Searching for up to 100 curated homologs for RR42_RS01370 FitnessBrowser__Cup4G11:RR42_RS01370 (276 a.a.)
Found high-coverage hits (≥70%) to 30 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
thiD / O31620 4-amino-2-methyl-5-phosphomethylpyrimidine kinase (EC 2.7.1.49; EC 2.7.4.7) from Bacillus subtilis (strain 168) (see paper)
THID_BACSU / O31620 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; EC 2.7.1.49; EC 2.7.4.7 from Bacillus subtilis (strain 168) (see paper)
49% identity, 94% coverage of query (223 bits)
THID_SALTY / P55882 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; EC 2.7.1.49; EC 2.7.4.7 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
P55882 hydroxymethylpyrimidine kinase (EC 2.7.1.49); phosphooxymethylpyrimidine kinase (EC 2.7.4.7) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
48% identity, 94% coverage of query (217 bits)
ThiJ / b2103 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase (EC 2.7.1.49; EC 2.7.4.7) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
thiD / P76422 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase (EC 2.7.1.49; EC 2.7.4.7) from Escherichia coli (strain K12) (see 7 papers)
THID_ECOLI / P76422 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; EC 2.7.1.49; EC 2.7.4.7 from Escherichia coli (strain K12) (see paper)
P76422 hydroxymethylpyrimidine kinase (EC 2.7.1.49); phosphooxymethylpyrimidine kinase (EC 2.7.4.7) from Escherichia coli (see 2 papers)
48% identity, 94% coverage of query (216 bits)
bcmD / A5HZW4 bacimethrin diphosphokinase from Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) (see paper)
42% identity, 95% coverage of query (214 bits)
Q2UVH9 thiamine phosphate synthase (EC 2.5.1.3) from Zea mays (see paper)
46% identity, 95% coverage of query (212 bits)
7r8yA Ancestral protein ancthen of phosphomethylpyrimidine kinases family
58% identity, 90% coverage of query (209 bits)
TH1 / Q5M731 4-amino-2-methyl-5-phosphomethylpyrimidine kinase (EC 2.7.1.49; EC 2.5.1.3; EC 2.7.4.7) from Arabidopsis thaliana (see 4 papers)
TPS1L_ARATH / Q5M731 Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic; EC 2.5.1.3; EC 2.7.1.49 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
46% identity, 97% coverage of query (208 bits)
1jxiA / P55882 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from salmonella typhimurium complexed with 4-amino-5-hydroxymethyl-2- methylpyrimidine (see paper)
45% identity, 94% coverage of query (201 bits)
AN10762 thiamin biosynthesis protein (Thi-4), putative (AFU_orthologue; AFUA_2G10740) from Emericella nidulans (see paper)
44% identity, 94% coverage of query (201 bits)
P66915 hydroxymethylpyrimidine kinase (EC 2.7.1.49); phosphooxymethylpyrimidine kinase (EC 2.7.4.7) from Staphylococcus aureus (see paper)
41% identity, 95% coverage of query (197 bits)
TPS1_BRANA / O48881 Thiamine biosynthetic bifunctional enzyme BTH1, chloroplastic; EC 2.5.1.3; EC 2.7.1.49 from Brassica napus (Rape) (see paper)
O48881 hydroxymethylpyrimidine kinase (EC 2.7.1.49); phosphooxymethylpyrimidine kinase (EC 2.7.4.7) from Brassica napus (see paper)
45% identity, 94% coverage of query (195 bits)
thiDN / A3MSR0 ThiDN monomer (EC 2.5.1.3; EC 2.7.4.7; EC 2.7.1.49) from Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) (see 5 papers)
A3MSR0 thiamine phosphate synthase (EC 2.5.1.3) from Pyrobaculum calidifontis (see paper)
46% identity, 93% coverage of query (187 bits)
7l07A Last common ancestor of hmppk and plk/hmppk vitamin kinases (see paper)
44% identity, 89% coverage of query (178 bits)
THI22_SCHPO / O94266 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Hydroxymethylpyrimidine kinase 2; HMP kinase 2; Hydroxymethylpyrimidine phosphate kinase 2; HMP-P kinase 2; HMP-phosphate kinase 2; HMPP kinase 2; EC 2.7.1.49; EC 2.7.4.7 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 94% coverage of query (178 bits)
D4GV38 hydroxymethylpyrimidine kinase (EC 2.7.1.49); phosphooxymethylpyrimidine kinase (EC 2.7.4.7) from Haloferax volcanii (see paper)
45% identity, 95% coverage of query (173 bits)
THI22_YEAST / Q06490 Thiamine biosynthesis protein THI22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
37% identity, 95% coverage of query (168 bits)
Q5SKG3 hydroxymethylpyrimidine kinase (EC 2.7.1.49); phosphooxymethylpyrimidine kinase (EC 2.7.4.7) from Thermus thermophilus (see paper)
56% identity, 93% coverage of query (167 bits)
2i5bA / P39610 The crystal structure of an adp complex of bacillus subtilis pyridoxal kinase provides evidence for the parralel emergence of enzyme activity during evolution (see paper)
40% identity, 94% coverage of query (166 bits)
PDXK_BACSU / P39610 Pyridoxine kinase; PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase; EC 2.7.1.35 from Bacillus subtilis (strain 168) (see 2 papers)
40% identity, 94% coverage of query (166 bits)
THI21_YEAST / Q08975 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; EC 2.7.1.49; EC 2.7.4.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
39% identity, 97% coverage of query (165 bits)
THID_MYCTU / P9WG77 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; EC 2.7.1.49; EC 2.7.4.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
48% identity, 95% coverage of query (162 bits)
THI20_YEAST / Q08224 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; EC 2.7.1.49; EC 2.7.4.7; EC 3.5.99.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Q08224 hydroxymethylpyrimidine kinase (EC 2.7.1.49); phosphooxymethylpyrimidine kinase (EC 2.7.4.7); aminopyrimidine aminohydrolase (EC 3.5.99.2) from Saccharomyces cerevisiae (see 3 papers)
38% identity, 95% coverage of query (159 bits)
THI21_SCHPO / O94265 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Hydroxymethylpyrimidine kinase 1; HMP kinase 1; Hydroxymethylpyrimidine phosphate kinase 1; HMP-P kinase 1; HMP-phosphate kinase 1; HMPP kinase 1; EC 2.7.1.49; EC 2.7.4.7 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 94% coverage of query (155 bits)
A0A0H3JTP0 pyridoxal kinase (EC 2.7.1.35); hydroxymethylpyrimidine kinase (EC 2.7.1.49) from Staphylococcus aureus (see paper)
39% identity, 96% coverage of query (153 bits)
4c5kD / A0A0H3JTP0 Structure of the pyridoxal kinase from staphylococcus aureus in complex with adp (see paper)
39% identity, 96% coverage of query (153 bits)
4c5mA Structure of the pyridoxal kinase from staphylococcus aureus in complex with amp-pcp
39% identity, 96% coverage of query (150 bits)
4c5lB Structure of the pyridoxal kinase from staphylococcus aureus in complex with pyridoxal
39% identity, 96% coverage of query (150 bits)
4c5lA Structure of the pyridoxal kinase from staphylococcus aureus in complex with pyridoxal
38% identity, 96% coverage of query (146 bits)
YJK5_SCHPO / Q9USL6 Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; EC 2.7.1.49; EC 2.7.4.7 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
32% identity, 88% coverage of query (133 bits)
4ywrA / A0A140UHE5 Structure of a putative phosphomethylpyrimidine kinase from acinetobacter baumannii in non-covalent complex with pyridoxal phosphate
37% identity, 84% coverage of query (121 bits)
Build an alignment for RR42_RS01370 and 30 homologs with ≥ 30% identity
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Lawrence Berkeley National Laboratory