Searching for up to 100 curated homologs for PfGW456L13_2506 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2506 (344 a.a.)
Found high-coverage hits (≥70%) to 65 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
P51017 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see paper)
nahM / AAA89107.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
86% identity, 99% coverage of query (605 bits)
nahM / BAE92172.1 4-hydroxy-2-oxovalerate aldolase NahM from Pseudomonas putida (see 2 papers)
86% identity, 99% coverage of query (604 bits)
tesG / Q83VZ3 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Comamonas testosteroni (see 2 papers)
77% identity, 99% coverage of query (527 bits)
HOA4_PARXL / P51015 4-hydroxy-2-oxovalerate aldolase 4; HOA 4; 4-hydroxy-2-keto-pentanoic acid aldolase 4; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase 4; EC 4.1.3.39; EC 4.1.3.43 from Paraburkholderia xenovorans (strain LB400) (see 3 papers)
P51015 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39); 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Paraburkholderia xenovorans LB400 (see 2 papers)
bphI / GB|ABE37049.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Burkholderia xenovorans LB400 (see paper)
74% identity, 100% coverage of query (520 bits)
bphI / CAA54036.1 4-hydroxy-2-oxovalerate aldolase from Paraburkholderia xenovorans LB400 (see paper)
74% identity, 100% coverage of query (519 bits)
HOA_PSESP / Q9KWS0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (see paper)
53% identity, 99% coverage of query (382 bits)
cmtG / Q51983 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
cmtG / AAB62295.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see 3 papers)
53% identity, 96% coverage of query (369 bits)
carE / BAC41556.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas resinovorans (see 9 papers)
55% identity, 98% coverage of query (368 bits)
MhpE / b0352 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
mhpE / P51020 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli (strain K12) (see 3 papers)
HOA_ECOLI / P51020 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Escherichia coli (strain K12) (see 2 papers)
mhpE / GB|BAA13057.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Escherichia coli K12 (see 4 papers)
55% identity, 97% coverage of query (365 bits)
xylK / P51019 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see 5 papers)
55% identity, 97% coverage of query (363 bits)
hsaF / Q0S815 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Rhodococcus jostii (strain RHA1) (see paper)
52% identity, 97% coverage of query (362 bits)
dmpG / P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (strain CF600) (see paper)
HOA_PSEUF / P51016 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (strain CF600) (see 3 papers)
P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (see paper)
dmpG / CAA43227.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas sp. CF600 (see paper)
54% identity, 96% coverage of query (354 bits)
todH / P51018 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
54% identity, 96% coverage of query (353 bits)
4jn6C / P9WMK5 Crystal structure of the aldolase-dehydrogenase complex from mycobacterium tuberculosis hrv37 (see paper)
51% identity, 96% coverage of query (353 bits)
1nvmA / P51016 Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate (see paper)
54% identity, 96% coverage of query (353 bits)
hsaF / P9WMK5 4-hydroxy-2-oxohexanoate aldolase monomer (EC 4.1.3.43) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HOA_MYCTU / P9WMK5 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.43; EC 4.1.3.39 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WMK5 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Mycobacterium tuberculosis (see paper)
51% identity, 96% coverage of query (353 bits)
todH / AAA61944.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
53% identity, 96% coverage of query (350 bits)
HOA_THET8 / Q53WI0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39; EC 4.1.3.43 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q53WI0 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Thermus thermophilus (see paper)
52% identity, 94% coverage of query (341 bits)
4lrsA / D1A3K8 Crystal and solution structures of the bifunctional enzyme (aldolase/aldehyde dehydrogenase) from thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and coa accommodation whithin the shared cofactor-binding site
48% identity, 97% coverage of query (327 bits)
HOA_STRTE / Q9X9Q0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Streptomyces tendae (see paper)
42% identity, 97% coverage of query (237 bits)
OAADC_MYCTU / O06334 Oxaloacetate decarboxylase; OAA decarboxylase; EC 4.1.1.112 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
30% identity, 89% coverage of query (154 bits)
Build an alignment for PfGW456L13_2506 and 21 homologs with ≥ 30% identity
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rhiG / D4HRI4 rhiG aldolase subunit from Bacillus subtilis subsp. spizizenii ATCC 6633 (see paper)
29% identity, 83% coverage of query (119 bits)
A0A0S6UXF5 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. DOA9 (see paper)
30% identity, 75% coverage of query (78.2 bits)
CA265_RS15855 2-isopropylmalate synthase (EC 2.3.3.13) from Pedobacter sp. GW460-11-11-14-LB5
25% identity, 83% coverage of query (77.8 bits)
LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
28% identity, 79% coverage of query (77.4 bits)
A0A1Y6KBA1 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. ORS 285 (see 2 papers)
31% identity, 70% coverage of query (76.3 bits)
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
27% identity, 79% coverage of query (73.2 bits)
B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
25% identity, 70% coverage of query (72.8 bits)
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
26% identity, 76% coverage of query (71.2 bits)
Echvi_3833 2-isopropylmalate synthase (EC 2.3.3.13) from Echinicola vietnamensis KMM 6221, DSM 17526
27% identity, 71% coverage of query (70.5 bits)
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
25% identity, 75% coverage of query (70.1 bits)
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
25% identity, 78% coverage of query (69.7 bits)
P58637 homocitrate synthase (EC 2.3.3.14) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
25% identity, 78% coverage of query (66.6 bits)
PYCB_METJA / Q58628 Pyruvate carboxylase subunit B; Pyruvic carboxylase B; EC 6.4.1.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
23% identity, 81% coverage of query (65.9 bits)
Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus (see 2 papers)
27% identity, 74% coverage of query (65.5 bits)
nifV / P05342 homocitrate synthase monomer (EC 2.3.3.14) from Azotobacter vinelandii (see paper)
NIFV_AZOVI / P05342 Homocitrate synthase; EC 2.3.3.14 from Azotobacter vinelandii (see paper)
26% identity, 74% coverage of query (65.5 bits)
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
26% identity, 80% coverage of query (65.5 bits)
A0A0G2T6D7 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum pennellii (see paper)
25% identity, 70% coverage of query (65.5 bits)
DVU1914 (R)-citramalate synthase (EC 2.3.3.21) from Desulfovibrio vulgaris Hildenborough JW710
25% identity, 70% coverage of query (64.7 bits)
K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
26% identity, 70% coverage of query (64.3 bits)
3rmjB / Q9JZG1 Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
26% identity, 79% coverage of query (63.5 bits)
6e1jA / C5J4P1 Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
26% identity, 74% coverage of query (62.8 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
25% identity, 78% coverage of query (61.6 bits)
CIMA_SULAC / Q4J6H1 (R)-citramalate synthase; Citramalate synthase; CMS; EC 2.3.3.21 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
24% identity, 72% coverage of query (61.2 bits)
frbC / Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (strain ATCC 31215) (see 2 papers)
FRBC_STRR3 / Q0ZQ46 2-phosphonomethylmalate synthase; EC 2.3.3.19 from Streptomyces rubellomurinus (strain ATCC 31215) (see paper)
Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (see paper)
25% identity, 74% coverage of query (60.8 bits)
LYS21 / Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSM_YEAST / Q12122 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Q12122 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see paper)
25% identity, 89% coverage of query (60.5 bits)
2nx9B / Q6A1F6 Crystal structure of the carboxyltransferase domain of the oxaloacetate decarboxylase na+ pump from vibrio cholerae (see paper)
24% identity, 75% coverage of query (60.1 bits)
HMGCL_BACSU / O34873 Hydroxymethylglutaryl-CoA lyase YngG; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Bacillus subtilis (strain 168) (see paper)
24% identity, 75% coverage of query (59.7 bits)
LYS20 / P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
HOSC_YEAST / P48570 Homocitrate synthase, cytosolic isozyme; HCS; EC 2.3.3.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P48570 homocitrate synthase (EC 2.3.3.14) from Saccharomyces cerevisiae (see 2 papers)
26% identity, 89% coverage of query (59.3 bits)
Q6A1F6 oxaloacetate decarboxylase (EC 4.1.1.112) from Vibrio cholerae (see paper)
TC 3.B.1.1.6 / Q6A1F6 Oxaloacetate decarboxylase, component of Na+-exporting oxaloacetate decarboxylase with three subunits, OadA (α), OadB (β) and OadG (γ) of 599 aas and 0 TMSs, 433 aas and 11 TMSs, and 90 aas and 1 TMS, respectively from Vibrio cholerae
24% identity, 75% coverage of query (58.5 bits)
K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
24% identity, 70% coverage of query (58.2 bits)
HMGCL_MOUSE / P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Mus musculus (Mouse) (see paper)
24% identity, 78% coverage of query (58.2 bits)
pycB / Q6M0D1 pyruvate carboxylase subunit B (EC 6.4.1.1) from Methanococcus maripaludis (strain S2 / LL) (see paper)
21% identity, 72% coverage of query (57.8 bits)
2OCL_HYDTT / D3DJ41 2-oxoglutarate carboxylase large subunit; 2-oxoglutarate carboxylase alpha subunit; EC 6.4.1.7 from Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) (see 2 papers)
22% identity, 84% coverage of query (57.4 bits)
1rqhA Propionibacterium shermanii transcarboxylase 5s subunit bound to pyruvic acid
22% identity, 75% coverage of query (53.9 bits)
1rr2A Propionibacterium shermanii transcarboxylase 5s subunit bound to 2- ketobutyric acid
22% identity, 75% coverage of query (53.9 bits)
1rqeA Propionibacterium shermanii transcarboxylase 5s subunit bound to oxaloacetate
22% identity, 75% coverage of query (53.9 bits)
1rqbA / Q70AC7 Propionibacterium shermanii transcarboxylase 5s subunit (see paper)
22% identity, 75% coverage of query (53.9 bits)
4ov9A / B0SN40 Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
21% identity, 76% coverage of query (53.5 bits)
4ov4A Isopropylmalate synthase binding with ketoisovalerate
21% identity, 76% coverage of query (53.5 bits)
MAM3 / Q9FN52 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see paper)
MAM3_ARATH / Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9FN52 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 4 papers)
22% identity, 74% coverage of query (53.5 bits)
PFREUD_18870 / Q70AC7 methylmalonyl-CoA carboxyltransferase 5S subunit (EC 2.1.3.1) from Propionibacterium freudenreichii subsp. shermanii (see 3 papers)
5S_PROFR / Q70AC7 Methylmalonyl-CoA carboxyltransferase 5S subunit; Transcarboxylase 5S subunit; EC 2.1.3.1 from Propionibacterium freudenreichii subsp. shermanii (see paper)
22% identity, 75% coverage of query (53.5 bits)
MAM1 / Q9FG67 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 2 papers)
MAM1_ARATH / Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9FG67 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana (see 7 papers)
23% identity, 74% coverage of query (52.8 bits)
5ks8D / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
21% identity, 72% coverage of query (45.8 bits)
5ks8C / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
21% identity, 72% coverage of query (45.8 bits)
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Lawrence Berkeley National Laboratory