Searching for up to 100 curated homologs for RR42_RS06400 FitnessBrowser__Cup4G11:RR42_RS06400 (546 a.a.)
Found high-coverage hits (≥70%) to 23 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Pf6N2E2_5849 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N2E2
69% identity, 94% coverage of query (716 bits)
Pf1N1B4_3673 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N1B4
69% identity, 94% coverage of query (714 bits)
PS417_08865 large component of pyruvate transporter (actP-like) from Pseudomonas simiae WCS417
68% identity, 94% coverage of query (706 bits)
YjcG / b4067 acetate/glycolate:cation symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
actP / P32705 acetate/glycolate:cation symporter from Escherichia coli (strain K12) (see 5 papers)
ACTP_ECOLI / P32705 Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.21.7.2 / P32705 Acetate/glyoxylate permease, ActP from Escherichia coli (see 6 papers)
66% identity, 100% coverage of query (700 bits)
TC 2.A.21.7.1 / O50471 Phenylacetate permease, Ppa from Pseudomonas putida (see paper)
64% identity, 94% coverage of query (649 bits)
AZOBR_RS02940 large component of pyruvate transporter (actP-like) from Azospirillum brasilense Sp245
59% identity, 94% coverage of query (618 bits)
TC 2.A.21.7.5 / D5APM1 Acetate permease ActP-2/ActP2/ActP3 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
58% identity, 96% coverage of query (609 bits)
TC 2.A.21.7.4 / D5AU53 Acetate uptake permease, ActP1; also takes up tellurite from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
60% identity, 95% coverage of query (591 bits)
MCTC_CORGL / Q8NS49 Monocarboxylic acid transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 2.A.21.7.3 / Q8NS49 Pyruvate/acetate/propionate: H+ symporter, MctC (DhlC; cg0953) from Corynebacterium glutamicum (see paper)
43% identity, 89% coverage of query (352 bits)
Build an alignment for RR42_RS06400 and 9 homologs with ≥ 30% identity
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OPUE_BACSU / O06493 Osmoregulated proline transporter OpuE; Osmoprotectant uptake; Proline uptake system from Bacillus subtilis (strain 168) (see 2 papers)
TC 2.A.21.2.5 / M1TZ79 Proline uptake porter, OpuE (YerK) from Bacillus subtilis subsp. subtilis 6051-HGW
opuE / AAB72182.1 OpuE from Bacillus subtilis (see paper)
26% identity, 90% coverage of query (115 bits)
TC 2.A.21.2.3 / Q9I5F5 L-proline uptake porter, PutP from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
28% identity, 80% coverage of query (110 bits)
Psest_3078 L-proline:Na+ symporter from Pseudomonas stutzeri RCH2
27% identity, 80% coverage of query (103 bits)
PUTP_BACSU / P94392 High-affinity proline transporter PutP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.21.2.4 / J7JIE8 The high affinity nutritional proline uptake porter, PutP from Bacillus subtilis QB928
25% identity, 77% coverage of query (99.8 bits)
PutC / b1015 proline:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 7 papers)
putP / P07117 proline:Na+ symporter from Escherichia coli (strain K12) (see 12 papers)
PUTP_ECOLI / P07117 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) (see 9 papers)
TC 2.A.21.2.1 / P07117 Proline:Na+ symporter, PutP from Escherichia coli (see 12 papers)
29% identity, 80% coverage of query (97.1 bits)
PUTP_STAA8 / Q2FWY7 Sodium/proline symporter; Proline permease from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
TC 2.A.21.2.2 / Q7A4Q7 Sodium/proline symporter (Proline permease) from Staphylococcus aureus (strain N315) (see paper)
26% identity, 88% coverage of query (95.9 bits)
putP / AAA79365.1 proline permease homolog from Staphylococcus aureus (see paper)
26% identity, 79% coverage of query (95.5 bits)
PUTP_SALTY / P10502 Sodium/proline symporter; Proline permease from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
28% identity, 90% coverage of query (94.0 bits)
TC 2.A.21.2.6 / O24896 High affinity proline-specific Na+:proline symporter, PutP (Rivera-Ordaz et al. 2013). Proline is a preferred source of energy for this microaerophilic bacterium. PutP is efficiently inhibited by the proline analogs, 3,4-dehydro-D,L-proline and L-azetidine-2-carboxylic acid from Helicobacter pylori (strain ATCC 700392 / 26695)
24% identity, 92% coverage of query (84.7 bits)
NANT_ALIF1 / Q5E733 N-acetylneuraminate transporter from Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri) (see paper)
22% identity, 70% coverage of query (70.9 bits)
SGLT_VIBPH / P96169 Sodium/glucose cotransporter; Na(+)/glucose symporter from Vibrio parahaemolyticus (see paper)
TC 2.A.21.3.2 / P96169 Glucose or galactose:Na+ symporter, SglS or SglT of 543 aas and 14 TMSs (Turk et al. 2006). The 3.0 Å structure is known (Faham et al., 2008). Sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required for substrate exit (Watanabe et al., 2010). The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined (see 3 papers)
AAF80602.1 Na+/galactose cotransporter SGLT from Vibrio parahaemolyticus (see paper)
22% identity, 81% coverage of query (57.8 bits)
5nv9A / B4EZY7 Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site (see paper)
19% identity, 71% coverage of query (52.4 bits)
MCTP_RHIJ3 / Q1M7A2 Monocarboxylate transport permease protein from Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium leguminosarum bv. viciae) (see paper)
21% identity, 81% coverage of query (50.1 bits)
TC 2.A.21.4.1 / Q8VM88 The monocarboxylate uptake (H+ symport?) permease, MctP (transports lactate (Km = 4.4 μM), pyruvate (Km = 3.8), propionate, butyrate (butanoic acid), α-hydroxybutyrate, L- and D-alanine (Km = 0.5 mM), and possibly cysteine and histidine) from Rhizobium leguminosarum (biovar viciae) (see paper)
mctP / CAD19128.1 monocarboxylic acid permease from Rhizobium leguminosarum bv. viciae (see paper)
21% identity, 81% coverage of query (47.8 bits)
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Lawrence Berkeley National Laboratory