Searching for up to 100 curated homologs for Pf6N2E2_3170 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_3170 (559 a.a.)
Found high-coverage hits (≥70%) to 40 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
leuA / CAA50295.1 2-isopropylmalate synthase from Corynebacterium glutamicum (see paper)
55% identity, 97% coverage of query (630 bits)
LEU1_CORGL / P42455 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
55% identity, 97% coverage of query (629 bits)
LEU1_MYCTO / P9WQB2 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) (see paper)
LEU1_MYCTU / P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WQB3 2-isopropylmalate synthase (EC 2.3.3.13) from Mycobacterium tuberculosis (see 6 papers)
52% identity, 97% coverage of query (605 bits)
CH_124190 2-isopropylmalate synthase 2 from Magnaporthe grisea 70-15 (see paper)
53% identity, 98% coverage of query (604 bits)
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
54% identity, 97% coverage of query (601 bits)
1sr9A Crystal structure of leua from mycobacterium tuberculosis
54% identity, 97% coverage of query (601 bits)
3figB / P9WQB3 Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
54% identity, 97% coverage of query (600 bits)
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
54% identity, 97% coverage of query (600 bits)
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
53% identity, 97% coverage of query (597 bits)
LEU4 putative 2-isopropylmalalate synthase from Candida albicans (see paper)
53% identity, 99% coverage of query (589 bits)
LEU1_YEAST / P06208 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
52% identity, 98% coverage of query (573 bits)
LEU9_YEAST / Q12166 2-isopropylmalate synthase 2, mitochondrial; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
50% identity, 98% coverage of query (570 bits)
GLOH_GLAL2 / S3D9F8 Isopropyl malate synthase gloH; L-homotyrosine biosynthesis sub-cluster protein gloH; Pneumocandin biosynthesis cluster protein H; EC 2.3.3.13 from Glarea lozoyensis (strain ATCC 20868 / MF5171) (see 5 papers)
47% identity, 75% coverage of query (419 bits)
HtyA / K0E4E5 2-(4-hydroxybenzyl)-malate synthase from Aspergillus rugulosus (see paper)
HTYA_ASPRU / K0E4E5 Isopropyl malate synthase htyA; L-homotyrosine biosynthetic cluster protein A; EC 2.3.3.13 from Aspergillus rugulosus (Emericella rugulosa) (see paper)
42% identity, 97% coverage of query (403 bits)
AMT7_ALTAL / C9K7B8 Isopropyl malate synthase AMT7; AM-toxin biosynthesis protein 7; EC 2.3.3.13 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
44% identity, 78% coverage of query (383 bits)
B0SN40 2-isopropylmalate synthase (EC 2.3.3.13) from Leptospira biflexa (see paper)
30% identity, 70% coverage of query (145 bits)
Build an alignment for Pf6N2E2_3170 and 16 homologs with ≥ 30% identity
Or download the sequences
Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis (see paper)
27% identity, 92% coverage of query (140 bits)
LEU12_LEPIN / Q8F8T4 2-isopropylmalate synthase 2; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 2 papers)
29% identity, 71% coverage of query (138 bits)
LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 2 papers)
28% identity, 92% coverage of query (137 bits)
K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
27% identity, 99% coverage of query (137 bits)
LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 3 papers)
27% identity, 93% coverage of query (135 bits)
4ov4A Isopropylmalate synthase binding with ketoisovalerate
29% identity, 70% coverage of query (135 bits)
4ov9A / B0SN40 Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
29% identity, 70% coverage of query (134 bits)
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
27% identity, 94% coverage of query (132 bits)
Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
28% identity, 91% coverage of query (127 bits)
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus (see paper)
27% identity, 92% coverage of query (127 bits)
Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
28% identity, 92% coverage of query (126 bits)
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
26% identity, 91% coverage of query (125 bits)
Echvi_3833 2-isopropylmalate synthase (EC 2.3.3.13) from Echinicola vietnamensis KMM 6221, DSM 17526
27% identity, 72% coverage of query (124 bits)
LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
25% identity, 92% coverage of query (119 bits)
Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus (see 2 papers)
25% identity, 92% coverage of query (119 bits)
LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
25% identity, 92% coverage of query (115 bits)
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
24% identity, 92% coverage of query (112 bits)
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
24% identity, 97% coverage of query (111 bits)
LEU1_SOYBN / Q39891 Probable 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; Late nodulin-56; N-56; EC 2.3.3.13 from Glycine max (Soybean) (Glycine hispida) (see paper)
26% identity, 93% coverage of query (108 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
23% identity, 92% coverage of query (76.3 bits)
HOSA_SULAC / Q4J989 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J989 homocitrate synthase (EC 2.3.3.14) from Sulfolobus acidocaldarius (see paper)
25% identity, 74% coverage of query (59.7 bits)
cimA / Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
CIMA_GEOSL / Q74C76 (R)-citramalate synthase; Citramalate synthase; EC 2.3.3.21 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (see paper)
21% identity, 92% coverage of query (59.3 bits)
6ktqA / Q4J989 Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
25% identity, 71% coverage of query (58.9 bits)
P58637 homocitrate synthase (EC 2.3.3.14) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
24% identity, 71% coverage of query (53.9 bits)
Or start over
Lawrence Berkeley National Laboratory