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Searching for up to 100 curated homologs for PfGW456L13_2810 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2810 (327 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PLH35_FORAG / T2KNC8 Oxidoreductase P35; P35_oxidoreductase; Polysaccharide utilization locus H protein P35; PUL H protein P35; EC 1.-.-.- from Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) (see paper)
    35% identity, 97% coverage of query (205 bits)

Q92KZ3 1,5-anhydro-D-fructose reductase (EC 1.1.1.263); 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Sinorhizobium meliloti (see paper)
4koaA / Q92KZ3 Crystal structure analysis of 1,5-anhydro-d-fructose reductase from sinorhizobium meliloti (see paper)
    33% identity, 80% coverage of query (120 bits)

2glxA / Q2I8V6 Crystal structure analysis of bacterial 1,5-af reductase (see paper)
    31% identity, 80% coverage of query (113 bits)

afr / Q2I8V6 1,5-anhydro-D-fructose reductase (EC 1.1.1.292) from Ensifer adhaerens (see 3 papers)
AFR_ENSAD / Q2I8V6 1,5-anhydro-D-fructose reductase; Anhydrofructose reductase; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292 from Ensifer adhaerens (Sinorhizobium morelense) (see 2 papers)
Q2I8V6 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Ensifer adhaerens (see 2 papers)
    31% identity, 80% coverage of query (112 bits)

Build an alignment

Build an alignment for PfGW456L13_2810 and 4 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

iolG / Q9WYP5 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
IOLG_THEMA / Q9WYP5 Myo-inositol 2-dehydrogenase; EC 1.1.1.18 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9WYP5 D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Thermotoga maritima (see paper)
    28% identity, 77% coverage of query (100 bits)

6a3iA Levoglucosan dehydrogenase, complex with nadh and levoglucosan
    29% identity, 77% coverage of query (98.2 bits)

Q5KYQ3 inositol 2-dehydrogenase (EC 1.1.1.18) from Geobacillus kaustophilus (see paper)
    28% identity, 83% coverage of query (96.3 bits)

6a3jC / F0M433 Levoglucosan dehydrogenase, complex with nadh and l-sorbose (see paper)
    29% identity, 72% coverage of query (94.7 bits)

3q2kC / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    29% identity, 77% coverage of query (93.2 bits)

3q2kK / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    29% identity, 77% coverage of query (93.2 bits)

slgS4 / CBA11563.1 NDP-hexose-3-ketoreductase from Streptomyces lydicus (see paper)
    30% identity, 84% coverage of query (92.0 bits)

Asphe3_10730 / F0M433 levoglucosan dehydrogenase monomer (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (see 2 papers)
LGDH_PSEPM / F0M433 Levoglucosan dehydrogenase; LGDH; 1,6-anhydro-beta-D-glucose dehydrogenase; PpLGDH; EC 1.1.1.425 from Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (Arthrobacter phenanthrenivorans) (see paper)
F0M433 levoglucosan dehydrogenase (EC 1.1.1.425) from Pseudarthrobacter phenanthrenivorans (see paper)
    28% identity, 79% coverage of query (91.3 bits)

3rc1A / B3TMR8 Crystal structure of kijd10, a 3-ketoreductase from actinomadura kijaniata incomplex with NADP and tdp-benzene (see paper)
    28% identity, 78% coverage of query (87.4 bits)

KIJDR_ACTKI / B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase; 3-ketoreductase; NADPH-dependent C3-ketoreductase; EC 1.1.1.384 from Actinomadura kijaniata (see paper)
B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase (EC 1.1.1.384) from Actinomadura kijaniata (see paper)
    28% identity, 78% coverage of query (87.4 bits)

Q148L6 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Bos taurus (see paper)
    28% identity, 76% coverage of query (85.5 bits)

DHDH_PIG / Q9TV69 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Sus2DD; EC 1.3.1.20; EC 1.1.1.179 from Sus scrofa (Pig) (see 3 papers)
    26% identity, 98% coverage of query (84.3 bits)

YcjS / b1315 D-glucoside 3-dehydrogenase from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ycjS / P77503 D-glucoside 3-dehydrogenase from Escherichia coli (strain K12) (see 3 papers)
YCJS_ECOLI / P77503 D-glucoside 3-dehydrogenase; EC 1.1.1.- from Escherichia coli (strain K12) (see paper)
ycjS / MB|P77503 uncharacterized oxidoreductase ycjS from Escherichia coli K12 (see paper)
    25% identity, 98% coverage of query (83.6 bits)

1zh8A / Q9WYE8 Crystal structure of oxidoreductase (tm0312) from thermotoga maritima at 2.50 a resolution
    21% identity, 78% coverage of query (83.2 bits)

3q2iA / Q7NQL0 Crystal structure of the wlba dehydrognase from chromobactrium violaceum in complex with nadh and udp-glcnaca at 1.50 a resolution (see paper)
    27% identity, 77% coverage of query (82.8 bits)

5a03C / Q9A8X3 Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose (see paper)
    27% identity, 76% coverage of query (82.8 bits)

5a05A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with maltotriose
    27% identity, 76% coverage of query (82.8 bits)

5a04A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glucose
    27% identity, 76% coverage of query (82.8 bits)

5a03E Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose
    27% identity, 76% coverage of query (82.8 bits)

5a02A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glycerol
    27% identity, 76% coverage of query (82.8 bits)

5a06A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with sorbitol
    27% identity, 76% coverage of query (82.8 bits)

Q7NQL0 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (EC 1.1.1.335) from Chromobacterium violaceum (see paper)
    27% identity, 77% coverage of query (82.4 bits)

DHDH_RABIT / Q9TV70 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Ory2DD; EC 1.3.1.20; EC 1.1.1.179 from Oryctolagus cuniculus (Rabbit) (see 2 papers)
    26% identity, 90% coverage of query (80.5 bits)

6jw7A / Q6L737 The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin a (see paper)
    29% identity, 82% coverage of query (79.3 bits)

6norA / Q70KD1 Crystal structure of gend2 from gentamicin a biosynthesis in complex with NAD (see paper)
    30% identity, 72% coverage of query (79.3 bits)

6jw6A The crystal structure of kand2 in complex with NAD
    29% identity, 82% coverage of query (79.3 bits)

6jw8A The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin b
    29% identity, 82% coverage of query (79.3 bits)

YM94_YEAST / Q04869 Uncharacterized protein YMR315W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    25% identity, 80% coverage of query (78.2 bits)

iolX / P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (strain 168) (see paper)
IOLX_BACSU / P40332 scyllo-inositol 2-dehydrogenase (NAD(+)); EC 1.1.1.370 from Bacillus subtilis (strain 168) (see paper)
P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (see 2 papers)
    27% identity, 77% coverage of query (77.8 bits)

Q9EZV8 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium fredii (see paper)
    28% identity, 83% coverage of query (77.4 bits)

APSD_PARG4 / B1G894 D-apiose dehydrogenase; EC 1.1.1.420 from Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M) (see paper)
    28% identity, 80% coverage of query (77.4 bits)

cbaC / Q44258 3-chlorobenzoate-cis-diol hydrogenase from Comamonas testosteroni (see paper)
cbaC / AAC45718.1 1-carboxy-3-chloro-3,4-dihydroxycyclohexa-1, 5-diene dehydrogenase from Conidiobolus coronatus (see 4 papers)
    28% identity, 74% coverage of query (74.7 bits)

Echvi_3375 predicted 3-ketohexose reductase from Echinicola vietnamensis KMM 6221, DSM 17526
    25% identity, 81% coverage of query (73.9 bits)

SM_b20330 glucoside 3-dehydrogenase; active on raffinose or trehalose (thuB) (EC 1.1.99.13) from Sinorhizobium meliloti 1021
    29% identity, 70% coverage of query (73.2 bits)

apsD / B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium radiobacter (strain K84 / ATCC BAA-868) (see paper)
APSD_RHIR8 / B9JK80 D-apiose dehydrogenase; EC 1.1.1.420 from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter) (see paper)
B9JK80 D-apiose dehydrogenase (EC 1.1.1.420) from Agrobacterium tumefaciens (see paper)
    28% identity, 79% coverage of query (72.8 bits)

spnN / Q9ALN5 dTDP-3,4-diketo-2,6-dideoxy-D-glucose 3-ketoreductase (EC 1.1.1.384) from Saccharopolyspora spinosa (see paper)
SPNN_SACSN / Q9ALN5 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase; dTDP-3,4-diketo-2,6-dideoxy-D-glucose 3-ketoreductase; EC 1.1.1.384 from Saccharopolyspora spinosa (see 2 papers)
Q9ALN5 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase (EC 1.1.1.384) from Saccharopolyspora spinosa (see paper)
    27% identity, 81% coverage of query (72.4 bits)

dfgE / I5AX46 C-glycoside oxidase (EC 1.1.3.50) from [Eubacterium] cellulosolvens 6 (see 2 papers)
    26% identity, 74% coverage of query (72.4 bits)

5uhwA / B9JK80 Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+ and magnesium
    28% identity, 78% coverage of query (71.2 bits)

5uiaA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, r-2,3-dihydroxyisovalerate and magnesium
    28% identity, 78% coverage of query (71.2 bits)

5ui9A Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, 2 -hydroxy-2-hydroxymethyl propanoic acid and magnesium
    28% identity, 78% coverage of query (71.2 bits)

5uhzA Crystal structure of an oxidoreductase from agrobacterium radiobacter in complex with NAD+, d-apionate and magnesium
    28% identity, 78% coverage of query (71.2 bits)

K7ZP76 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Paracoccus laeviglucosivorans (see paper)
lgdA / BAM68195.1 scyllo-inositol dehydrogenase with L-glucose dehydrogenase activity from Paracoccus laeviglucosivorans (see 2 papers)
    30% identity, 78% coverage of query (63.9 bits)

5yaqB Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with scyllo-inosose
    30% identity, 78% coverage of query (62.0 bits)

5ya8A Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with myo-inositol
    30% identity, 78% coverage of query (62.0 bits)

6ktkC / K7ZP76 Crystal structure of scyllo-inositol dehydrogenase r178a mutant, complexed with nadh and l-glucono-1,5-lactone, from paracoccus laeviglucosivorans (see paper)
    29% identity, 78% coverage of query (59.3 bits)

6z3cAAA / A0A2N5NNS3 6z3cAAA (see paper)
    24% identity, 74% coverage of query (57.4 bits)

4mjlD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD and d-chiro-inositol
    25% identity, 80% coverage of query (55.5 bits)

4mioD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    25% identity, 80% coverage of query (55.5 bits)

4mioA Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    25% identity, 80% coverage of query (55.5 bits)

4minA / A0A0J9X1Y2 Crystal structure of myo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD
    25% identity, 80% coverage of query (55.5 bits)

3dtyA / Q880Y1 Crystal structure of an oxidoreductase from pseudomonas syringae
    21% identity, 79% coverage of query (49.7 bits)

3m2tA / Q7NY68 The crystal structure of dehydrogenase from chromobacterium violaceum
    24% identity, 70% coverage of query (44.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory