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Searching for up to 100 curated homologs for RR42_RS14625 FitnessBrowser__Cup4G11:RR42_RS14625 (312 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HUTGL_PSEAE / Q9HZ59 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; EC 3.5.3.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    51% identity, 100% coverage of query (268 bits)

BWI76_RS08725 Formiminoglutamase (EC 3.5.3.8) from Klebsiella michiganensis M5al
    48% identity, 98% coverage of query (235 bits)

4mynA / Q4DSA0 Crystal structure of trypanosoma cruzi formiminoglutamase n114h variant with mn2+2 (see paper)
    31% identity, 94% coverage of query (103 bits)

Q4DSA0 formimidoylglutamase (EC 3.5.3.8) from Trypanosoma cruzi (see paper)
    32% identity, 88% coverage of query (101 bits)

Build an alignment

Build an alignment for RR42_RS14625 and 4 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

3m1rD / P42068 The crystal structure of formimidoylglutamase from bacillus subtilis subsp. Subtilis str. 168
    24% identity, 92% coverage of query (76.6 bits)

HUTG_BACSU / P42068 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; EC 3.5.3.8 from Bacillus subtilis (strain 168) (see paper)
    24% identity, 92% coverage of query (76.6 bits)

speB / P70999 agmatinase (EC 3.5.3.11) from Bacillus subtilis (strain 168) (see paper)
    28% identity, 87% coverage of query (71.2 bits)

3lhlA / Q18A84 Crystal structure of a putative agmatinase from clostridium difficile
    24% identity, 82% coverage of query (70.1 bits)

AGMAT / Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
GDAH_HUMAN / Q9BSE5 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Homo sapiens (Human) (see 3 papers)
Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
    26% identity, 82% coverage of query (68.2 bits)

A0A146AXJ2 agmatinase (EC 3.5.3.11) from Apostichopus japonicus (see paper)
    25% identity, 95% coverage of query (67.4 bits)

3pzlB / Q97BB8 The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
    26% identity, 80% coverage of query (67.0 bits)

W5PHZ9 agmatinase (EC 3.5.3.11) from Ovis aries (see 2 papers)
    26% identity, 82% coverage of query (67.0 bits)

6dktA Crystal structure of arginase from bacillus subtilis
    26% identity, 82% coverage of query (66.2 bits)

6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    26% identity, 82% coverage of query (65.5 bits)

6dktE / P39138 Crystal structure of arginase from bacillus subtilis
    25% identity, 82% coverage of query (64.7 bits)

7esrA / P73270 Crystal structure of synechocystis sp pcc6803 guanidinium hydrolase (r32) (see paper)
    25% identity, 82% coverage of query (64.3 bits)

gdmH / P73270 Ni2+-dependent guanidine hydrolase monomer from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    25% identity, 82% coverage of query (64.3 bits)

3nioA / Q9I3S3 Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
    26% identity, 82% coverage of query (63.9 bits)

gbuA / Q9I3S3 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
GBUA_PSEAE / Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3S3 guanidinobutyrase (EC 3.5.3.7) from Pseudomonas aeruginosa (see paper)
    26% identity, 82% coverage of query (63.9 bits)

A4IJM8 arginase (EC 3.5.3.1) from Geobacillus thermodenitrificans (see paper)
    26% identity, 82% coverage of query (61.2 bits)

2ef5A / Q5SI78 Crystal structure of the arginase from thermus thermophilus
    29% identity, 74% coverage of query (61.2 bits)

ARGI_BACCD / P53608 Arginase; EC 3.5.3.1 from Bacillus caldovelox (see paper)
P53608 arginase (EC 3.5.3.1) from [Bacillus] caldovelox (see paper)
1cevA / P53608 Arginase from bacillus caldovelox, native structure at ph 5.6 (see paper)
    26% identity, 76% coverage of query (61.2 bits)

5cevA Arginase from bacillus caldevelox, l-lysine complex
    26% identity, 76% coverage of query (61.2 bits)

4cevA Arginase from bacillus caldevelox, l-ornithine complex
    26% identity, 76% coverage of query (61.2 bits)

3cevA Arginase from bacillus caldevelox, complexed with l-arginine
    26% identity, 76% coverage of query (61.2 bits)

2cevB Arginase from bacillus caldevelox, native structure at ph 8.5
    26% identity, 76% coverage of query (61.2 bits)

1wogA / Q9RZ04 Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily (see paper)
    26% identity, 82% coverage of query (59.7 bits)

SPEB_PROMI / Q7X3P1 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Proteus mirabilis (see paper)
    25% identity, 82% coverage of query (59.7 bits)

Ac3H11_701 Arginase (EC 3.5.3.1) from Acidovorax sp. GW101-3H11
    26% identity, 81% coverage of query (58.2 bits)

1gq6B / P0DJQ3 Proclavaminate amidino hydrolase from streptomyces clavuligerus (see paper)
    28% identity, 87% coverage of query (58.2 bits)

gbuA / Q88EE2 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    23% identity, 82% coverage of query (57.8 bits)

pah / P0DJQ3 proclavaminate amidino hydrolase subunit (EC 3.5.3.22) from Streptomyces clavuligerus (see paper)
PAH_STRCL / P0DJQ3 Proclavaminate amidinohydrolase; Proclavaminic acid amidino hydrolase; EC 3.5.3.22 from Streptomyces clavuligerus (see paper)
    28% identity, 87% coverage of query (57.8 bits)

4q41A Crystal structure of schistosoma mansoni arginase in complex with l- lysine
    27% identity, 78% coverage of query (54.7 bits)

gbuA / A0A0A1DPD5 5-guanidino-2-oxopentanoate ureohydrolase (EC 3.5.3.7) from Nocardioides simplex (see paper)
    27% identity, 87% coverage of query (53.9 bits)

6nbkA / W8YSI5 Crystal structure of arginase from bacillus cereus
    25% identity, 82% coverage of query (53.9 bits)

Sama_3201 Formiminoglutamase (EC 3.5.3.8) from Shewanella amazonensis SB2B
    29% identity, 78% coverage of query (52.0 bits)

AGMT_PYRHO / O57839 Agmatinase; EC 3.5.3.11 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
    25% identity, 74% coverage of query (50.8 bits)

4q40A Crystal structure of schistosoma mansoni arginase in complex with l- valine
    27% identity, 78% coverage of query (50.8 bits)

4q3sA Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhpe
    27% identity, 78% coverage of query (50.8 bits)

4q3qA Crystal structure of schistosoma mansoni arginase in complex with inhibitor abh
    27% identity, 78% coverage of query (50.8 bits)

4q3uA Crystal structure of schistosoma mansoni arginase in complex with inhibitor nor-noha
    27% identity, 78% coverage of query (50.4 bits)

4q3tA Crystal structure of schistosoma mansoni arginase in complex with inhibitor noha
    27% identity, 78% coverage of query (50.4 bits)

4q42A Crystal structure of schistosoma mansoni arginase in complex with l- ornithine
    27% identity, 78% coverage of query (50.4 bits)

4q3rA Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhdp
    27% identity, 78% coverage of query (50.4 bits)

4q3vC / Q6WVP6 Crystal structure of schistosoma mansoni arginase in complex with inhibitor bec (see paper)
    27% identity, 78% coverage of query (50.1 bits)

CH_124010 agmatinase from Magnaporthe grisea 70-15 (see 3 papers)
    25% identity, 98% coverage of query (49.7 bits)

3nipB / Q9I6K2 Crystal structure of pseudomonas aeruginosa guanidinopropionase complexed with 1,6-diaminohexane (see paper)
    24% identity, 87% coverage of query (49.7 bits)

3niqA Crystal structure of pseudomonas aeruginosa guanidinopropionase
    24% identity, 87% coverage of query (49.7 bits)

GPUA_PSEAE / Q9I6K2 Guanidinopropionase; EC 3.5.3.17 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6K2 Guanidinopropionase (EC 3.5.3.17) from Pseudomonas aeruginosa (see paper)
    24% identity, 87% coverage of query (49.3 bits)

KlGBU1 / Q6CIB4 guanidinobutyrase (EC 3.5.3.7) from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (see paper)
GBU1_KLULA / Q6CIB4 Guanidinobutyrase; EC 3.5.3.7 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    24% identity, 82% coverage of query (48.9 bits)

B5XDG2 arginase (EC 3.5.3.1) from Salmo salar (see paper)
    25% identity, 75% coverage of query (48.9 bits)

7lolA The structure of agmatinase from e. Coli at 1.8 a displaying urea and agmatine
    25% identity, 77% coverage of query (43.9 bits)

SpeB / b2937 agmatinase (EC 3.5.3.11) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
speB / P60651 agmatinase (EC 3.5.3.11) from Escherichia coli (strain K12) (see 35 papers)
SPEB_ECOLI / P60651 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Escherichia coli (strain K12) (see 2 papers)
speB / RF|NP_417412 agmatinase; EC 3.5.3.11 from Escherichia coli K12 (see 7 papers)
    25% identity, 77% coverage of query (43.9 bits)

7lbaB / P60651 E. Coli agmatinase (see paper)
    25% identity, 77% coverage of query (43.9 bits)

1t5gA Arginase-f2-l-arginine complex
    25% identity, 81% coverage of query (43.5 bits)

1t5fA Arginase i-aoh complex
    25% identity, 81% coverage of query (43.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory