Searching for up to 100 curated homologs for Pf6N2E2_372 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_372 (308 a.a.)
Found high-coverage hits (≥70%) to 77 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
5vg6B / A7IIH0 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from xanthobacter autotrophicus py2 in complex with NADPH and mes.
40% identity, 89% coverage of query (203 bits)
7jqhA / A0A140NAE3 Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with phosphate and NADP+
37% identity, 100% coverage of query (197 bits)
7jqiA Structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with alpha-ketoglutarate and NADP+
37% identity, 100% coverage of query (197 bits)
6p35A 2.5 angstrom structure of wild type glyoxylate/hydroxypyruvate reductase a from escherichia coli in complex with 2-keto arginine and NADP
37% identity, 100% coverage of query (197 bits)
GhrA / b1033 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ghrA / P75913 glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) from Escherichia coli (strain K12) (see 4 papers)
GHRA_ECOLI / P75913 Glyoxylate/hydroxypyruvate reductase A; 2-ketoacid reductase; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli (strain K12) (see paper)
37% identity, 100% coverage of query (196 bits)
3kboA / Q8ZQ30 2.14 angstrom crystal structure of putative oxidoreductase (ycdw) from salmonella typhimurium in complex with NADP
35% identity, 100% coverage of query (187 bits)
4zqbB / Q3IWN8 Crystal structure of NADP-dependent dehydrogenase from rhodobactersphaeroides in complex with NADP and sulfate
40% identity, 82% coverage of query (179 bits)
5bqfA / Q2KDT2 Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADP, hepes and l(+)-tartaric acid
34% identity, 89% coverage of query (161 bits)
4xcvA Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH
34% identity, 89% coverage of query (161 bits)
5tsdA Crystal structure of NADPH-dependent 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADPH and oxalate
34% identity, 89% coverage of query (161 bits)
4weqA / Q92T34 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADP and sulfate (see paper)
36% identity, 90% coverage of query (154 bits)
Q92T34 hydroxypyruvate reductase (EC 1.1.1.81) from Sinorhizobium meliloti (see paper)
36% identity, 90% coverage of query (154 bits)
4z0pA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc02828 (smghra) from sinorhizobium meliloti in complex with NADPH and oxalate
36% identity, 90% coverage of query (154 bits)
Build an alignment for Pf6N2E2_372 and 13 homologs with ≥ 30% identity
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serA / GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis (see paper)
serA / AAC83943.1 phosphoglycerate dehydrogenase from Bacillus subtilis (see 3 papers)
27% identity, 76% coverage of query (97.8 bits)
FDH_SOLTU / Q07511 Formate dehydrogenase, mitochondrial; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Solanum tuberosum (Potato) (see 3 papers)
CAA79702.2 mitochondrial formate dehydrogenase precursor from Solanum tuberosum (see paper)
30% identity, 71% coverage of query (97.4 bits)
HPR2 / Q9CA90 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 11 papers)
HPR2_ARATH / Q9CA90 Glyoxylate/hydroxypyruvate reductase A HPR2; NAD(P)H-dependent hydroxypyruvate reductase 2; AtHPR2; HPR 2; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9CA90 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 4 papers)
29% identity, 79% coverage of query (94.0 bits)
O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pyrococcus horikoshii (see paper)
29% identity, 80% coverage of query (93.6 bits)
B6VPZ9 formate dehydrogenase (EC 1.17.1.9) from Lotus japonicus (see paper)
28% identity, 81% coverage of query (92.4 bits)
7arzA / A9SQZ2 Ternary complex of NAD-dependent formate dehydrogenase from physcomitrium patens
29% identity, 71% coverage of query (91.3 bits)
GRHPR / Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.81; EC 1.1.1.79) from Homo sapiens (see 2 papers)
GRHPR_HUMAN / Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase; EC 1.1.1.79; EC 1.1.1.81 from Homo sapiens (Human) (see 4 papers)
Q9UBQ7 glyoxylate reductase (EC 1.1.1.26); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Homo sapiens (see 2 papers)
30% identity, 71% coverage of query (90.1 bits)
2gcgA / Q9UBQ7 Ternary crystal structure of human glyoxylate reductase/hydroxypyruvate reductase (see paper)
30% identity, 71% coverage of query (90.1 bits)
PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
28% identity, 85% coverage of query (89.0 bits)
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution
28% identity, 76% coverage of query (88.6 bits)
6rj3A Crystal structure of phgdh in complex with compound 15
28% identity, 76% coverage of query (88.6 bits)
Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
28% identity, 85% coverage of query (88.2 bits)
SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
28% identity, 85% coverage of query (88.2 bits)
7dkmA / O43175 Phgdh covalently linked to oridonin (see paper)
28% identity, 76% coverage of query (88.2 bits)
6plfA Crystal structure of human phgdh complexed with compound 1
28% identity, 76% coverage of query (88.2 bits)
6plgA Crystal structure of human phgdh complexed with compound 15
28% identity, 76% coverage of query (88.2 bits)
7ewhA Crystal structure of human phgdh in complex with homoharringtonine
28% identity, 76% coverage of query (88.2 bits)
6rihA Crystal structure of phgdh in complex with compound 9
28% identity, 76% coverage of query (88.2 bits)
6rj5A Crystal structure of phgdh in complex with compound 39
28% identity, 76% coverage of query (88.2 bits)
6rj2A Crystal structure of phgdh in complex with compound 40
28% identity, 76% coverage of query (88.2 bits)
6plfB Crystal structure of human phgdh complexed with compound 1
29% identity, 79% coverage of query (87.4 bits)
A0A178WMD4 hydroxyphenylpyruvate reductase (EC 1.1.1.237); glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 2 papers)
27% identity, 74% coverage of query (86.3 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
26% identity, 79% coverage of query (85.9 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
26% identity, 79% coverage of query (85.9 bits)
HPR3 / Q9LE33 glyoxylate reductase (NADP+) (EC 1.1.1.79; EC 1.1.1.81) from Arabidopsis thaliana (see 8 papers)
HPR3_ARATH / Q9LE33 Glyoxylate/hydroxypyruvate reductase HPR3; NAD(P)H-dependent hydroxypyruvate reductase 3; AtHPR3; HPR 3; EC 1.1.1.79; EC 1.1.1.81 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LE33 hydroxyphenylpyruvate reductase (EC 1.1.1.237); hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see 3 papers)
26% identity, 74% coverage of query (85.9 bits)
A0A0A7RFJ3 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Salvia miltiorrhiza (see paper)
26% identity, 82% coverage of query (83.6 bits)
HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
25% identity, 78% coverage of query (83.2 bits)
H9JRZ9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Bombyx mori (see paper)
27% identity, 76% coverage of query (80.9 bits)
TkrA / b3553 glyoxylate reductase (EC 1.1.1.79; EC 1.1.1.215) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ghrB / P37666 glyoxylate reductase (EC 1.1.1.79; EC 1.1.1.215) from Escherichia coli (strain K12) (see 4 papers)
GHRB_ECOLI / P37666 Glyoxylate/hydroxypyruvate reductase B; 2-ketoaldonate reductase; 2-ketogluconate reductase; 2KR; EC 1.1.1.79; EC 1.1.1.81; EC 1.1.1.215 from Escherichia coli (strain K12) (see 2 papers)
ghrB / GB|AAC76577.2 glyoxylate/hydroxypyruvate reductase B; EC 1.1.1.215; EC 1.1.1.79; EC 1.1.1.81 from Escherichia coli K12 (see 6 papers)
28% identity, 74% coverage of query (80.5 bits)
HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
28% identity, 76% coverage of query (79.3 bits)
kguD / Q5TM04 2-dehydro-6-phosphogluconate reductase (EC 1.1.1.43) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see 2 papers)
29% identity, 72% coverage of query (77.8 bits)
EFUE_HORCR / A0A2Z4HPZ6 Dehydrogenase efuE; Enfumafungin biosynthesis cluster protein E; EC 1.-.-.- from Hormonema carpetanum (see paper)
25% identity, 82% coverage of query (76.6 bits)
A9ZNT9 formate dehydrogenase (EC 1.17.1.9) from Gelatoporia subvermispora (see paper)
27% identity, 77% coverage of query (75.5 bits)
hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
25% identity, 71% coverage of query (74.7 bits)
2KGR_VITVI / A5CAL1 Glyoxylate/hydroxypyruvate/pyruvate reductase 2KGR; 2-keto-L-gulonate reductase; Vv2KGR; EC 1.1.1.26; EC 1.1.1.28; EC 1.1.1.79; EC 1.1.1.- from Vitis vinifera (Grape) (see paper)
24% identity, 79% coverage of query (74.3 bits)
A9ZNT8 formate dehydrogenase (EC 1.17.1.9) from Gelatoporia subvermispora (see paper)
26% identity, 77% coverage of query (73.9 bits)
A0A1Z4EAX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
25% identity, 74% coverage of query (73.6 bits)
6t9wB / G8NTI5 Crystal structure of formate dehydrogenase fdh2 d222a/q223r enzyme from granulicella mallensis mp5actx8 in complex with NADP and azide.
26% identity, 75% coverage of query (72.8 bits)
6ttbA / A0A0H3JSR9 Crystal structure of NAD-dependent formate dehydrogenase from staphylococcus aureus in complex with NAD
23% identity, 84% coverage of query (72.8 bits)
SERA1_ARATH / O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
27% identity, 74% coverage of query (72.4 bits)
BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) from Burkholderia phytofirmans PsJN
26% identity, 71% coverage of query (72.4 bits)
SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 3 papers)
26% identity, 74% coverage of query (71.6 bits)
5v7gA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADPH and oxalate
27% identity, 78% coverage of query (70.9 bits)
5v7nA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and 2-keto-d-gluconic acid
27% identity, 78% coverage of query (70.9 bits)
FDH1 / O13437 formate dehydrogenase (EC 1.17.1.9) from Candida boidinii (see 3 papers)
FDH_CANBO / O13437 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Candida boidinii (Yeast) (see 6 papers)
O13437 formate dehydrogenase (EC 1.17.1.9) from [Candida] boidinii (see 12 papers)
fdh3 / CAB54834.1 formate dehydrogenase from [Candida] boidinii (see paper)
25% identity, 71% coverage of query (70.9 bits)
5v6qB / Q92LZ4 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and malonate (see paper)
27% identity, 78% coverage of query (70.5 bits)
5j23A Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with 2'-phospho-adp-ribose
27% identity, 78% coverage of query (70.5 bits)
8bxxAA Formate dehydrogenase
26% identity, 75% coverage of query (69.7 bits)
CTBP1_CAEEL / Q20595 C-terminal-binding protein 1 from Caenorhabditis elegans (see 4 papers)
26% identity, 71% coverage of query (69.3 bits)
6d4bA / A0A0A1EQY0 Crystal structure of candida boidinii formate dehydrogenase v123a mutant complexed with NAD+ and azide
25% identity, 71% coverage of query (68.9 bits)
8grvA / Q54UF7 Dictyostelium discoideum lactate dehydrogenase (dicldha)with NAD
24% identity, 81% coverage of query (67.8 bits)
2gsdA / O08375 NAD-dependent formate dehydrogenase from bacterium moraxella sp.C2 in complex with NAD and azide (see paper)
24% identity, 71% coverage of query (64.7 bits)
6jujA Crystal structure of formate dehydrogenase mutant v198i/c256i/p260s/e261p/s381n/s383f from pseudomonas sp. 101in complex with non-natural cofactor nicotinamide cytosine dinucleotide
24% identity, 71% coverage of query (62.0 bits)
5z21B / Q8RG11 The ternary structure of d-lactate dehydrogenase from fusobacterium nucleatum with nadh and oxamate (see paper)
24% identity, 77% coverage of query (61.6 bits)
2nadA High resolution structures of holo and apo formate dehydrogenase
24% identity, 71% coverage of query (61.2 bits)
FDH_PSESR / P33160 Formate dehydrogenase; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Pseudomonas sp. (strain 101) (Achromobacter parvulus T1) (see 2 papers)
P33160 formate dehydrogenase (EC 1.17.1.9) from Pseudomonas sp. 101 (see paper)
24% identity, 71% coverage of query (60.8 bits)
DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lacticaseibacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
25% identity, 71% coverage of query (60.5 bits)
1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
25% identity, 71% coverage of query (60.5 bits)
8oq2A Binding of NADP to a formate dehydrogenase from starkeya novella.
23% identity, 71% coverage of query (57.0 bits)
1qp8A / Q8ZXP5 Crystal structure of a putative formate dehydrogenase from pyrobaculum aerophilum
24% identity, 71% coverage of query (52.4 bits)
6ih6A / G4XDR8 Phosphite dehydrogenase mutant i151r/p176r/m207a from ralstonia sp. 4506 in complex with non-natural cofactor nicotinamide cytosine dinucleotide
23% identity, 79% coverage of query (48.5 bits)
O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus (see paper)
3kb6B / O66939 Crystal structure of d-lactate dehydrogenase from aquifex aeolicus complexed with NAD and lactic acid (see paper)
21% identity, 76% coverage of query (48.1 bits)
2w2lA / Q7LLW9 Crystal structure of the holo forms of rhodotorula graminis d- mandelate dehydrogenase at 2.5a.
24% identity, 81% coverage of query (47.0 bits)
4xkjA / A0A0M3KL04 A novel d-lactate dehydrogenase from sporolactobacillus sp
24% identity, 77% coverage of query (43.1 bits)
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