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Searching for up to 100 curated homologs for Pf6N2E2_3903 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_3903 (301 a.a.)

Found high-coverage hits (≥70%) to 14 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7qyrD / Q9HTZ2 Crystal structure of rimk from pseudomonas aeruginosa pao1 (see paper)
    92% identity, 97% coverage of query (557 bits)

4iwxA / P0C0U4 Rimk structure at 2.85a (see paper)
    66% identity, 96% coverage of query (395 bits)

Nek / b0852 ribosomal protein S6 modification protein from Escherichia coli K-12 substr. MG1655 (see 3 papers)
rimK / P0C0U4 ribosomal protein S6 modification protein from Escherichia coli (strain K12) (see 6 papers)
RIMK_ECOLI / P0C0U4 Ribosomal protein bS6--L-glutamate ligase; Polyglutamate synthase; Ribosomal protein bS6 modification protein; EC 6.3.2.- from Escherichia coli (strain K12) (see 2 papers)
    66% identity, 96% coverage of query (395 bits)

5zctH The crystal structure of the poly-alpha-l-glutamate peptides synthetase rimk at 2.05 angstrom resolution.
    66% identity, 96% coverage of query (395 bits)

5zctA The crystal structure of the poly-alpha-l-glutamate peptides synthetase rimk at 2.05 angstrom resolution.
    66% identity, 96% coverage of query (395 bits)

ARGX_SULTO / Q970U6 Glutamate--LysW ligase ArgX; EC 6.3.2.- from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
3vpbB / Q970U6 Argx from sulfolobus tokodaii complexed with lysw/glu/adp/mg/zn/sulfate (see paper)
    31% identity, 79% coverage of query (91.3 bits)

Build an alignment

Build an alignment for Pf6N2E2_3903 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

lysX / Q5SH23 L-2-aminoadipate--LysW ligase monomer (EC 6.3.2.43) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 3 papers)
LYSX_THET8 / Q5SH23 Alpha-aminoadipate--LysW ligase LysX; AAA--LysW ligase LysX; EC 6.3.2.43 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 3 papers)
Q5SH23 [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Thermus thermophilus (see 2 papers)
    29% identity, 78% coverage of query (82.0 bits)

argX / Q4J8E7 glutamate--LysW ligase monomer (EC 6.3.2.60) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
ARGX_SULAC / Q4J8E7 Glutamate--LysW ligase ArgX; EC 6.3.2.- from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J8E7 glutamate---[amino group carrier protein] ligase (EC 6.3.2.60) from Sulfolobus acidocaldarius (see paper)
    30% identity, 79% coverage of query (81.6 bits)

mptN / Q58037 tetrahydrosarcinapterin synthase monomer (EC 6.3.2.33) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
MPTN_METJA / Q58037 Tetrahydromethanopterin:alpha-L-glutamate ligase; H(4)MPT:alpha-L-glutamate ligase; EC 6.3.2.33 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58037 tetrahydrosarcinapterin synthase (EC 6.3.2.33) from Methanocaldococcus jannaschii (see paper)
    28% identity, 80% coverage of query (79.7 bits)

3vpdA / Q5SH23 Lysx from thermus thermophilus complexed with amp-pnp (see paper)
    29% identity, 78% coverage of query (77.4 bits)

RIMKA_MOUSE / Q6PFX8 N-acetylaspartylglutamate synthase A; NAAG synthetase A; NAAGS; N-acetylaspartylglutamylglutamate synthase A; Ribosomal protein S6 modification-like protein A; EC 6.3.2.41; EC 6.3.2.42 from Mus musculus (Mouse) (see 2 papers)
Q6PFX8 N-acetylaspartylglutamate synthase (EC 6.3.2.41); N-acetylaspartylglutamylglutamate synthase (EC 6.3.2.42) from Mus musculus (see 2 papers)
    27% identity, 77% coverage of query (73.9 bits)

Q5JFW0 lysyltransferase (EC 2.3.2.3); [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43); glutamate---[amino group carrier protein] ligase (EC 6.3.2.60) from Thermococcus kodakarensis (see paper)
5k2mG / Q5JFW0 Bifunctional lysx/argx from thermococcus kodakarensis with lysw-gamma- aaa (see paper)
    26% identity, 71% coverage of query (62.8 bits)

5k2mI Bifunctional lysx/argx from thermococcus kodakarensis with lysw-gamma- aaa
    26% identity, 71% coverage of query (62.8 bits)

1uc9A / Q5SH23 Crystal structure of a lysine biosynthesis enzyme, lysx, from thermus thermophilus hb8 (see paper)
    28% identity, 78% coverage of query (55.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory