Searching for up to 100 curated homologs for RR42_RS05150 FitnessBrowser__Cup4G11:RR42_RS05150 (312 a.a.)

Found high-coverage hits (≥70%) to 27 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

lra6 / Q1NEI7 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Sphingomonas sp. (strain SKA58) (see paper)
    42% identity, 80% coverage of query (182 bits)

8gsrA / Q1NEI7 Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
    42% identity, 80% coverage of query (181 bits)

SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase from Sinorhizobium meliloti 1021
    39% identity, 80% coverage of query (181 bits)

8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form)
    42% identity, 80% coverage of query (181 bits)

UGL_BURL3 / Q39BA7 Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3 from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) (see paper)
    41% identity, 78% coverage of query (175 bits)

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
    40% identity, 77% coverage of query (174 bits)

C785_RS20550 / A0A2E7P912 5-hydroxy-2,4-dioxopentanoate hydrolase (EC 3.7.1.26) from Herbaspirillum sp. (see paper)
    40% identity, 77% coverage of query (172 bits)

8skyB / A0A0D6X359 Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
    36% identity, 97% coverage of query (171 bits)

8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
    36% identity, 97% coverage of query (168 bits)

YISK_BACSU / O06724 Uncharacterized protein YisK from Bacillus subtilis (strain 168) (see paper)
    36% identity, 96% coverage of query (167 bits)

6v77B / A0QTY3 Crystal structure of a putative hpce protein from mycobacterium smegmatis
    37% identity, 92% coverage of query (151 bits)

dntG / Q8VUC7 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate isomerase from Burkholderia cepacia (see 2 papers)
    33% identity, 97% coverage of query (147 bits)

Y2993_MYCTU / I6Y276 Protein Rv2993c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    36% identity, 84% coverage of query (147 bits)

G2IPX5 maleylpyruvate hydrolase (EC 3.7.1.23) from Sphingobium sp. SYK-6 (see paper)
    35% identity, 84% coverage of query (126 bits)

6j5xA / Q8NLC0 Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
    33% identity, 82% coverage of query (115 bits)

A0A1R4GQY2 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Corynebacterium glutamicum (see paper)
    33% identity, 82% coverage of query (115 bits)

6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate
    33% identity, 82% coverage of query (115 bits)

6jvwB / G2IPX5 Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
    33% identity, 84% coverage of query (114 bits)

3r6oA / B1MJ53 Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
    30% identity, 85% coverage of query (114 bits)

3v77A / D2YW46 Crystal structure of a putative fumarylacetoacetate isomerase/hydrolase from oleispira antarctica (see paper)
    31% identity, 70% coverage of query (103 bits)

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Build an alignment for RR42_RS05150 and 20 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

xacE / D4GP28 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43; EC 4.2.1.141) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
KDXD_HALVD / D4GP28 Probable 2-keto-3-deoxyxylonate dehydratase; KDXD; EC 4.2.1.141 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
    27% identity, 97% coverage of query (71.6 bits)

FAAA_RAT / P25093 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Rattus norvegicus (Rat) (see paper)
    24% identity, 83% coverage of query (59.7 bits)

1hyoB / P35505 Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid (see paper)
    25% identity, 84% coverage of query (58.9 bits)

FAAA_MOUSE / P35505 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) (see 3 papers)
P35505 fumarylacetoacetase (EC 3.7.1.2) from Mus musculus (see 2 papers)
    25% identity, 84% coverage of query (58.9 bits)

2hzyA Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate
    25% identity, 84% coverage of query (58.9 bits)

1qcoA Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate
    25% identity, 84% coverage of query (58.9 bits)

Q4J7I6 2-dehydro-3-deoxy-D-arabinonate dehydratase (EC 4.2.1.141) from Sulfolobus acidocaldarius (see paper)
    24% identity, 84% coverage of query (54.7 bits)

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