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Searching for up to 100 curated homologs for Pf6N2E2_5281 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_5281 (300 a.a.)

Found high-coverage hits (≥70%) to 39 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

MEST_MOUSE / Q07646 Mesoderm-specific transcript protein; Paternally-expressed gene 1 protein; EC 3.-.-.- from Mus musculus (Mouse) (see 2 papers)
    40% identity, 93% coverage of query (202 bits)

MEST_HUMAN / Q5EB52 Mesoderm-specific transcript homolog protein; Paternally-expressed gene 1 protein; EC 3.-.-.- from Homo sapiens (Human) (see 3 papers)
    40% identity, 93% coverage of query (199 bits)

MEST_BOVIN / Q2HJM9 Mesoderm-specific transcript homolog protein; Paternally-expressed gene 1 protein; EC 3.-.-.- from Bos taurus (Bovine) (see paper)
    39% identity, 94% coverage of query (197 bits)

Build an alignment

Build an alignment for Pf6N2E2_5281 and 3 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

oleB / Q8EG65 3-alkyl-4-acyloxetan-2-one decarboxylase (EC 4.1.1.114) from Shewanella oneidensis (strain MR-1) (see paper)
OLEB_SHEON / Q8EG65 Cis-3-alkyl-4-alkyloxetan-2-one decarboxylase; EC 4.1.1.114 from Shewanella oneidensis (strain MR-1) (see paper)
    27% identity, 91% coverage of query (80.9 bits)

6i8wB / Q9KJG6 Crystal structure of a membrane phospholipase a, a novel bacterial virulence factor (see paper)
    25% identity, 85% coverage of query (72.8 bits)

Q9KJG6 triacylglycerol lipase (EC 3.1.1.3) from Pseudomonas aeruginosa (see paper)
    25% identity, 85% coverage of query (72.4 bits)

Q2KTB5 triacylglycerol lipase (EC 3.1.1.3) from Psychrobacter sp. (see paper)
    24% identity, 87% coverage of query (64.3 bits)

6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
    31% identity, 88% coverage of query (62.8 bits)

Q84II3 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13) from Janthinobacterium sp. J3 (see paper)
    24% identity, 88% coverage of query (62.0 bits)

EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
    24% identity, 89% coverage of query (61.2 bits)

carC / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase monomer (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
CARC_PSERE / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase; HOPDA; EC 3.7.1.13 from Pseudomonas resinovorans (see 3 papers)
Q9AQM4 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
carC / BAC41548.1 meta cleavage compound hydrolase from Pseudomonas resinovorans (see 9 papers)
    24% identity, 88% coverage of query (60.8 bits)

6eb3B Structural and enzymatic characterization of an esterase from a metagenomic library
    31% identity, 88% coverage of query (58.5 bits)

4uhfA / A0A0M3KKY6 Structural studies of a thermophilic esterase from thermogutta terrifontis (l37a mutant with butyrate bound) (see paper)
    26% identity, 86% coverage of query (57.0 bits)

4uhdA Structural studies of a thermophilic esterase from thermogutta terrifontis (acetate bound)
    26% identity, 86% coverage of query (57.0 bits)

4uheA Structural studies of a thermophilic esterase from thermogutta terrifontis (malate bound)
    26% identity, 86% coverage of query (57.0 bits)

Q6EUU8 haloalkane dehalogenase (EC 3.8.1.5) from Mycobacterium tuberculosis variant bovis (see paper)
dmbB / CAH04660.2 haloalkane dehalogenase DmbB from Mycobacterium tuberculosis variant bovis (see paper)
    27% identity, 72% coverage of query (56.6 bits)

D2J2T6 quorum-quenching N-acyl-homoserine lactonase (EC 3.1.1.81) from Ochrobactrum sp. T63 (see 2 papers)
    27% identity, 85% coverage of query (55.8 bits)

4g8bA / D2J2T6 Crystal structures of n-acyl homoserine lactonase aidh s102g mutant complexed with n-hexanoyl homoserine lactone (see paper)
    27% identity, 85% coverage of query (55.5 bits)

4g9eA Crystal structures of n-acyl homoserine lactonase aidh complexed with n-butanoyl homoserine
    27% identity, 85% coverage of query (55.5 bits)

A4Q9R7 haloalkane dehalogenase (EC 3.8.1.5) from Mycobacterium tuberculosis variant bovis (see paper)
    26% identity, 85% coverage of query (55.1 bits)

estRB8 / CAE54381.1 carboxylesterase, partial from Oleispira antarctica (see paper)
estRB8 / CAE54384.1 carboxylesterase from Oleispira antarctica (see paper)
    21% identity, 86% coverage of query (54.7 bits)

4g8cA Crystal structures of n-acyl homoserine lactonase aidh e219g mutant complexed with n-hexanoyl homoserine
    27% identity, 85% coverage of query (54.7 bits)

P96965 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas fluorescens (see 2 papers)
cumD / BAA12150.1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase from Pseudomonas fluorescens (see paper)
    25% identity, 72% coverage of query (53.9 bits)

1iunB / P96965 Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant hexagonal (see paper)
    25% identity, 72% coverage of query (52.8 bits)

1ukaA Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with (s)-2-methylbutyrate
    25% identity, 72% coverage of query (52.8 bits)

1uk9A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with isovalerate
    25% identity, 72% coverage of query (52.8 bits)

1uk8A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-valerate
    25% identity, 72% coverage of query (52.8 bits)

1uk7A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-butyrate
    25% identity, 72% coverage of query (52.8 bits)

1iupA Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant complexed with isobutyrates
    25% identity, 72% coverage of query (52.8 bits)

G3XCP3 haloalkane dehalogenase (EC 3.8.1.5) from Rhodopirellula baltica (see paper)
Q7UF99 haloalkane dehalogenase (EC 3.8.1.5) from Rhodopirellula baltica (see paper)
    23% identity, 84% coverage of query (52.0 bits)

Q73Y99 haloalkane dehalogenase (EC 3.8.1.5) from Mycobacterium avium (see paper)
Q93K00 haloalkane dehalogenase (EC 3.8.1.5) from Mycobacterium avium (see paper)
    27% identity, 71% coverage of query (50.8 bits)

5esrA / Q9A919 Crystal structure of haloalkane dehalogenase (dcca) from caulobacter crescentus (see paper)
    26% identity, 82% coverage of query (50.8 bits)

Q9A919 haloalkane dehalogenase (EC 3.8.1.5) from Caulobacter vibrioides (see paper)
    26% identity, 82% coverage of query (50.8 bits)

HYES_RAT / P80299 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Rattus norvegicus (Rat) (see 3 papers)
P80299 soluble epoxide hydrolase (EC 3.3.2.10) from Rattus norvegicus (see 11 papers)
    24% identity, 83% coverage of query (49.7 bits)

8agsAAA / A0A1U9WZ52 8agsAAA
    25% identity, 83% coverage of query (45.8 bits)

8agnAAA Alpha/beta epoxide hydrolase
    25% identity, 83% coverage of query (45.8 bits)

8agmAAA Alpha/beta epoxide hydrolase
    25% identity, 83% coverage of query (45.8 bits)

8agpAAA Alpha/beta epoxide hydrolase
    25% identity, 83% coverage of query (45.8 bits)

5ng7B Novel epoxide hydrolases belonging to the alpha/beta hydrolases superfamily in metagenomes from hot environments
    25% identity, 83% coverage of query (45.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory