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Searching for up to 100 curated homologs for RR42_RS04555 FitnessBrowser__Cup4G11:RR42_RS04555 (344 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
    50% identity, 100% coverage of query (335 bits)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
    49% identity, 100% coverage of query (333 bits)

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
    49% identity, 100% coverage of query (333 bits)

6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
    49% identity, 100% coverage of query (330 bits)

METN_BACSU / O32169 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.24.2 / O32169 MetN (C) (aka YusC), component of The L- and D-methionine porter (also transports methionine sulfoxide from Bacillus subtilis subsp. subtilis str. 168 (see 2 papers)
    48% identity, 100% coverage of query (326 bits)

TC 3.A.1.24.5 / Q9HT70 Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    51% identity, 98% coverage of query (313 bits)

TC 3.A.1.24.3 / Q8K8K8 AtmD (MetN), component of The methionine porter, AtmBDE from Streptococcus pyogenes serotype M3 (see 2 papers)
    43% identity, 98% coverage of query (284 bits)

TC 3.A.1.24.4 / Q8NSN2 Methionine import ATP-binding protein metN, component of L-Methionine uptake porter, MetQNI from Corynebacterium glutamicum (see paper)
    44% identity, 96% coverage of query (264 bits)

4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
    44% identity, 71% coverage of query (195 bits)

3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
    41% identity, 71% coverage of query (189 bits)

3c4jA Abc protein artp in complex with atp-gamma-s
    41% identity, 71% coverage of query (189 bits)

2olkA Abc protein artp in complex with adp-beta-s
    41% identity, 71% coverage of query (189 bits)

2oljA Abc protein artp in complex with adp/mg2+
    41% identity, 71% coverage of query (189 bits)

SMc02121 ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component from Sinorhizobium meliloti 1021
    38% identity, 71% coverage of query (184 bits)

GLUA_CORGL / P48243 Glutamate transport ATP-binding protein GluA; Glutamate uptake system protein GluA; EC 7.4.2.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 3.A.1.3.9 / P48243 GluA aka CGL1950, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
    40% identity, 72% coverage of query (183 bits)

TC 3.A.1.3.16 / A3ZI83 PEB1C, component of Uptake system for glutamate and aspartate from Campylobacter jejuni subsp. jejuni 84-25
    39% identity, 71% coverage of query (183 bits)

YhdZ / b3271 putative ABC transporter ATP-binding subunit YhdZ from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yhdZ / RF|NP_417737 uncharacterized amino-acid ABC transporter ATP-binding protein yhdZ from Escherichia coli K12 (see 3 papers)
    39% identity, 71% coverage of query (178 bits)

GLNQ_BACSU / O34677 Glutamine transport ATP-binding protein GlnQ; EC 7.4.2.- from Bacillus subtilis (strain 168) (see paper)
    39% identity, 71% coverage of query (177 bits)

Pf6N2E2_5405 ABC transporter for D-Alanine, ATPase component from Pseudomonas fluorescens FW300-N2E2
    37% identity, 71% coverage of query (177 bits)

PP_3597 L-lysine and D-lysine ABC transporter, ATPase component from Pseudomonas putida KT2440
    40% identity, 71% coverage of query (174 bits)

2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
    35% identity, 70% coverage of query (157 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    36% identity, 70% coverage of query (150 bits)

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    32% identity, 71% coverage of query (141 bits)

sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    35% identity, 72% coverage of query (136 bits)

MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
    32% identity, 73% coverage of query (132 bits)

1q12A Crystal structure of the atp-bound e. Coli malk
    32% identity, 73% coverage of query (132 bits)

3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
    32% identity, 73% coverage of query (132 bits)

3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
    32% identity, 73% coverage of query (132 bits)

3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
    32% identity, 73% coverage of query (132 bits)

3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
    32% identity, 73% coverage of query (132 bits)

2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    32% identity, 73% coverage of query (132 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    31% identity, 70% coverage of query (132 bits)

MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    31% identity, 74% coverage of query (128 bits)

7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
    32% identity, 72% coverage of query (120 bits)

7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
    32% identity, 71% coverage of query (119 bits)

7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
    32% identity, 71% coverage of query (118 bits)

7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
    31% identity, 74% coverage of query (112 bits)

Build an alignment

Build an alignment for RR42_RS04555 and 37 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

SapD / b1291 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
SapD / P0AAH4 putrescine ABC exporter ATP binding protein SapD (EC 7.6.2.16) from Escherichia coli (strain K12) (see 5 papers)
SAPD_ECOLI / P0AAH4 Putrescine export system ATP-binding protein SapD from Escherichia coli (strain K12) (see 2 papers)
    29% identity, 70% coverage of query (112 bits)

RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
    28% identity, 73% coverage of query (102 bits)

6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
    30% identity, 74% coverage of query (100 bits)

3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    30% identity, 74% coverage of query (100 bits)

3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
    30% identity, 74% coverage of query (100 bits)

ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
    27% identity, 83% coverage of query (99.8 bits)

7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
    31% identity, 74% coverage of query (98.6 bits)

7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
    31% identity, 74% coverage of query (98.6 bits)

7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
    31% identity, 74% coverage of query (98.6 bits)

CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
    26% identity, 71% coverage of query (93.6 bits)

7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
    28% identity, 74% coverage of query (91.3 bits)

8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
    29% identity, 70% coverage of query (88.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory