Searching for up to 100 curated homologs for Pf6N2E2_4963 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_4963 (352 a.a.)
Found high-coverage hits (≥70%) to 33 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
35% identity, 99% coverage of query (190 bits)
A0A0H2WVX4 homoserine dehydrogenase (EC 1.1.1.3) from Staphylococcus aureus (see 2 papers)
36% identity, 97% coverage of query (183 bits)
F9VNG5 homoserine dehydrogenase (EC 1.1.1.3) from Sulfurisphaera tokodaii (see paper)
34% identity, 96% coverage of query (179 bits)
DvMF_1412 homoserine dehydrogenase (EC 1.1.1.3) from Desulfovibrio vulgaris Miyazaki F
36% identity, 98% coverage of query (178 bits)
D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus (see paper)
34% identity, 97% coverage of query (177 bits)
7f4cA The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon sulfurisphaera tokodaii.
33% identity, 96% coverage of query (177 bits)
5x9dA / F9VNG5 Crystal structure of homoserine dehydrogenase in complex with l- cysteine and NAD (see paper)
33% identity, 96% coverage of query (173 bits)
hom / AAF21129.1 homoserine dehydrogenase from Methylobacillus flagellatus (see paper)
39% identity, 78% coverage of query (169 bits)
4pg7A / A0A0M3KKV6 Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
35% identity, 97% coverage of query (169 bits)
DHOM_CORGL / P08499 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 2 papers)
P08499 homoserine dehydrogenase (EC 1.1.1.3) from Corynebacterium glutamicum (see 2 papers)
37% identity, 98% coverage of query (169 bits)
6dzsA / K5BJC9 Mycobacterial homoserine dehydrogenase thra in complex with NADP
36% identity, 95% coverage of query (164 bits)
Q56R01 homoserine dehydrogenase (EC 1.1.1.3) from Streptomyces clavuligerus (see paper)
34% identity, 95% coverage of query (161 bits)
P46806 homoserine dehydrogenase (EC 1.1.1.3) from Mycobacterium leprae (see paper)
41% identity, 72% coverage of query (151 bits)
Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima (see paper)
35% identity, 71% coverage of query (144 bits)
Ga0059261_2711 homoserine dehydrogenase (EC 1.1.1.3) from Sphingomonas koreensis DSMZ 15582
34% identity, 97% coverage of query (136 bits)
4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH
30% identity, 95% coverage of query (133 bits)
O58802 homoserine dehydrogenase (EC 1.1.1.3) from Pyrococcus horikoshii (see paper)
4xb1A / O58802 Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
31% identity, 95% coverage of query (132 bits)
Q5SL04 homoserine dehydrogenase (EC 1.1.1.3) from Thermus thermophilus (see paper)
6a0tB / Q5SL04 Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
34% identity, 98% coverage of query (132 bits)
6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH
34% identity, 98% coverage of query (132 bits)
2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
34% identity, 98% coverage of query (132 bits)
Build an alignment for Pf6N2E2_4963 and 20 homologs with ≥ 30% identity
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CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
28% identity, 94% coverage of query (117 bits)
O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
27% identity, 96% coverage of query (112 bits)
Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
29% identity, 97% coverage of query (112 bits)
AAA16972.1 aspartokinase-homoserine dehydrogenase, partial from Daucus carota (see paper)
29% identity, 96% coverage of query (109 bits)
AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
28% identity, 88% coverage of query (108 bits)
AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
27% identity, 96% coverage of query (108 bits)
3ingA / Q9HIZ7 Crystal structure of homoserine dehydrogenase (np_394635.1) from thermoplasma acidophilum at 1.95 a resolution
27% identity, 97% coverage of query (99.8 bits)
3jsaA / Q97BR6 Homoserine dehydrogenase from thermoplasma volcanium complexed with NAD
26% identity, 96% coverage of query (89.0 bits)
ThrD / b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
thrA / P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 33 papers)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli (see paper)
27% identity, 91% coverage of query (89.0 bits)
BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
27% identity, 89% coverage of query (85.1 bits)
MetM / b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655 (see paper)
metL / P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12) (see 9 papers)
26% identity, 96% coverage of query (78.6 bits)
Q3S3F6 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max (see paper)
26% identity, 97% coverage of query (78.6 bits)
thrA1A2 / CAA43212.1 aspartate kinase from Serratia marcescens (see paper)
27% identity, 89% coverage of query (73.6 bits)
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Lawrence Berkeley National Laboratory