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Searching for up to 100 curated homologs for Pf6N2E2_2655 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_2655 (316 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

gbuA / Q88EE2 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    93% identity, 100% coverage of query (612 bits)

gbuA / Q9I3S3 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
GBUA_PSEAE / Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3S3 guanidinobutyrase (EC 3.5.3.7) from Pseudomonas aeruginosa (see paper)
    90% identity, 100% coverage of query (593 bits)

3nioA / Q9I3S3 Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
    91% identity, 99% coverage of query (590 bits)

A0A146AXJ2 agmatinase (EC 3.5.3.11) from Apostichopus japonicus (see paper)
    63% identity, 99% coverage of query (422 bits)

W5PHZ9 agmatinase (EC 3.5.3.11) from Ovis aries (see 2 papers)
    65% identity, 97% coverage of query (420 bits)

AGMAT / Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
GDAH_HUMAN / Q9BSE5 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Homo sapiens (Human) (see 3 papers)
Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
    63% identity, 99% coverage of query (412 bits)

GDAH_MOUSE / A2AS89 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Mus musculus (Mouse) (see paper)
    62% identity, 94% coverage of query (387 bits)

GPUA_PSEAE / Q9I6K2 Guanidinopropionase; EC 3.5.3.17 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6K2 Guanidinopropionase (EC 3.5.3.17) from Pseudomonas aeruginosa (see paper)
    51% identity, 96% coverage of query (317 bits)

3nipB / Q9I6K2 Crystal structure of pseudomonas aeruginosa guanidinopropionase complexed with 1,6-diaminohexane (see paper)
    51% identity, 96% coverage of query (316 bits)

3niqA Crystal structure of pseudomonas aeruginosa guanidinopropionase
    51% identity, 96% coverage of query (316 bits)

gbh / Q8KZT5 guanidinobutyrase subunit (EC 3.5.3.7) from Arthrobacter sp. (strain KUJ 8602) (see paper)
Q8KZT5 D-arginase (EC 3.5.3.10); guanidinobutyrase (EC 3.5.3.7) from Arthrobacter sp. (see paper)
    41% identity, 96% coverage of query (265 bits)

gbuA / A0A0A1DPD5 5-guanidino-2-oxopentanoate ureohydrolase (EC 3.5.3.7) from Nocardioides simplex (see paper)
    45% identity, 97% coverage of query (264 bits)

1gq6B / P0DJQ3 Proclavaminate amidino hydrolase from streptomyces clavuligerus (see paper)
    42% identity, 92% coverage of query (231 bits)

pah / P0DJQ3 proclavaminate amidino hydrolase subunit (EC 3.5.3.22) from Streptomyces clavuligerus (see paper)
PAH_STRCL / P0DJQ3 Proclavaminate amidinohydrolase; Proclavaminic acid amidino hydrolase; EC 3.5.3.22 from Streptomyces clavuligerus (see paper)
    42% identity, 92% coverage of query (231 bits)

Q1K7T0 agmatinase (EC 3.5.3.11) from Neurospora crassa (see paper)
    37% identity, 97% coverage of query (209 bits)

CH_124010 agmatinase from Magnaporthe grisea 70-15 (see 3 papers)
    39% identity, 93% coverage of query (208 bits)

SPEB_PROMI / Q7X3P1 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Proteus mirabilis (see paper)
    44% identity, 86% coverage of query (199 bits)

KlGBU1 / Q6CIB4 guanidinobutyrase (EC 3.5.3.7) from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (see paper)
GBU1_KLULA / Q6CIB4 Guanidinobutyrase; EC 3.5.3.7 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    36% identity, 95% coverage of query (198 bits)

4dz4B / Q2T3W4 X-ray crystal structure of a hypothetical agmatinase from burkholderia thailandensis (see paper)
    40% identity, 93% coverage of query (194 bits)

7lbaB / P60651 E. Coli agmatinase (see paper)
    41% identity, 91% coverage of query (184 bits)

SpeB / b2937 agmatinase (EC 3.5.3.11) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
speB / P60651 agmatinase (EC 3.5.3.11) from Escherichia coli (strain K12) (see 35 papers)
SPEB_ECOLI / P60651 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Escherichia coli (strain K12) (see 2 papers)
speB / RF|NP_417412 agmatinase; EC 3.5.3.11 from Escherichia coli K12 (see 7 papers)
    41% identity, 91% coverage of query (184 bits)

7lolA The structure of agmatinase from e. Coli at 1.8 a displaying urea and agmatine
    41% identity, 91% coverage of query (184 bits)

7loxA The structure of agmatinase from e. Coli at 3.2 a displaying guanidine in the active site
    40% identity, 91% coverage of query (172 bits)

W8R465 guanidinobutyrase (EC 3.5.3.7) from Aspergillus niger (see paper)
    35% identity, 93% coverage of query (167 bits)

speB / P70999 agmatinase (EC 3.5.3.11) from Bacillus subtilis (strain 168) (see paper)
    34% identity, 92% coverage of query (164 bits)

7esrA / P73270 Crystal structure of synechocystis sp pcc6803 guanidinium hydrolase (r32) (see paper)
    32% identity, 94% coverage of query (152 bits)

gdmH / P73270 Ni2+-dependent guanidine hydrolase monomer from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    32% identity, 94% coverage of query (152 bits)

1wogA / Q9RZ04 Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily (see paper)
    34% identity, 92% coverage of query (147 bits)

Build an alignment

Build an alignment for Pf6N2E2_2655 and 28 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3lhlA / Q18A84 Crystal structure of a putative agmatinase from clostridium difficile
    28% identity, 86% coverage of query (136 bits)

arginase / P46637 arginase (EC 3.5.3.1) from Arabidopsis thaliana (see paper)
ARGI1_ARATH / P46637 Arginase 1, mitochondrial; Agmatinase ARGAH1; Arginine amidohydrolase 1; AtARGAH1; EC 3.5.3.1; EC 3.5.3.11 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    34% identity, 89% coverage of query (135 bits)

6vsuE / P46637 Arginase from arabidopsis thaliana in complex with ornithine (see paper)
    34% identity, 89% coverage of query (135 bits)

ARG2 / Q5UNS1 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
Q5UNS1 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
    33% identity, 85% coverage of query (129 bits)

ARG1 / Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
    34% identity, 85% coverage of query (129 bits)

3pzlB / Q97BB8 The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
    33% identity, 83% coverage of query (126 bits)

ARGI1_ORYSI / B8AU84 Arginase 1, mitochondrial; Arginine amidohydrolase 1; EC 3.5.3.1 from Oryza sativa subsp. indica (Rice) (see paper)
    33% identity, 85% coverage of query (125 bits)

ARGI2_ARATH / Q9ZPF5 Arginase 2, chloroplastic/mitochondrial; Agmatinase ARGAH2; Arginine amidohydrolase 2; EC 3.5.3.1; EC 3.5.3.11 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    31% identity, 89% coverage of query (122 bits)

ARGI_MEDTR / G7JFU5 Arginase, mitochondrial; Agmatinase ARGAH; Arginine amidohydrolase; MtARGAH; EC 3.5.3.1; EC 3.5.3.11 from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
    34% identity, 85% coverage of query (122 bits)

6vstD / G7JFU5 Arginase from medicago truncatula in complex with ornithine (see paper)
    33% identity, 85% coverage of query (121 bits)

6vstA Arginase from medicago truncatula in complex with ornithine
    33% identity, 85% coverage of query (121 bits)

SPEBH_THET2 / Q72JK8 N(1)-aminopropylagmatine ureohydrolase; Protein SpeB homolog; EC 3.5.3.24 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
    32% identity, 83% coverage of query (118 bits)

TTHA1129 / Q5SJ85 aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
SEPBH_THET8 / Q5SJ85 N(1)-aminopropylagmatine ureohydrolase; Protein SpeB homolog; EC 3.5.3.24 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q5SJ85 N1-aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermus thermophilus (see paper)
    31% identity, 83% coverage of query (115 bits)

SPEB_METJA / Q57757 Agmatinase; EC 3.5.3.11 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q57757 agmatinase (EC 3.5.3.11) from Methanocaldococcus jannaschii (see paper)
    27% identity, 85% coverage of query (110 bits)

AGMT_PYRHO / O57839 Agmatinase; EC 3.5.3.11 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
    30% identity, 90% coverage of query (105 bits)

HUTG_BACSU / P42068 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; EC 3.5.3.8 from Bacillus subtilis (strain 168) (see paper)
    28% identity, 85% coverage of query (104 bits)

3m1rD / P42068 The crystal structure of formimidoylglutamase from bacillus subtilis subsp. Subtilis str. 168
    28% identity, 85% coverage of query (104 bits)

D4GWG4 agmatinase (EC 3.5.3.11) from Haloferax volcanii (see paper)
    32% identity, 86% coverage of query (102 bits)

6dktE / P39138 Crystal structure of arginase from bacillus subtilis
    29% identity, 84% coverage of query (98.6 bits)

6dktA Crystal structure of arginase from bacillus subtilis
    29% identity, 84% coverage of query (98.6 bits)

A4IJM8 arginase (EC 3.5.3.1) from Geobacillus thermodenitrificans (see paper)
    28% identity, 84% coverage of query (98.2 bits)

6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    29% identity, 84% coverage of query (97.8 bits)

TK0882 / Q5JI38 aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
SPEBH_THEKO / Q5JI38 N(1)-aminopropylagmatine ureohydrolase; Agmatinase; Protein SpeB homolog; EC 3.5.3.24; EC 3.5.3.11 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
Q5JI38 N1-aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermococcus kodakarensis (see paper)
    29% identity, 84% coverage of query (96.3 bits)

ARGI_BACCD / P53608 Arginase; EC 3.5.3.1 from Bacillus caldovelox (see paper)
P53608 arginase (EC 3.5.3.1) from [Bacillus] caldovelox (see paper)
1cevA / P53608 Arginase from bacillus caldovelox, native structure at ph 5.6 (see paper)
    27% identity, 84% coverage of query (95.1 bits)

6nbkA / W8YSI5 Crystal structure of arginase from bacillus cereus
    31% identity, 84% coverage of query (94.7 bits)

5cevA Arginase from bacillus caldevelox, l-lysine complex
    27% identity, 84% coverage of query (94.7 bits)

4cevA Arginase from bacillus caldevelox, l-ornithine complex
    27% identity, 84% coverage of query (94.7 bits)

3cevA Arginase from bacillus caldevelox, complexed with l-arginine
    27% identity, 84% coverage of query (94.7 bits)

2cevB Arginase from bacillus caldevelox, native structure at ph 8.5
    27% identity, 84% coverage of query (94.7 bits)

2ef5A / Q5SI78 Crystal structure of the arginase from thermus thermophilus
    29% identity, 85% coverage of query (92.0 bits)

6nfpA / P39138 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    28% identity, 84% coverage of query (91.7 bits)

argI / P39138 arginase (EC 3.5.3.1) from Bacillus subtilis (strain 168) (see 3 papers)
ARGI_BACSU / P39138 Arginase; EC 3.5.3.1 from Bacillus subtilis (strain 168) (see 2 papers)
P39138 arginase (EC 3.5.3.1) from Bacillus subtilis (see paper)
    28% identity, 84% coverage of query (90.1 bits)

O08701 arginase (EC 3.5.3.1) from Rattus norvegicus (see paper)
    26% identity, 91% coverage of query (79.0 bits)

A0A0D5ZYA4 arginase (EC 3.5.3.1) from Heteropneustes fossilis (see paper)
    26% identity, 85% coverage of query (77.8 bits)

ARGI2_MOUSE / O08691 Arginase-2, mitochondrial; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase; EC 3.5.3.1 from Mus musculus (Mouse) (see 6 papers)
    24% identity, 90% coverage of query (76.3 bits)

Q4A3J2 arginase (EC 3.5.3.1) from Cyprinus carpio (see paper)
    25% identity, 88% coverage of query (75.5 bits)

7k4gE / P05089 Human arginase 1 in complex with compound 01. (see paper)
    24% identity, 83% coverage of query (74.7 bits)

ARG1 / P05089 Arginase-1 (EC 3.5.3.1) from Homo sapiens (see 7 papers)
ARGI1_HUMAN / P05089 Arginase-1; Liver-type arginase; Type I arginase; EC 3.5.3.1 from Homo sapiens (Human) (see 15 papers)
P05089 arginase (EC 3.5.3.1) from Homo sapiens (see 12 papers)
    24% identity, 83% coverage of query (74.7 bits)

8aupA Structure of harg1 with a novel inhibitor.
    24% identity, 83% coverage of query (74.7 bits)

7k4hA Human arginase 1 in complex with compound 04.
    24% identity, 83% coverage of query (74.7 bits)

6v7fA Human arginase1 complexed with bicyclic inhibitor compound 13
    24% identity, 83% coverage of query (74.7 bits)

6v7dA Human arginase1 complexed with bicyclic inhibitor compound 10
    24% identity, 83% coverage of query (74.7 bits)

6qafA Crystal structure of human arginase-1 at ph 9.0 in complex with cb- 1158/incb001158
    24% identity, 83% coverage of query (74.7 bits)

6q92A Crystal structure of human arginase-1 at ph 7.0 in complex with abh
    24% identity, 83% coverage of query (74.7 bits)

4mynA / Q4DSA0 Crystal structure of trypanosoma cruzi formiminoglutamase n114h variant with mn2+2 (see paper)
    25% identity, 78% coverage of query (74.3 bits)

1wvaA Crystal structure of human arginase i from twinned crystal
    25% identity, 81% coverage of query (74.3 bits)

3th7A Crystal structure of unliganded co2+2-hai (ph 7.0)
    25% identity, 81% coverage of query (74.3 bits)

3skkA Crystal structure of human arginase i in complex with the inhibitor fabh, resolution 1.70 a, twinned structure
    25% identity, 81% coverage of query (74.3 bits)

3mjlA Crystal structure of human arginase i in complex with 2- aminoimidazole. Resolution 1.90 a.
    25% identity, 81% coverage of query (74.3 bits)

3mfwA Crystal structure of human arginase i in complex with l-2- aminohistidine and sulphate
    25% identity, 81% coverage of query (74.3 bits)

3gn0A Crystal structure of human arginase i in complex with difluoromethylornithine (dfmo)
    25% identity, 81% coverage of query (74.3 bits)

3gmzA Crystal of human arginase in complex with l-ornithine. Resolution 1.43 a.
    25% identity, 81% coverage of query (74.3 bits)

4ie1A Crystal structure of human arginase-1 complexed with inhibitor 1h
    25% identity, 81% coverage of query (74.3 bits)

4hxqA Crystal structure of human arginase-1 complexed with inhibitor 14
    25% identity, 81% coverage of query (74.3 bits)

4hwwA Crystal structure of human arginase-1 complexed with inhibitor 9
    25% identity, 81% coverage of query (74.3 bits)

2aebA Crystal structure of human arginase i at 1.29 a resolution and exploration of inhibition in immune response.
    25% identity, 81% coverage of query (74.3 bits)

8e5nA Structure of arg1 complex with pyrrolidine-based non-boronic acid inhibitor 10
    25% identity, 81% coverage of query (74.3 bits)

8e5mA Structure of arg1 complex with pyrrolidine-based non-boronic acid inhibitor 6
    25% identity, 81% coverage of query (74.3 bits)

7klmA Human arginase1 complexed with inhibitor compound 24a
    25% identity, 81% coverage of query (74.3 bits)

7kllA Human arginase1 complexed with inhibitor compound 18
    25% identity, 81% coverage of query (74.3 bits)

7klkA Human arginase1 complexed with inhibitor compound 3a
    25% identity, 81% coverage of query (74.3 bits)

7k4kA Human arginase 1 in complex with compound 52.
    25% identity, 81% coverage of query (74.3 bits)

7k4jA Human arginase 1 in complex with compound 51.
    25% identity, 81% coverage of query (74.3 bits)

7k4iA Human arginase 1 in complex with compound 06.
    25% identity, 81% coverage of query (74.3 bits)

6v7eA Human arginase1 complexed with bicyclic inhibitor compound 12
    25% identity, 81% coverage of query (74.3 bits)

6v7cA Human arginase1 complexed with bicyclic inhibitor compound 3
    25% identity, 81% coverage of query (74.3 bits)

3sjtA Crystal structure of human arginase i in complex with the inhibitor me-abh, resolution 1.60 a, twinned structure
    25% identity, 81% coverage of query (74.3 bits)

3mfvA Crystal structure of human arginase i in complex with 2- aminohomohistidine
    25% identity, 81% coverage of query (74.3 bits)

3lp7A Crystal structure of human arginase i in complex with inhibitor n(omega)-hydroxy-l-arginine (noha), 2.04a resolution
    25% identity, 81% coverage of query (74.3 bits)

3lp4A Crystal structure of human arginase i in complex with l-lysine, 1.90a resolution.
    25% identity, 81% coverage of query (74.3 bits)

3kv2A High resolution structure of human arginase i in complex with the strong inhibitor n(omega)-hydroxy-nor-l-arginine (nor-noha)
    25% identity, 81% coverage of query (74.3 bits)

3f80A (S)-2-amino-6-nitrohexanoic acid binds to human arginase i through multiple nitro-metal coordination interactions in the binuclear manganese cluster. Resolution 1.60 a.
    25% identity, 81% coverage of query (74.3 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory