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Searching for up to 100 curated homologs for Pf6N2E2_3128 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_3128 (345 a.a.)

Found high-coverage hits (≥70%) to 33 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YdcT / b1441 putative ABC transporter ATP-binding protein YdcT from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ydcT / P77795 putative ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see 3 papers)
YDCT_ECOLI / P77795 Uncharacterized ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see paper)
    67% identity, 98% coverage of query (446 bits)

Q8YM92 ABC-type polyamine transporter (subunit 3/3) (EC 7.6.2.11) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    46% identity, 98% coverage of query (313 bits)

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    43% identity, 97% coverage of query (272 bits)

PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
    39% identity, 98% coverage of query (265 bits)

TC 3.A.1.11.4 / O50559 ChtG, component of Chrysopine porter from Agrobacterium sp
    44% identity, 88% coverage of query (259 bits)

A0A142UTH4 ABC-type polyamine transporter (subunit 4/4) (EC 7.6.2.11) from Streptococcus suis (see paper)
    51% identity, 71% coverage of query (258 bits)

TC 3.A.1.11.3 / Q44383 MotB, component of Mannopine porter from Agrobacterium tumefaciens (see paper)
    42% identity, 90% coverage of query (254 bits)

TC 3.A.1.11.7 / Q97Q42 Spermidine/putrescine import ATP-binding protein PotA, component of The spermidine/putrescine uptake porter, PotABCD from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    47% identity, 76% coverage of query (253 bits)

TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
    44% identity, 81% coverage of query (252 bits)

YagC / b0262 CP4-6 prophage; ABC transporter ATP-binding protein AfuC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    43% identity, 84% coverage of query (251 bits)

Dshi_0546 ABC transporter for Xylitol, ATPase component from Dinoroseobacter shibae DFL-12
    46% identity, 79% coverage of query (250 bits)

TC 3.A.1.6.3 / P0A4W2 Sulfate/thiosulfate import ATP-binding protein CysA aka RV2397C aka MT2468 aka MTCY253.24, component of Sulfate porter from Mycobacterium tuberculosis (see 3 papers)
    46% identity, 78% coverage of query (249 bits)

TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    41% identity, 87% coverage of query (248 bits)

TC 3.A.1.1.15 / Q97ZC0 TreV, component of Trehalose porter from Sulfolobus solfataricus (see paper)
    41% identity, 88% coverage of query (243 bits)

PGA1_c27970 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Phaeobacter inhibens BS107
    46% identity, 81% coverage of query (243 bits)

TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
    46% identity, 72% coverage of query (242 bits)

SMc02869 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Sinorhizobium meliloti 1021
    45% identity, 75% coverage of query (241 bits)

PGA1_c13180 ABC transporter for D-Sorbitol, ATPase component from Phaeobacter inhibens BS107
    45% identity, 76% coverage of query (239 bits)

TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    40% identity, 88% coverage of query (238 bits)

TC 3.A.1.1.22 / Q9X103 MalK; aka Sugar ABC transporter, ATP-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
    42% identity, 86% coverage of query (234 bits)

sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    46% identity, 72% coverage of query (232 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    43% identity, 75% coverage of query (223 bits)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    36% identity, 83% coverage of query (185 bits)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    36% identity, 83% coverage of query (185 bits)

GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
    36% identity, 83% coverage of query (185 bits)

3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
    36% identity, 90% coverage of query (159 bits)

MacB / b0879 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MacB / P75831 ABC-type tripartite efflux pump ATP binding/membrane subunit from Escherichia coli (strain K12) (see 16 papers)
MACB_ECOLI / P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.122.1 / P75831 MacB aka B0879, component of Macrolide (14- and 15- but not 16-membered lactone macrolides including erythromycin) exporter, MacAB (formerly YbjYZ). Both MacA and MacB are required for activity (Tikhonova et al., 2007). MacAB functions with TolC to export multiple drugs and heat-stable enterotoxin II (enterotoxin STII) (Yamanaka et al., 2008). The crystal structure of MacA is available (Yum et al., 2009). MacB is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA (Lin et al., 2009). Xu et al. (2009) have reported the crystal structure of the periplasmic region of MacB which they claim resembles the periplasmic domain of RND-type transporters such as AcrB (TC# 2.A.6.2.2). Also exports L-cysteine (Yamada et al., 2006). The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by the MacB transporter from Escherichia coli (see 5 papers)
macB / BAB64542.1 macrolide-specific ABC-type efflux carrier from Escherichia coli (see paper)
    33% identity, 80% coverage of query (118 bits)

Build an alignment

Build an alignment for Pf6N2E2_3128 and 27 homologs with ≥ 30% identity

Select sequences

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Additional hits (identity < 30%)

ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
    25% identity, 97% coverage of query (104 bits)

8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
    29% identity, 78% coverage of query (97.4 bits)

DPPD_CALS4 / Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
    29% identity, 73% coverage of query (96.3 bits)

8wooA Structure of the wild-type arabidopsis abcb19 in the brassinolide and amp-pnp bound state
    31% identity, 79% coverage of query (88.2 bits)

8womA / Q9LJX0 Structure of the wild-type arabidopsis abcb19 in the brassinolide- bound state (see paper)
    31% identity, 79% coverage of query (88.2 bits)

8wp0A Structure of the arabidopsis e529q/e1174q abcb19 in the atp bound state
    31% identity, 79% coverage of query (86.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory