paper)
    29% identity, 92% coverage of query (102 bits)

Q5DD64 aldose reductase (EC 1.1.1.21) from Schistosoma japonicum (see paper)
    28% identity, 92% coverage of query (102 bits)

Y2971_MYCTU / P9WQA5 Aldo-keto reductase Rv2971; AKR; EC 1.1.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    31% identity, 91% coverage of query (101 bits)

E3W861 carbonyl reductase (NADPH) (EC 1.1.1.184) from Bacillus sp. (in: Bacteria) (see paper)
3b3dA / O34678 B.Subtilis ytbe (see paper)
    35% identity, 92% coverage of query (100 bits)

Y2996_MYCBO / Q7TXI6 Aldo-keto reductase BQ2027_MB2996; EC 1.1.1.- from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
    31% identity, 91% coverage of query (100 bits)

Q5FYA7 prostaglandin-F synthase (EC 1.1.1.188) from Canis lupus familiaris (see 2 papers)
    30% identity, 94% coverage of query (99.4 bits)

GCY1_YEAST / P14065 Glycerol 2-dehydrogenase (NADP(+)); Galactose-inducible crystallin-like protein 1; EC 1.1.1.156 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 13 papers)
    26% identity, 97% coverage of query (99.4 bits)

3cv6A / Q91WR5 The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase gg225.226pp mutant in complex with inhibitor and cofactor NADP+. (see paper)
    28% identity, 92% coverage of query (99.4 bits)

AK1CL_MOUSE / Q91WR5 Aldo-keto reductase family 1 member C21; 17-alpha-hydroxysteroid dehydrogenase; 17-alpha-HSD; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; Dihydrodiol dehydrogenase type 1; DD1; Dihydrodiol dehydrogenase type 3; DD3; EC 1.1.1.-; EC 1.1.1.209 from Mus musculus (Mouse) (see 7 papers)
Q91WR5 estradiol 17alpha-dehydrogenase (EC 1.1.1.148); 3(or 17)alpha-hydroxysteroid dehydrogenase (EC 1.1.1.209); 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (EC 1.1.1.50) from Mus musculus (see 5 papers)
    29% identity, 92% coverage of query (99.4 bits)

2ipfA Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone
    29% identity, 92% coverage of query (99.4 bits)

2he5A Crystal structure of 17alpha-hydroxysteroid dehydrogenase in binary complex with NADP(h) in an open conformation
    29% identity, 92% coverage of query (99.4 bits)

IOLS_BACSU / P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 4 papers)
    27% identity, 83% coverage of query (99.0 bits)

AKR1C2 / P52895 3α hydroxysteroid dehydrogenase III (EC 1.1.1.52; EC 1.1.1.395; EC 1.1.1.213; EC 1.1.1.357) from Homo sapiens (see 12 papers)
AK1C2_HUMAN / P52895 Aldo-keto reductase family 1 member C2; 3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase 2; DD-2; DD2; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Type III 3-alpha-hydroxysteroid dehydrogenase; EC 1.-.-.-; EC 1.1.1.112; EC 1.1.1.209; EC 1.1.1.53; EC 1.1.1.62; EC 1.3.1.20; EC 1.1.1.357 from Homo sapiens (Human) (see 9 papers)
P52895 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) (EC 1.1.1.213); 3alpha-hydroxysteroid 3-dehydrogenase (EC 1.1.1.357); 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (EC 1.1.1.50); trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Homo sapiens (see 9 papers)
    29% identity, 92% coverage of query (99.0 bits)

1pz0A / P46336 Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
    27% identity, 83% coverage of query (99.0 bits)

4l1wA / P52895 Crystal structuer of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+ and progesterone (see paper)
    29% identity, 92% coverage of query (99.0 bits)

1ihiA Crystal structure of human type iii 3-alpha-hydroxysteroid dehydrogenase/bile acid binding protein (akr1c2) complexed with NADP+ and ursodeoxycholate
    29% identity, 92% coverage of query (99.0 bits)

4jtrB Akr1c2 complex with ibuprofen
    29% identity, 92% coverage of query (99.0 bits)

4jtrA Akr1c2 complex with ibuprofen
    29% identity, 92% coverage of query (99.0 bits)

4jtqA Akr1c2 complex with flurbiprofen
    29% identity, 92% coverage of query (99.0 bits)

4jqaA Akr1c2 complex with mefenamic acid
    29% identity, 92% coverage of query (99.0 bits)

4jq4A Akr1c2 complex with indomethacin
    29% identity, 92% coverage of query (99.0 bits)

4jq3A Akr1c2 complex with zomepirac
    29% identity, 92% coverage of query (99.0 bits)

4jq2A Akr1c2 complex with sulindac
    29% identity, 92% coverage of query (99.0 bits)

4jq1A Akr1c2 complex with naproxen
    29% identity, 92% coverage of query (99.0 bits)

4xo7A Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one
    29% identity, 92% coverage of query (99.0 bits)

2hdjA Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(h)
    29% identity, 92% coverage of query (99.0 bits)

4xo6B Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one
    29% identity, 92% coverage of query (99.0 bits)

4xo6A Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one
    29% identity, 92% coverage of query (99.0 bits)

1xjbA Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(h), citrate and acetate molecules
    29% identity, 92% coverage of query (99.0 bits)

1j96A Human 3alpha-hsd type 3 in ternary complex with NADP and testosterone
    29% identity, 92% coverage of query (98.6 bits)

6ijxA Crystal structure of akr1c1 complexed with meclofenamic acid
    29% identity, 92% coverage of query (98.6 bits)

6a7aA Akr1c1 complexed with new inhibitor with novel scaffold
    29% identity, 92% coverage of query (98.6 bits)

4yvpA Crystal structure of akr1c1 complexed with glibenclamide
    29% identity, 92% coverage of query (98.6 bits)

3ntyA Crystal structure of akr1c1 in complex with NADP and 5-phenyl,3- chlorosalicylic acid
    29% identity, 92% coverage of query (98.6 bits)

AKR1C4 / P17516 aldo-keto reductase family 1 member C4 (EC 1.1.1.213; EC 1.3.1.20; EC 1.1.1.225; EC 1.1.1.357) from Homo sapiens (see 9 papers)
AK1C4_HUMAN / P17516 Aldo-keto reductase family 1 member C4; 3-alpha-hydroxysteroid dehydrogenase type I; 3-alpha-HSD1; 3alpha-hydroxysteroid 3-dehydrogenase; Chlordecone reductase; CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA; EC 1.1.1.-; EC 1.1.1.209; EC 1.1.1.210; EC 1.1.1.51; EC 1.1.1.53; EC 1.1.1.62; EC 1.1.1.357; EC 1.1.1.225 from Homo sapiens (Human) (see 11 papers)
P17516 3alpha-hydroxysteroid 3-dehydrogenase (EC 1.1.1.357) from Homo sapiens (see 4 papers)
    29% identity, 92% coverage of query (98.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory