Searching for up to 100 curated homologs for PfGW456L13_4977 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_4977 (236 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
44% identity, 97% coverage of query (197 bits)
pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
31% identity, 97% coverage of query (87.8 bits)
Build an alignment for PfGW456L13_4977 and 2 homologs with ≥ 30% identity
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5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
26% identity, 97% coverage of query (78.2 bits)
gra-orf6 / BAD51477.1 ketoreductase from Streptomyces violaceoruber (see 3 papers)
28% identity, 97% coverage of query (72.0 bits)
FABG_RICPR / P50941 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Rickettsia prowazekii (strain Madrid E)
P50941 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Rickettsia prowazekii (see paper)
31% identity, 95% coverage of query (70.9 bits)
5t2uA / A0R723 Short chain dehydrogenase/reductase family protein (see paper)
28% identity, 96% coverage of query (68.2 bits)
A0R723 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); acetoacetyl-CoA reductase (EC 1.1.1.36) from Mycolicibacterium smegmatis (see paper)
28% identity, 96% coverage of query (68.2 bits)
8bcjB / Q9HZ96 Crystal structure of short-chain dehydrogenase pa3128 from pseudomonas aeruginosa pao1 in complex with NADP+
30% identity, 96% coverage of query (67.8 bits)
4iqgD / Q12GY8 Crystal structure of bpro0239 oxidoreductase from polaromonas sp. Js666 in NADP bound form
28% identity, 96% coverage of query (63.9 bits)
swb2 / D2KTX1 3-hydroxykynurenate reductase/dehydratase from Streptomyces sp. SNA15896 (see paper)
30% identity, 99% coverage of query (62.8 bits)
YqfD / b2902 putative oxidoreductase YgfF from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ygfF / RF|NP_417378 uncharacterized oxidoreductase ygfF from Escherichia coli K12 (see paper)
25% identity, 97% coverage of query (61.6 bits)
ptmO8 / D8L2W5 ent-kauranol 7β-dehydrogenase from Streptomyces platensis (see paper)
29% identity, 95% coverage of query (61.6 bits)
6rx6A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 4 (nmt- c0026)
28% identity, 95% coverage of query (61.2 bits)
6rx0A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 3 (nmt- c0013)
28% identity, 95% coverage of query (61.2 bits)
6howA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 2a (f219).
28% identity, 95% coverage of query (61.2 bits)
6gexA Trypanosoma brucei ptr1 in complex with inhibitor 2h (f246)
28% identity, 95% coverage of query (61.2 bits)
6gdoA Trypanosoma brucei ptr1 in complex with inhibitor 2g (f240)
28% identity, 95% coverage of query (61.2 bits)
5k6aA Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
28% identity, 95% coverage of query (61.2 bits)
2x9nA High resolution structure of tbptr1 in complex with cyromazine
28% identity, 95% coverage of query (61.2 bits)
5iz4A / Q13GL4 Crystal structure of a putative short-chain dehydrogenase/reductase from burkholderia xenovorans
30% identity, 75% coverage of query (60.8 bits)
DCXR_HUMAN / Q7Z4W1 L-xylulose reductase; XR; Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Short chain dehydrogenase/reductase family 20C member 1; Sperm surface protein P34H; EC 1.1.1.10 from Homo sapiens (Human) (see 5 papers)
Q7Z4W1 L-xylulose reductase (EC 1.1.1.10) from Homo sapiens (see 3 papers)
3d3wA / Q7Z4W1 Structure of l-xylulose reductase with bound coenzyme, phosphate and hydroxide. (see paper)
27% identity, 95% coverage of query (60.8 bits)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii
26% identity, 100% coverage of query (60.8 bits)
1pr9A Human l-xylulose reductase holoenzyme
27% identity, 95% coverage of query (60.8 bits)
fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
24% identity, 96% coverage of query (60.5 bits)
4iinA Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from helicobacter pylori 26695 complexed with NAD+
25% identity, 100% coverage of query (60.5 bits)
3jq8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7- trimethyl-7,8-dihydropteridine-2,4-diamine (dx3)
28% identity, 95% coverage of query (60.1 bits)
8jfhD Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-octanoyl-acp from helicobacter pylori in an inactive form that priors the acyl substrate delivery
26% identity, 100% coverage of query (60.1 bits)
3iccA / A0A6L7HAY4 Crystal structure of a putative 3-oxoacyl-(acyl carrier protein) reductase from bacillus anthracis at 1.87 a resolution (see paper)
28% identity, 95% coverage of query (59.7 bits)
4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
23% identity, 98% coverage of query (59.7 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
28% identity, 95% coverage of query (59.7 bits)
5jdcA Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
27% identity, 95% coverage of query (59.7 bits)
5jcxA Trypanosoma brucei ptr1 in complex with inhibitor np-29
27% identity, 95% coverage of query (59.7 bits)
5jcjA Trypanosoma brucei ptr1 in complex with inhibitor nmt-h037 (compound 7)
27% identity, 95% coverage of query (59.7 bits)
5izcA Trypanosoma brucei ptr1 in complex with inhibitor f032
27% identity, 95% coverage of query (59.7 bits)
4wcfA Trypanosoma brucei ptr1 in complex with inhibitor 9
27% identity, 95% coverage of query (59.7 bits)
4cmeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (59.7 bits)
4cm9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (59.7 bits)
3jqgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4- methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (ax6)
27% identity, 95% coverage of query (59.7 bits)
3jqfA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5- triazine-2,4,6-triamine (ax2)
27% identity, 95% coverage of query (59.7 bits)
3jqeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (dx8)
27% identity, 95% coverage of query (59.7 bits)
3jqdA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-4-oxo-6-phenyl-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (dx7)
27% identity, 95% coverage of query (59.7 bits)
3jqcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-bromo-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (ju2)
27% identity, 95% coverage of query (59.7 bits)
3jqbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-5-(2-phenylethyl)-3,7-dihydro-4h-pyrrolo[2,3-d]pyrimidin-4-one (dx6)
27% identity, 95% coverage of query (59.7 bits)
3jqaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-1,9-dihydro-6h-purine-6-thione (dx4)
27% identity, 95% coverage of query (59.7 bits)
3jq9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (ax1)
27% identity, 95% coverage of query (59.7 bits)
3jq7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
27% identity, 95% coverage of query (59.7 bits)
3jq6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7- bis(1-methylethyl)pteridine-2,4-diamine (dx1)
27% identity, 95% coverage of query (59.7 bits)
3gn2A Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00066730)
27% identity, 95% coverage of query (59.7 bits)
2yhiA Trypanosoma brucei ptr1 in complex with inhibitor wh16
27% identity, 95% coverage of query (59.7 bits)
2wd8A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00071204
27% identity, 95% coverage of query (59.7 bits)
2wd7A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066750
27% identity, 95% coverage of query (59.7 bits)
2vz0A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066641
27% identity, 95% coverage of query (59.7 bits)
8of2A Trypanosoma brucei pteridine reductase 1 (tbptr1) in complex with 2,4, 6 triamminopyrimidine (tap)
27% identity, 95% coverage of query (59.3 bits)
6tbxA Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
27% identity, 95% coverage of query (59.3 bits)
6hnrA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 1 (f217)
27% identity, 95% coverage of query (59.3 bits)
6hncA Trypanosoma brucei ptr1 in complex with cycloguanil
27% identity, 95% coverage of query (59.3 bits)
5jdiA Trypanosoma brucei ptr1 in complex with cofactor and inhibitor nmt- h024 (compound 2)
27% identity, 95% coverage of query (59.3 bits)
ARMD4_ARMGA / A0A2H3D8Y2 Short-chain dehydrogenase/reductase ARMGADRAFT_1018421; Melleolide biosynthesis cluster protein ARMGADRAFT_1018421; EC 1.1.1.- from Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa) (see 9 papers)
27% identity, 95% coverage of query (58.9 bits)
6t62A / V5VHN7 Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
25% identity, 100% coverage of query (58.9 bits)
4cm7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (58.9 bits)
dhuD / Q8E370 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase monomer (EC 1.1.1.127) from Streptococcus agalactiae serotype III (strain NEM316) (see paper)
25% identity, 73% coverage of query (58.5 bits)
3bmqA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax5)
27% identity, 95% coverage of query (58.5 bits)
4clhA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (58.5 bits)
4cleA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (58.5 bits)
DCXR / Q91XV4 L-xylulose reductase subunit (EC 1.1.1.10) from Mesocricetus auratus (see paper)
DCXR_MESAU / Q91XV4 L-xylulose reductase; XR; Dicarbonyl/L-xylulose reductase; Sperm antigen P26h; EC 1.1.1.10 from Mesocricetus auratus (Golden hamster) (see 3 papers)
Q91XV4 L-xylulose reductase (EC 1.1.1.10) from Mesocricetus auratus (see paper)
27% identity, 95% coverage of query (58.2 bits)
Elen_0198 / C8WJW0 NAD-dependent bile acid 3β-dehydrogenase (EC 1.1.1.391) from Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) (see 4 papers)
3BHD1_EGGLE / C8WJW0 3beta-hydroxysteroid dehydrogenase 1; 3beta-HSDH 1; 3beta-hydroxycholanate 3-dehydrogenase (NAD(+)) 1; NAD-dependent bile acid 3beta-dehydrogenase; EC 1.1.1.-; EC 1.1.1.391 from Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) (Eubacterium lentum) (see paper)
C8WJW0 3beta-hydroxycholanate 3-dehydrogenase (NAD+) (EC 1.1.1.391) from Eggerthella lenta (see paper)
29% identity, 95% coverage of query (58.2 bits)
4bo2A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9a resolution
25% identity, 100% coverage of query (58.2 bits)
5k6aC Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
27% identity, 95% coverage of query (58.2 bits)
7opjA Trypanosoma brucei ptr1 (tbptr1) in complex with pyrimethamine
27% identity, 95% coverage of query (58.2 bits)
6gd4A Trypanosoma brucei ptr1 in complex with inhibitor 4c (f188)
27% identity, 95% coverage of query (58.2 bits)
6gclA Trypanosoma brucei ptr1 in complex with inhibitor 3a (f020)
27% identity, 95% coverage of query (58.2 bits)
4wcdA Trypanosoma brucei ptr1 in complex with inhibitor 10
27% identity, 95% coverage of query (58.2 bits)
4cmkA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (58.2 bits)
4cm8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (58.2 bits)
4clrA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (58.2 bits)
2x9vA High resolution structure of tbptr1 with trimetrexate
27% identity, 95% coverage of query (58.2 bits)
4bo0A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4a resolution
25% identity, 100% coverage of query (58.2 bits)
4bo8A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7a resolution
25% identity, 100% coverage of query (58.2 bits)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
26% identity, 96% coverage of query (58.2 bits)
4cmiA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (57.8 bits)
4cmgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (57.8 bits)
4cmaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (57.8 bits)
4cm6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (57.8 bits)
4cm5A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (57.8 bits)
8jfiC Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-hexanoyl-acp from helicobacter pylori
26% identity, 100% coverage of query (57.8 bits)
5jdcC Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
28% identity, 95% coverage of query (57.8 bits)
8jfgA / G2M827 Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-octanoyl-acp from helicobacter pylori (see paper)
25% identity, 100% coverage of query (57.4 bits)
Q2FZ53 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Staphylococcus aureus (see paper)
26% identity, 100% coverage of query (57.4 bits)
FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
26% identity, 100% coverage of query (57.4 bits)
6tbxC Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cmjA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cmcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cmbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cm4A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cm3A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4clxA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cloA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cldA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
4cl8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 95% coverage of query (56.6 bits)
3mcvA Structure of ptr1 from trypanosoma brucei in ternary complex with 2,4- diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+
27% identity, 95% coverage of query (56.6 bits)
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Lawrence Berkeley National Laboratory