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Searching for up to 100 curated homologs for RR42_RS10975 FitnessBrowser__Cup4G11:RR42_RS10975 (443 a.a.)

Found high-coverage hits (≥70%) to 44 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

NICT_PSEPK / Q88FY6 Putative metabolite transport protein NicT; Nicotinate degradation protein T from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    49% identity, 97% coverage of query (421 bits)

TC 2.A.1.14.8 / Q9RPP3 Phthalate porter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    42% identity, 93% coverage of query (343 bits)

ABAQ_ACIBT / P0DPR4 Quinolone resistance transporter from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see 2 papers)
    39% identity, 96% coverage of query (316 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    37% identity, 92% coverage of query (265 bits)

PS417_07265 2-deoxy-D-ribonate transporter 1 from Pseudomonas simiae WCS417
    36% identity, 89% coverage of query (253 bits)

YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
    38% identity, 90% coverage of query (252 bits)

BPHYT_RS04765 2-deoxy-D-ribonate transporter from Burkholderia phytofirmans PsJN
    35% identity, 91% coverage of query (233 bits)

H281DRAFT_00642 2-deoxy-D-ribonate transporter from Paraburkholderia bryophila 376MFSha3.1
    34% identity, 96% coverage of query (231 bits)

Build an alignment

Build an alignment for RR42_RS10975 and 8 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

CH_124132 transporter of Nicotinic Acid from Magnaporthe grisea 70-15 (see paper)
    29% identity, 87% coverage of query (169 bits)

CH_124319 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 88% coverage of query (160 bits)

CH_124128 MFS transporter from Magnaporthe grisea 70-15 (see paper)
    30% identity, 73% coverage of query (157 bits)

orf19.3232 putative transporter from Candida albicans (see paper)
    27% identity, 88% coverage of query (155 bits)

CH_124317 phthalate transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 89% coverage of query (147 bits)

CH_124318 MFS transporter from Magnaporthe grisea 70-15 (see 2 papers)
    27% identity, 89% coverage of query (144 bits)

CH_124029 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see paper)
    27% identity, 91% coverage of query (144 bits)

CH_124204 putative monocarboxylate exporter from Magnaporthe grisea 70-15 (see paper)
    28% identity, 88% coverage of query (143 bits)

TNA1 putative nicotinic acid transporter from Candida albicans (see paper)
    26% identity, 81% coverage of query (137 bits)

YIZG_SCHPO / Q9US44 Uncharacterized transporter C1002.16c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    28% identity, 85% coverage of query (134 bits)

YHDC_SCHPO / Q9P6J0 Uncharacterized transporter C1683.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    23% identity, 88% coverage of query (130 bits)

CNSO_PENEN / A0A0A2IBP6 MFS-type transporter cnsO; Communesin biosynthesis cluster protein O from Penicillium expansum (Blue mold rot fungus) (see paper)
    27% identity, 76% coverage of query (120 bits)

orf19.2397.3 putative uncharacterized protein VHT1 from Candida albicans (see paper)
    22% identity, 99% coverage of query (108 bits)

HXNP_EMENI / C8VJW1 Major facilitator-type transporter hxnP; Nicotinate catabolism cluster protein hxnP from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
    27% identity, 87% coverage of query (107 bits)

YFZ4_SCHPO / Q9US37 Uncharacterized transporter C1039.04 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    27% identity, 87% coverage of query (107 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    24% identity, 90% coverage of query (106 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    24% identity, 91% coverage of query (95.9 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    24% identity, 91% coverage of query (95.9 bits)

CH_124323 high-affinity nicotinic acid transporter from Magnaporthe grisea 70-15 (see 2 papers)
    24% identity, 75% coverage of query (94.0 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    24% identity, 88% coverage of query (87.0 bits)

ANTR6_ARATH / Q3E9A0 Probable anion transporter 6, chloroplastic; Phosphate transporter PHT4;5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    24% identity, 90% coverage of query (82.0 bits)

TC 2.A.1.14.26 / F2YPN7 The plasma membrane Lethal (2)01810 glutamate uptake porter (Km=0.07μM) (Inhibited by aspartate) from Drosophila melanogaster
    25% identity, 79% coverage of query (80.1 bits)

LgoT / b4356 galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lgoT / P39398 galactonate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
LGOT_ECOLI / P39398 Probable L-galactonate transporter; Galactonate:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
yjjL / RF|NP_418776 inner membrane transport protein yjjL from Escherichia coli K12 (see 2 papers)
    22% identity, 90% coverage of query (79.7 bits)

GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
    22% identity, 88% coverage of query (79.3 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    24% identity, 90% coverage of query (77.4 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    24% identity, 91% coverage of query (76.6 bits)

ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    24% identity, 75% coverage of query (75.1 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    23% identity, 89% coverage of query (72.4 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    23% identity, 85% coverage of query (71.6 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    23% identity, 85% coverage of query (67.0 bits)

VGLU2_RAT / Q9JI12 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Rattus norvegicus (Rat) (see 10 papers)
TC 2.A.1.14.16 / Q9JI12 The broad specificity brain synaptic vesicle anion transporter (transports glutamate in a Δψ-dependent fashion requiring Cl- but phosphate by a Na+-dependent mechanism via a different pathway/mechanism from Rattus norvegicus (see 8 papers)
    23% identity, 87% coverage of query (64.7 bits)

7t3nA / Q9JI12 R184q/e191q mutant of rat vesicular glutamate transporter 2 (vglut2)
    23% identity, 87% coverage of query (62.4 bits)

S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
    22% identity, 81% coverage of query (56.6 bits)

S17A5_MOUSE / Q8BN82 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Mus musculus (Mouse) (see 3 papers)
    23% identity, 77% coverage of query (52.0 bits)

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans
    23% identity, 80% coverage of query (48.9 bits)

S17A5_RAT / Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
    22% identity, 77% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory