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Searching for up to 100 curated homologs for PfGW456L13_4590 Beta-ketoadipyl CoA thiolase (EC 2.3.1.-) (400 a.a.)

Found high-coverage hits (≥70%) to 99 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pcaF / Q51956 subunit of β-ketoadipyl CoA thiolase (EC 2.3.1.174; EC 2.3.1.16) from Pseudomonas putida (see paper)
pcaF / AAA85138.1 PcaF from Pseudomonas putida (see paper)
    91% identity, 100% coverage of query (721 bits)

PCAF_PSEKB / Q8VPF1 Beta-ketoadipyl-CoA thiolase; 3-oxoadipyl-CoA thiolase; EC 2.3.1.174 from Pseudomonas knackmussii (strain DSM 6978 / CCUG 54928 / LMG 23759 / B13) (see paper)
    85% identity, 100% coverage of query (697 bits)

6pcbA / Q88N39 Crystal structure of beta-ketoadipyl-coa thiolase mutant (h356a) in complex with coa (see paper)
    89% identity, 100% coverage of query (695 bits)

6pccA Crystal structure of beta-ketoadipyl-coa thiolase mutant (h356a) in complex hexanoyl coenzyme a
    89% identity, 100% coverage of query (695 bits)

6pcdA Crystal structure of beta-ketoadipyl-coa thiolase mutant (c90s-h356a) in complex octanoyl coenzyme a
    88% identity, 100% coverage of query (680 bits)

pcaF / Q0K4S3 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
    70% identity, 100% coverage of query (571 bits)

H281DRAFT_05723 bifunctional thiolase PaaJ: 3-oxo-5,6-didehydrosuberyl-CoA thiolase (EC 2.3.1.223); 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) from Paraburkholderia bryophila 376MFSha3.1
    70% identity, 100% coverage of query (569 bits)

BPHYT_RS17345 bifunctional thiolase PaaJ: 3-oxo-5,6-didehydrosuberyl-CoA thiolase (EC 2.3.1.223); 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) from Burkholderia phytofirmans PsJN
    69% identity, 100% coverage of query (560 bits)

paaJ / Q845J8 β-ketoadipyl-CoA thiolase (EC 2.3.1.174; EC 2.3.1.223) from Pseudomonas sp. Y2 (see 2 papers)
Q845J8 3-oxo-5,6-didehydrosuberyl-CoA thiolase (EC 2.3.1.223) from Pseudomonas sp. (see paper)
    67% identity, 100% coverage of query (550 bits)

HSERO_RS20660 bifunctional thiolase PaaJ: 3-oxo-5,6-dehydrosuberyl-CoA thiolase (EC 2.3.1.223); 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) from Herbaspirillum seropedicae SmR1
    69% identity, 100% coverage of query (543 bits)

catF / AAC46434.1 beta-ketoadipyl CoA thiolase from Acinetobacter baylyi (see 8 papers)
    65% identity, 100% coverage of query (543 bits)

pcaF / AAC37148.1 beta-ketoadipyl CoA thiolase from Acinetobacter baylyi (see 11 papers)
    65% identity, 100% coverage of query (542 bits)

YdbW / b1397 β-ketoadipyl-CoA thiolase (EC 2.3.1.223; EC 2.3.1.174) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
paaJ / P0C7L2 β-ketoadipyl-CoA thiolase (EC 2.3.1.223; EC 2.3.1.174) from Escherichia coli (strain K12) (see 5 papers)
PAAJ_ECOLI / P0C7L2 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase; EC 2.3.1.174; EC 2.3.1.223 from Escherichia coli (strain K12) (see 5 papers)
    65% identity, 100% coverage of query (537 bits)

HP15_2695 Beta-ketoadipyl CoA thiolase (EC 2.3.1.-) from Marinobacter adhaerens HP15
    66% identity, 100% coverage of query (516 bits)

Tfu_0875 / Q47RK4 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) from Thermobifida fusca (strain YX) (see 2 papers)
    53% identity, 100% coverage of query (385 bits)

PS417_10515 / A0A1N7U0F8 acetyl-CoA C-acetyltransferase (EC 2.3.1.16) from Pseudomonas simiae (see paper)
    47% identity, 100% coverage of query (322 bits)

THLA_SYNWW / Q0AVM3 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; EC 2.3.1.9 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) (see paper)
    44% identity, 99% coverage of query (321 bits)

AO356_21640 acetyl-CoA C-acetyltransferase [EC: 2.3.1.9] from Pseudomonas fluorescens FW300-N2C3
    47% identity, 100% coverage of query (321 bits)

thlA1 / A5N3I5 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) (see 3 papers)
    45% identity, 100% coverage of query (320 bits)

thl / P45359 acetoacetyl-CoA thiolase monomer (EC 2.3.1.16) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 3 papers)
THLA_CLOAB / P45359 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; CaTHL; EC 2.3.1.9 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W) (see 2 papers)
P45359 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Clostridium acetobutylicum (see paper)
    45% identity, 100% coverage of query (316 bits)

THIL_THIVI / P45363 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Thiocystis violacea (see paper)
    44% identity, 99% coverage of query (314 bits)

THIL_ALLVD / P45369 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) (Chromatium vinosum) (see paper)
    44% identity, 100% coverage of query (313 bits)

4xl4A / A0A0R4I970 Crystal structure of thiolase from clostridium acetobutylicum in complex with coa (see paper)
    45% identity, 100% coverage of query (311 bits)

AtoB / b2224 acetyl-CoA acetyltransferase (EC 2.3.1.16; EC 2.3.1.9) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
atoB / P76461 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Escherichia coli (strain K12) (see 7 papers)
P76461 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Escherichia coli (see 2 papers)
    46% identity, 100% coverage of query (308 bits)

5f38D / P76461 X-ray crystal structure of a thiolase from escherichia coli at 1.8 a resolution (see paper)
    46% identity, 100% coverage of query (308 bits)

ACAA2 / P42765 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) from Homo sapiens (see paper)
THIM_HUMAN / P42765 3-ketoacyl-CoA thiolase, mitochondrial; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1; EC 2.3.1.16; EC 2.3.1.9; EC 3.1.2.-; EC 3.1.2.1; EC 3.1.2.2 from Homo sapiens (Human) (see 2 papers)
P42765 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Homo sapiens (see 2 papers)
    43% identity, 100% coverage of query (305 bits)

5f38B X-ray crystal structure of a thiolase from escherichia coli at 1.8 a resolution
    46% identity, 100% coverage of query (303 bits)

PfGW456L13_2411 Acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Pseudomonas fluorescens GW456-L13
    44% identity, 100% coverage of query (302 bits)

G3CH53 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Ovis aries (see paper)
    42% identity, 100% coverage of query (300 bits)

Q8BWT1 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Mus musculus (see paper)
    43% identity, 100% coverage of query (300 bits)

phbA / P14611 acetyl-CoA acetyltransferase subunit (EC 2.3.1.16) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see 4 papers)
THIL_CUPNH / P14611 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see 4 papers)
P14611 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Cupriavidus necator (see paper)
    46% identity, 100% coverage of query (300 bits)

SMc03879 Acetyl-CoA acetyltransferase (EC 2.3.1.9) from Sinorhizobium meliloti 1021
THIL_RHIME / P50174 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
phbA / AAA90982.1 beta-ketothiolase from Sinorhizobium meliloti (see 2 papers)
    44% identity, 99% coverage of query (298 bits)

4o9cC / P14611 Crystal structure of beta-ketothiolase (phaa) from ralstonia eutropha h16 (see paper)
    46% identity, 100% coverage of query (296 bits)

Sama_0031 Acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Shewanella amazonensis SB2B
    44% identity, 100% coverage of query (295 bits)

THIM_RAT / P13437 3-ketoacyl-CoA thiolase, mitochondrial; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; EC 2.3.1.16; EC 2.3.1.9; EC 3.1.2.-; EC 3.1.2.1; EC 3.1.2.2 from Rattus norvegicus (Rat) (see paper)
    42% identity, 100% coverage of query (295 bits)

5bz4K / A0QUH3 Crystal structure of a t1-like thiolase (coa-complex) from mycobacterium smegmatis (see paper)
    42% identity, 100% coverage of query (295 bits)

4c2jD / P42765 Crystal structure of human mitochondrial 3-ketoacyl-coa thiolase in complex with coa (see paper)
    42% identity, 100% coverage of query (294 bits)

YqeF / b2844 putative acyltransferase from Escherichia coli K-12 substr. MG1655 (see 7 papers)
    44% identity, 100% coverage of query (291 bits)

1ou6A / P07097 Biosynthetic thiolase from zoogloea ramigera in complex with acetyl-o- pantetheine-11-pivalate
    43% identity, 99% coverage of query (290 bits)

bktB / Q0KBP1 β-ketothiolase (EC 2.3.1.16; EC 2.3.1.9) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
BKTB_CUPNH / Q0KBP1 Beta-ketothiolase BktB; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; EC 2.3.1.16; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
Q0KBP1 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Cupriavidus necator (see paper)
bktB / AAC38322.1 beta-ketothiolase from Cupriavidus necator (see paper)
    43% identity, 100% coverage of query (290 bits)

THIL_SHIZO / P07097 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Shinella zoogloeoides (Crabtreella saccharophila) (see 3 papers)
    43% identity, 98% coverage of query (290 bits)

phaA / Q3IZW1 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (see paper)
    42% identity, 100% coverage of query (290 bits)

2vu2A Biosynthetic thiolase from z. Ramigera. Complex with s-pantetheine-11- pivalate.
    43% identity, 99% coverage of query (290 bits)

1dm3A Acetylated biosynthetic thiolase from zoogloea ramigera in complex with acetyl-coa
    43% identity, 99% coverage of query (290 bits)

1dlvA Biosynthetic thiolase from zoogloea ramigera in complex with coa
    43% identity, 99% coverage of query (290 bits)

2vu1A Biosynthetic thiolase from z. Ramigera. Complex of with o-pantheteine- 11-pivalate.
    43% identity, 99% coverage of query (290 bits)

PGA1_c03400 acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16) from Phaeobacter inhibens BS107
    42% identity, 100% coverage of query (288 bits)

Shewana3_0023 Acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Shewanella sp. ANA-3
    42% identity, 100% coverage of query (288 bits)

2wkuA Biosynthetic thiolase from z. Ramigera. The n316h mutant.
    42% identity, 99% coverage of query (288 bits)

8jg2A / A0A848BQU5 Crystal structure of a biosynthetic thiolase from megasphaera hexanoica soaked with hexanoyl-coa
    42% identity, 100% coverage of query (287 bits)

1m1oA Crystal structure of biosynthetic thiolase, c89a mutant, complexed with acetoacetyl-coa
    42% identity, 99% coverage of query (286 bits)

P28790 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Pseudomonas fragi (see paper)
    43% identity, 100% coverage of query (284 bits)

2d3tC / P28790 Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form v (see paper)
    43% identity, 100% coverage of query (284 bits)

ACAT2 / Q9BWD1 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Homo sapiens (see 11 papers)
THIC_HUMAN / Q9BWD1 Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase; EC 2.3.1.9 from Homo sapiens (Human) (see 2 papers)
    40% identity, 99% coverage of query (282 bits)

1wl4A / Q9BWD1 Human cytosolic acetoacetyl-coa thiolase complexed with coa (see paper)
    40% identity, 99% coverage of query (282 bits)

8oqlC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
    42% identity, 100% coverage of query (282 bits)

8oqoC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
    42% identity, 100% coverage of query (282 bits)

8oqmD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-10
    42% identity, 100% coverage of query (281 bits)

8opxC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with trehalose (fragment-b-tre)
    42% identity, 100% coverage of query (281 bits)

8opuC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with sulfamethoxazole (fragment-b-e1)
    41% identity, 100% coverage of query (281 bits)

8opyD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-b-dnq
    41% identity, 100% coverage of query (281 bits)

8pf8C Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
    41% identity, 100% coverage of query (280 bits)

8oqsC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
    41% identity, 100% coverage of query (280 bits)

8oqpC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-76
    41% identity, 100% coverage of query (280 bits)

4b3iC Crystal structure of mycobacterium tuberculosis fatty acid beta- oxidation complex with coenzymea bound at the hydratase active sites
    41% identity, 100% coverage of query (280 bits)

Y0859_MYCTU / O53871 Putative acyltransferase Rv0859; EC 2.3.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
7o4tD / O53871 Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme with coenzyme a bound at the hydratase, thiolase active sites and possible additional binding site (coa(ech/had)) (see paper)
    41% identity, 100% coverage of query (280 bits)

7cw5B / Q814S6 Acetyl-coa acetyltransferase from bacillus cereus atcc 14579 (see paper)
    40% identity, 98% coverage of query (260 bits)

7feaB / A0A7U5Y2I6 Py14 in complex with col-d (see paper)
    43% identity, 100% coverage of query (257 bits)

8gqmA / Q9HZQ7 Crystal structure of thiolase complexed with acetyl coenzyme a
    40% identity, 100% coverage of query (254 bits)

6bn2A / A0A077EEP0 Crystal structure of acetyl-coa acetyltransferase from elizabethkingia anophelis nuhp1
    38% identity, 100% coverage of query (253 bits)

7ei4A Crystal structure of masl in complex with a novel covalent inhibitor, collimonin c
    43% identity, 100% coverage of query (249 bits)

8gqnA / G3XD40 X-ray structure of thiolase with coa
    40% identity, 99% coverage of query (242 bits)

THILH_CAEEL / Q22100 Acetyl-CoA acetyltransferase homolog, mitochondrial; 3-ketoacyl-CoA thiolase; EC 2.3.1.- from Caenorhabditis elegans (see 3 papers)
Q22100 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Caenorhabditis elegans (see paper)
    37% identity, 100% coverage of query (241 bits)

A0R1Y7 Probable acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; EC 2.3.1.9 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    38% identity, 97% coverage of query (235 bits)

2ib8D / P24752 Crystallographic and kinetic studies of human mitochondrial acetoacetyl-coa thiolase (t2): the importance of potassium and chloride for its structure and function (see paper)
    38% identity, 100% coverage of query (234 bits)

ACAT1 / P24752 acetyl-CoA acetyltransferase monomer (EC 2.3.1.16) from Homo sapiens (see 11 papers)
THIL_HUMAN / P24752 Acetyl-CoA acetyltransferase, mitochondrial; Acetoacetyl-CoA thiolase; T2; EC 2.3.1.9 from Homo sapiens (Human) (see 6 papers)
    38% identity, 100% coverage of query (234 bits)

2f2sA Human mitochondrial acetoacetyl-coa thiolase
    38% identity, 100% coverage of query (232 bits)

ACAA1 / P09110 3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.223; EC 2.3.1.16) from Homo sapiens (see 20 papers)
THIK_HUMAN / P09110 3-ketoacyl-CoA thiolase, peroxisomal; Acetyl-CoA C-myristoyltransferase; Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase; EC 2.3.1.16; EC 2.3.1.155; EC 2.3.1.9 from Homo sapiens (Human) (see 2 papers)
    38% identity, 99% coverage of query (228 bits)

6l2cA / B0XMC1 Crystal structure of aspergillus fumigatus mitochondrial acetyl-coa acetyltransferase in complex with coa (see paper)
    37% identity, 100% coverage of query (221 bits)

ER10A_ASPFC / B0XMC1 Acetyl-CoA acetyltransferase erg10A, mitochondrial; Acetoacetyl-CoA thiolase erg10A; Ergosterol biosynthesis protein 10A; EC 2.3.1.9 from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya fumigata) (see paper)
ER10A_ASPFU / Q4WLA8 Acetyl-CoA acetyltransferase erg10A, mitochondrial; Acetoacetyl-CoA thiolase erg10A; Ergosterol biosynthesis protein 10A; EC 2.3.1.9 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
B0XMC1 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Aspergillus fumigatus (see paper)
    37% identity, 100% coverage of query (221 bits)

PED1 / Q56WD9 3-ketoacyl-CoA thiolase 2, peroxisomal (EC 2.3.1.16) from Arabidopsis thaliana (see 2 papers)
THIK2_ARATH / Q56WD9 3-ketoacyl-CoA thiolase 2, peroxisomal; Acetyl-CoA acyltransferase 2; Beta-ketothiolase 2; Peroxisomal 3-oxoacyl-CoA thiolase 2; Peroxisome defective protein 1; EC 2.3.1.16 from Arabidopsis thaliana (Mouse-ear cress) (see 13 papers)
Q56WD9 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Arabidopsis thaliana (see 4 papers)
    37% identity, 99% coverage of query (220 bits)

6aqpA Aspergillus fumigatus cytosolic thiolase: acetylated enzyme in complex with coa and potassium ions
    37% identity, 99% coverage of query (220 bits)

6aqpC / Q4WCL5 Aspergillus fumigatus cytosolic thiolase: acetylated enzyme in complex with coa and potassium ions
    37% identity, 99% coverage of query (216 bits)

ER10B_ASPFC / B0YA65 Acetyl-CoA acetyltransferase erg10B, cytosolic; Acetoacetyl-CoA thiolase erg10B; ACAT; Cytosolic thiolase erg10B; CT; Ergosterol biosynthesis protein 10B; EC 2.3.1.9 from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya fumigata) (see 4 papers)
ER10B_ASPFU / Q4WCL5 Acetyl-CoA acetyltransferase erg10B, cytosolic; Acetoacetyl-CoA thiolase erg10B; ACAT; Cytosolic thiolase erg10B; CT; Ergosterol biosynthesis protein 10B; EC 2.3.1.9 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 2 papers)
    37% identity, 99% coverage of query (216 bits)

ERG10 / P41338 Erg10 (EC 2.3.1.16) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
ERG10_YEAST / P41338 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10; EC 2.3.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
P41338 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Saccharomyces cerevisiae (see paper)
    37% identity, 100% coverage of query (213 bits)

4ubvA Structure of the 3-ketoacyl-coa thiolase fada5 from m. Tuberculosis with an partially acetylated cysteine in complex with acetyl-coa and coa
    36% identity, 99% coverage of query (206 bits)

fadA5 / I6XHI4 steroid 3-ketoacyl-CoA thiolase monomer (EC 2.3.1.16; EC 2.3.1.176) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
FADA5_MYCTU / I6XHI4 Steroid 3-ketoacyl-CoA thiolase; Acetyl-CoA acetyltransferase FadA5; Beta-ketoacyl-CoA thiolase; EC 2.3.1.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    36% identity, 99% coverage of query (206 bits)

6bjbA / F1KYX0 Crystal structure of acat2-c91s thiolase from ascaris suum in complex with propionyl-coa and nitrate (see paper)
    34% identity, 100% coverage of query (203 bits)

4ubtA / I6XHI4 Structure of the c93s variant of the 3-ketoacyl-coa thiolase fada5 from m. Tuberculosis in complex with a steroid and coa. (see paper)
    36% identity, 99% coverage of query (202 bits)

6bjaA / F1L3N8 Crystal structure of acat5 thiolase from ascaris suum in complex with coenzyme a (see paper)
    35% identity, 100% coverage of query (196 bits)

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Build an alignment for PfGW456L13_4590 and 90 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

SCP2 / P22307 Non-specific lipid-transfer protein (EC 2.3.1.16) from Homo sapiens (see 17 papers)
SCP2_HUMAN / P22307 Sterol carrier protein 2; SCP-2; Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCPX; Sterol carrier protein X; SCP-X; EC 2.3.1.155; EC 2.3.1.176; EC 2.3.1.16 from Homo sapiens (Human) (see 6 papers)
P22307 propanoyl-CoA C-acyltransferase (EC 2.3.1.176) from Homo sapiens (see 3 papers)
    24% identity, 84% coverage of query (60.5 bits)

mvaE / A0A384E138 acetyl-CoA C-acetyltransferase (EC 2.3.1.16) from Methanothermococcus thermolithotrophicus (see paper)
A0A384E138 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Methanothermococcus thermolithotrophicus (see paper)
6esqA / A0A384E138 Structure of the acetoacetyl-coa thiolase/hmg-coa synthase complex from methanothermococcus thermolithotrophicus soaked with acetyl-coa (see paper)
    23% identity, 94% coverage of query (55.5 bits)

7pytD Benzoylsuccinyl-coa thiolase with coenzyme a
    24% identity, 73% coverage of query (53.5 bits)

7pytB / Q39VG1 Benzoylsuccinyl-coa thiolase with coenzyme a (see paper)
    24% identity, 73% coverage of query (53.5 bits)

6hsjB / Q6P4V5 Crystal structure of the zebrafish peroxisomal scp2-thiolase (type-1) in complex with coa (see paper)
    23% identity, 75% coverage of query (52.8 bits)

NLTP2_CAEEL / G5EDP2 Non-specific lipid-transfer protein-like 2; NSL-TP2; 3-keto-acyl-CoA thiolase; Abnormal dauer formation protein 22; Propanoyl-CoA C-acyltransferase; Protein P-44; EC 2.3.1.176 from Caenorhabditis elegans (see 3 papers)
    23% identity, 75% coverage of query (50.8 bits)

5lotA Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with acetyl-coa.
    22% identity, 73% coverage of query (46.6 bits)

5lnqA / E9AW84 Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with acetoacetyl-coa. (see paper)
    22% identity, 73% coverage of query (46.6 bits)

3zbnA Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with coenzyme a.
    22% identity, 73% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory