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Searching for up to 100 curated homologs for RR42_RS00755 FitnessBrowser__Cup4G11:RR42_RS00755 (280 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pcaL / AAC38246.1 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Rhodococcus opacus (see paper)
    41% identity, 86% coverage of query (177 bits)

Q13KT2 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Paraburkholderia xenovorans (see 2 papers)
    39% identity, 91% coverage of query (176 bits)

2xuaH / Q13KT2 Crystal structure of the enol-lactonase from burkholderia xenovorans lb400 (see paper)
    39% identity, 91% coverage of query (176 bits)

catD / BAA75208.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see paper)
catD / BAC82535.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see 3 papers)
    36% identity, 93% coverage of query (172 bits)

Q0SH24 3-oxoadipate enol-lactonase (EC 3.1.1.24); 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) from Rhodococcus jostii (see paper)
    41% identity, 86% coverage of query (171 bits)

pcaD / Q88N36 subunit of 3-oxoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 5 papers)
Q88N36 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Pseudomonas putida (see paper)
    38% identity, 91% coverage of query (156 bits)

pcaD / AAF34270.1 beta-ketoadipate enol-lactone hydrolase from Agrobacterium tumefaciens (see 2 papers)
    35% identity, 91% coverage of query (153 bits)

AO353_17230 Beta-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas fluorescens FW300-N2E3
    34% identity, 91% coverage of query (149 bits)

pcaD / AAC37150.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 11 papers)
    31% identity, 89% coverage of query (141 bits)

catD / AAC46435.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 8 papers)
    30% identity, 90% coverage of query (139 bits)

6eb3B Structural and enzymatic characterization of an esterase from a metagenomic library
    34% identity, 93% coverage of query (119 bits)

6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
    34% identity, 93% coverage of query (116 bits)

6eb3C Structural and enzymatic characterization of an esterase from a metagenomic library
    34% identity, 93% coverage of query (115 bits)

Build an alignment

Build an alignment for RR42_RS00755 and 13 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

bioH / BAB39459.1 BioH from Kurthia sp. 538-KA26 (see paper)
    29% identity, 89% coverage of query (112 bits)

4uhfA / A0A0M3KKY6 Structural studies of a thermophilic esterase from thermogutta terrifontis (l37a mutant with butyrate bound) (see paper)
    30% identity, 90% coverage of query (99.0 bits)

4uheA Structural studies of a thermophilic esterase from thermogutta terrifontis (malate bound)
    30% identity, 90% coverage of query (99.0 bits)

4uhdA Structural studies of a thermophilic esterase from thermogutta terrifontis (acetate bound)
    30% identity, 90% coverage of query (99.0 bits)

O73957 carboxylesterase (EC 3.1.1.1) from Sulfolobus acidocaldarius (see paper)
    25% identity, 95% coverage of query (85.9 bits)

Q8KT44 carboxylesterase (EC 3.1.1.1) from Lacticaseibacillus casei (see paper)
    25% identity, 88% coverage of query (83.2 bits)

EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
    27% identity, 86% coverage of query (82.4 bits)

5h3hB / K0ACL0 Esterase (eaest) from exiguobacterium antarcticum (see paper)
    25% identity, 88% coverage of query (80.9 bits)

G3KFX4 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas sp. (see paper)
    30% identity, 88% coverage of query (76.6 bits)

flnE / BAC75995.1 meta cleavage compound hydrolase from Terrabacter sp. DBF63 (see paper)
    28% identity, 88% coverage of query (75.9 bits)

lnmJ / Q8GGP2 leinamycin polyketide synthase LnmJ from Streptomyces atroolivaceus (see 5 papers)
    30% identity, 90% coverage of query (74.7 bits)

nahN / BAE92169.1 2-hydroxymuconic semialdehyde hydrolase NahN from Pseudomonas putida (see 2 papers)
    29% identity, 89% coverage of query (71.6 bits)

THAQ_BURTA / Q2T4P1 Polyketide synthase ThaQ from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CCUG 48851 / CIP 106301 / E264) (see paper)
    31% identity, 88% coverage of query (71.2 bits)

6brtA / A0A0D9Z3K8 F-box protein cth with hydrolase (see paper)
    27% identity, 88% coverage of query (71.2 bits)

D14_ORYSJ / Q10QA5 Strigolactone esterase D14; Protein DWARF 14; Protein DWARF 88; Protein HIGH-TILLERING DWARF 2; EC 3.1.-.- from Oryza sativa subsp. japonica (Rice) (see 11 papers)
    27% identity, 88% coverage of query (71.2 bits)

4ihaA Crystal structure of rice dwarf14 (d14) in complex with a gr24 hydrolysis intermediate
    27% identity, 88% coverage of query (71.2 bits)

3heaA The l29p/l124i mutation of pseudomonas fluorescens esterase
    25% identity, 87% coverage of query (71.2 bits)

5zhtA Crystal structure of osd14 in complex with covalently bound kk073
    27% identity, 88% coverage of query (71.2 bits)

5zhrA Crystal structure of osd14 in complex with covalently bound kk094
    27% identity, 88% coverage of query (71.2 bits)

5yz7A Crystal structure of osd14 in complex with d-ring-opened 7'-carba-4bd
    27% identity, 88% coverage of query (71.2 bits)

6ap8A Crystal structure of rice d14 bound to 2-(2-methyl-3-nitroanilino) benzoic acid
    27% identity, 88% coverage of query (71.2 bits)

5zhsA Crystal structure of osd14 in complex with covalently bound kk052
    27% identity, 88% coverage of query (71.2 bits)

5dj5A Crystal structure of rice dwarf14 in complex with synthetic strigolactone gr24
    27% identity, 88% coverage of query (71.2 bits)

3hi4A Switching catalysis from hydrolysis to perhydrolysis in p. Fluorescens esterase
    25% identity, 87% coverage of query (71.2 bits)

8pi1B / P22862 Bicyclic incypro pseudomonas fluorescens esterase (see paper)
    25% identity, 87% coverage of query (70.9 bits)

ESTE_PSEFL / P22862 Arylesterase; Aryl-ester hydrolase; Carboxylic acid perhydrolase; PFE; Putative bromoperoxidase; EC 3.1.1.2; EC 1.-.-.- from Pseudomonas fluorescens (see 8 papers)
GI|951089 arylesterase; EC 1.-.-.-; EC 3.1.1.2 from Pseudomonas fluorescens (see 3 papers)
AAB60168.1 esterase from Pseudomonas fluorescens (see 2 papers)
    25% identity, 87% coverage of query (70.9 bits)

bphD / BAM76235.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Janibacter sp. TYM3221 (see paper)
    30% identity, 87% coverage of query (70.9 bits)

3ia2A Pseudomonas fluorescens esterase complexed to the r-enantiomer of a sulfonate transition state analog
    25% identity, 87% coverage of query (70.9 bits)

2d0dA Crystal structure of a meta-cleavage product hydrolase (cumd) a129v mutant
    27% identity, 88% coverage of query (70.1 bits)

aamsh1 / Q988D4 2-(acetamidomethylene)succinate hydrolase monomer (EC 3.5.1.29) from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (see 7 papers)
AAMHY_RHILO / Q988D4 2-(acetamidomethylene)succinate hydrolase; alpha-(N-acetylaminomethylene)succinic acid amidohydrolase; AAMS amidohydrolase; EC 3.5.1.29 from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099)) (see 2 papers)
Q988D4 2-(acetamidomethylene)succinate hydrolase (EC 3.5.1.29) from Mesorhizobium loti (see 2 papers)
    28% identity, 75% coverage of query (69.7 bits)

dehH1 / Q01398 fluoroacetate dehalogenase monomer (EC 3.8.1.3) from Moraxella sp. (strain B) (see 2 papers)
dehH1 / RF|NP_904256.1 haloacetate dehalogenase H-1; EC 3.8.1.3 from Moraxella sp. B (see paper)
dehH1 / BAB85585.1 haloacetate dehalogenase H-1 from Delftia acidovorans (see 3 papers)
dehH1 / BAC81979.1 haloacetate dehalogenase H-1 from Delftia acidovorans (see 3 papers)
    26% identity, 78% coverage of query (69.3 bits)

BPOC_MYCTU / P9WNH1 Putative non-heme bromoperoxidase BpoC from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    28% identity, 90% coverage of query (69.3 bits)

5fp0A Ligand complex structure of soluble epoxide hydrolase
    23% identity, 91% coverage of query (69.3 bits)

bpdF / AAB17100.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus sp. M5 (see paper)
    27% identity, 92% coverage of query (68.9 bits)

P96965 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas fluorescens (see 2 papers)
cumD / BAA12150.1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase from Pseudomonas fluorescens (see paper)
    27% identity, 88% coverage of query (68.2 bits)

xylF / P23106 2-hydroxymuconic semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas putida (see paper)
XYLF_PSEPU / P23106 2-hydroxymuconate semialdehyde hydrolase; HMSH; 2-hydroxymuconic semialdehyde hydrolase; EC 3.7.1.9 from Pseudomonas putida (Arthrobacter siderocapsulatus)
    28% identity, 77% coverage of query (67.4 bits)

5aljA / P34913 Ligand complex structure of soluble epoxide hydrolase (see paper)
    23% identity, 91% coverage of query (67.4 bits)

5z7wB / A0A0M4AV81 Crystal structure of striga hermonthica htl1 (shhtl1) (see paper)
    24% identity, 87% coverage of query (66.6 bits)

1iunB / P96965 Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant hexagonal (see paper)
    27% identity, 88% coverage of query (66.6 bits)

HYES_RAT / P80299 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Rattus norvegicus (Rat) (see 3 papers)
P80299 soluble epoxide hydrolase (EC 3.3.2.10) from Rattus norvegicus (see 11 papers)
    26% identity, 90% coverage of query (66.6 bits)

7a7gA Soluble epoxide hydrolase in complex with tk90
    23% identity, 91% coverage of query (66.6 bits)

1ukaA Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with (s)-2-methylbutyrate
    27% identity, 88% coverage of query (66.6 bits)

1uk9A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with isovalerate
    27% identity, 88% coverage of query (66.6 bits)

1uk8A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-valerate
    27% identity, 88% coverage of query (66.6 bits)

1uk7A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-butyrate
    27% identity, 88% coverage of query (66.6 bits)

1iupA Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant complexed with isobutyrates
    27% identity, 88% coverage of query (66.6 bits)

dnrP / Q54809 rhodomycinone D methyl-esterase from Streptomyces peucetius (see 3 papers)
    29% identity, 81% coverage of query (65.9 bits)

dauP / Q55217 rhodomycinone D methylesterase from Streptomyces sp. (strain C5) (see 2 papers)
DNRP_STRS5 / Q55217 Rhodomycin D methylesterase DauP; 10-carbomethoxy-13-deoxycarminomycin esterase; 4-O-methylrhodomycin D methylesterase; EC 3.1.1.- from Streptomyces sp. (strain C5) (see paper)
    29% identity, 81% coverage of query (65.5 bits)

5am2A Ligand complex structure of soluble epoxide hydrolase
    23% identity, 91% coverage of query (65.5 bits)

5alvA Ligand complex structure of soluble epoxide hydrolase
    23% identity, 91% coverage of query (65.5 bits)

2ociA Crystal structure of valacyclovir hydrolase complexed with a product analogue
    26% identity, 92% coverage of query (65.1 bits)

2ocgA / Q86WA6 Crystal structure of human valacyclovir hydrolase (see paper)
    26% identity, 92% coverage of query (65.1 bits)

BPHL_HUMAN / Q86WA6 Valacyclovir hydrolase; VACVase; Valacyclovirase; Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA; EC 3.1.-.- from Homo sapiens (Human) (see 2 papers)
    26% identity, 92% coverage of query (65.1 bits)

BIOH_SERMA / Q8GHL1 Pimeloyl-[acyl-carrier protein] methyl ester esterase; Biotin synthesis protein BioH; Carboxylesterase BioH; EC 3.1.1.85 from Serratia marcescens (see paper)
    24% identity, 85% coverage of query (64.7 bits)

1cr6B / P34914 Crystal structure of murine soluble epoxide hydrolase complexed with cpu inhibitor (see paper)
    24% identity, 90% coverage of query (64.7 bits)

HYES_MOUSE / P34914 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Mus musculus (Mouse) (see 6 papers)
P34914 soluble epoxide hydrolase (EC 3.3.2.10) from Mus musculus (see 31 papers)
    24% identity, 90% coverage of query (64.7 bits)

AGH13449.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
    23% identity, 93% coverage of query (64.7 bits)

1ek1A Crystal structure of murine soluble epoxide hydrolase complexed with ciu inhibitor
    24% identity, 90% coverage of query (64.7 bits)

1ek2A Crystal structure of murine soluble epoxide hydrolase complexed with cdu inhibitor
    24% identity, 90% coverage of query (64.7 bits)

5akkA Ligand complex structure of soluble epoxide hydrolase
    23% identity, 91% coverage of query (64.7 bits)

BPHD_PARXL / P47229 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Paraburkholderia xenovorans (strain LB400) (see 2 papers)
P47229 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Paraburkholderia xenovorans (see 2 papers)
BphD / CAA46911.1 2-hydroxy-6-oxo-6-phenylhexa-2, 4-dienoate hydrolase from Pseudomonas sp (see paper)
    24% identity, 97% coverage of query (64.3 bits)

4haiA / P34913 Crystal structure of human soluble epoxide hydrolase complexed with n- cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide. (see paper)
    22% identity, 91% coverage of query (64.3 bits)

HYES_HUMAN / P34913 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Homo sapiens (Human) (see 12 papers)
P34913 2-lysophosphatidate phosphatase (EC 3.1.3.106); soluble epoxide hydrolase (EC 3.3.2.10) from Homo sapiens (see 47 papers)
    22% identity, 91% coverage of query (64.3 bits)

6yl4A Soluble epoxide hydrolase in complex with 3-((r)-3-(1-hydroxyureido) but-1-yn-1-yl)-n-((s)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl) benzamide
    22% identity, 91% coverage of query (64.3 bits)

6hgxA Soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl) morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea
    22% identity, 91% coverage of query (64.3 bits)

6hgwA Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-n-(4- phenoxybenzyl)ethanamine
    22% identity, 91% coverage of query (64.3 bits)

6hgvA Soluble epoxide hydrolase in complex with talinolol
    22% identity, 91% coverage of query (64.3 bits)

6fr2A Soluble epoxide hydrolase in complex with lk864
    22% identity, 91% coverage of query (64.3 bits)

3pdcA Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor
    22% identity, 91% coverage of query (64.3 bits)

8qn0A Soluble epoxide hydrolase in complex with rk3
    22% identity, 91% coverage of query (64.3 bits)

7ebaA Co-crystal of kurarinone with seh
    22% identity, 91% coverage of query (64.3 bits)

5ak6A Ligand complex structure of soluble epoxide hydrolase
    22% identity, 91% coverage of query (64.3 bits)

8qmzA Soluble epoxide hydrolase in complex with rk4
    22% identity, 91% coverage of query (64.3 bits)

4c4zA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with a8
    22% identity, 91% coverage of query (64.3 bits)

5akiA Ligand complex structure of soluble epoxide hydrolase
    22% identity, 91% coverage of query (64.3 bits)

4oczA Crystal structure of human soluble epoxide hydrolase complexed with 1- (1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
    22% identity, 91% coverage of query (64.3 bits)

4j03A Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant
    22% identity, 91% coverage of query (64.3 bits)

6aumA Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.
    22% identity, 91% coverage of query (64.3 bits)

5aibA Ligand complex structure of soluble epoxide hydrolase
    22% identity, 91% coverage of query (64.3 bits)

1zd5A Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex
    22% identity, 91% coverage of query (64.3 bits)

1zd4A Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex
    22% identity, 91% coverage of query (64.3 bits)

1zd3A Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-butyric acid complex
    22% identity, 91% coverage of query (64.3 bits)

1zd2P Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex
    22% identity, 91% coverage of query (64.3 bits)

1vj5A Human soluble epoxide hydrolase- n-cyclohexyl-n'-(4-iodophenyl)urea complex
    22% identity, 91% coverage of query (64.3 bits)

TGND_ACIAD / Q6F9F4 (E)-2-((N-methylformamido)methylene)succinate hydrolase; MFMS hydrolase; EC 3.5.1.- from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    24% identity, 88% coverage of query (63.9 bits)

3otqA Soluble epoxide hydrolase in complex with pyrazole antagonist
    22% identity, 91% coverage of query (63.9 bits)

3kooA Crystal structure of soluble epoxide hydrolase
    22% identity, 91% coverage of query (63.9 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory