Searching for up to 100 curated homologs for Pf6N2E2_665 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_665 (325 a.a.)
Found high-coverage hits (≥70%) to 63 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q52014 acetoin dehydrogenase system (EC 2.3.1.190) from Pseudomonas putida (see paper)
85% identity, 100% coverage of query (585 bits)
Q9HWN1 acetoin dehydrogenase system (subunit 2/2) (EC 2.3.1.190) from Pseudomonas aeruginosa (see paper)
87% identity, 100% coverage of query (550 bits)
P27745 acetoin dehydrogenase system (EC 2.3.1.190) from Alcaligenes eutrophus H16 (see paper)
GI|141894 acetoin:2,6-dichlorophenolindophenol oxidoreductase, alpha subunit; EC 1.1.1.- from Ralstonia eutropha H16 (see 2 papers)
acoA / AAA21948.1 acetoin:DCPIP oxidoreductase-alpha from Cupriavidus necator (see paper)
64% identity, 99% coverage of query (432 bits)
acoA / Q3A7P1 acetoin:DCPIP oxidoreductase α subunit from Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) (see paper)
acoA / AAA18915.1 acetoin:DCPIP oxidoreductase alpha subunit from Pelobacter carbinolicus (see paper)
62% identity, 100% coverage of query (381 bits)
ACOA_BACSU / O31404 Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 3 papers)
58% identity, 98% coverage of query (368 bits)
Q46142 acetoin dehydrogenase system (EC 2.3.1.190) from Clostridium magnum (see paper)
acoA TPP-dependent acetoin dehydrogenase complex, E1 component, alpha subunit; EC 1.1.1.- from Clostridium magnum (see paper)
AAA21744.1 TPP-dependent acetoin dehydrogenase alpha-subunit from Clostridium magnum (see paper)
49% identity, 98% coverage of query (312 bits)
A2XPT6 pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Oryza sativa Indica Group (see paper)
38% identity, 98% coverage of query (236 bits)
ODPA_MOUSE / P35486 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Mus musculus (Mouse) (see 6 papers)
P35486 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Mus musculus (see 2 papers)
38% identity, 100% coverage of query (234 bits)
G3H5K6 pyruvate dehydrogenase system (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Cricetulus griseus (see paper)
38% identity, 100% coverage of query (234 bits)
ODPA_RAT / P26284 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Rattus norvegicus (Rat) (see 2 papers)
38% identity, 100% coverage of query (230 bits)
ODPAT_HUMAN / P29803 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; PDHE1-A type II; EC 1.2.4.1 from Homo sapiens (Human) (see 5 papers)
38% identity, 99% coverage of query (229 bits)
PDHA1 / P26267 pyruvate dehydrogenase α1 subunit from Ascaris suum (see paper)
39% identity, 99% coverage of query (225 bits)
P26267 Pyruvate dehydrogenase E1 component subunit alpha type I, mitochondrial; PDHA1; PDHE1-A; EC 1.2.4.1 from Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
39% identity, 99% coverage of query (225 bits)
P74490 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Synechocystis sp. PCC 6803 (see 2 papers)
38% identity, 98% coverage of query (224 bits)
ODPAT_RAT / Q06437 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; PDHE1-A type II; EC 1.2.4.1 from Rattus norvegicus (Rat) (see paper)
39% identity, 100% coverage of query (218 bits)
PDHA1 / P08559 pyruvate dehydrogenase E1 component α subunit (somatic) from Homo sapiens (see 6 papers)
ODPA_HUMAN / P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Homo sapiens (Human) (see 24 papers)
P08559 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Homo sapiens (see 2 papers)
39% identity, 100% coverage of query (215 bits)
Q97YF6 acetoin dehydrogenase system (EC 2.3.1.190) from Saccharolobus solfataricus (see paper)
38% identity, 98% coverage of query (215 bits)
3exeA / P08559 Crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex (see paper)
39% identity, 100% coverage of query (214 bits)
6cfoA Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate
39% identity, 100% coverage of query (214 bits)
1ni4A Human pyruvate dehydrogenase
39% identity, 100% coverage of query (214 bits)
ODPA_PIG / P29804 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; EC 1.2.4.1 from Sus scrofa (Pig) (see paper)
38% identity, 100% coverage of query (213 bits)
ODPA_YEAST / P16387 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; Pyruvate dehydrogenase complex component E1 alpha; PDHE1-A; EC 1.2.4.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P16387 pyruvate dehydrogenase system (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (EC 1.2.4.1) from Saccharomyces cerevisiae (see 2 papers)
37% identity, 99% coverage of query (205 bits)
P52903 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104) from Solanum tuberosum (see paper)
CAA81558.1 E1 alpha subunit of pyruvate dehydrogenase precursor from Solanum tuberosum (see paper)
37% identity, 99% coverage of query (204 bits)
P52902 pyruvate dehydrogenase system (subunit 2/3) (EC 1.2.1.104) from Pisum sativum (see paper)
35% identity, 99% coverage of query (197 bits)
6cerE Human pyruvate dehydrogenase complex e1 component v138m mutation
37% identity, 100% coverage of query (197 bits)
ODPA1_ARATH / P52901 Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial; PDHE1-A; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
34% identity, 98% coverage of query (195 bits)
6cerA / P08559 Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
37% identity, 100% coverage of query (193 bits)
ODPA2_ARATH / Q8H1Y0 Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial; PDHE1-A; Protein IAA-CONJUGATE-RESISTANT 4; EC 1.2.4.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8H1Y0 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Arabidopsis thaliana (see paper)
34% identity, 99% coverage of query (193 bits)
Q10489 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; PDHE1-A; EC 1.2.4.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
35% identity, 98% coverage of query (192 bits)
pdhB pyruvate dehydrogenase (lipoamide) from Emericella nidulans (see 2 papers)
36% identity, 98% coverage of query (190 bits)
ODPA_CHATD / G0SHF3 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; Pyruvate dehydrogenase complex component E1 alpha; PDHE1-A; EC 1.2.4.1 from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila) (see 2 papers)
G0SHF3 pyruvate dehydrogenase system (subunit 2/2) (EC 1.2.1.104); pyruvate dehydrogenase (acetyl-transferring) (subunit 2/2) (EC 1.2.4.1) from Chaetomium thermophilum (see paper)
38% identity, 89% coverage of query (187 bits)
3exhE Crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex
36% identity, 100% coverage of query (185 bits)
bfmBAA / P37940 2-keto-isovalerate dehydrogenase component α subunit (EC 1.2.4.4) from Bacillus subtilis (strain 168) (see 2 papers)
34% identity, 98% coverage of query (152 bits)
1umbA / Q5SLR4 Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
30% identity, 99% coverage of query (140 bits)
1umdA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate
30% identity, 99% coverage of query (140 bits)
1umcA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate
30% identity, 99% coverage of query (140 bits)
ODBA_THET8 / Q5SLR4 2-oxoisovalerate dehydrogenase subunit alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
30% identity, 99% coverage of query (139 bits)
3dufA / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
30% identity, 99% coverage of query (137 bits)
Build an alignment for Pf6N2E2_665 and 38 homologs with ≥ 30% identity
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Q72GU1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) from Thermus thermophilus (see paper)
29% identity, 99% coverage of query (137 bits)
1w85A The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2
29% identity, 99% coverage of query (133 bits)
ODPA_BACCE / Q4MTG0 Pyruvate dehydrogenase E1 component subunit alpha; EC 1.2.4.1 from Bacillus cereus (see paper)
30% identity, 99% coverage of query (130 bits)
BCKDHA / P12694 branched-chain α-keto acid dehydrogenase E1 component α subunit (EC 1.2.4.4) from Homo sapiens (see 15 papers)
ODBA_HUMAN / P12694 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Homo sapiens (Human) (see 13 papers)
P12694 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Homo sapiens (see 5 papers)
29% identity, 99% coverage of query (130 bits)
pdhA / AAC24932.1 pyruvate decarboxylase E-1 alpha subunit from Bacillus subtilis (see 3 papers)
31% identity, 99% coverage of query (130 bits)
3dv0A Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex
29% identity, 99% coverage of query (128 bits)
ODBA_BOVIN / P11178 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Bos taurus (Bovine) (see paper)
28% identity, 99% coverage of query (127 bits)
ODBA_CAEEL / O45924 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; EC 1.2.4.4 from Caenorhabditis elegans (see paper)
29% identity, 97% coverage of query (127 bits)
ODBA_RAT / P11960 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Rattus norvegicus (Rat) (see paper)
28% identity, 99% coverage of query (125 bits)
3dv0E / P21873 Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
28% identity, 99% coverage of query (125 bits)
1w88A The crystal structure of pyruvate dehydrogenase e1(d180n,e183q) bound to the peripheral subunit binding domain of e2
28% identity, 99% coverage of query (125 bits)
P50136 branched-chain alpha-keto acid dehydrogenase system (subunit 2/2) (EC 1.2.1.25) from Mus musculus (see paper)
28% identity, 99% coverage of query (124 bits)
2bffA / P12694 Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch (see paper)
28% identity, 99% coverage of query (122 bits)
Q9HIA3 branched-chain-2-oxoacid decarboxylase (subunit 1/2) (EC 4.1.1.72) from Thermoplasma acidophilum (see paper)
27% identity, 99% coverage of query (121 bits)
ODBA2_ARATH / Q84JL2 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
27% identity, 90% coverage of query (121 bits)
ODBA1_ARATH / Q9LPL5 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 99% coverage of query (119 bits)
1dtwA Human branched-chain alpha-keto acid dehydrogenase
28% identity, 99% coverage of query (119 bits)
2bewA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
28% identity, 99% coverage of query (119 bits)
2bevA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
28% identity, 99% coverage of query (119 bits)
2beuA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
28% identity, 99% coverage of query (119 bits)
1wciA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
28% identity, 99% coverage of query (118 bits)
1v1mA / P12694 Crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine (see paper)
28% identity, 99% coverage of query (114 bits)
1oluA Roles of his291-alpha and his146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase
27% identity, 99% coverage of query (113 bits)
2bfcA Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
28% identity, 99% coverage of query (112 bits)
1qs0A / P09060 Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
27% identity, 97% coverage of query (100 bits)
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