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Searching for up to 100 curated homologs for Pf6N2E2_5575 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_5575 (283 a.a.)

Found high-coverage hits (≥70%) to 99 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GlpF / b3927 glycerol facilitator from Escherichia coli K-12 substr. MG1655 (see 43 papers)
glpF / P0AER0 glycerol facilitator from Escherichia coli (strain K12) (see 57 papers)
GLPF_ECOLI / P0AER0 Glycerol uptake facilitator protein; Aquaglyceroporin; Glycerol facilitator from Escherichia coli (strain K12) (see 9 papers)
TC 1.A.8.1.1 / P0AER0 Glycerol facilitator, GlpF. Transports various polyols with decreasing rates as size increases (Heller et al. 1980); also transports arsenite (As(III) and antimonite (Sb(III)) (Meng et al., 2004). Oligomerization may play a role in determining the rate of transport from Escherichia coli (see 11 papers)
glpF / RF|NP_418362 aquaglyceroporin from Escherichia coli K12 (see 44 papers)
    67% identity, 98% coverage of query (387 bits)

1fx8A / P0AER0 Crystal structure of the e. Coli glycerol facilitator (glpf) with substrate glycerol (see paper)
    72% identity, 90% coverage of query (376 bits)

PDUF_CITFR / B1VB61 Propanediol uptake facilitator PduF from Citrobacter freundii (see paper)
    64% identity, 95% coverage of query (359 bits)

PDUF_SALTY / P37451 Propanediol uptake facilitator PduF from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
    66% identity, 91% coverage of query (356 bits)

AQP9 / O43315 aquaporin-9 from Homo sapiens (see 14 papers)
AQP9_HUMAN / O43315 Aquaporin-9; AQP-9; Aquaglyceroporin-9; Small solute channel 1 from Homo sapiens (Human) (see 3 papers)
    40% identity, 98% coverage of query (183 bits)

AQP10_HUMAN / Q96PS8 Aquaporin-10; AQP-10; Aquaglyceroporin-10; Small intestine aquaporin from Homo sapiens (Human) (see 6 papers)
TC 1.A.8.9.5 / Q96PS8 Aquaporin 10 from Homo sapiens
    39% identity, 93% coverage of query (174 bits)

6f7hC / Q96PS8 Crystal structure of human aqp10 (see paper)
    40% identity, 89% coverage of query (170 bits)

AQP3_PIG / A9Y006 Aquaporin-3; Aquaglyceroporin-3 from Sus scrofa (Pig) (see paper)
    38% identity, 93% coverage of query (168 bits)

AQP3_MOUSE / Q8R2N1 Aquaporin-3; AQP-3; Aquaglyceroporin-3 from Mus musculus (Mouse) (see 3 papers)
    38% identity, 93% coverage of query (167 bits)

AQP3_RAT / P47862 Aquaporin-3; AQP-3; 31.4 kDa water channel protein; Aquaglyceroporin-3 from Rattus norvegicus (Rat) (see 2 papers)
TC 1.A.8.9.1 / P47862 Aquaporin 3. 95% identical to the human orthologue. Poorly permeable to water, but more permeable to glycerol and arsenic trioxide from Rattus norvegicus (Rat) (see 3 papers)
    39% identity, 92% coverage of query (166 bits)

AQP3_HUMAN / Q92482 Aquaporin-3; AQP-3; Aquaglyceroporin-3 from Homo sapiens (Human) (see 3 papers)
    38% identity, 93% coverage of query (166 bits)

AQP9_RAT / P56627 Aquaporin-9; AQP-9; Aquaglyceroporin-9 from Rattus norvegicus (Rat) (see paper)
TC 1.A.8.9.2 / P56627 Aquaporin-9 (Aqp9) (permeable to glycerol, urea, polyols, carbamides, purines, pyrmidines, nucleosides, monocarboxylates, pentavalent methylated arsenicals and the arsenic chemotherapeutic drug, trisenox from Rattus norvegicus (Rat) (see 3 papers)
Aqp9 / RF|NP_075249.1 aquaporin-9 from Rattus norvegicus (see paper)
    37% identity, 97% coverage of query (163 bits)

AQP10_MILTA / G5CTG7 Aquaporin-10; AQP-10 from Milnesium tardigradum (Water bear) (Tardigrade) (see 2 papers)
    36% identity, 90% coverage of query (163 bits)

AQP9_BOTFB / A0A384JSZ0 Aquaglyceroporin-9 from Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) (see paper)
    41% identity, 86% coverage of query (163 bits)

TC 1.A.8.9.12 / Q6IRR9 Basolateral Aqp3 of 292 aas and 6 TMSs in the frog urinary bladder from Xenopus laevis
    36% identity, 94% coverage of query (162 bits)

AQP71_LACBI / I1Z8E9 Aquaporin-7-1 from Laccaria bicolor (Bicoloured deceiver) (Laccaria laccata var. bicolor) (see 4 papers)
    39% identity, 85% coverage of query (159 bits)

AQP7_MOUSE / O54794 Aquaporin-7; AQP-7; Aquaglyceroporin-7 from Mus musculus (Mouse) (see 6 papers)
    35% identity, 91% coverage of query (157 bits)

AQP7_LACBS / B0D4J9 Aquaporin Lacbi1:317173 from Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) (see paper)
    40% identity, 85% coverage of query (156 bits)

AQP7_RAT / P56403 Aquaporin-7; AQP-7; Aquaglyceroporin-7 from Rattus norvegicus (Rat) (see paper)
    36% identity, 91% coverage of query (153 bits)

AQP2_RHIIR / I3W9F7 Aquaglyceroporin-2 from Rhizophagus irregularis (Arbuscular mycorrhizal fungus) (Glomus intraradices) (see paper)
    39% identity, 87% coverage of query (152 bits)

AQP72_LACBI / I1Z8F0 Aquaporin-7-2 from Laccaria bicolor (Bicoloured deceiver) (Laccaria laccata var. bicolor) (see 3 papers)
    39% identity, 85% coverage of query (150 bits)

AQP7 / O14520 aquaporin-7 from Homo sapiens (see 7 papers)
AQP7_HUMAN / O14520 Aquaporin-7; AQP-7; Aquaglyceroporin-7; Aquaporin adipose; AQPap; Aquaporin-7-like from Homo sapiens (Human) (see 6 papers)
    34% identity, 94% coverage of query (150 bits)

TC 1.A.8.9.9 / F6QEC2 Aquaporin/glycerol facilitator of 294 aas and 6 TMSs from Xenopus tropicalis
    36% identity, 95% coverage of query (150 bits)

AQP5_LACBS / B0D4E4 Aquaporin Lacbi1:247946 from Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) (see paper)
    38% identity, 86% coverage of query (148 bits)

8c9hA / O14520 Aqp7_inhibitor (see paper)
    35% identity, 88% coverage of query (147 bits)

AQP6_LACBS / B0DLE4 Aquaporin Lacbi1:391485 from Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) (see paper)
    37% identity, 88% coverage of query (147 bits)

6n1gA Crystal structure of aquaglyceroporin aqp7
    35% identity, 87% coverage of query (145 bits)

AQP2_GIBZE / I1RHJ1 Probable aquaglyceroporin-2 from Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) (see paper)
    39% identity, 87% coverage of query (144 bits)

TC 1.A.8.9.4 / Q6ZXT4 Aquaporin 1 (permeable to water, glycerol, dihydroxyacetone and urea) from Trypanosoma brucei brucei (see paper)
AQP1 / GI|46518239 aquaglyceroporin 1 from Trypanosoma brucei brucei (see paper)
    37% identity, 85% coverage of query (143 bits)

AQP1_RHIO9 / I1CR68 Aquaporin-1 from Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar) (see paper)
    39% identity, 84% coverage of query (143 bits)

AQP6_LACBI / I1Z8E8 Aquaporine-6 from Laccaria bicolor (Bicoloured deceiver) (Laccaria laccata var. bicolor) (see 5 papers)
    35% identity, 88% coverage of query (142 bits)

aqp / CAR66115.1 water-specific aquaporin from Rhipicephalus sanguineus (see paper)
    32% identity, 92% coverage of query (142 bits)

AQY3_YEAST / P43549 Aquaglycerol porin AQY3; Aquaporin-3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 1.A.8.9.7 / P43549 Glycerol facilitator, Yf1054c (70.5 kDa protein) from Saccharomyces cerevisiae (Baker's yeast) (see 4 papers)
RF|NP_116601.1 uncharacterized membrane protein YFL054C from Saccharomyces cerevisiae (see paper)
    39% identity, 75% coverage of query (142 bits)

AQP2_RHIO9 / I1CS06 Aquaporin-2 from Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar) (see paper)
    38% identity, 86% coverage of query (140 bits)

AQP2_MILTA / G5CTF9 Aquaporin-2; AQP-2 from Milnesium tardigradum (Water bear) (Tardigrade) (see paper)
    33% identity, 89% coverage of query (139 bits)

AQP7_MILTA / G5CTG4 Aquaporin-7; AQP-7 from Milnesium tardigradum (Water bear) (Tardigrade) (see paper)
    34% identity, 92% coverage of query (135 bits)

AQP5_LACBI / I1Z8E7 Aquaporin-5 from Laccaria bicolor (Bicoloured deceiver) (Laccaria laccata var. bicolor) (see 3 papers)
    35% identity, 86% coverage of query (135 bits)

AQP8_MILTA / G5CTG5 Aquaporin-8; AQP-8 from Milnesium tardigradum (Water bear) (Tardigrade) (see paper)
    32% identity, 95% coverage of query (135 bits)

TC 1.A.8.9.3 / Q6Q1Q6 Major aquaglyceroporin, LmAQP1: transports water, glycerol, methylglyoxal, trivalent metalloids such as arsenite and antimonite, dihydroxyacetone and sugar alcohols. Also takes up the activated form or the drug, pentostam from Leishmania major (see paper)
    36% identity, 86% coverage of query (132 bits)

TC 1.A.8.9.11 / C4PYI6 Aqp1 of 304 aas and 6 TMSs; the most abundant transmembrane protein in the tegument of Schistosoma mansoni. This protein is expressed in all developmental stages and seems to be essential in parasite survival since it plays a crucial role in osmoregulation, nutrient transport and drug uptake from Schistosoma mansoni
    33% identity, 91% coverage of query (128 bits)

AQP4_BOTFB / A0A384JPP3 Aquaglyceroporin-4 from Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) (see paper)
    37% identity, 73% coverage of query (122 bits)

AQP4_GIBZE / I1RIY3 Probable aquaglyceroporin-4 from Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) (see paper)
    31% identity, 87% coverage of query (118 bits)

TC 1.A.8.9.13 / Q8WPZ6 Aquaglycerolporin, Aqp (high permeability to ammonium, methylamine, glycerol and water) (Beitz et al., 2004) NH4+/NH3+CH3 transporter from Plasmodium falciparum (see paper)
AQP / CAC88373.1 aquaglyceroporin from Plasmodium falciparum (see paper)
    35% identity, 90% coverage of query (116 bits)

3c02A / Q8WPZ6 X-ray structure of the aquaglyceroporin from plasmodium falciparum (see paper)
    35% identity, 89% coverage of query (115 bits)

Build an alignment

Build an alignment for Pf6N2E2_5575 and 44 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

FPS1 / P23900 FPS1p monomer from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 65 papers)
FPS1_YEAST / P23900 Glycerol uptake/efflux facilitator protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 1.A.8.5.1 / P23900 FPS1 glycerol efflux facilitator (important for maintaining osmotic balance during mating-induced yeast cell fusion and for tolerating hypoosmotic shock; also transports arsenite and antimonite). FPS1 is a homotetramer from Saccharomyces cerevisiae (Baker's yeast) (see 8 papers)
FPS1 / RF|NP_013057.1 glycerol uptake/efflux facilitator protein from Saccharomyces cerevisiae
    29% identity, 86% coverage of query (114 bits)

AQP2 / GI|46518241 aquaglyceroporin 2 from Trypanosoma brucei brucei (see paper)
    34% identity, 85% coverage of query (110 bits)

TC 1.A.8.2.1 / P18156 Glycerol facilitator from Bacillus subtilis (see 4 papers)
    37% identity, 88% coverage of query (110 bits)

GLPF2_LACPL / F9USY3 Glycerol uptake facilitator protein 2 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
TC 1.A.8.2.5 / D7V7W8 GlpF2 from Lactobacillus plantarum subsp. plantarum ATCC 14917
    35% identity, 84% coverage of query (108 bits)

AQP3_MILTA / G5CTG0 Aquaporin-3; AQP-3 from Milnesium tardigradum (Water bear) (Tardigrade) (see 2 papers)
    32% identity, 88% coverage of query (108 bits)

GLPF3_LACPL / F9UTW9 Glycerol uptake facilitator protein 3 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
TC 1.A.8.2.6 / D7V8E7 GlpF3 from Lactobacillus plantarum subsp. plantarum ATCC 14917
    34% identity, 87% coverage of query (108 bits)

AQP4_MILTA / G5CTG1 Aquaporin-4; AQP-4 from Milnesium tardigradum (Water bear) (Tardigrade) (see 2 papers)
    30% identity, 89% coverage of query (105 bits)

TC 1.A.8.13.2 / Q9C4Z5 Hg2+-inhibitable aquaporin, AqpM (transports both water and glycerol as well as CO2) (Kozono et al., 2003; Araya-Secchi et al., 2011). Its 3-d structure has been determined to 1.7 Å. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies from Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133) (see 2 papers)
    33% identity, 89% coverage of query (104 bits)

2evuA / Q9C4Z5 Crystal structure of aquaporin aqpm at 2.3a resolution (see paper)
    34% identity, 88% coverage of query (104 bits)

TC 1.A.8.5.2 / Q75CI7 Fps1 hyperactive orthologue of the S. cerevisiae from Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (see paper)
    30% identity, 87% coverage of query (101 bits)

AQP1_MILTA / G5CTF8 Aquaporin-1; AQP-1 from Milnesium tardigradum (Water bear) (Tardigrade) (see paper)
    28% identity, 92% coverage of query (100 bits)

AQP9_MILTA / G5CTG6 Aquaporin-9; AQP-9 from Milnesium tardigradum (Water bear) (Tardigrade) (see 2 papers)
    29% identity, 79% coverage of query (95.9 bits)

NIP71_ARATH / Q8LAI1 Probable aquaporin NIP7-1; NOD26-like intrinsic protein 7-1; AtNIP7;1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 1.A.8.12.6 / Q8LAI1 Nip7;1 arsenite and borate channel from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    29% identity, 88% coverage of query (94.4 bits)

NIP12_ORYSJ / Q0JPT5 Aquaporin NIP1-2; NOD26-like intrinsic protein 1-2; OsNIP1;2 from Oryza sativa subsp. japonica (Rice) (see paper)
    32% identity, 85% coverage of query (93.2 bits)

NIP12_ARATH / Q8LFP7 Aquaporin NIP1-2; NOD26-like intrinsic protein 1-2; AtNIP1;2; Nodulin-26-like major intrinsic protein 2; NodLikeMip2; Protein NLM2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.12.7 / Q8LFP7 Aquaporin NIP1-2 (NOD26-like intrinsic protein 1-2) (AtNIP1;2) (Nodulin-26-like major intrinsic protein 2) (NodLikeMip2) (Protein NLM2) from Arabidopsis thaliana (see 5 papers)
nlm2 / CAC14597.1 aquaglyceroporin from Arabidopsis thaliana (see paper)
    32% identity, 86% coverage of query (92.8 bits)

GLPF5_LACPL / F9UUB3 Glycerol uptake facilitator protein-like 5 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
TC 1.A.8.2.7 / D7VEY8 GlpF4.  Transports water, dihydroxyacetone and glycerol as well as D,L-lactic acid from Lactobacillus plantarum subsp. plantarum ATCC 14917
    32% identity, 87% coverage of query (90.1 bits)

GLPF4_LACPL / F9UMX3 Glycerol uptake facilitator protein 4; D/L-lactic acid transporter; Lactic acid channel from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
    31% identity, 87% coverage of query (89.0 bits)

LARD_LACPL / F9UST3 D/L-lactic acid transporter; Lactate racemization operon protein LarD; Lactic acid channel from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see 3 papers)
TC 1.A.8.2.4 / C6VJ63 GlpF1; transports water, dihydroxyacetone and glycerol as well as D,L-lactic acid from Lactobacillus plantarum (strain JDM1)
    30% identity, 87% coverage of query (88.2 bits)

TC 1.A.8.13.1 / O28846 MIP family homologue from Archaeoglobus fulgidus (see paper)
    32% identity, 87% coverage of query (87.4 bits)

GLPF6_LACPL / F9UUD2 Glycerol uptake facilitator protein-like 6 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
    31% identity, 86% coverage of query (85.9 bits)

AQP2_RAT / P34080 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Rattus norvegicus (Rat) (see 3 papers)
    30% identity, 98% coverage of query (85.9 bits)

NIP11_ORYSJ / Q40746 Aquaporin NIP1-1; NOD26-like intrinsic protein 1-1; OsNIP1;1 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
YK347 / BAA04257.1 major intrinsic protein from Oryza sativa (see paper)
    31% identity, 72% coverage of query (84.7 bits)

AQP2_HUMAN / P41181 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Homo sapiens (Human) (see 23 papers)
TC 1.A.8.8.8 / P41181 Vasopressin-sensitive aquaporin-2 (Aqp2) in the apical membrane of the renal collecting duct from Homo sapiens (Human) (see 22 papers)
    31% identity, 94% coverage of query (84.3 bits)

NIP22_ORYSJ / Q67WJ8 Aquaporin NIP2-2; Low silicon protein 6; NOD26-like intrinsic protein 2-2; OsNIP2;2 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
TC 1.A.8.12.5 / Q67WJ8 The silicon (silicic acid) transporter, Nip2-2 (Nip2;2) (Mitani et al., 2008). Also transports arsenite from Oryza sativa subsp. japonica (Rice) (see 5 papers)
    28% identity, 87% coverage of query (84.0 bits)

NIP31_ORYSJ / Q0IWF3 Aquaporin NIP3-1; NOD26-like intrinsic protein 3-1; OsNIP3;1 from Oryza sativa subsp. japonica (Rice) (see paper)
    29% identity, 89% coverage of query (83.6 bits)

AQP2_MOUSE / P56402 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Mus musculus (Mouse) (see 5 papers)
    30% identity, 98% coverage of query (82.0 bits)

P08995 Nodulin-26; N-26 from Glycine max (Soybean) (Glycine hispida)
    30% identity, 95% coverage of query (80.5 bits)

AQP8_HUMAN / O94778 Aquaporin-8; AQP-8 from Homo sapiens (Human) (see 10 papers)
TC 1.A.8.10.15 / O94778 The Aquaporin-8 (Aqp8) transporter is permeable to water, NH3, formamide and H2O2, and it is present in the inner membrane of mitochondria and the plasma membrane (Bienert et al., 2007; Saparov et al., 2007; Soria et al., 2010). Cholesterol, via sterol regulatory element-binding protein (SREBP) transcription factors, activates or represses genes involved in its hepatic biosynthetic pathway, and also modulates the expression of hepatocyte mitochondrial aquaporin-8 (mtAQP8), a channel that can function as peroxiporin by facilitating the transmembrane diffusion of H2O2. The peroxiporin, mtAQP8, plays a role in the SREBP-controlled hepatocyte cholesterogenesis from Homo sapiens (Human) (see 3 papers)
    33% identity, 72% coverage of query (79.3 bits)

NIP2-1 / Q6Z2T3 aquaporin NIP2-1 from Oryza sativa subsp. japonica (see 7 papers)
NIP21_ORYSJ / Q6Z2T3 Aquaporin NIP2-1; Low silicon protein 1; NOD26-like intrinsic protein 2-1; OsNIP2;1; Silicon influx transporter LSI1 from Oryza sativa subsp. japonica (Rice) (see 6 papers)
TC 1.A.8.12.2 / Q6Z2T3 The silicon (silicic acid) (undissociated form) transporter, Lsi1 (Ma et al., 2007a, b; Mitani et al., 2008). The barley orthologue Lsi1 (also called NIP2-1) is also a silicon (silicic acid) uptake channel (Chiba et al., 2009). Rice Lsi1 also transports arsenite and pentavalent mono and dimethyl arsenite (Li et al., 2009). In addition to silicon (Si), selenite (Se) uptake is mediated by Lsi1, also called NIP2;1 from Oryza sativa (Rice) (see 6 papers)
NIP2-1 / GI|90855460 aquaporin NIP2-1 from Oryza sativa (japonica cultivar-group) (see paper)
    29% identity, 85% coverage of query (78.6 bits)

4nefA / P41181 X-ray structure of human aquaporin 2 (see paper)
    31% identity, 89% coverage of query (77.8 bits)

NIP61_ARATH / Q9SAI4 Aquaporin NIP6-1; NOD26-like intrinsic protein 6-1; AtNIP6;1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.12.9 / Q9SAI4 Aquaporin NIP6-1 (NOD26-like intrinsic protein 6-1) (AtNIP6;1) from Arabidopsis thaliana (see 3 papers)
    32% identity, 90% coverage of query (77.4 bits)

MIP_HUMAN / P30301 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Homo sapiens (Human) (see 14 papers)
    28% identity, 99% coverage of query (77.4 bits)

MIP_BOVIN / P06624 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Bos taurus (Bovine) (see 5 papers)
TC 1.A.8.8.2 / P06624 The lens fiber MIP aquaporin (Aqp0) of B. taurus (forms membrane junctions in vivo and double layered crystals in vitro that resemble the in vivo junctions). The water pore is closed in the in vitro structure (Gonen et al., 2004b). It interacts directly with the intracellular loop of connexin 45.6 via its C-terminal extension (Yu et al., 2005). Forms human cataract lens membranes from Bos taurus (Bovine) (see 4 papers)
    26% identity, 98% coverage of query (77.0 bits)

P09011 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Rattus norvegicus (Rat)
    28% identity, 98% coverage of query (76.3 bits)

AQP5_HUMAN / P55064 Aquaporin-5; AQP-5 from Homo sapiens (Human) (see 6 papers)
TC 1.A.8.8.9 / P55064 Aquaporin 5 (x-ray structure at 2.0 Å resolution (PDB# 3D9S) is available) (Horsefield et al., 2008). Aqp5 is a marker for proliferation and migration of human breast cancer cells (Jung et al., 2011). Plays a role in chronic obstructive pulmonary diseases (COPD) from Homo sapiens (see 2 papers)
    32% identity, 84% coverage of query (72.0 bits)

8sjxA / Q6J8I9 Structure of lens aquaporin-0 array in sphingomyelin/cholesterol bilayer (2sm:1chol)
    28% identity, 86% coverage of query (72.0 bits)

5dyeD / P55064 Crystal structure of the full length s156e mutant of human aquaporin 5 (see paper)
    32% identity, 84% coverage of query (71.6 bits)

PIP23_ARATH / P30302 Aquaporin PIP2-3; Plasma membrane intrinsic protein 2-3; AtPIP2;3; Plasma membrane intrinsic protein 2c; PIP2c; RD28-PIP; TMP2C; Water stress-induced tonoplast intrinsic protein; WSI-TIP from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    28% identity, 75% coverage of query (71.2 bits)

PIP14_ARATH / Q39196 Probable aquaporin PIP1-4; Plasma membrane intrinsic protein 1-4; AtPIP1;4; Transmembrane protein C; TMP-C from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    28% identity, 88% coverage of query (71.2 bits)

PIP22_ARATH / P43287 Aquaporin PIP2-2; Plasma membrane intrinsic protein 2-2; AtPIP2;2; Plasma membrane intrinsic protein 2b; PIP2b; TMP2b from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    28% identity, 75% coverage of query (70.5 bits)

PIP13_ARATH / Q08733 Aquaporin PIP1-3; AtPIP1;3; Plasma membrane intrinsic protein 1c; PIP1c; Transmembrane protein B; TMP-B from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    28% identity, 88% coverage of query (70.1 bits)

PIP21_ARATH / P43286 Aquaporin PIP2-1; Plasma membrane intrinsic protein 2-1; AtPIP2;1; Plasma membrane intrinsic protein 2a; PIP2a from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 1.A.8.11.4 / P43286 Plasma membrane intrinsic protein 2a (forms active heterotetramers with PIP1;1 (TC# 1.A.8.11.3); down regulated under drought stress (Najafabadi et al., 2008). Transports H2O2 (Dynowski et al., 2008). The Mesembryanthemum crystallinum PIP2;1 orthologue is an aquaporin impermeable to urea and glycerol. It is positively regulated by PKA- and PKC- mediated phosphorylation (Amezcua-Romero et al., 2010). PIP1;1 and PIP2;2 (Q9ATM8) co-expression modulates the membrane water permeability in the halophyte Beta vulgaris storage root through a pH regulatory response, enhancing membrane versatility to adjust its water transfer capacity from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
    27% identity, 75% coverage of query (70.1 bits)

TIP21_ARATH / Q41951 Aquaporin TIP2-1; Delta-tonoplast intrinsic protein; Delta-TIP; Tonoplast intrinsic protein 2-1; AtTIP2;1 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
TC 1.A.8.10.10 / Q41951 Aquaporin TIP2-1 (Delta-tonoplast intrinsic protein) (Delta-TIP) (Tonoplast intrinsic protein 2-1) (AtTIP2;1) (Daniels et al. 1996). Transports water and ammonia, and can be activated by mercury (Kirscht et al. 2016). The 3-d structure is known to 1.2Å resolution (Kirscht et al. 2016). It may participate in vacuolar compartmentation and detoxification of ammonium from Arabidopsis thaliana (see 10 papers)
AAC49281.1 delta tonoplast integral protein from Arabidopsis thaliana (see paper)
    29% identity, 71% coverage of query (69.3 bits)

AQP4_MOUSE / P55088 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Mus musculus (Mouse) (see 11 papers)
    29% identity, 85% coverage of query (67.8 bits)

PIP11_ARATH / P61837 Aquaporin PIP1-1; AtPIP1;1; Plasma membrane aquaporin-1; Plasma membrane intrinsic protein 1a; PIP1a from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.11.3 / P61837 Plasma membrane aquaporin 1, PIP1, of 286 aas and 6 TMSs from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
PIP1-1 / RF|NP_191702.1 aquaporin PIP1-1 from Arabidopsis thaliana (see paper)
    28% identity, 88% coverage of query (67.8 bits)

PIP12_ARATH / Q06611 Aquaporin PIP1-2; AtPIP1;2; Plasma membrane intrinsic protein 1b; PIP1b; Transmembrane protein A; AthH2; TMP-A from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    28% identity, 88% coverage of query (67.4 bits)

PIP25_MAIZE / Q9XF58 Aquaporin PIP2-5; Plasma membrane intrinsic protein 2-5; ZmPIP2-5; ZmPIP2;5; ZmPIP2a from Zea mays (Maize) (see 4 papers)
TC 1.A.8.11.7 / Q9XF58 Aquaporin PIP2;5 (PIP2-5) of 285 aas from Zea mays
    27% identity, 75% coverage of query (67.4 bits)

MIP_CAVPO / Q6RZ07 Lens fiber major intrinsic protein; Aquaporin-0 from Cavia porcellus (Guinea pig) (see paper)
    27% identity, 98% coverage of query (65.5 bits)

3nkaA Crystal structure of aqpz h174g,t183f
    31% identity, 73% coverage of query (63.5 bits)

AQP4_RAT / P47863 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Rattus norvegicus (Rat) (see 7 papers)
    30% identity, 74% coverage of query (63.5 bits)

PIP11_MAIZE / Q41870 Aquaporin PIP1-1; Plasma membrane intrinsic protein 1-1; ZmPIP1-1; ZmPIP1;1; ZmPIP1a from Zea mays (Maize) (see 3 papers)
    28% identity, 92% coverage of query (58.5 bits)

8ct2D / P29972 Local refinement of aqp1 tetramer (c1; refinement mask included d1 of protein 4.2 and ankyrin-1 ar1-5) in class 2 of erythrocyte ankyrin-1 complex (see paper)
    27% identity, 73% coverage of query (57.8 bits)

BniP / b0875 water channel AqpZ from Escherichia coli K-12 substr. MG1655 (see 28 papers)
aqpZ / P60844 water channel AqpZ from Escherichia coli (strain K12) (see 40 papers)
AQPZ_ECOLI / P60844 Aquaporin Z; Bacterial nodulin-like intrinsic protein; Water channel AqpZ from Escherichia coli (strain K12) (see 5 papers)
TC 1.A.8.3.1 / P60844 Aquaporin Z water channel (aqpZ gene expression is under sigma S control; induced at the onset of stationary phase) from Escherichia coli (see 13 papers)
    30% identity, 73% coverage of query (57.8 bits)

2o9eA / P60844 Crystal structure of aqpz mutant t183c complexed with mercury (see paper)
    30% identity, 74% coverage of query (57.0 bits)

TIP11_ARATH / P25818 Aquaporin TIP1-1; Aquaporin TIP; Gamma-tonoplast intrinsic protein; Gamma-TIP; Tonoplast intrinsic protein 1-1; AtTIP1;1; Tonoplast intrinsic protein, root-specific RB7 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 1.A.8.10.3 / P25818 Tonoplast intrinsic protein 1.1 (permeable to water and H2O2) from Arabidopsis thaliana (Mouse-ear cress) (see 14 papers)
TIP1-1 / RF|NP_181221.1 aquaporin TIP1-1 from Arabidopsis thaliana
    26% identity, 75% coverage of query (51.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory