Searching for up to 100 curated homologs for Pf6N2E2_240 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_240 (296 a.a.)
Found high-coverage hits (≥70%) to 31 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
OSMV_SALTY / Q8ZPK4 Osmoprotectant import ATP-binding protein OsmV; EC 7.6.2.- from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.12.14 / Q8ZPK4 ABC-type proline/glycine betaine transport system, component of OsmU (OsmVWXY) transporter for glycine betaine and choline-O-sulfate uptake. Induced by osmotic stress (0.3M NaCl) (Frossard et al., 2012). Also called OpuCA/CB1/CB2/CC from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
40% identity, 98% coverage of query (239 bits)
TC 3.A.1.12.11 / Q8Q041 Glycine betaine transporter, ATP-binding protein, component of The glycine betaine uptake porter, GbpABCD from Methanosarcina mazei (see paper)
48% identity, 74% coverage of query (211 bits)
TC 3.A.1.12.8 / Q93A35 BilEA aka OpuBA protein, component of A proline/glycine betaine uptake system. Also reported to be a bile exclusion system that exports oxgall and other bile compounds, BilEA/EB or OpuBA/BB (required for normal virulence) from Listeria monocytogenes (see 2 papers)
41% identity, 94% coverage of query (204 bits)
TMOW_PELUB / Q4FL37 Trimethylamine N-oxide transport system ATP-binding protein TmoW; TMAO transport system ATP-binding protein TmoW; EC 7.6.2.9 from Pelagibacter ubique (strain HTCC1062) (see paper)
41% identity, 74% coverage of query (168 bits)
OPUAA_BACSU / P46920 Glycine betaine transport ATP-binding protein OpuAA; Quaternary-amine-transporting ATPase; EC 7.6.2.9 from Bacillus subtilis (strain 168) (see 2 papers)
P46920 ABC-type quaternary amine transporter (EC 7.6.2.9) from Bacillus subtilis (see paper)
TC 3.A.1.12.2 / P46920 OPAA aka OpuAA, component of Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 4 papers)
36% identity, 97% coverage of query (167 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
37% identity, 97% coverage of query (165 bits)
7ahhC Opua inhibited inward-facing, sbd docked
37% identity, 97% coverage of query (165 bits)
TC 3.A.1.12.5 / Q9RQ06 BusAA, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport from Lactococcus lactis (see paper)
35% identity, 94% coverage of query (163 bits)
AO353_07790 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2E3
42% identity, 73% coverage of query (159 bits)
AO356_13805 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2C3
42% identity, 73% coverage of query (155 bits)
Pf6N2E2_4681 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2E2
42% identity, 73% coverage of query (155 bits)
A0A077T7Z1 ABC-type quaternary amine transporter (subunit 1/3) (EC 7.6.2.9) from Vibrio anguillarum serotype O1 (see paper)
34% identity, 94% coverage of query (150 bits)
TC 3.A.1.12.13 / A9CI32 ABC transporter, nucleotide binding/ATPase protein (Proline/glycine betaine), component of High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7) from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (see 2 papers)
38% identity, 77% coverage of query (147 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
38% identity, 74% coverage of query (140 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
38% identity, 74% coverage of query (139 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
38% identity, 74% coverage of query (139 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
38% identity, 74% coverage of query (139 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
38% identity, 74% coverage of query (139 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
38% identity, 74% coverage of query (139 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
38% identity, 74% coverage of query (139 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
37% identity, 73% coverage of query (136 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
39% identity, 72% coverage of query (134 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
36% identity, 77% coverage of query (127 bits)
8hprD Lpqy-sugabc in state 4
36% identity, 77% coverage of query (127 bits)
8hprC Lpqy-sugabc in state 4
36% identity, 77% coverage of query (127 bits)
Build an alignment for Pf6N2E2_240 and 25 homologs with ≥ 30% identity
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4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
29% identity, 75% coverage of query (88.2 bits)
DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
29% identity, 75% coverage of query (86.7 bits)
8bmpA Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp
31% identity, 74% coverage of query (78.2 bits)
5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
31% identity, 74% coverage of query (78.2 bits)
8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
31% identity, 74% coverage of query (77.0 bits)
3gd7A / P13569,P68187 Crystal structure of human nbd2 complexed with n6-phenylethyl-atp (p- atp)
26% identity, 71% coverage of query (63.5 bits)
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Lawrence Berkeley National Laboratory