Searching for up to 100 curated homologs for PfGW456L13_3582 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3582 (548 a.a.)
Found high-coverage hits (≥70%) to 59 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ASPP_BACSU / O07002 Aspartate-proton symporter; L-aspartate transporter from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.11.1 / O07002 The aspartate uptake permease, YveA from Bacillus subtilis (see 3 papers)
58% identity, 95% coverage of query (612 bits)
BPHYT_RS17540 L-aspartate/L-glutamate/L-glutamine:H+ symporter from Burkholderia phytofirmans PsJN
37% identity, 97% coverage of query (348 bits)
AIMA_BACSU / Q45577 Glutamate/serine transporter AimA; Amino acid importer A from Bacillus subtilis (strain 168) (see 2 papers)
35% identity, 95% coverage of query (332 bits)
Build an alignment for PfGW456L13_3582 and 3 homologs with ≥ 30% identity
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5oqtA Crystal structure of a bacterial cationic amino acid transporter (cat) homologue
29% identity, 75% coverage of query (123 bits)
6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
29% identity, 75% coverage of query (122 bits)
MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
28% identity, 81% coverage of query (119 bits)
BCAP_BACSU / O07576 Branched-chain amino acid permease BcaP; BCAA permease from Bacillus subtilis (strain 168) (see 4 papers)
26% identity, 83% coverage of query (118 bits)
TC 2.A.3.8.9 / Q19834 Heteromeric amino acid transporter #1 (transports most neutral aas with highest rates for Ala and Ser (Km≈100 μM)). They function by obligatory aa:aa exchange (Veljkovic et al., 2004b) (see paper)
26% identity, 73% coverage of query (100 bits)
CCNA_00435 L-proline transporter from Caulobacter crescentus NA1000
25% identity, 83% coverage of query (95.9 bits)
CTR2_HUMAN / P52569 Cationic amino acid transporter 2; CAT-2; CAT2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 from Homo sapiens (Human) (see 3 papers)
TC 2.A.3.3.8 / P52569 Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2) from Homo sapiens (see 6 papers)
25% identity, 71% coverage of query (95.5 bits)
CAAT2_ARATH / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.13 / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (see 4 papers)
25% identity, 74% coverage of query (92.4 bits)
CTR1_RAT / P30823 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Rattus norvegicus (Rat) (see paper)
25% identity, 72% coverage of query (92.0 bits)
BAT1_MOUSE / Q9QXA6 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Mus musculus (Mouse) (see 2 papers)
25% identity, 72% coverage of query (91.7 bits)
CTR1_MOUSE / Q09143 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; ERR; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Mus musculus (Mouse) (see 7 papers)
TC 2.A.3.3.1 / Q09143 System Y+ high affinity basic amino acid transporter (CAT1) (ecotropic retrovival leukemia virus receptor (ERR)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 2 papers)
Slc7a1 / RF|NP_031539.3 high affinity cationic amino acid transporter 1 from Mus musculus
24% identity, 72% coverage of query (89.4 bits)
TC 2.A.3.1.6 / P37460 Proline-specific permease (ProY) from Salmonella typhimurium (see 2 papers)
24% identity, 76% coverage of query (88.6 bits)
TC 2.A.3.8.3 / Q26594 The schistosome neutral and cationic amino acid transporter, SPRM1lc (Na+-independent), (takes up phe, arg, lys, ala, gln, his, trp and leu; functions with SPRM1hc (TC# 8.A.9.3.1) from Schistosoma mansoni (Blood fluke)
27% identity, 71% coverage of query (87.8 bits)
BAT1_HUMAN / P82251 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Homo sapiens (Human) (see 16 papers)
TC 2.A.3.8.19 / P82251 B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) from Homo sapiens (see 9 papers)
25% identity, 72% coverage of query (87.4 bits)
CAAT4_ARATH / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.14 / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (see 4 papers)
26% identity, 71% coverage of query (87.4 bits)
N515DRAFT_2924 L-proline transporter from Dyella japonica UNC79MFTsu3.2
25% identity, 75% coverage of query (86.3 bits)
GABP_BACSU / P46349 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.3.1.5 / P46349 β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP from Bacillus subtilis (see 4 papers)
gabP / AAC44641.1 gamma-aminobutyrate permease from Bacillus subtilis (see 2 papers)
24% identity, 72% coverage of query (84.3 bits)
gabP / AAB62306.1 GabP from Bacillus subtilis (see 4 papers)
24% identity, 72% coverage of query (83.6 bits)
Ga0059261_1577 L-glutamine and L-histidine transporter from Sphingomonas koreensis DSMZ 15582
26% identity, 80% coverage of query (83.6 bits)
BAT1_RABIT / Q9N1R6 b(0,+)-type amino acid transporter 1; b(0,+)AT; 4F2-LC6; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Oryctolagus cuniculus (Rabbit) (see paper)
25% identity, 72% coverage of query (83.2 bits)
BAT1_RAT / P82252 b(0,+)-type amino acid transporter 1; b(0,+)AT; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Rattus norvegicus (Rat) (see 2 papers)
TC 2.A.3.8.15 / P82252 The b0,+ amino acid (cystine) transporter associated with the cystinuria-related type II membrane glycoprotein, BAT1 which forms a heterodimer with rBAT (TC# 8.A.9.1.1). Present in the apical membrane of renal proximal tubules from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 72% coverage of query (83.2 bits)
6li9B / P82251 Heteromeric amino acid transporter b0,+at-rbat complex bound with arginine (see paper)
25% identity, 71% coverage of query (82.4 bits)
SLC7A8 / Q9UHI5 large neutral amino acids transporter small subunit 2 from Homo sapiens (see 4 papers)
LAT2_HUMAN / Q9UHI5 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.3.8.20 / Q9UHI5 Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8). Certain detergents stabilize and allow purification of the 4F2hc-LAT2 complex, allowing the measurement of substrate binding. In addition, an improved 3D map could be obtained from Homo sapiens (see 12 papers)
26% identity, 78% coverage of query (81.6 bits)
CAAT5_ARATH / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.12 / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (see 3 papers)
24% identity, 78% coverage of query (80.9 bits)
TC 2.A.3.3.2 / P18581 Low affinity basic amino acid transporter (CAT2) (T-cell early activation protein (TEA)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 9 papers)
Slc7a2 / RF|NP_031540.2 low affinity cationic amino acid transporter 2 from Mus musculus (see paper)
24% identity, 70% coverage of query (80.1 bits)
LAT2_MOUSE / Q9QXW9 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) (see 6 papers)
26% identity, 78% coverage of query (80.1 bits)
LAT2_RABIT / Q9N1Q4 Large neutral amino acids transporter small subunit 2; 4F2-LC5; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Oryctolagus cuniculus (Rabbit) (see paper)
26% identity, 78% coverage of query (79.7 bits)
CTR2_MOUSE / P18581 Cationic amino acid transporter 2; CAT-2; CAT2; 20.5; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2; T-cell early activation protein; TEA from Mus musculus (Mouse) (see 6 papers)
24% identity, 72% coverage of query (79.7 bits)
TC 2.A.3.8.29 / F1R8V8 Cationic amino acid transporter, y+LAT1 from Danio rerio
24% identity, 85% coverage of query (79.7 bits)
LAT2_RAT / Q9WVR6 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Rattus norvegicus (Rat) (see 4 papers)
TC 2.A.3.8.6 / Q9WVR6 L-type neutral amino acid transporter, LAT2 (Na+-independent with broad specificity for all L-isomers of neutral amino acids; preferred substrate: Phe, His, Trp, Ile, Val, Leu, Gln, Cys, Ser; catalyzes obligatory exchange with μM affinities on the outside and mM affinities on the inside [1000x difference]). Both LAT2 and LAT1 (2.A.3.8.1) catalyze uptake of S-nitro-L-cysteine (Li and Whorton, 2005). Also transports thyroid hormones from Rattus norvegicus (Rat) (see 3 papers)
26% identity, 78% coverage of query (79.7 bits)
CAAT3_ARATH / Q8GYB4 Cationic amino acid transporter 3, mitochondrial from Arabidopsis thaliana (Mouse-ear cress) (see paper)
22% identity, 72% coverage of query (79.3 bits)
CTR3_HUMAN / Q8WY07 Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3 from Homo sapiens (Human) (see paper)
TC 2.A.3.3.10 / Q8WY07 Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3) from Homo sapiens (see 5 papers)
24% identity, 71% coverage of query (79.0 bits)
CTR2_CHICK / B3TP03 Cationic amino acid transporter 2; CAT-2; CAT2; cCAT-2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 from Gallus gallus (Chicken) (see paper)
22% identity, 70% coverage of query (79.0 bits)
6f2wA / A8UCQ5 Bacterial asc transporter crystal structure in open to in conformation (see paper)
25% identity, 71% coverage of query (78.6 bits)
7nf6B / A0A6P3EL78 Ovine b0,+at-rbat heterodimer (see paper)
25% identity, 71% coverage of query (78.6 bits)
Q16N01 ABC-type polar-amino-acid transporter (EC 7.4.2.1) from Aedes aegypti (see paper)
25% identity, 70% coverage of query (76.6 bits)
7cmhB / Q9UHI5 The lat2-4f2hc complex in complex with tryptophan (see paper)
25% identity, 76% coverage of query (75.1 bits)
7cmiB The lat2-4f2hc complex in complex with leucine
25% identity, 76% coverage of query (75.1 bits)
7b00A Human lat2-4f2hc complex in the apo-state
25% identity, 76% coverage of query (75.1 bits)
XCT_MOUSE / Q9WTR6 Cystine/glutamate transporter; Amino acid transport system xc-; Solute carrier family 7 member 11; Subtle gray protein; xCT from Mus musculus (Mouse) (see 8 papers)
TC 2.A.3.8.5 / Q9WTR6 Cystine/glutamate antiporter, xCT (requires the 4F2hc protein (TC #8.A.9.2.1)). Functions in the generation of glutathione and plays a role in the oxidative stress response from Mus musculus (Mouse) (see 3 papers)
25% identity, 72% coverage of query (74.7 bits)
AO356_18530 L-tyrosine transporter from Pseudomonas fluorescens FW300-N2C3
25% identity, 71% coverage of query (74.7 bits)
YajM / b0402 putative transporter ProY from Escherichia coli K-12 substr. MG1655 (see 6 papers)
TC 2.A.3.1.23 / P0AAE2 ProY of 457 aas and 12 TMSs from Escherichia coli (strain K12)
23% identity, 76% coverage of query (74.3 bits)
YLAT1_RAT / Q9R0S5 Y+L amino acid transporter 1; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Rattus norvegicus (Rat) (see 2 papers)
TC 2.A.3.8.7 / Q9R0S5 y+LAT1 (transports neutral amino acids (i.e., Leu) in symport with Na+, Li+ or H+ in 1:1 stoichiometry; transports basic amino acids (i.e., Lys) by facilitated diffusion without a symported cation). Also transports the neurotoxicant, methylmercury-L-cysteine by molecular mimicry. Causes the Lysinuric protein intolerance condition in humans (Q9UM01) (Broer, 2008) (see 2 papers)
24% identity, 72% coverage of query (73.6 bits)
YLAT1_MOUSE / Q9Z1K8 Y+L amino acid transporter 1; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Mus musculus (Mouse) (see 3 papers)
24% identity, 72% coverage of query (72.8 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
24% identity, 72% coverage of query (72.4 bits)
PfGW456L13_4291 L-tryptophan transporter from Pseudomonas fluorescens GW456-L13
25% identity, 70% coverage of query (72.4 bits)
RR42_RS33495 L-phenylalanine:H+ symporter AroP from Cupriavidus basilensis FW507-4G11
24% identity, 73% coverage of query (72.0 bits)
AroR / b0112 aromatic amino acid:H+ symporter AroP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
aroP / P15993 aromatic amino acid:H+ symporter AroP from Escherichia coli (strain K12) (see 6 papers)
AROP_ECOLI / P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli (see 6 papers)
24% identity, 72% coverage of query (71.6 bits)
SLC7A5 / Q01650 large neutral amino acids transporter small subunit 1 from Homo sapiens (see 4 papers)
LAT1_HUMAN / Q01650 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) (see 19 papers)
TC 2.A.3.8.25 / Q01650 Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain; SLC3A2) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic and neutral amino acid transporter) from Homo sapiens (see 24 papers)
24% identity, 77% coverage of query (69.7 bits)
LAT1_RABIT / Q7YQK4 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; L-type amino acid transporter 1; LAT1; Solute carrier family 7 member 5 from Oryctolagus cuniculus (Rabbit) (see 4 papers)
25% identity, 77% coverage of query (68.6 bits)
7dsqB Overall structure of the lat1-4f2hc bound with 3,5-diiodo-l-tyrosine
24% identity, 76% coverage of query (68.2 bits)
7dsnB Overall structure of the lat1-4f2hc bound with jx-119
24% identity, 76% coverage of query (68.2 bits)
7dslB Overall structure of the lat1-4f2hc bound with jx-078
24% identity, 76% coverage of query (68.2 bits)
7dskB / Q01650 Overall structure of the lat1-4f2hc bound with jx-075 (see paper)
24% identity, 76% coverage of query (68.2 bits)
6irtB Human lat1-4f2hc complex bound with bch
25% identity, 75% coverage of query (65.1 bits)
6jmqA / Q01650 Lat1-cd98hc complex bound to mem-108 fab (see paper)
25% identity, 76% coverage of query (56.6 bits)
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Lawrence Berkeley National Laboratory