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Searching for up to 100 curated homologs for PfGW456L13_877 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_877 (216 a.a.)

Found high-coverage hits (≥70%) to 32 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TcyL / b1918 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
tcyL / P0AFT2 cystine ABC transporter membrane subunit (EC 7.4.2.12) from Escherichia coli (strain K12) (see 3 papers)
TCYL_ECOLI / P0AFT2 L-cystine transport system permease protein TcyL from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.3.10 / P0AFT2 Inner membrane amino-acid ABC transporter permease protein YECS CysY aka B1918, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 4 papers)
    37% identity, 95% coverage of query (135 bits)

TC 3.A.1.3.25 / Q9CES5 Glutamine ABC transporter permease and substrate binding protein protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
    34% identity, 96% coverage of query (130 bits)

TC 3.A.1.3.12 / P73544 BgtB aka GLNH aka SLL1270, component of Arginine/lysine/histidine/glutamine porter (see paper)
    38% identity, 94% coverage of query (127 bits)

TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
    38% identity, 92% coverage of query (127 bits)

TC 3.A.1.3.16 / A1VZQ3 PEP1B, component of Uptake system for glutamate and aspartate from Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
    30% identity, 100% coverage of query (124 bits)

GLNM_BACSU / O34671 Probable glutamine ABC transporter permease protein GlnM from Bacillus subtilis (strain 168) (see paper)
    32% identity, 97% coverage of query (121 bits)

4ymtC / Q8RCC3 Crystal structure of an amino acid abc transporter complex with arginines (see paper)
    35% identity, 93% coverage of query (120 bits)

4ymwC Crystal structure of an amino acid abc transporter with histidines
    36% identity, 92% coverage of query (119 bits)

TCYB_BACSU / P42200 L-cystine transport system permease protein TcyB from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.3.14 / P42200 TcyB (YckJ), component of Uptake system for L-cystine from Bacillus subtilis (see 4 papers)
    32% identity, 96% coverage of query (117 bits)

Ac3H11_2554 ABC transporter for L-Histidine, permease component 1 from Acidovorax sp. GW101-3H11
    31% identity, 98% coverage of query (110 bits)

GlnP / b0810 L-glutamine ABC transporter membrane subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnP / P0AEQ6 L-glutamine ABC transporter membrane subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.3.2 / P0AEQ6 Glutamine transport system permease protein GlnP aka B0810, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
    33% identity, 96% coverage of query (108 bits)

BPHYT_RS24010 L-histidine ABC transporter, permease component 2 from Burkholderia phytofirmans PsJN
    37% identity, 97% coverage of query (107 bits)

AO356_00470 ABC transporter for D-Glucosamine, permease component 1 from Pseudomonas fluorescens FW300-N2C3
Pf6N2E2_2051 ABC transporter for D-Glucosamine Hydrochloride, permease component 1 from Pseudomonas fluorescens FW300-N2E2
    31% identity, 95% coverage of query (103 bits)

PP_3594 L-lysine and D-lysine ABC transporter, permease component 1 from Pseudomonas putida KT2440
    32% identity, 93% coverage of query (102 bits)

AO356_09910 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
    31% identity, 97% coverage of query (102 bits)

AO353_21720 ABC transporter for D-glucosamine, permease component 2 from Pseudomonas fluorescens FW300-N2E3
    30% identity, 95% coverage of query (99.4 bits)

ARTQ_BACSU / P54536 Arginine transport system permease protein ArtQ from Bacillus subtilis (strain 168) (see paper)
    31% identity, 94% coverage of query (99.4 bits)

TC 3.A.1.3.22 / Q9I403 Amino acid ABC transporter membrane protein, component of Amino acid transporter, AatJMQP. Probably transports L-glutamic acid, D-glutamine acid, L-glutamine and N-acetyl L-glutamic acid (Johnson et al. 2008). Very similar to 3.A.1.3.19 of P. putida from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    32% identity, 92% coverage of query (99.4 bits)

TC 3.A.1.3.6 / P35113 NocM aka ATU6025 aka AGR_PTI_65, component of Nopaline porter from Agrobacterium tumefaciens (see 3 papers)
    31% identity, 88% coverage of query (99.0 bits)

TC 3.A.1.3.23 / Q9HU29 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    30% identity, 95% coverage of query (98.2 bits)

YXEN_BACSU / P54953 Probable amino-acid permease protein YxeN from Bacillus subtilis (strain 168) (see paper)
    35% identity, 83% coverage of query (97.4 bits)

TC 3.A.1.3.18 / Q8YPM7 NatH, component of Acidic and neutral amino acid uptake transporter NatFGH/BgtA. BgtA is shared with BgtAB (see paper)
    36% identity, 83% coverage of query (97.4 bits)

GLNP_BACSU / O34606 Probable glutamine ABC transporter permease protein GlnP from Bacillus subtilis (strain 168) (see paper)
    33% identity, 95% coverage of query (96.7 bits)

TC 3.A.1.3.18 / Q8YPM8 NatG, component of Acidic and neutral amino acid uptake transporter NatFGH/BgtA. BgtA is shared with BgtAB (see paper)
    33% identity, 78% coverage of query (95.5 bits)

SMc00138 L-lysine ABC transporter, permease component 2 from Sinorhizobium meliloti 1021
    33% identity, 93% coverage of query (94.7 bits)

GLUC_CORGL / P48244 Glutamate transport system permease protein GluC; Glutamate uptake system protein GluC from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 3.A.1.3.9 / P48244 GluC aka CGL1952, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
    31% identity, 96% coverage of query (93.6 bits)

TC 3.A.1.3.8 / Q52814 AapM, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) from Rhizobium leguminosarum (biovar viciae) (see 2 papers)
aapM / CAA57935.1 general amino acid ABC type transporter from Rhizobium leguminosarum (see paper)
    32% identity, 92% coverage of query (93.2 bits)

YhdY / b3270 putative ABC transporter membrane subunit YhdY from Escherichia coli K-12 substr. MG1655 (see 5 papers)
    32% identity, 92% coverage of query (92.4 bits)

ARGU_CORGL / Q8NQU3 Arginine transport system permease protein ArgU from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    31% identity, 97% coverage of query (92.4 bits)

HISM_SALTY / P0A2I7 Histidine/lysine/arginine/ornithine transport system permease protein HisM from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
TC 3.A.1.3.1 / P0A2I7 Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
    31% identity, 91% coverage of query (92.4 bits)

Build an alignment

Build an alignment for PfGW456L13_877 and 30 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

ArtM / b0861 L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see paper)
ArtM / P0AE30 L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1) from Escherichia coli (strain K12) (see 2 papers)
ARTM_ECOLI / P0AE30 Arginine ABC transporter permease protein ArtM from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P0AE30 Arginine transport system permease protein ArtM aka B0861, component of Arginine porter from Escherichia coli (see 6 papers)
    29% identity, 95% coverage of query (92.0 bits)

Pf6N2E2_5404 ABC transporter for D-Alanine, permease component 1 from Pseudomonas fluorescens FW300-N2E2
    30% identity, 92% coverage of query (90.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory