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Searching for up to 100 curated homologs for RR42_RS15740 FitnessBrowser__Cup4G11:RR42_RS15740 (159 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

cpsI polysaccharide capsule synthesis protein CpsI from Streptococcus iniae (see paper)
    33% identity, 76% coverage of query (67.8 bits)

Y3034_MYCTU / O53281 Probable acetyltransferase Rv3034c; Peroxisome homeostasis protein Rv3034c; EC 2.3.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    34% identity, 75% coverage of query (67.0 bits)

Q5HCZ5 galactoside O-acetyltransferase (EC 2.3.1.18) from Staphylococcus aureus (see paper)
    35% identity, 74% coverage of query (60.8 bits)

5u2kA / Q5HCZ5 Crystal structure of galactoside o-acetyltransferase complex with coa (h3 space group)
    35% identity, 74% coverage of query (60.5 bits)

4isxA / Q18A66 The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
    33% identity, 72% coverage of query (60.1 bits)

GB|CAA68625.1 nodulation protein L from Rhizobium leguminosarum bv. viciae (see paper)
    34% identity, 74% coverage of query (60.1 bits)

RF|NP_435661.1 nodulation protein L from Sinorhizobium meliloti (see paper)
    33% identity, 75% coverage of query (59.3 bits)

4mzuF / Q12KT8 Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
    33% identity, 79% coverage of query (58.9 bits)

Build an alignment

Build an alignment for RR42_RS15740 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

fdtD / Q12KT8 bifunctional ketoisomerase / N-acetyltransferase FdtD subunit (EC 5.3.2.3; EC 2.3.1.197) from Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) (see paper)
    28% identity, 79% coverage of query (58.9 bits)

WbbJ / b2033 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ from Escherichia coli K-12 substr. MG1655 (see paper)
    32% identity, 74% coverage of query (56.2 bits)

3igjC / A0A6L7H2S4 Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
    33% identity, 77% coverage of query (55.8 bits)

Q6F4D7 serine O-acetyltransferase (EC 2.3.1.30) from Thermus thermophilus HB8 (see paper)
    28% identity, 83% coverage of query (55.5 bits)

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans
    31% identity, 79% coverage of query (55.1 bits)

fdtC / Q6T1W7 dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose 3-N-acetyltransferase (EC 2.3.1.197) from Aneurinibacillus thermoaerophilus (see 2 papers)
FDTC_ANETH / Q6T1W7 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase; dTDP-D-Fucp3N acetylase; EC 2.3.1.197 from Aneurinibacillus thermoaerophilus (see paper)
Q6T1W7 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase (EC 2.3.1.197) from Aneurinibacillus thermoaerophilus (see paper)
    30% identity, 83% coverage of query (52.4 bits)

1kruA / P07464 Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
    25% identity, 82% coverage of query (51.6 bits)

LacA / b0342 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lacA / P07464 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli (strain K12) (see 19 papers)
THGA_ECOLI / P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 5 papers)
P07464 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli (see paper)
    25% identity, 82% coverage of query (51.6 bits)

qdtC / Q6TFC6 dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose:acetyl-CoA acetyltransferase from Thermoanaerobacterium thermosaccharolyticum (see paper)
    26% identity, 73% coverage of query (51.6 bits)

3fsbA / Q6TFC6 Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-quinovose (see paper)
    26% identity, 73% coverage of query (51.6 bits)

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a
    25% identity, 82% coverage of query (51.6 bits)

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal
    25% identity, 82% coverage of query (51.6 bits)

3fscA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-fucose
    26% identity, 73% coverage of query (51.6 bits)

3fs8A Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d- glucose n-acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with acetyl-coa
    26% identity, 73% coverage of query (51.6 bits)

WcaF / b2054 colanic acid biosynthesis acetyltransferase WcaF from Escherichia coli K-12 substr. MG1655 (see 7 papers)
wcaF / P0ACD2 colanic acid biosynthesis acetyltransferase WcaF from Escherichia coli (strain K12) (see 6 papers)
    29% identity, 79% coverage of query (51.2 bits)

D9E73_16825 / A0A0A8J6R7 dTDP-viosamine (S)-3-hydroxybutanoyltransferase from Escherichia coli (see paper)
    32% identity, 75% coverage of query (50.8 bits)

wbaL / Q00480 α-L-Rha-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Gal-PP-Und 2IV-O acetyltransferase (EC 2.3.1.303) from Salmonella enterica (see 6 papers)
    25% identity, 92% coverage of query (48.1 bits)

Q46674 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase (EC 2.3.1.45) from Escherichia coli (see paper)
    25% identity, 94% coverage of query (47.8 bits)

wckD / Q93NQ3 sialate O-acetyltransferase from Escherichia coli (see 7 papers)
    28% identity, 90% coverage of query (47.4 bits)

8vr7E / Q1QD51 Crystal structure of the pcryo_0619 n-acetyltransferase from psychrobacter cryohalolentis k5 int he presence of acetyl coenzyme a
    28% identity, 82% coverage of query (46.6 bits)

8vr7B Crystal structure of the pcryo_0619 n-acetyltransferase from psychrobacter cryohalolentis k5 int he presence of acetyl coenzyme a
    28% identity, 82% coverage of query (46.6 bits)

8vr6A Crystal structure of the pcryo_0619 n-acetryltransferase from psychrobacter cryohalolentis k5 in the presence of coa-disulfide
    28% identity, 82% coverage of query (46.6 bits)

B2RGM6 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Porphyromonas gingivalis (see paper)
    29% identity, 73% coverage of query (46.2 bits)

vioB / Q9XCW3 dTDP-4-amino-4,6-dideoxy-D-glucose acetyltransferase (EC 2.3.1.209) from Escherichia coli (see 2 papers)
VIOB_ECOLX / Q9XCW3 dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase; EC 2.3.1.209 from Escherichia coli (see paper)
Q9XCW3 dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase (EC 2.3.1.209) from Escherichia coli (see paper)
    26% identity, 81% coverage of query (45.1 bits)

3dhoA Structure of streptogramin acetyltransferase in complex with an inhibitor
    25% identity, 90% coverage of query (45.1 bits)

1kk4A Crystal structure of vat(d) in complex with acetyl-coa
    25% identity, 90% coverage of query (44.7 bits)

1mrlA Crystal structure of streptogramin a acetyltransferase with dalfopristin
    25% identity, 90% coverage of query (44.7 bits)

1khrA / P50870 Crystal structure of vat(d) in complex with virginiamycin and coenzyme a (see paper)
    25% identity, 90% coverage of query (44.7 bits)

P50870 Streptogramin A acetyltransferase; Virginiamycin acetyltransferase D; Vat(D); EC 2.3.1.- from Enterococcus faecium (Streptococcus faecium)
    25% identity, 90% coverage of query (44.7 bits)

3nz2J / Q9KLB0 Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
    27% identity, 75% coverage of query (43.5 bits)

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
    27% identity, 75% coverage of query (43.5 bits)

6x3cE Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47)
    23% identity, 91% coverage of query (43.1 bits)

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
    28% identity, 72% coverage of query (43.1 bits)

6x3cA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47)
    23% identity, 91% coverage of query (43.1 bits)

6x3jA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f0224 (46)
    23% identity, 91% coverage of query (43.1 bits)

4hurA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with acetyl coenzyme a
    23% identity, 91% coverage of query (43.1 bits)

4husA / P26839 Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
    23% identity, 91% coverage of query (43.1 bits)

7txsA X-ray structure of the viob n-aetyltransferase from acinetobacter baumannii in the presence of a reaction intermediate
    29% identity, 87% coverage of query (42.7 bits)

7txqA X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in the present of tdp and acetyl-coenzymea
    29% identity, 87% coverage of query (42.7 bits)

7txpA / A0A334FGR6 X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in complex with tdp-4-amino-4,6-dideoxy-d-glucose (see paper)
    29% identity, 87% coverage of query (42.7 bits)

7s45A Crystal structure of an n-acetyltransferase, c80t mutant, from helicobacter pullorum in the presence of acetyl coenzyme a and dtdp
    28% identity, 79% coverage of query (41.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory