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Searching for up to 100 curated homologs for Pf6N2E2_2892 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_2892 (399 a.a.)

Found high-coverage hits (≥70%) to 21 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PS417_22145 glucose/xylose ABC transporter, periplasmic substrate-binding component from Pseudomonas simiae WCS417
    95% identity, 100% coverage of query (748 bits)

TC 3.A.1.1.30 / Q88P38 GtsA (GLcE), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
    89% identity, 96% coverage of query (685 bits)

PfGW456L13_1894 ABC transporter for D-Galactose and D-Glucose, periplasmic substrate-binding component from Pseudomonas fluorescens GW456-L13
    81% identity, 100% coverage of query (670 bits)

5dviA / H7BRJ8 High resolution crystal structure of glucose complexed periplasmic glucose binding protein (ppgbp) from p. Putida csv86 (see paper)
    68% identity, 100% coverage of query (536 bits)

5dvjA Crystal structure of galactose complexed periplasmic glucose binding protein (ppgbp) from p. Putida csv86
    68% identity, 100% coverage of query (536 bits)

Ac3H11_2062 glucose ABC transporter, substrate-binding component from Acidovorax sp. GW101-3H11
    54% identity, 95% coverage of query (409 bits)

8hqqA / Q4FMK2 Crystal structure of the glucose-binding protein sar11_0769 from "candidatus pelagibacter ubique" htcc1062 bound to glucose
    49% identity, 94% coverage of query (343 bits)

4r2bA / A6X5L9 Crystal structure of sugar transporter oant_3817 from ochrobactrum anthropi, target efi-510528, with bound glucose
    46% identity, 100% coverage of query (340 bits)

SMc04259 ABC transporter for D-Cellobiose and D-Salicin, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    36% identity, 84% coverage of query (198 bits)

TC 3.A.1.1.24 / Q72KX2 Glucose-binding protein aka TT_C0328, component of The glucose/mannose porter TTC0326-8 plus MalK1 (ABC protein, shared with 3.A.1.1.25) from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    31% identity, 88% coverage of query (134 bits)

2b3bA / Q72KX2 Thermus thermophilus glucose/galactose binding protein with bound glucose (see paper)
    31% identity, 88% coverage of query (128 bits)

2b3fA Thermus thermophilus glucose/galactose binding protein bound with galactose
    31% identity, 88% coverage of query (128 bits)

2b3bC Thermus thermophilus glucose/galactose binding protein with bound glucose
    31% identity, 88% coverage of query (128 bits)

Build an alignment

Build an alignment for Pf6N2E2_2892 and 13 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

XACG_HALVD / D4GP35 Xylose/arabinose-binding protein XacG from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
    25% identity, 92% coverage of query (91.7 bits)

GLCS_SACS2 / Q97UZ1 Glucose-binding protein GlcS; GBP from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
TC 3.A.1.1.13 / Q97UZ1 GlcS, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see paper)
    21% identity, 87% coverage of query (63.5 bits)

7c0kB / Q5SLB4 Crystal structure of a dinucleotide-binding protein of abc transporter endogenously bound to uridylyl-3'-5'-phospho-guanosine (form ii) (see paper)
    28% identity, 81% coverage of query (58.5 bits)

TC 3.A.1.1.50 / Q5SLB4 Sugar ABC transporter, periplasmic sugar-binding protein, component of Probable glycerophosphocholine (GPC) uptake porter (Chandravanshi et al. 2016). The system may include a receptor and three membrane proteins (of 378 aas and 6 TMSs, 299 aas and 7 TMSs, and 113 aas and 3 TMSs (?). The ATPase has not been identified from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    28% identity, 81% coverage of query (58.5 bits)

7c0oB Crystal structure of a dinucleotide-binding protein (y56f) of abc transporter endogenously bound to uridylyl-3'-5'-phospho-guanosine
    28% identity, 81% coverage of query (58.5 bits)

7c0kA Crystal structure of a dinucleotide-binding protein of abc transporter endogenously bound to uridylyl-3'-5'-phospho-guanosine (form ii)
    28% identity, 81% coverage of query (58.5 bits)

A0A3P4AR76 ABC-type glycerol 3-phosphate transporter (subunit 2/3) (EC 7.6.2.10) from Thermus thermophilus (see paper)
    28% identity, 81% coverage of query (55.5 bits)

MSME_STRMU / Q00749 Multiple sugar-binding protein from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
TC 3.A.1.1.28 / Q00749 MsmE aka SMU.878, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
    25% identity, 72% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory