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Searching for up to 100 curated homologs for Pf6N2E2_2401 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_2401 (270 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pcaL / AAC38246.1 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Rhodococcus opacus (see paper)
    35% identity, 91% coverage of query (103 bits)

Q0SH24 3-oxoadipate enol-lactonase (EC 3.1.1.24); 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) from Rhodococcus jostii (see paper)
    35% identity, 91% coverage of query (100 bits)

Build an alignment

Build an alignment for Pf6N2E2_2401 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q13KT2 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Paraburkholderia xenovorans (see 2 papers)
    28% identity, 100% coverage of query (100 bits)

2xuaH / Q13KT2 Crystal structure of the enol-lactonase from burkholderia xenovorans lb400 (see paper)
    28% identity, 99% coverage of query (100 bits)

pcaD / AAC37150.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 11 papers)
    26% identity, 89% coverage of query (89.4 bits)

4uhfA / A0A0M3KKY6 Structural studies of a thermophilic esterase from thermogutta terrifontis (l37a mutant with butyrate bound) (see paper)
    29% identity, 96% coverage of query (85.1 bits)

4uheA Structural studies of a thermophilic esterase from thermogutta terrifontis (malate bound)
    29% identity, 96% coverage of query (85.1 bits)

4uhdA Structural studies of a thermophilic esterase from thermogutta terrifontis (acetate bound)
    29% identity, 96% coverage of query (85.1 bits)

pcaD / Q88N36 subunit of 3-oxoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 5 papers)
Q88N36 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Pseudomonas putida (see paper)
    31% identity, 98% coverage of query (82.4 bits)

AO353_17230 Beta-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas fluorescens FW300-N2E3
    28% identity, 98% coverage of query (81.3 bits)

bioH / BAB39459.1 BioH from Kurthia sp. 538-KA26 (see paper)
    26% identity, 99% coverage of query (76.6 bits)

catD / BAA75208.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see paper)
catD / BAC82535.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see 3 papers)
    29% identity, 91% coverage of query (71.2 bits)

ESTE_PSEFL / P22862 Arylesterase; Aryl-ester hydrolase; Carboxylic acid perhydrolase; PFE; Putative bromoperoxidase; EC 3.1.1.2; EC 1.-.-.- from Pseudomonas fluorescens (see 8 papers)
GI|951089 arylesterase; EC 1.-.-.-; EC 3.1.1.2 from Pseudomonas fluorescens (see 3 papers)
AAB60168.1 esterase from Pseudomonas fluorescens (see 2 papers)
    29% identity, 97% coverage of query (70.9 bits)

3ia2A Pseudomonas fluorescens esterase complexed to the r-enantiomer of a sulfonate transition state analog
    29% identity, 97% coverage of query (70.9 bits)

catD / AAC46435.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 8 papers)
    25% identity, 96% coverage of query (70.5 bits)

pcaD / AAF34270.1 beta-ketoadipate enol-lactone hydrolase from Agrobacterium tumefaciens (see 2 papers)
    29% identity, 94% coverage of query (70.1 bits)

8pi1B / P22862 Bicyclic incypro pseudomonas fluorescens esterase (see paper)
    30% identity, 97% coverage of query (69.3 bits)

8agsAAA / A0A1U9WZ52 8agsAAA
    26% identity, 87% coverage of query (68.2 bits)

8agnAAA Alpha/beta epoxide hydrolase
    26% identity, 87% coverage of query (68.2 bits)

8agmAAA Alpha/beta epoxide hydrolase
    26% identity, 87% coverage of query (68.2 bits)

8agpAAA Alpha/beta epoxide hydrolase
    26% identity, 87% coverage of query (68.2 bits)

5ng7B Novel epoxide hydrolases belonging to the alpha/beta hydrolases superfamily in metagenomes from hot environments
    26% identity, 87% coverage of query (68.2 bits)

3hi4A Switching catalysis from hydrolysis to perhydrolysis in p. Fluorescens esterase
    29% identity, 97% coverage of query (67.8 bits)

3heaA The l29p/l124i mutation of pseudomonas fluorescens esterase
    29% identity, 97% coverage of query (67.8 bits)

4ccwA / Q59248 Crystal structure of naproxen esterase (carboxylesterase np) from bacillus subtilis (see paper)
    24% identity, 92% coverage of query (66.2 bits)

NAP_BACSU / P96688 Uncharacterized carboxylesterase nap; EC 3.1.1.1 from Bacillus subtilis (strain 168)
    24% identity, 92% coverage of query (65.1 bits)

D0EPY0 carboxylesterase (EC 3.1.1.1) from Bacillus subtilis (see paper)
    24% identity, 92% coverage of query (64.7 bits)

TGND_ACIAD / Q6F9F4 (E)-2-((N-methylformamido)methylene)succinate hydrolase; MFMS hydrolase; EC 3.5.1.- from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    25% identity, 96% coverage of query (63.5 bits)

YBFK_BACSU / O31452 Carboxylesterase YbfK; EC 3.1.1.1 from Bacillus subtilis (strain 168) (see paper)
    24% identity, 91% coverage of query (63.2 bits)

2d0dA Crystal structure of a meta-cleavage product hydrolase (cumd) a129v mutant
    27% identity, 94% coverage of query (61.2 bits)

P96965 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas fluorescens (see 2 papers)
cumD / BAA12150.1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase from Pseudomonas fluorescens (see paper)
    27% identity, 96% coverage of query (60.5 bits)

EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
    24% identity, 99% coverage of query (59.7 bits)

1iunB / P96965 Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant hexagonal (see paper)
    27% identity, 96% coverage of query (58.9 bits)

1ukaA Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with (s)-2-methylbutyrate
    27% identity, 94% coverage of query (58.9 bits)

1uk9A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with isovalerate
    27% identity, 94% coverage of query (58.9 bits)

1uk8A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-valerate
    27% identity, 94% coverage of query (58.9 bits)

1uk7A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-butyrate
    27% identity, 94% coverage of query (58.9 bits)

1iupA Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant complexed with isobutyrates
    27% identity, 94% coverage of query (58.9 bits)

Q9KJG6 triacylglycerol lipase (EC 3.1.1.3) from Pseudomonas aeruginosa (see paper)
    25% identity, 97% coverage of query (58.2 bits)

6i8wB / Q9KJG6 Crystal structure of a membrane phospholipase a, a novel bacterial virulence factor (see paper)
    26% identity, 97% coverage of query (58.2 bits)

BPOC_MYCTU / P9WNH1 Putative non-heme bromoperoxidase BpoC from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    28% identity, 95% coverage of query (57.4 bits)

A4Q9R7 haloalkane dehalogenase (EC 3.8.1.5) from Mycobacterium tuberculosis variant bovis (see paper)
    24% identity, 94% coverage of query (57.4 bits)

G3KFX4 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas sp. (see paper)
    28% identity, 94% coverage of query (56.6 bits)

hppC / AAB81313.1 2-hydroxy-6-ketonona-2,4-dienoate hydrolase from Rhodococcus globerulus (see paper)
    25% identity, 99% coverage of query (56.6 bits)

O73957 carboxylesterase (EC 3.1.1.1) from Sulfolobus acidocaldarius (see paper)
    28% identity, 91% coverage of query (56.2 bits)

RutD / b1009 putative aminoacrylate hydrolase RutD from Escherichia coli K-12 substr. MG1655 (see 2 papers)
RUTD_ECOLI / P75895 Putative carbamate hydrolase RutD; Aminohydrolase; EC 3.5.1.- from Escherichia coli (strain K12) (see 5 papers)
    24% identity, 88% coverage of query (56.2 bits)

6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
    27% identity, 75% coverage of query (55.5 bits)

8qn0A Soluble epoxide hydrolase in complex with rk3
    26% identity, 83% coverage of query (54.3 bits)

3pdcA Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor
    26% identity, 83% coverage of query (54.3 bits)

4haiA / P34913 Crystal structure of human soluble epoxide hydrolase complexed with n- cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide. (see paper)
    26% identity, 83% coverage of query (53.9 bits)

acoC / AAA21950.1 FMP from Cupriavidus necator (see paper)
    28% identity, 96% coverage of query (53.9 bits)

HYES_HUMAN / P34913 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Homo sapiens (Human) (see 12 papers)
P34913 2-lysophosphatidate phosphatase (EC 3.1.3.106); soluble epoxide hydrolase (EC 3.3.2.10) from Homo sapiens (see 47 papers)
    26% identity, 83% coverage of query (53.9 bits)

4c4zA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with a8
    26% identity, 83% coverage of query (53.9 bits)

6yl4A Soluble epoxide hydrolase in complex with 3-((r)-3-(1-hydroxyureido) but-1-yn-1-yl)-n-((s)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl) benzamide
    26% identity, 83% coverage of query (53.9 bits)

6hgxA Soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl) morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea
    26% identity, 83% coverage of query (53.9 bits)

6hgwA Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-n-(4- phenoxybenzyl)ethanamine
    26% identity, 83% coverage of query (53.9 bits)

6hgvA Soluble epoxide hydrolase in complex with talinolol
    26% identity, 83% coverage of query (53.9 bits)

6fr2A Soluble epoxide hydrolase in complex with lk864
    26% identity, 83% coverage of query (53.9 bits)

8qmzA Soluble epoxide hydrolase in complex with rk4
    26% identity, 83% coverage of query (53.9 bits)

4oczA Crystal structure of human soluble epoxide hydrolase complexed with 1- (1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
    26% identity, 83% coverage of query (53.9 bits)

4j03A Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant
    26% identity, 83% coverage of query (53.9 bits)

7ebaA Co-crystal of kurarinone with seh
    26% identity, 83% coverage of query (53.9 bits)

6i5gA X-ray structure of human soluble epoxide hydrolasE C-terminal domain (hseh ctd)in complex with 15d-pgj2
    26% identity, 83% coverage of query (53.9 bits)

4x6yA Human soluble epoxide hydrolase in complex with a cyclopropyl urea derivative
    26% identity, 83% coverage of query (53.9 bits)

4x6xA Human soluble epoxide hydrolase in complex with a three substituted cyclopropane derivative
    26% identity, 83% coverage of query (53.9 bits)

3otqA Soluble epoxide hydrolase in complex with pyrazole antagonist
    26% identity, 83% coverage of query (53.9 bits)

3kooA Crystal structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

3i28A Crystal structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

3i1yA Crystal structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

3antA Human soluble epoxide hydrolase in complex with a synthetic inhibitor
    26% identity, 83% coverage of query (53.9 bits)

3ansA Human soluble epoxide hydrolase in complex with a synthetic inhibitor
    26% identity, 83% coverage of query (53.9 bits)

5am5A Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5am4A Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5am1A Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5am0A Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alzA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alyA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alxA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alwA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5aluA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5altA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alpA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5aloA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alnA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5almA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5allA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alkA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5aliA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alhA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5algA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5alfA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5aleA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5aldA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5akzA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5akyA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5akxA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5akjA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5akiA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5akhA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

5akgA Ligand complex structure of soluble epoxide hydrolase
    26% identity, 83% coverage of query (53.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory