Searching for up to 100 curated homologs for PfGW456L13_2186 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2186 (345 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
wbjB / Q9KID0 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Pseudomonas aeruginosa (see 2 papers)
85% identity, 98% coverage of query (607 bits)
V5RBP5 UDP-glucose 4-epimerase (EC 5.1.3.2) from Acinetobacter baumannii (see paper)
82% identity, 99% coverage of query (592 bits)
4j2oC / P37362 Crystal structure of NADP-bound wbjb from a. Baumannii community strain d1279779 (see paper)
79% identity, 97% coverage of query (542 bits)
wbvB / Q8L348 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Vibrio cholerae O37 (see 3 papers)
73% identity, 99% coverage of query (522 bits)
3w1vA / A0A0H3JPH0 Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with inihibitor (see paper)
68% identity, 96% coverage of query (474 bits)
4g5hA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with by-product
68% identity, 96% coverage of query (474 bits)
A0A0H3JPH0 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Staphylococcus aureus (see paper)
68% identity, 95% coverage of query (473 bits)
CAPD_RICPR / Q9ZDJ5 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Rickettsia prowazekii (strain Madrid E) (see paper)
62% identity, 95% coverage of query (443 bits)
3vvcA Crystal structure of capsular polysaccharide synthesizing enzyme cape , k126e, in apo form
64% identity, 96% coverage of query (437 bits)
3vvbA / A0A0H3JPH0 Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in apo form (see paper)
57% identity, 95% coverage of query (357 bits)
BC_3750 / Q81A42 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.135) from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see 5 papers)
Q81A42 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Bacillus cereus (see 2 papers)
45% identity, 81% coverage of query (243 bits)
pseB / O25511 UDP-N-acetylglucosamine 4,6-dehydratase subunit (EC 4.2.1.115) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 4 papers)
PSEB_HELPY / O25511 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see 3 papers)
41% identity, 93% coverage of query (240 bits)
2gn4A / O25511 Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADPH and udp-glcnac (see paper)
41% identity, 93% coverage of query (240 bits)
2gn8A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp
41% identity, 93% coverage of query (240 bits)
2gnaA Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-gal
41% identity, 93% coverage of query (240 bits)
2gn9A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glc
41% identity, 93% coverage of query (240 bits)
2gn6A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glcnac
41% identity, 93% coverage of query (240 bits)
Q6VYQ6 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Helicobacter pylori (see paper)
40% identity, 93% coverage of query (239 bits)
Q6VYQ5 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Helicobacter pylori (see paper)
40% identity, 93% coverage of query (238 bits)
PSEB_CAMJJ / Q5QKR8 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) (see 2 papers)
38% identity, 92% coverage of query (216 bits)
PSEB_CAMJE / Q0P8W4 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
37% identity, 94% coverage of query (214 bits)
6bwcC X-ray structure of pen from bacillus thuringiensis (see paper)
35% identity, 94% coverage of query (213 bits)
G5CSR9 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Megavirus chiliensis (see paper)
35% identity, 82% coverage of query (181 bits)
4tqgA / G5CSR9 Crystal structure of megavirus udp-glcnac 4,6-dehydratase, 5-epimerase mg534 (see paper)
34% identity, 81% coverage of query (164 bits)
RfbU / CAA69127.1 mannosyl-transferase from Vibrio cholerae (see paper)
31% identity, 94% coverage of query (152 bits)
5bjuA / O86159 X-ray structure of the pglf dehydratase from campylobacter jejuni in complex with udp and NAD(h) (see paper)
36% identity, 78% coverage of query (151 bits)
cpsE polysaccharide capsule synthesis protein CpsE from Streptococcus iniae (see paper)
36% identity, 77% coverage of query (151 bits)
wbiI / GI|3135688 putative epimerase/dehydratase WbiI from Burkholderia pseudomallei (see paper)
35% identity, 76% coverage of query (150 bits)
pglF / Q0P9D4 UDP-N-acetylglucosamine C-6 dehydratase (EC 4.2.1.135) from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 3 papers)
PGLF_CAMJE / Q0P9D4 UDP-N-acetyl-alpha-D-glucosamine C6 dehydratase; UDP-GlcNAc C6 dehydratase; Protein glycosylation pathway protein F; UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining); EC 4.2.1.135 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
36% identity, 78% coverage of query (150 bits)
P72145 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115) from Pseudomonas aeruginosa (see paper)
33% identity, 75% coverage of query (149 bits)
wbpM / Q9KIC5 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Pseudomonas aeruginosa (see 6 papers)
33% identity, 75% coverage of query (148 bits)
EPSC_BACSU / P71052 Probable polysaccharide biosynthesis protein EpsC from Bacillus subtilis (strain 168) (see paper)
35% identity, 76% coverage of query (147 bits)
5bjvA X-ray structure of the pglf udp-n-acetylglucosamine 4,6-dehydratase from campylobacterjejuni, d396n/k397a variant in complex with udp-n- acrtylglucosamine
36% identity, 78% coverage of query (147 bits)
wbgZ / Q9F736 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Shigella sonnei (see paper)
34% identity, 77% coverage of query (146 bits)
wbkD / Q2YMM0 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135) from Brucella abortus (strain 2308) (see 2 papers)
31% identity, 80% coverage of query (138 bits)
Build an alignment for PfGW456L13_2186 and 35 homologs with ≥ 30% identity
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N0A414 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
26% identity, 72% coverage of query (62.8 bits)
1r66A / Q9ZGH3 Crystal structure of desiv (dtdp-glucose 4,6-dehydratase) from streptomyces venezuelae with NAD and tyd bound (see paper)
27% identity, 74% coverage of query (62.8 bits)
1r6dA Crystal structure of desiv double mutant (dtdp-glucose 4,6- dehydratase) from streptomyces venezuelae with NAD and dau bound
27% identity, 74% coverage of query (60.8 bits)
Q5D9E1 UDP-glucose 4-epimerase (EC 5.1.3.2) from Schistosoma japonicum (see paper)
26% identity, 76% coverage of query (60.1 bits)
GALE_LACHE / Q7WTB1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
26% identity, 76% coverage of query (58.2 bits)
N0A8N8 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
24% identity, 71% coverage of query (57.4 bits)
Q9SN95 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
25% identity, 77% coverage of query (55.8 bits)
N0A422 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
25% identity, 71% coverage of query (55.1 bits)
RHM1 / Q9SYM5 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM1 (EC 4.2.1.76) from Arabidopsis thaliana (see 3 papers)
RHM1_ARATH / Q9SYM5 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; Protein REPRESSOR OF LRX1 1; Rhamnose biosynthetic enzyme 1; AtRHM1; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
24% identity, 73% coverage of query (51.6 bits)
6k0iA Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp-glc
24% identity, 77% coverage of query (51.2 bits)
6k0hA Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp-glcnac
24% identity, 77% coverage of query (51.2 bits)
6k0gA / E8MF10 Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp (see paper)
24% identity, 77% coverage of query (51.2 bits)
3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
25% identity, 72% coverage of query (50.1 bits)
6dntA / D3E402 Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
23% identity, 73% coverage of query (48.5 bits)
2hunA / O58151 Crystal structure of hypothetical protein ph0414 from pyrococcus horikoshii ot3
22% identity, 74% coverage of query (46.6 bits)
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Lawrence Berkeley National Laboratory